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Patent # Description
2017/0355792 OLEFIN POLYMERIZATION CATALYST CARRIER, SOLID CATALYST COMPONENT AND USE THEREOF
Provided is an olefin polymerization catalyst carrier with a general structure formula of Mg(OR.sup.I).sub.n(OR.sup.II).sub.2-n, wherein: 0.ltoreq.n.ltoreq.2,...
2017/0355791 METHODS OF CHANGING POLYOLEFIN PRODUCTION RATE WITH THE COMPOSITION OF THE INDUCED CONDENSING AGENTS
Polyolefin polymerization performed by contacting in a reactor an olefin monomer and optionally a comonomer with a catalyst system in the presence of induced...
2017/0355790 METHODS OF CHANGING POLYOLEFIN PRODUCTION CONDITIONS TO MITIGATE SMALL GELS IN A POLYOLEFIN ARTICLE
The number of small gels that form in polyolefin thin films may be reduced by altering certain production parameters of the polyolefin. In some instances, the...
2017/0355789 POLYMERS INCLUDING A METHYLENE BETA-KETOESTER AND PRODUCTS FORMED THEREFROM
The present teachings are directed at 1,1-disubstituted alkene monomers (e.g., methylene beta-ketoester monomers), methods for producing the same,...
2017/0355788 POLYETHYLENE COMPOSITION HAVING HIGH STRESS CRACKING RESISTANCE
A polyethylene composition made from or containing a polyethylene, having the following features: 1) a density from about 0.930 to about 0.945 g/cm.sup.3,...
2017/0355787 PROCESS FOR THE PREPARATION OF A POLYOLEFIN HAVING ONE OR MULTIPLE END-FUNCTIONALIZED BRANCHES
The present invention relates to a process for the preparation of branched polyolefins having end-functionalized branches via the copolymerization of an olefin...
2017/0355786 PROCESS FOR THE PREPARATION OF A BRANCHED POLYOLEFIN
The present invention relates to a process for the preparation of a branched polyolefin via the polymerization of an olefin monomer and an alefin monomer...
2017/0355785 PEROXIDE VULCANIZATION OF RUBBER LATEXES
A peroxide formulation includes at least one peroxide and at least one compound having a secondary amine group selected from amino acids, such as arginine,...
2017/0355784 ORGANIC ACID CARBOHYDRATE BINDERS AND MATERIALS MADE THEREWITH
A binder comprising a polymeric binder comprising the products of a carbohydrate reactant and organic acid is disclosed. The binder is useful for consolidating...
2017/0355783 EFFICIENT PROCESS FOR PREPARING AN ESTER OF A CELLULOSE ETHER
A process for producing an esterified cellulose ether can be efficiently be produced by reacting a moist cellulose ether having a water content of at least 10...
2017/0355782 PROCESS FOR PRODUCING A WATER-SOLUBLE CELLULOSE DERIVATIVE HAVING A REDUCED CONTENT OF WATER-INSOLUBLE PARTICLES
A process for producing a water-soluble cellulose derivative of a reduced content of water-insoluble particles comprises the steps of a) reacting cellulose...
2017/0355781 ANTIBODIES TO CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE (CEACAM)
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of...
2017/0355780 ANTI-COAGULATION FACTOR XI ANTIBODIES
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by...
2017/0355779 METHODS OF USING BISPECIFIC ANTIGEN-BINDING CONSTRUCTS TARGETING HER2
Described herein methods of using antigen-binding constructs to treat HER2+ tumors in a subject such as breast, lung, or head and neck tumors. In some aspects,...
2017/0355778 COMPOSITIONS AND METHODS OF TREATING TUMORS
Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are...
2017/0355777 Monoclonal Antibodies, Compositions and Methods for Detecting Mucin-like Protein (MLP) as a Biomarker for...
In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker...
2017/0355776 USE OF CHIMERIC ANTIGEN RECEPTOR MODIFIED CELLS TO TREAT CANCER
The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using chimeric antigen receptor (CAR)...
2017/0355775 Monoclonal Antibodies and Methods of Use
This disclosure relates to immunogens and monoclonal antibodies useful in the identification and/or treatment of cancer cells, including those of the dog. In...
2017/0355774 ANTI-GITR ANTIBODIES AND USES THEREOF
Provided herein are antibodies, and antigen-binding fragments thereof that specifically bind glucocorticoid-induced tumor necrosis factor receptor (GITR) and...
2017/0355773 ANTI-TNFRSF25 ANTIBODIES
Anti-TNFRSF25 antibodies and variants thereof, including those that bind to an epitope in the region of amino acids 48-71, are disclosed. Also contemplated are...
2017/0355771 ANTI-GPIIB/IIIA ANTIBODIES AND USES THEREOF
Antibodies and antibody fragments that specifically bind to glycoprotein IIb/IIIa (GPIIb/IIIa) are disclosed. Chimeric molecules comprising such antibodies or...
