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Patent # Description
2017/0362639 METHODS AND COMPOSITIONS FOR GENERATING ASYMMETRICALLY-TAGGED NUCLEIC ACID FRAGMENTS
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and...
2017/0362638 USING CELL-FREE DNA FRAGMENT SIZE TO DETERMINE COPY NUMBER VARIATIONS
Disclosed are methods for determining copy number variation (CNV) known or suspected to be associated with a variety of medical conditions. In some...
2017/0362637 HIGHLY SPECIFIC AND SENSITIVE METHODS FOR DETECTING ENTEROHEMORRHAGIC ESCHERICHIA COLI SEROTYPES O157:H7 AND/OR...
The present invention relates to methods and kits for the specific detection of Escherichia coli (E.coli) serotypes O157:H7 and/or O145:H28. The methods and...
2017/0362636 NUCLEIC ACID REACTIONS AND RELATED METHODS AND COMPOSITIONS
The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic...
2017/0362635 MUSCLE-SPECIFIC CRISPR/CAS9 EDITING OF GENES
Pharmaceutical compositions including a muscle-specific nuclease cassette, one or more guide RNA cassettes, and a delivery system for delivery of the...
2017/0362634 NUCLEIC ACID ANALYSIS DEVICE
The substrate 100 for use in the analysis of a nucleic acid according to the present invention has multiple analysis areas 12 which are partitioned on a...
2017/0362633 NRAS RELATED CANCER THERAPY
The present invention encompasses the recognition that identification of alternative means to block RAS oncogenic signaling may be required for developing...
2017/0362632 ENZYMATIC ACTIVITY ASSAYS FOR I2S
In certain embodiments of the present invention, kinetic parameters of I2S enzyme are determined. In some instances, a sample including I2S enzyme is incubated...
2017/0362631 METHOD AND DEVICE FOR DETERMINING THE PRESENCE OF A MICRO-ORGANISM IN STOOLS WITH ACTIVATED CARBON PRETREATMENT
The invention provides a determination method for determining the presence of a target microorganism in a patient from a sample of said patient's stools, the...
2017/0362630 OBSERVATION METHOD USING BINDING AND DISSOCIATION PROBE
An observation method of a sample containing a target substance, the observation method including an imaging step in which a step of obtaining a speckle image...
2017/0362629 OYSTER PEPTIDE CAPABLE OF ENHANCING SEXUAL FUNCTION, AND PREPARATION METHOD AND APPLICATION THEREOF
An oyster peptide capable of enhancing a sexual function, and a preparation method and application thereof are provided. In the method, oyster meat is...
2017/0362628 ENHANCED PROTEIN EXPRESSION
The present invention relates in general to bacterial cells having genetic alterations that result in increased expression of a protein of interest and methods...
2017/0362627 MULTIPARAMETRIC NUCLEIC ACID OPTIMIZATION
The present disclosure provides multiparametric codon optimization methods to improve at least a property in a candidate nucleic acid sequence. Such parameters...
2017/0362626 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent....
2017/0362625 PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
2017/0362624 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In...
2017/0362623 AMPLIFICATION OF NUCLEIC ACIDS
Provided herein are methods of amplifying nucleic acids. In particular, methods are provided for amplifying circular RNA molecules. In certain embodiments,...
2017/0362622 Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
The present invention relates to polypeptides having cellulolytic enhancing activity, catalytic domains, and carbohydrate binding domains, and polynucleotides...
2017/0362621 ENGINEERED MULTIFUNCTIONAL ENZYMES AND METHODS OF USE
Provided are certain glycosyl hydrolase family 3 (GH3) beta-glucosidase enzymes engineered to acquire beta-xylosidase activities. Provided also are...
2017/0362620 PROCESS FOR THE FERMENTATION OF FUNGAL STRAINS
The present invention relates to a process for the fermentation of fungal strains which secrete glucans with a .beta.-1,3-glycosidically linked main chain and...
2017/0362619 METHOD FOR PREPARING AN AQUEOUS SOLUTION OF BETA-GLUCAN
The presently claimed invention is directed to a method for the preparation of an aqueous solution comprising at least one beta-glucan comprising at least the...
2017/0362618 HIGH SOLIDS ENZYMATIC HYDROLYSIS AND FERMENTATION OF PRETREATED BIOMASS
The present disclosure generally relates to a methods and systems for conversion of chemically pretreated lignocellulosic biomass to monosaccharides by...
2017/0362617 PTERIN-DEPENDENT BIOCATALYSTS AND USES THEREOF
Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in...
2017/0362616 BIOSYNTHETIC PRODUCTION OF CAFFEINE
The present invention provides an enzymatic means for the biosynthetic production of caffeine. The present invention provides biosynthetic methods for...
2017/0362615 METHOD FOR PREPARING ORGANIC COMPOUNDS
The invention relates to a method for preparing organic compounds with recovery of product liquids, which comprise short-chain and medium length-chain...
