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Patent # Description
2017/0349621 TRIAZOLE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective,...
2017/0349620 Novel Diterpene Glycosides, Compositions and Purification Methods
Novel diterpene glycosides and methods for purifying the same are provided herein. In addition, compositions comprising the novel diterpene glycosides, as well...
2017/0349619 ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS
An embodiment of the present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a...
2017/0349618 DISACCHARIDE SYNTHETIC LIPID COMPOUNDS AND USES THEREOF
Essentially pure compounds of the formulas (I) to (V) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided....
2017/0349617 Novel compositions and methods for the dissolution and depolymerization of lignin
The present invention provides for a method for dissolving and/or depolymerizing lignin comprising: (a) providing a composition comprising lignin, (b)...
2017/0349616 METAL COMPLEXES
The present invention provides novel metal complexes, methods of making, and methods of using the same.
2017/0349615 PLATINUM COMPOUNDS HAVING A HETEROCYCLE LIGAND, NANOPARTICLES, AND USES THEREOF
The present disclosure relates to novel platinum compositions having a heterocycle ligand and nanoparticles and methods using such compositions, e.g. for...
2017/0349614 ORGANOSILICON COMPOUND CONTAINING ISOCYANATE GROUP, PROCESS FOR PRODUCING SAME, ADHESIVE, PRESSURE-SENSITIVE...
The purpose of the present invention is to obtain an organosilicon compound containing an isocyanate group by thiol-ene addition reaction from a corresponding...
2017/0349613 Method for Depolymerising Oxygenated Polymer Materials
The present invention concerns a method for depolymerizing oxygenated polymer materials and the use of said method in the recycling of plastic materials and...
2017/0349612 FUNCTIONALIZED PARTICLES HAVING MODIFIED PHASES
Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a...
2017/0349611 DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2017/0349610 PROCESS FOR PREPARING ALKYL-INDIUM COMPOUNDS AND THE USE THEREOF
The invention relates to a process for the cost-effective and environmentally responsible preparation of alkyl indium sesquichloride in high yield and with...
2017/0349609 NOVEL CRYSTALLINE FORM OF CEFAMANDOLE NAFATE COMPOUND, PREPARATION AND PREPARING METHOD THEREOF
A novel crystalline form is defined by diffraction angle 2.theta..degree. of X-ray powder diffraction pattern and characteristic peak of differential scanning...
2017/0349608 NOVEL CRYSTALLINE FORM OF RIFAXIMIN AND PROCESS FOR ITS PREPARATION
A novel crystalline form of rifaximin and process for its preparation are described. A pharmaceutical composition comprising crystalline rifaximin is also...
2017/0349607 COMPOUNDS ACTIVE TOWARDS BROMODOMAINS
Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy. ##STR00001##
2017/0349606 ANTIPARASITIC COMPOSITIONS AND METHODS UTILIZING SUBSTITUTED ...
The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure...
2017/0349605 CONDENSED HETEROCYCLIC COMPOUND
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention...
2017/0349604 SUBSTITUTED PYRIDINE COMPOUNDS HAVING HERBICIDAL ACTIVITY
The present invention provides a substituted pyridine compound of the formula I ##STR00001## or an agriculturally suitable salt or N-oxide thereof, wherein the ...
2017/0349603 Efficient Method for Producing and Purifying Anhydrous Sugar Alcohol
The present invention relates to a method of producing and purifying a high-purity anhydrosugar alcohol in high yield by a simple process and apparatus, the...
2017/0349602 PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE...
The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an...
2017/0349601 IMPROVED PROCESS FOR THE PREPARATION OF LURASIDONE AND ITS INTERMEDIATE
The present invention provides an improved process for preparation of the substantially pure ...
2017/0349600 INDOLINE ANALOGS AND USES THEREOF
Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided. Also provided are pharmaceutical compositions of the indoline...
2017/0349599 IMIDAZO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
The invention provides substituted imidazo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits,...
2017/0349598 PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits,...
2017/0349597 IMIDAZOPYRIMIDINE AND IMIDAZOTRIAZINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising...
