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Patent # Description
2017/0355741 Production Of Glycoproteins Using Manganese
Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.
2017/0355740 METHODS OF USING FIBROBLAST GROWTH FACTOR (FGF) 1 WITH MUTATION IN THE HEPARIN BINDING DOMAIN AND METHODS TO...
The present disclosure provides FGF1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an N-terminal...
2017/0355739 FIBROBLAST GROWTH FACTOR (FGF) 1 WITH MUTATION IN THE HEPARIN BINDING DOMAIN AND METHODS OF USE TO REDUCE BLOOD...
The present disclosure provides FGF1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an N-terminal...
2017/0355738 CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine...
2017/0355737 STABLE AMYLOID BETA MONOMERS AND OLIGOMERS
The invention provides monomeric and oligomeric amyloid beta peptide isomers that are resistant towards fibrillogenesis and their use as screening reagents or...
2017/0355736 MORTALIN PEPTIDES AND ANTIBODIES AND USES THEREOF FOR INHIBITING MORTALIN ACTIVITY AND TREATING A DISEASE...
Isolated mortalin peptides and antibodies are provided. Accordingly there is provided an isolated peptide comprising no more than 30 amino acids having a...
2017/0355735 CONJUGATED KNOTTIN MINI-PROTEINS CONTAINING NON-NATURAL AMINO ACIDS
Disclosed are knottin peptides containing non-natural amino acids so that they can be formed by chemical conjugation into two or more knottin monomers. The...
2017/0355734 Metabolically Stable Apelin Analogs in the Treatment of Disease Mediated by the Apelin Receptor
The invention is related to metabolically stable apelin analogs and their use for the prevention or the treatment of diseases mediated by the apelin receptor...
2017/0355733 MODIFIED FAB REGION-BINDING PEPTIDE
A first Fab region-binding peptide includes an amino acid sequence selected from the group consisting of SEQ ID NOs: 1 to 5 with substitution of one or more...
2017/0355732 Bacillus Sp. Biosurfactants, Composition Including Same, Method for Obtaining Same, and Use Thereof
Biosurfactants produced by a strain of Bacillus sp and to uses thereof. A composition comprising the biosurfactants, and a method for producing the ...
2017/0355731 AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
The invention disclosed herein relates to cytotoxic cyclic peptides of Formula (I), methods of inhibiting RNA polymerase with such cyclic peptides,...
2017/0355730 CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF
Disclosed herein are compounds having activity as cell penetrating peptides. In some examples, the compounds can comprise a cell penetrating peptide moiety and...
2017/0355729 METHODS AND COMPOSITIONS FOR CONTROLLING ANTIBODY AGGREGATION
Disclosed herein are methods of purifying monoclonal antibodies and related compositions.
2017/0355728 NEUROACTIVE 13, 17-SUBSTITUTED STEROIDS AS MODULATORS FOR GABA TYPE-A RECEPTORS
The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof,...
2017/0355727 CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to...
2017/0355726 NEW TYPE OF CYTIDINE DERIVATIVE AND APPLICATION THEREOF
The present disclosure provides a new cytidine derivative having the general formula (I), and applications thereof: ##STR00001## As demonstrated by experiments...
2017/0355725 CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
The invention relates generally to a calicheamicin molecule activated with a leaving group. The invention further relates generally to an antibody-drug...
2017/0355724 ANTHELMINTHIC MACROLIDE SYNTHESIS
Disclosed herein is a novel and inventive synthesis of amino-deoxyavermectins, and in particular, the economically significant, anthelminthic macrolide...
2017/0355723 METHOD FOR PRODUCING HIGH PURITY LIGNIN
The method is for separation of lignin from original black liquor (BL.sub.IN) that has a first precipitation stage (PR) for precipitation of lignin by a first...
2017/0355722 ARSENOPLATIN ANTI-CANCER AGENTS
Disclosed herein are methods of treating a cancer cell that include contacting a cancer cell with a compound having the structure of formula (I) ...
2017/0355721 SILOXANE-CONTAINING PHOSPHOLIPIDS, COMPOSITIONS AND USES THEREOF
The present application relates to siloxane-containing phospholipids such as the compounds of Formula I, methods of preparation, compositions and uses...
