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Patent # Description
2018/0009899 ANTI-CD73 ANTIBODIES
Provided herein are, inter alia, anti-CD73 antibodies and methods of using the same. The antibodies provided include amino acid substitution embodiments...
2018/0009898 ANTIBODIES AGAINST P97 AND CONJUGATES THEREOF
Provided are conjugates between (a) an antibody or antigen-binding fragment thereof that binds to p97 (melanotransferrin; MTf) and (b) an agent of interest,...
2018/0009895 ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (SCCARS) FOR CANCER IMMUNOTHERAPY
The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and...
2018/0009891 METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY
The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular...
2018/0009890 METHODS FOR TREATING VASCULAR LEAK SYNDROME AND CANCER
Disclosed are methods for treating Vascular Leak Syndrome and preventing cancer metastasis. Further disclosed are methods for treating vascular leakage due to...
2018/0009886 TREATMENT OF CANCER WITH ANTI-LAP MONOCLONAL ANTIBODIES
Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of...
2018/0009885 ANTI-C5 ANTIBODIES HAVING IMPROVED PHARMACOKINETICS
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9...
2018/0009881 POLYPEPTIDES
There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain comprising three complementarity determining regions (CDR1-CDR3)...
2018/0009880 IMMUNOLOGICAL DETECTION METHOD AND KIT FOR MYCOPLASMA PNEUMONIAE
The present invention aims at providing a specific antibody that can simply and rapidly detect Mycoplasma pneumoniae which is a causative bacterium of...
2018/0009879 HUMAN MONOCLONAL ANTIBODIES ENDOWED WITH STRONG NEUTRALIZING ACTIVITY AGAINST HSV-1 AND HSV-2
The present invention is in the field of monoclonal antibodies suitable for passive immunotherapy of Herpes Simplex Virus infections and relates to human...
2018/0009878 MULTISTEP FINAL FILTRATION
Herein is reported a method for the final filtration of concentrated polypeptide solutions comprising the combination of two immediately consecutive filtration...
2018/0009874 PLATELET TARGETED TREATMENT
The present disclosure relates to compositions and methods for targeting expression of exogenous genes to platelets. In particular, the present disclosure...
2018/0009873 FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In...
2018/0009871 GLUCAGON-RECEPTOR SELECTIVE POLYPEPTIDES AND METHODS OF USE THEREOF
This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for...
2018/0009870 THERAPEUTIC TARGETING OF SET1B/COMPASS PATHWAY FOR TREATING CANCERS
Disclosed are methods for treating Set1/COMPASS-associated cancers characterized by expression of Set1B/COMPASS. The methods typically include administering a...
2018/0009867 MUTANT CHICKEN INTERLEUKIN-1BETA PROTEIN AS CHICKEN INTERLEUKIN-1BETA ANTAGONIST AND USES THEREOF
The present invention provides a mutant chicken interleukin-1.beta. protein as a chicken interleukin-1.beta. antagonist, which has a substituted peptide at...
2018/0009866 ALTERNATIVE NUCLEIC ACID MOLECULES CONTAINING REDUCED URACIL CONTENT AND USES THEREOF
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides...
2018/0009862 MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE
This document relates to materials and methods for controlling ligand gated ion channel (LGIC) activity. For example, modified LGICs including at least one...
2018/0009861 COMPOSITIONS AND METHODS OF USING ISLET NEOGENESIS PEPTIDES AND ANALOGS THEREOF
The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and...
2018/0009860 PEPTIDE FOR TREATING INFLAMMATORY DISEASES
The present invention provides a peptide having anti-inflammatory activity. The present invention also provides the method of preparation of the peptide and...
2018/0009858 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2018/0009856 PROTEIN EXPRESSION STRAINS
The invention provides an improved host strain for production of desired protein.
2018/0009854 Non-Natural Consensus Albumin Binding Domains
Non-natural albumin binding domains, polynucleotides encoding thereof and methods of making and using these domains and polynucleotides are useful in...
2018/0009853 CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM S. AUREUS
A composition-of-matter comprising a crystallized form of a large ribosomal (50S) subunit of a pathogenic bacterium, and the atomic coordinates of the...
