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Patent # Description
2017/0360968 RADIOEMBOLIC PARTICLES
Provided are radiopaque compositions comprising one or more of yttrium (Y), strontium (Sr), gallium (Ga), and silicon, or oxides and salts thereof. The...
2017/0360967 Collagen Targeted Imaging Probes
Disclosed herein are collagen-targeted imaging agents for positron emission tomography and related imaging methods using the collagen-targeted imaging agents....
2017/0360966 LIPID ENCAPSULATED GAS MICROSPHERE COMPOSITIONS AND RELATED METHODS
The invention provides improved compositions relating to lipid-encapsulated gas microspheres and methods of their use.
2017/0360965 IMMUNO-THERAPY FOR CANCER TREATMENT USING IRON OXIDE NANOPARTICLES
An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle...
2017/0360964 CHEMICAL MODEL OF A NEURODEGENERATIVE DISEASE, METHOD FOR PREPARATION AND USES OF SAME
The invention concerns the use of pyridinium furosemide or one of the derivatives, analogues, salts, metabolites, or prodrugs thereof in the preparation of a...
2017/0360963 IN VIVO METHODS FOR IDENTIFYING CANCER-ASSOCIATED IMMUNOTHERAPY TARGETS
The invention provides in vivo methods for identifying cancer-associated immunotherapy targets.
2017/0360962 NOVEL RECOMBINANT ADENO-ASSOCIATED VIRUS CAPSIDS RESISTANT TO PRE-EXISTING HUMAN NEUTRALIZING ANTIBODIES
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased...
2017/0360961 AAV/XBP1S-HA VIRUS, GENE THERAPY METHOD AND USE THEREOF IN THE OPTIMISATION AND IMPROVEMENT OF LEARNING, MEMORY...
This invention presents a sequence of the virus AAV/XBP1s-HA, method and its use in the improvement of cognitive functions, of memory and of learning, as...
2017/0360960 AAV Vectors Targeted to the Central Nervous System
The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to...
2017/0360959 FORMULATIONS FOR TARGETED RELEASE OF AGENTS UNDER LOW PH CONDITIONS AND METHODS OF USE THEREOF
Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug...
2017/0360958 METHODS AND COMPOSITIONS FOR TREATING DYSBIOSIS AND GASTROINTESTINAL AND INFLAMMATORY DISORDERS
The present invention relates to the use of NS1/2 region of murine norovirus MNV or a corresponding region from a member of the Caliciviridae family or a...
2017/0360957 METHOD OF GENE TRANSFER FOR THE TREATMENT OF RECESSIVE CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA (CPVT)
The present invention concerns a method for the treatment of recessive Catecholaminergic Polymorphic Ventricular Tachycardia comprising delivering a gene into...
2017/0360956 FUNCTIONALIZED LINEAR LIGANDS AND COMPLEXES THEREOF
The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.
2017/0360955 CYSTEINE LINKED NANOBODY DIMERS
The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at...
2017/0360954 COMPOSITIONS AND METHODS FOR THE DEPLETION OF CD117+ CELLS
The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic...
2017/0360953 BINDING PROTEIN DRUG CONJUGATES COMPRISING ANTHRACYCLINE DERIVATIVES
The present invention relates to an anthracycline (PNU) derivative conjugate comprising a derivative of the anthracycline PNU-159682 having the formula (i) or...
2017/0360952 BIOMOLECULE CONJUGATES
The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the...
2017/0360951 BIOLOGICAL MATERIALS AND USES THEREOF
The invention provides compounds comprising a therapeutic agent coupled to a carrier molecule, with a minimum coupling ratio of 5:1; wherein the carrier...
2017/0360950 DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING
Described herein are drug delivery conjugates for targeted therapy. In particular, described herein are drug delivery conjugates that include polyvalent...
2017/0360949 POLYPEPTIDE COMPLEX AS POLYPEPTIDE OR PROTEIN DRUG CARRIER, METHOD OF USING THE POLYPEPTIDE COMPLEX, AND FUSION...
The present invention provides a polypeptide complex on the basis of Titin-Telethonin beta-pleated sheet structure as a polypeptide or protein drug carrier, a...
2017/0360948 OLIGOMER-BETA BLOCKER CONJUGATES
The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when...
2017/0360947 POLYMER PARTICLES AND BIOMATERIALS COMPRISING THE SAME
The present invention relates to polymer particles comprising antibiotics which are deliverable in situ, as well as a method of preparation thereof. The...
2017/0360946 ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES
Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the...
2017/0360945 ORGANIC ANION TRANSPORTING PEPTIDE-BASED CANCER IMAGING AND THERAPY
A dye-drug conjugate for preventing, treating, or imaging cancer having the following structure: ##STR00001## wherein R.sub.1 and R.sub.2 are independently...
2017/0360944 CARDIOVASCULAR DISEASE TREATMENT AND PREVENTION
The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell...
2017/0360943 METHOD FOR REMOVING ACETALDEHYDE
A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging...
2017/0360942 LINEAR POLYSACCHARIDE BASED FILM PRODUCTS
Film products, especially suitable for oral delivery, which can be formed during manufacture in the form of large and/or heavy film strips or sheets and...