2017/0355770 PD-L1 Specific Monoclonal Antibodies for Disease Treatment and Diagnosis
The present invention relates to compositions and methods for immunotherapy of a subject afflicted with diseases such as cancer, an infectious disease, or a...
2017/0355769 ANTI-B7-H3 ANTIBODIES AND ANTIBODY DRUG CONJUGATES
The invention relates to B7 homology 3 protein (B7-H3) antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said...
2017/0355768 COMBINATION OF ANTI-CS1 AND ANTI-PD1 ANTIBODIES TO TREAT CANCER (MYELOMA)
The invention described herein relates to therapeutic dosing regimens and combinations thereof for use in enhancing the therapeutic efficacy of anti-CS1...
2017/0355767 BISPECIFIC ANTIBODIES AGAINST CD3 AND CD20
Bispecific antibodies directed to CD3 and CD20 and uses of such bispecific antibodies, in particular use thereof in the treatment of diseases in which specific...
2017/0355766 METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS IN IGG4-RELATED DISEASES
The present disclosure relates to immunoglobulins that bind Fc.gamma.RIIb+ B cells and coengage CD19 on the cell's surface and an Fc.gamma.RIIb on the cell's...
2017/0355765 TEM8 ANTIBODIES AND THEIR USE IN TREATMENT AND DETECTION OF TUMORS
Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are...
2017/0355764 METHODS FOR THE TREATMENT OF GOUT
Disclosed are methods for the treatment and/or prevention of gout, comprising administering to a subject an effective amount of anti-IL-1.beta. antibody or...
2017/0355763 USE OF IL-31 MONOCLONAL ANTIBODIES FOR REDUCING PRURITUS
The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced...
2017/0355762 IL-17 Antagonistic Antibodies
An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable...
2017/0355761 CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount...
2017/0355760 METHODS FOR MODULATING THE GLYCOSYLATION PROFILE OF RECOMBINANT PROTEINS USING SUGARS
The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant...
2017/0355759 Nebulization of Monoclonal Antibodies for Treating Pulmonary Diseases
The present application relates to methods and compositions employing an antibody that inhibits activation of the complement system and can be used to prevent...
2017/0355758 Anti-PHF-tau Antibodies and Their Uses
The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
2017/0355757 ANTI-C5 ANTIBODIES AND USES THEREOF
The present invention provides monoclonal antibodies that bind to the complement factor 5 (C5) protein, and methods of use thereof. In various embodiments of...
2017/0355756 TDP-43-Binding Polypeptides Useful for the Treatment of Neurodegenerative Diseases
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of...
2017/0355755 COMPOSITIONS AND METHODS FOR MODULATING SALM5 AND HVEM
The invention provides compositions and methods for regulating immune responses. In one embodiment, compositions of the invention include one or more...
2017/0355754 TREATMENT OF NEONATAL HYPOXIA INCLUDING IMPAIRMENTS OR EFFECTS THEREOF
The invention provides methods for the treatment of neonatal hypoxia and associated white matter disease or injury, particularly in infant, including neonatal,...
2017/0355753 FACTOR H POTENTIATING ANTIBODIES AND USES THEREOF
The invention relates to isolated, synthetic or recombinant antibodies and fragments thereof specific for factor H. The invention further relates to the use of...
2017/0355752 COLON DISEASE TARGETS AND USES THEREOF
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or...
2017/0355751 HUMAN ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN
The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions...
2017/0355750 HIGH-THROUGHPUT SCREENING OF FUNCTIONAL ANTIBODY FRAGMENTS, IMMUNOCONJUGATE COMPRISING THE SAME, AND...
Disclosed herein are methods for high-throughput screening of a functional antibody fragment for an immunoconjugate that targets a protein antigen. The method...
2017/0355749 THERAPEUTIC VARIANT ALPHA-2-MACROGLOBULIN COMPOSTIONS
A2M polypeptide compositions containing a non-natural bait region are disclosed. Methods of producing wild-type and variant A2M polypeptides and...
2017/0355748 METHOD FOR THE DESIGN OF FIBRILLAR COLLAGEN-MIMETIC PEPTIDE SELF-ASSEMBLIES
Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble...
2017/0355747 PEPTIDES FOR MODULATING T-CELL ACTIVITY AND USES THEROF
The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the...
2017/0355746 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2017/0355745 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2017/0355744 Targeted Therapeutic Lysosomal Enzyme Fusion Proteins and Uses Thereof
The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases....
2017/0355743 INSULIN RECEPTOR PARTIAL AGONISTS
Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
2017/0355742 GM-CSF Variants and Methods of Use
GM-CSF variants, polynucleotides encoding them, and methods of making and using the foregoing are useful in treatment of immune-related disorders, such as...
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