2018/0009852 IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS
Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can...
2018/0009850 INFLUENZA TREATMENT AND/OR CHARACTERIZATION, HUMAN-ADAPTED HA POLYPEPTIDES; VACCINES
The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza...
2018/0009848 GLYCOPEPTIDES CONJUGATES AND USES THEREOF
Vancomycin conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complexes thereof is described in...
2018/0009847 PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF
The present invention provides a new type of alpha-helix nucleating cross-link ("staple") formed by olefin metathesis of a proline derivative with an alkenyl...
2018/0009846 NOVEL PEPTIDE AND USES THEREOF
This present invention provides a novel peptide for inhibiting growth of microorganisms, a pharmaceutical composition, an antimicrobial composition comprising...
2018/0009844 SUGAR-DIPEPTIDE CONJUGATES AS FLAVOR MOLECULES
The present invention relates to compounds and compositions for use in enhancing flavor and umami taste of food products. Particularly, the present invention...
2018/0009843 MODULATION OF ANTIGEN IMMUNOGENICITY BY DELETING EPITOPES RECOGNIZED BY NKT CELLS
The invention describes a method and compounds for the prevention of immune responses towards allofactors, towards viral vectors used for gene therapy and gene...
2018/0009841 METHOD FOR PREPARING NANOPRECIPITATES OF LOW MOLECULAR WEIGHT PEPTIDE OR PROTEIN
The present invention relates to a method for the non-denaturing preparation of peptide or protein nanoprecipitates, or of peptide or protein and metal ion...
2018/0009840 ENHANCED FUNCTIONALITY AND DELIVERY OF A PROTEIN FROM A POROUS SUBSTRATE
Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins.
2018/0009839 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethy- ...
2018/0009838 NOVEL, HEAVY VITAMIN B12 DERIVATIVES
The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment...
2018/0009835 NON-CALORIC SWEETENER
Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
2018/0009833 LIPID A MIMICS, METHODS OF PREPARATION, AND USES THEREOF
The invention provides lipid A mimics in which one or both of the sugar residues of a natural lipid A disaccharide backbone has been replaced with an aromatic...
2018/0009832 Method for Producing Branched Oligoarylsilanes
Branched oligoarylsilanes of general formula (I) X.sub.m Q.sub.k-Si Ar.sub.n--R).sub.3].sub.2 (I). A method of preparation of branched oligoarylsilanes is that a...
2018/0009831 PROCESS FOR THE PREPARATION OF NOVEL POLYMORPHIC FORMS OF 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE
Novel polymorphic forms of tavaborole, Form A and Form B, and methods of making same are disclosed. Methods are disclosed for the manufacture of the novel...
2018/0009830 ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
The inventive compounds are small molecule therapeutics that are potent inhibitors of arginase 1 and arginase 2 activity. The inventions also provides...
2018/0009829 GOLD NANOPARTICLES AND METHODS OF MAKING AND USING GOLD NANOPARTICLES
Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes...
2018/0009826 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is independently CH or...
2018/0009825 METHODS OF MAKING ERIBULIN MESYLATE
Novel processes are disclosed for the preparation of eribulin mesylate. Novel intermediate compounds used in the processes for making eribulin mesylate as well...
2018/0009824 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are certain crystalline forms of Compound 3, as well as pharmaceutical compositions employing the crystalline forms. Also provided are...
2018/0009822 FUROQUINOLINEDIONES AS INHIBITORS OF TDP2
Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X.sup.1, X.sup.2, and R.sup.1-4 are disclosed...
2018/0009821 METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively,...
2018/0009820 IMIDAZOLE DERIVATIVE USED AS ANTIVIRAL AGENT AND USE THEREOF IN PREPARATION OF MEDICAMENT
Disclosed are an antiviral compound and a use thereof in the preparation of a medicament for the treatment of virus infections. Specifically, the present...
2018/0009816 HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS
This application relates to compounds of Formula (I): ##STR00001## or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of...
2018/0009815 BICYCLIC FUSED PYRIMIDINE COMPOUNDS AS TAM INHIBITORS
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
2018/0009810 CALCIUM CHANNEL AGONISTS
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel...
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