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| Patent # | Description |
|---|---|
| 2017/0275287 |
NOVEL N2, N4, N7, 6-TETRASUBSTITUTED PTERIDINE-2,4,7-TRIAMINE AND 2, 4, 6,
7-TETRASUBSTITUTED PTERIDINE... Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and... |
| 2017/0275286 |
Novel Sulfonimidoylpurinone Compounds and Derivatives for the Treatment
and Prophylaxis of Virus Infection The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or... |
| 2017/0275285 |
INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of... |
| 2017/0275284 |
Macrocyclic Compounds as IRAK1/4 Inhibitors and Uses Thereof The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors. |
| 2017/0275283 |
INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The... |
| 2017/0275282 |
FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof... |
| 2017/0275281 |
IMIDAZO[4,5-C]PYRIDINE DERIVED SSAO INHIBITORS A compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereof and the use of the same in therapy: wherein Z, Y, R.sup.1, W, V, and... |
| 2017/0275280 |
NOVEL CAPSAZEPINE ANALOGS FOR THE TREATMENT OF CANCER AND OTHER
PROLIFERATIVE DISEASES The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using... |
| 2017/0275279 |
SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the... |
| 2017/0275278 |
Mammalian and Bacterial Nitric Oxide Synthase Inhibitors Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions... |
| 2017/0275277 |
NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC
ANTAGONIST ACTIVITIES The present invention relates to novel compounds having .beta.2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions... |
| 2017/0275276 |
N-PYRIDINYL ACETAMIDE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALING
PATHWAY Disclosed are compounds useful as inhibitors of the Wnt signalling pathway. Specifically, inhibitors of Porcupine (Porcn) are contemplated by the invention. In... |
| 2017/0275275 |
BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to... |
| 2017/0275274 |
ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE
O-ACYLTRANSFERASE 2 The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors... |
| 2017/0275273 |
ESTROGEN RECEPTOR MODULATORS AND USES THEREOF Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds... |
| 2017/0275272 |
6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS The present invention provides compounds of Formula (I): ##STR00001## wherein all variables are as defined in the specification, and compositions comprising any... |
| 2017/0275271 |
6-(5-HYDROXY-1H-PYRAZOL-1-YL)NICOTINAMIDE INHIBITORS OF PHD The present invention provides compounds of the formula: ##STR00001## which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for... |
| 2017/0275270 |
BENZYL SUBSTITUTED INDAZOLES Compounds of formula (I) and their use as pharmaceuticals. ##STR00001## |
| 2017/0275269 |
BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS Compounds of formula (I) and their use as pharmaceuticals. ##STR00001## |
| 2017/0275268 |
HETEROARYL SUBSTITUTED INDAZOLES Compounds of formula (I), which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals. |
| 2017/0275267 |
SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF
CANCER Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or... |
| 2017/0275266 |
HISTONE DEMETHYLASE INHIBITORS Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising... |
| 2017/0275265 |
4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS The disclosures herein relate to novel compounds of formula wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and n are defined herein, and their use in treating,... |
| 2017/0275264 |
CARBAMATE/UREA DERIVATIVES The invention relates to compound of the formula I ##STR00001## or a salt thereof, wherein the substituents are as defined in the specification; to its... |
| 2017/0275263 |
Compounds for the treatment of HPV-induced carcinoma A compound of Formula 1 ##STR00001## wherein, X represents an alkyl, alkylene, alkenyl, alkenylene, alkynyl or alkynylene group, optionally having at least... |
| 2017/0275262 |
CYCLOPROPANE DERIVATIVES IN FLAVOR AND FRAGRANCE COMPOSITIONS The present invention relates to novel cyclopropane derivatives represented by Formula I: ##STR00001## wherein R represents a hydrocarbon group containing 1-20... |
| 2017/0275261 |
1,3,4-THIADIAZOLES HAVING A HERBICIDAL ACTIVITY, THEIR AGRONOMICAL
COMPOSITIONS AND RELATIVE USE The present invention relates to new thiadiazoles having general formula (I): ##STR00001## and their use as herbicides. |
| 2017/0275260 |
ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS The present disclosure relates to compounds of formula I that are useful as modulators of .alpha.7 nAChR, compositions comprising such compounds, and the use... |