2017/0355720 PROCESS FOR PREPARING ALKOXYSILANES
A transesterification process for preparing alkoxysilane includes removal of metal transesterification catalyst from the alkoxysilane transesterification...
2017/0355719 BORON-CONTAINING SMALL MOLECULES
This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
2017/0355718 Novel 5,6-Dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives
There are provided inter alia compounds which are intended to treat or prevent respiratory syncytial virus infections and associated disease particularly...
2017/0355717 NOVEL 5,6-DIHYDRO-4H-BENZO[B]THIENO-[2,3-D]AZEPINE DERIVATIVES
There are provided 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives which are useful in the treatment of respiratory syncytial virus (RSV) infection...
2017/0355716 SYNTHETIC METHOD OF FUSED HETEROAROMATIC COMPOUND AND FUSED HETEROAROMATIC COMPOUND AND INTERMEDIATE THEREFOR
A synthetic method of a fused heteroaromatic compound includes preparing a first intermediate represented by Chemical Formula 1, obtaining a second...
2017/0355715 COMPOUND AND PHARMACEUTICAL COMPOSITION FOR NEUROPSYCHOLOGICAL DISORDER OR MALIGNANT TUMOR
The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and...
2017/0355714 BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS
The present application relates to novel bicyclic compounds, to their use for controlling animal pests and to processes and intermediates for their preparation.
2017/0355713 COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
2017/0355712 AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS
The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing...
2017/0355711 THIENOPYRIMIDINES AND USES THEREOF
Described herein are thienopyrimidine compounds of Formula (I), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided...
2017/0355710 IMPROVED PROCESS FOR THE PREPARATION OF A BENZENE COMPOUND
A benzene compound is prepared by reacting a furan compound to produce an unsaturated bicyclic ether having an unsaturated carbon-carbon bond; hydrogenating...
2017/0355709 NEW PHOTOCHROMIC COMPOUNDS AND INTERMEDIATE COMPOUNDS FOR PRODUCTION THEREOF
The invention covers new bicyclic bridged [1,3]oksazepine derivatives of the general formula (I) and (II): ##STR00001## which exhibit enhanced photochromic...
2017/0355708 POTASSIUM CHANNEL MODULATORS
Provided are novel compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases,...
2017/0355707 BICYCLIC HETEROARYL AMINE COMPOUNDS
Disclosed are compounds of Formula (I) or a salt thereof; wherein: X is N or CH; Q.sub.1 is: (i) Cl, Br, I, --CN, --CH.sub.3, or --CF.sub.3; (ii) a 5-membered...
2017/0355706 METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER
The invention provides compounds of formula I: ##STR00001## wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical...
2017/0355705 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding...
2017/0355704 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE
Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.
2017/0355703 COMPOUNDS FOR THE INHIBITION OF INDOLEAMINE-2,3-DIOXYGENASE
The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of IDO, and for the treatment of...
2017/0355702 SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b] PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE...
The invention provides substituted imidazo[1,2-b]pyridazine compounds, substituted imidazo[1,5-b]pyridazine compounds, related compounds, compositions...
2017/0355701 HEPATITIS B ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: ##STR00001## which inhibit the protein(s) encoded by...
2017/0355700 PYRAZOLOPYRIMIDINE ANTIBACTERIAL AGENTS
Pyrazolopyrimidine compounds for inhibition of isoprenoid biosynthesis have a formula (I) ##STR00001## or a pharmaceutically acceptable salt thereof. In formula...
2017/0355699 FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE
Described herein are fused bicyclic compounds, compositions, and methods for their use for the treatment of disease.
2017/0355698 HETEROARYL SUBSTITUTED PYRROLOTRIAZINE AMINE COMPOUNDS AS PI3K INHIBITORS
Disclosed are compounds of Formula (I); or a salt thereof; wherein Qi is (i) Cl, Br, I, --CN, --CH.sub.3, or --CF.sub.3; or (ii) pyrazole, triazole, or...
2017/0355697 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use...
2017/0355696 PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF
The present invention disclosed a class of pyrimidine or pyridine compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof,...
2017/0355695 SMYD Inhibitors
The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y,...
2017/0355694 FXR (NR1H4) MODULATING COMPOUNDS
The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the...
2017/0355693 FXR (NR1H4) MODULATING COMPOUNDS
The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the...
2017/0355691 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers...
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