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| Patent # | Description |
|---|---|
| 2017/0305900 |
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001## |
| 2017/0305899 |
ANTIBIOTIC COMPOUNDS AND COMPOSITIONS, AND METHODS FOR IDENTIFICATION
THEREOF Disclosed herein are compounds and methods for inhibiting bacterial DNA repair enzymes, including AddAB and RecBCD helicase-nucleases. Pharmaceutical... |
| 2017/0305898 |
Composition and Method for Treating Metabolic Disorders Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of... |
| 2017/0305897 |
BENZIMIDAZOLE-PROLINE DERIVATIVES The present invention relates to compounds of the formula (II) ##STR00001## wherein Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b and (R.sup.5).sub.n... |
| 2017/0305896 |
PYRIMIDINONE COMPOUND A pyrimidinone compound represented by formula (1): ##STR00001## wherein: A.sup.1 represents a nitrogen atom or a CR.sup.4; A.sup.2 represents a nitrogen atom... |
| 2017/0305895 |
SUBSTITUTED AMINOTHIAZOLES FOR THE TREATMENT OF TUBERCULOSIS Disclosed ore substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the... |
| 2017/0305894 |
PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE
THEREOF Provided herein are compounds of Formula (I) and compositions useful in increasing PPARS activity. The compounds and compositions provided herein are useful... |
| 2017/0305893 |
HETEROCYCLIC COMPOUNDS AS DCTPP1 MODULATORS The invention relates to compounds of formula I, or a pharmaceutically-acceptable salt thereof. The present invention also relates to pharmaceutical... |
| 2017/0305892 |
NOVEL AMINOPYRIDINE COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN PRENYLATION A compound for use in the treatment and/or prevention of diseases or disorders wherein an inhibition of protein prenylation is required, which is alternatively... |
| 2017/0305891 |
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, m, Z, G.sup.1, R.sup.2, and R.sup.3 have any of the values defined in... |
| 2017/0305890 |
METHODS OF TREATING CANCER The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need... |
| 2017/0305889 |
METHODS OF TREATING CANCER The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need... |
| 2017/0305888 |
NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic... |
| 2017/0305887 |
ANTI-ENDOTHELIAL LIPASE COMPOUNDS AND METHODS OF USING THE SAME IN THE
TREATMENT AND/OR PREVENTION OF... Endothelial Lipase (EL) inhibitors and methods of using such inhibitors for treating conditions implicating EL are provided herein. The present invention meets... |
| 2017/0305886 |
PLANT GROWTH-PROMOTION AGENT AND METHOD FOR PROMOTING PLANT GROWTH The present invention concerns: a plant growth-promoting agent comprising a compound represented by Formula (I) or a salt thereof: ##STR00001## wherein Ar.sup.1... |
| 2017/0305885 |
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described... |
| 2017/0305884 |
PREPARATION METHOD FOR BEMACICLB Disclosed are an intermediate of bemaciclib or abemaciclib and a preparation method therefor. The preparation method comprises condensation, amidine reaction,... |
| 2017/0305883 |
Compositions and Methods for Inhibiting BMP The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and... |
| 2017/0305882 |
BENZYL SUBSTITUTED INDAZOLES AS BUB1 KINASE INHIBITORS Compounds of formula (I) and their use as pharmaceuticals. ##STR00001## |
| 2017/0305881 |
NON-PLATINUM METAL COMPLEXES FOR EXCIMER BASED SINGLE DOPANT WHITE ORGANIC
LIGHT EMITTING DIODES Complexes and devices, such as organic light emitting devices and full color displays, including a compound of the formula wherein: M is Pd.sup.2+, Ir.sup.+,... |
| 2017/0305880 |
SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables... |
| 2017/0305879 |
PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID
ESTERS The invention relates to an industrial scale process for the preparation of a compound of general formula (I): (Formula (I)) wherein R.sup.1, R.sup.2 and... |
| 2017/0305878 |
sGC STIMULATORS Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be... |
| 2017/0305877 |
Processes for the Preparation of Rotigotine and Intermediates Thereof The present invention provides processes for the preparation of a compound of Formula 2 or a salt thereof, wherein R.sup.1 is selected from the group... |
| 2017/0305876 |
7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS,
AND METHODS RELATED THERETO In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided... |
| 2017/0305875 |
2-(ALKOXY OR ARYLOXY CARBONYL)-4-METHYL-6-(2,6,6-TRIMETHYLCYCLOHEX-1-
ENYL)HEX-2-ENOIC ACID COMPOUNDS, ITS... Compounds of the formula 1 ##STR00001## wherein, R is hydrogen, alkyl or substituted alkyl, aryl or substituted aryl, are useful intermediates in the synthesis... |
| 2017/0305874 |
Diastereoselective Synthesis of (.+-.)-Epianastrephin, (.+-.)-Anastrephin
and Analogs Thereof A process for the synthesis of trans-fused .gamma.-lactones having Formula (IV) from substituted cyclic ketones having Formula (I). A diastereoselective... |