2017/0360941 TOPICAL GEL COMPOSITIONS INCLUDING POLYCAPROLACTONE POLYMER AND METHODS FOR ENHANCING THE TOPICAL APPLICATION...
A composition comprising: a benefit agent; at least one polymer including a polycaprolactone polymer; at least one lower alcohol; and at least one co-solvent;...
2017/0360940 NUCLEOPHILE-TRIGGERED DEGRADABLE MATERIALS AND METHODS OF MAKING AND USING THE SAME
Disclosed herein are degradable materials comprising the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent...
2017/0360939 Liquid Formulation of Protein Conjugate Comprising The Oxyntomodulin And An Immunoglobulin Fragment
The present invention relates to an albumin-free liquid formulation comprising a long-lasting oxyntomodulin conjugate in which an oxyntomodulin peptide...
2017/0360938 Compositions Containing Carbohydrate Partial Ester
The present invention relates to a composition containing carbohydrate partial esters, the preparation thereof and products containing the carbohydrate partial...
2017/0360937 Sprayable Topical Carrier and Composition Comprising Phosphatidylcholine
A pharmaceutical or cosmetic carrier for topical administration substantially consists of phosphatidylcholine, monoglyceride, fatty acid ester of...
2017/0360936 DEVICES AND METHODS FOR CONTROLLING HEADSPACE HUMIDITY AND OXYGEN LEVELS
A humidity control device for use in maintaining the desired humidity of a closed environment, e.g., a container, while also decreasing headspace oxygen, the...
2017/0360935 FORMULATIONS OF A PI3K/MTOR-INHIBITOR FOR INTRAVENOUS ADMINISTRATION
The present invention relates to a pharmaceutical aqueous formulation comprising -(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpho- ...
2017/0360934 USE OF CADHERIN-11 ANTAGONISTS TO TREAT OBESITY-ASSOCIATED CONDITIONS AND OTHER METABOLIC DISORDERS
Provided herein are methods and pharmaceutical compositions for the treatment of obesity-associated conditions using cadherin-11 antagonists.
2017/0360933 NUCLEIC ACID, MEDICAL NANOPARTICLE, AND PHARMACEUTICAL COMPOSITION THEREOF
A medical nanoparticle includes a core, an outer lipid layer, an inner lipid layer, a photosensitizer, and a nucleic acid. The core includes a bio-degradable...
2017/0360932 IMMUNE MODULATORS IN COMBINATION WITH RADIATION TREATMENT
Methods for treating tumors by administering ionizing radiation and an immune modulator to a patient with cancer are disclosed. The methods provide the dual...
2017/0360931 METHODS AND COMPOSITION FOR NEUTRALIZATION OF INFLUENZA
Provided herein are compositions useful for neutralization of influenza virus, and methods of use and manufacture thereof. In particular, compositions...
2017/0360930 VEGF ANTAGONIST FORMULATIONS
Formulations of a vascular endothelial growth factor (VEGF)-specific fusion protein antagonist are provided including a pre-lyophilized formulation, a...
2017/0360929 STABLE AQUEOUS ANTIBODY FORMULATION FOR ANTI TNF ALPHA ANTIBODIES
The present invention relates to the field of pharmaceutical formulations of antibodies. Specifically, the present invention relates to a stable liquid...
2017/0360928 GENE DETECTION ASSAY FOR IMPROVING THE LIKELIHOOD OF AN EFFECTIVE RESPONSE TO AN ErbB ANTAGONIST CANCER THERAPY
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene...
2017/0360927 DIAGNOSING AND TREATING IGA NEPHROPATHY
Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the...
2017/0360926 PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY
The invention provides methods for treating patients with anti-.alpha.4.beta.7 antibody comprising predicting outcome of the antibody therapy. The invention...
2017/0360925 Calcium Flux Agonists And Methods Therefor
Calcium flux agonists are used to enhance a TLR- or NOD-mediated stimulus and to so increase an immune response of a host and reduce healing time. Preferred...
2017/0360924 HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
Glycosphingolipids (GSLs) bearing .alpha.-glucose (.alpha.-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with...
2017/0360923 Novel immunogenic formulations comprising linear or branched polyacrylic acid polymer adjuvants
The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant....
2017/0360922 NUTRITIONAL SUPPLEMENTS AND METHODS FOR PRIMARY PREVENTION OF FOOD ALLERGIES
The present invention relates to formulations and methods for preventing food allergies in a subject. Embodiments of the invention provide for administration...
2017/0360921 VACCINE AGAINST INFECTIOUS BRONCHITIS VIRUS
Embodiments of the present invention relate to an infectious bronchitis virus (IBV) and an immunogenic composition comprising an IBV, respectively, wherein the...
2017/0360920 METHOD AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF A HIV INFECTION
Described herein are methods of preventing or treating a HIV infection comprising administering to a mammal in need thereof, a pharmaceutically effective...
2017/0360919 NANOEMULSION RESPIRATORY SYNCYTIAL VIRUS (RSV) SUBUNIT VACCINE
The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (RSV) surface proteins, Fusion...
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