2017/0362614 RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
Systems and methods for the production of malonate in recombinant host cells.
2017/0362613 Recombinant Host Cells For The Production Of 3-Hydroxypropionic Acid
Provided herein are recombinant host cells having an active 3-Hydroxypropionic Acid (3-HP) pathway wherein the host cells comprise a heterologous...
2017/0362612 METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS
The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells...
2017/0362611 SITE-DIRECTED CRISPR/RECOMBINASE COMPOSITIONS AND METHODS OF INTEGRATING TRANSGENES
Disclosed herein are targeted chimeric polypeptides, compositions thereof, expression vectors, and methods of use thereof, for the generation of transgenic...
2017/0362610 COMPOSITIONS AND METHODS FOR HELPER STRAIN-MEDIATED FUNGAL GENOME MODIFICATION
Compositions and methods are provided employing a helper strain system for promoting genetic alterations in a fungal host cell, e.g., a filamentous fungal host...
2017/0362609 AMPHIPHILIC NANOPARTICLES FOR CODELIVERY OF WATER-INSOLUBLE SMALL MOLECULES AND RNAi
Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for...
2017/0362608 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF scAAV
The present invention is directed to viral vectors and methods of their production and use.
2017/0362607 USE OF NON-SUBTYPE B GAG PROTEINS FOR LENTIVIRAL PACKAGING
The invention encompasses a lentiviral packaging vector comprising a non-subtype B gag-pol sequence, particularly a subtype D gag-pol sequence. The invention...
2017/0362606 SITE-SPECIFIC DNA RECOMBINATION
The present invention provides a method of stably integrating a DNA sequence of interest into a target genomic DNA sequence of a host cell, wherein the target...
2017/0362605 TERMINAL MODIFICATIONS OF POLYNUCLEOTIDES
The present invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides comprising at least one...
2017/0362604 METHODS AND COMPOSITIONS FOR PROVIDING RESISTANCE TO GLUFOSINATE
Compositions and methods comprising polynucleotides and polypeptides that confer glufosinate resistance to a host cell are provided. Further provided are...
2017/0362603 Transgenic Plants with Enhanced Traits
This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency and...
2017/0362602 METHODS FOR INCREASING OIL CONTENT IN PLANT TISSUES BY SUPPRESSING HYDROPHOBIC LIPID DROPLET PROTEIN
The present disclosure relates to increasing oil content in plants through manipulating expression of proteins, namely At5g16550 proteins. At5g16550 proteins...
2017/0362601 CHIMERIC PROTEINS WHICH ENHANCE THE ACTIVITY OF DNA BINDING DOMAINS (DBD) AND TRANSCRIPTION FACTORS IN PLANTS
The present invention relates to a method of enhancing the activity of a transcription factor in a plant comprising expressing in said plant a chimeric protein...
2017/0362600 Methodologies and Compositions for Creating Targeted Recombination and Breaking Linkage Between Traits
The current disclosure relates to methods and compositions for improving plant varieties through plant breeding and plant genetics. For instance, the...
2017/0362599 FRONT-END ANALOG SIGNAL PROCESSING FOR CELLULAR COMPUTATION
Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.
2017/0362598 ANTICANCER THERAPEUTIC INTERVENTION
The present invention is directed to a method of treating cancer using interfering RNA duplexes to mediate gene silencing. The present invention is also...
2017/0362597 EGFR NUCLEIC ACIDS AND USES THEREOF
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against EGFR. Also described herein include methods for treating a...
2017/0362596 METHODS AND MEANS OF GENERATING IL-17 ASSOCIATED ANTITUMOR EFFECTOR CELLS BY INHIBITION OF NR2F6 INHIBITION
Disclosed are means, methods, and compositions of matter useful for generation of cancer inhibitory effector cells producing interleukin-17 (IL-17). In one...
2017/0362595 METHODS AND MATERIALS FOR TREATING CANCER
This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate,...
2017/0362594 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the TMPRSS6 gene, and methods of using such RNAi agents to inhibit...
2017/0362593 USE OF RAD18 INHIBITORS IN THE TREATMENT OF TUMORS
The present invention relates to the use of an inhibitor of Rad18 expression or activity, in treating a tumor or in sensitizing a patient affected with a...
2017/0362592 MODULATION OF UBE3A-ATS EXPRESSION
Certain embodiments are directed to methods and compounds for inhibiting UBE3A-ATS, the endogenous antisense transcript of ubiquitin protein ligase E3A...
2017/0362591 NON-AGGREGATING IMMUNOSTIMULATORY OLIGONUCLEOTIDES
Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide...
2017/0362590 PHARMACEUTICAL COMPOSITIONS COMPRISING MICRORNA
Pharmaceutical compositions comprising one or more of miR-494-3p, miR-99b-5p, and/or miR-21-3p and a pharmaceutically acceptable carrier as well as methods of...
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