| 2017/0275259 |
CRYSTALLINE(2S,4R)-5-(5'-CHLORO-2'-FLUORO-[1,1'-BIPHENY]-4-YL)-2-(ETHOXYME-
... In one aspect, the invention relates to a crystalline form of the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, having neprilysin ... |
| 2017/0275258 |
METHOD FOR PRODUCING EPOXY COMPOUND CONTAINING HYDROGEN PEROXIDE
STABILIZER The present invention provides a method for producing an epoxy compound by a reaction of an olefin compound with hydrogen peroxide, wherein the epoxy compound... |
| 2017/0275257 |
2-THIOPYRIMIDINONES Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions. |
| 2017/0275256 |
COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS The present invention relates to compounds of Formula I, ##STR00001## a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate... |
| 2017/0275255 |
CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID The present invention relates to crystalline form of Eltrombopag free acid and its process for preparation. ##STR00001## |
| 2017/0275254 |
PYRAZOLES The invention relates to pyrazole derivatives which are NMDA NR2B receptor inhibitors, useful in treating central nervous system diseases. ##STR00001## |
| 2017/0275253 |
BENZAZEPINE SULFONAMIDE COMPOUNDS This invention relates to novel benzazepine sulfonamide compounds of the formula ##STR00001## wherein R.sup.4 or R.sup.5 is --SO.sub.2--NR.sup.7R.sup.8... |
| 2017/0275252 |
ASYMMETRIC BISAMINOQUINOLINES AND BISAMINOQUINOLINES WITH VARIED LINKERS
AS AUTOPHAGY INHIBITORS FOR CANCER AND... The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit... |
| 2017/0275251 |
Malate salt of
N-(4-phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and
crystalline forms... Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy- clo-propane-1,1-dicarboxamide, including a (L)-malate... |
| 2017/0275250 |
PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND
ITS USE Piperidine compounds and pharmaceutically useful salts thereof, a pharmaceutical composition including an effective amount of the racemic or enantiomerically... |
| 2017/0275249 |
SMALL LIPOPEPTIDOMIMETIC INHIBITORS OF GHRELIN O-ACYL TRANSFERASE Compositions and methods are disclosed that relate to small molecule lipopeptidomimetic inhibitors of mammalian ghrelin O-acyl transferase (GOAT). Compounds of... |
| 2017/0275248 |
Carbondisulfide Derived Zwitterions Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be... |
| 2017/0275247 |
METHOD FOR PRODUCING METHIONINE A method for producing methionine involves contacting 2-amino-4-(methylthio)butanenitrile with water in the presence of an oxide catalyst containing cerium.... |
| 2017/0275246 |
NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor... |
| 2017/0275245 |
Modularized System and Method for Urea Production Using Stranded Natural
Gas A modular system and method for producing urea from stranded natural gas includes removal of foreign particulate matter to obtain a substantially homogeneous... |
| 2017/0275244 |
C7-Fluoro Substituted Tetracycline Compounds The present invention is directed to a compound represented by Structural Formula (A): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables... |
| 2017/0275243 |
Lipids and Lipid Compositions for the Delivery of Active Agents This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R.sup.A, R.sup.B, R.sub.2 and R.sub.4 are defined... |
| 2017/0275241 |
TRANSESTERIFICATION REACTION BY MEANS OF IRON CATALYST Provided is a catalyst for transesterification reactions, which contains an iron salen complex. Also provided is a method for producing an ester compound,... |
| 2017/0275240 |
METHOD FOR PREPARING CHIRAL gamma-SECONDARY AMINO ALCOHOL A method for preparing chiral .gamma.-secondary amino alcohol includes: adding into a solvent an acid addition salt of .beta.-secondary amino ketone... |
| 2017/0275239 |
COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND
COMPOSITIONS INLUDING SUCH COMPOUNDS Antidegradant compounds are disclosed, and methods of making them, that are represented by the formula I: ##STR00001## wherein each X is independently selected... |
| 2017/0275238 |
METHODS OF MAKING COMPOUNDS AND MIXTURES HAVING ANTIDEGRADANT AND
ANTIFATIGUE EFFICACY Methods of making antidegradant compounds are disclosed in which a p-phenylenediamine is reacted with a diol to obtain mixtures comprising the antidegradant... |
| 2017/0275237 |
COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND
COMPOSITIONS INCLUDING SAID COMPOUNDS A compound represented by the formula: ##STR00001## wherein each R is independently selected from the group consisting of (i) substituted or unsubstituted... |
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