| 2017/0305873 |
FORMATION OF 2,5-FURAN DICARBOXYLIC ACID FROM ALDARIC ACIDS The disclosure relates to a method for forming 2,5-furan dicarboxylic acid (FDCA) from aldaric acids. The aldaric acids are dehydrating and cyclizing via acid... |
| 2017/0305872 |
IMPROVED 5-HYDROXYMETHYLFURFURAL PRODUCTION USING A MULTI-FLUORINATED
ALCOHOL COMPOUND The present invention relates to a process for producing a water cleavage product, a water cleavage product thus produced, a process for producing at least one... |
| 2017/0305871 |
LONG-CHAINED MONO AND DI-ESTERS OF 2,5-DI(HYDROXYMETHYL)TETRAHYDROFURAN,
USE AND PRODUCTION THEREOF The present invention relates to novel mono- and diesters of 2,5-di(hydroxymethyl)tetrahydrofuran, processes for their preparation by esterification in the... |
| 2017/0305870 |
METHOD FOR PRODUCING 3-CHLORO-2-HYDROXYPROPYL (METH)ACRYLATE AND METHOD
FOR PRODUCING GLYCIDYL (METH)ACRYLATE To reduce formation of side products and to enhance a selectivity rate in a method for producing 3-chloro-2-hydroxypropyl (meth)acrylate and in a method for... |
| 2017/0305869 |
HETEROCYCLIC IONIC LIQUIDS An ionic liquid compound includes an azepanium-functionalized cation. An electrochemical cell electrolyte for an electrical energy storage device includes the... |
| 2017/0305868 |
ARYLALKYL-AND ARYLOXYALKYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING
COMPOUNDS The present invention relates to the compound of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, as well as compositions containing the... |
| 2017/0305867 |
ROSUVASTATIN CALCIUM AND PROCESS FOR PRODUCING INTERMEDIATE THEREOF An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively... |
| 2017/0305866 |
Histone Deacetylase 6 Selective Inhibitors for the Treatment of Bone
Disease This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule... |
| 2017/0305865 |
PROCESS FOR SYNTHESIZING ERGOTHIONEINE AND RELATED COMPOUNDS The invention provides a process for synthesising a compound of formula V ##STR00001## wherein: n is 0, 1 or 2; and R is H or ##STR00002## or a physiologically... |
| 2017/0305864 |
HETEROCYCLIC COMPOUNDS AS PESTICIDES The present application relates to the use of heterocyclic compounds for controlling animal pests including arthropods, insects and nematodes, to novel... |
| 2017/0305863 |
N-((HET) ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA
KALLIKREIN INHIBITORS The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the... |
| 2017/0305862 |
METHYL-1H-PYRAZOLE ALKYLAMINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST
PAIN The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more... |
| 2017/0305861 |
HETEROARYL COMPOUNDS COMPRISING NITROGEN AND USE THEREOF The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect... |
| 2017/0305860 |
PROCESS FOR THE PREPARATION OF ESLICARBAZEPINE AND ESLICARBAZEPINE ACETATE An improved process for the preparation of Elsicarbazepine and Eslicarbazepine acetate by means of chiral Ruthenium catalysts is provided. |
| 2017/0305858 |
AMORPHOUS FORM OF LOMITAPIDE MESYLATE Provided is novel amorphous form of lomitapide mesylate salt and process for preparation thereof. |
| 2017/0305857 |
N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in... |
| 2017/0305856 |
Novel diacylated and mono-acylated alkylated imino sugars exhibiting
glucosidase inhibition and their method of use Described herein are alkylated imino sugars derivatives having a disease-modifying action in the treatment of diseases associated with glucosidase activity... |
| 2017/0305855 |
STERICALLY HINDERED AMINE AND OXYALKYL AMINE LIGHT STABILIZERS Compounds having hindered amine and oxyalkyl amine light stabilizers can mitigate the adverse effects of actinic radiation, such as visible and ultraviolet... |
| 2017/0305854 |
NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND AN ORGANIC
ELECTROLUMINESCENT DEVICE COMPRISING THE SAME The present disclosure relates to novel organic electroluminescent compounds and an organic electroluminescent device comprising the same. By using the organic... |
| 2017/0305853 |
THERMOSETTING RING-OPENING METATHESIS POLYMERIZATION MATERIALS WITH
THERMALLY DEGRADABLE LINKAGES The present invention provides a new class of thermosetting ring-opening metathesis polymerization materials based on norbornene and oxanorbornene ... |
| 2017/0305852 |
Tetracyline Compounds The present invention is directed to a compound represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables... |
| 2017/0305851 |
PHOTOIRRADIATION DEVICE, PHOTOREACTION METHOD USING THE SAME, AND METHOD
FOR PRODUCING LACTAM Provided are a photoirradiation device equipped with: a first optically transparent container for covering a light-emitting body provided with light-emitting... |
| 2017/0305850 |
PROCESS FOR PURIFYING ASTAXANTHIN AND CANTHAXANTHIN The present invention relates to a process for purifying the xanthophylls astaxanthin and canthaxanthin. The process comprises suspending the xanthophyll in an... |
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