2017/0349596 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions...
2017/0349595 SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND ABL AND METHODS OF USE
The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group...
2017/0349594 BIARYL DERIVATIVE AS GPR120 AGONIST
The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical...
2017/0349593 BTK INHIBITORS
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to...
2017/0349592 POLYMORPHIC SUBSTANCE OF YONKENAFIL HYDROCHLORIDE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND USE THEREOF
The present application discloses an A-type polymorphic substance of yonkenafil hydrochloride and a preparation method, a composition and use thereof. The...
2017/0349591 PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE...
The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory...
2017/0349590 MEROPENEM DERIVATIVES AND USES THEREOF
The present invention provides novel derivative of .beta.-lactam antibiotics, such as meropenem. The inventive compounds include compounds of Formula (I), and...
2017/0349589 Substituted Indoles
The invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have any of the values defined...
2017/0349588 1H-1,8-NAPHTHYRIDIN-2-ONES AS ANTI PROLIFERATIVE COMPOUNDS
The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: ...
2017/0349587 SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG
The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of...
2017/0349586 [9,10-DIMETHOXY-3-(2-METHYLPROPYL)-1H,2H,3H,4H,6H,7H,11BH-PYRIDO-[2,1-A]IS- OQUINOLIN-2-YL]METHANOL AND...
Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: ##STR00001## wherein R.sub.1 is...
2017/0349585 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Compounds of Formula I: ##STR00001## are HIV reverse transcriptase inhibitors, wherein R.sup.1, R.sup.2, R.sup.E, L, M and Z are defined herein. The compounds of...
2017/0349584 PROCESS FOR PREPARING N-(5-(3-(7-(3-FLUOROPHENYL)-3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1H-INDAZOL-5-Y- ...
Provided herein is a synthetic process for preparing a compound of Formula (1). ##STR00001## The disclosure also provides useful intermediates and salts,...
2017/0349583 QUINOLINE DERIVATIVE
A compound represented by general formula (I) and having a quinoline skeleton has a strong Axl inhibitory activity, and therefore the compound can be an agent...
2017/0349582 HETEROCYCLIC DERIVATIVES AS RORGAMMA MODULATORS
The present invention provides novel compounds of formula (I) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the...
2017/0349581 PESTICIDALLY ACTIVE TETRACYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and...
2017/0349580 DIHYDROINDOLIZINONE DERIVATIVE
A compound represented by general formula (I) (wherein all symbols are as defined in the description) or a salt, solvate, N-oxide form or prodrug thereof is a...
2017/0349579 PYRROLO[2,3-B]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-B]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS
The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are...
2017/0349578 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, A, and G are defined in the ...
2017/0349577 3-(6-ALKOXY-5-CHLOROBENZO[D]ISOXAZOL-3-YL)PROPANOIC ACID USEFUL AS KYNURENINE MONOOXYGENASE INHIBITORS
Compound of formula (I) ##STR00001## wherein: R.sup.1 is heteroaryl either unsubstituted or substituted by methyl, ethyl, halo or .dbd.O; and R.sup.2 is H,...
2017/0349576 HETEROARYL SUBSTITUTED PYRIDINES AND METHODS OF USE
The invention discloses compounds of Formula I, ##STR00001## wherein X.sup.1, X.sup.2, R.sup.1, and R.sup.2 are as defined herein. The present invention relates...
2017/0349575 NOVEL CHEMOKINE CXCR1 AND CXCR2 RECEPTOR ANTAGONIST COMPOUNDS, AND USE THEREOF IN THE TREATMENT OF...
Novel chemokine CXCR1 and CXCR2 receptor antagonist compounds of general formula (I) are described. Also described, are pharmaceutical compositions including...
2017/0349574 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where X, R.sup.a, R.sup.b, R.sup.2, and R.sup.7 are as defined in the ...
2017/0349573 HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES
The present invention provides compounds which antagonize hedgehog signaling and inhibit HDAC activity. The compounds can be used in methods of treating...
2017/0349572 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such...
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