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Patent # Description
2018/0009808 CGRP Receptor Antagonists
The disclosures herein relate to novel compounds of formula ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, and their use in treating,...
2018/0009807 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
The present invention provides compounds of Formula I (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel....
2018/0009805 THERAPEUTIC COMPOUNDS AND USES THEREOF
The present invention relates to compounds of formula (I): ##STR00001## and to salts thereof, wherein R.sup.1-R.sup.6 have any of the values defined in the...
2018/0009800 (R)-2-Methyl-piperazine Derivatives as CXCR3 Receptor Modulators
The invention relates to compounds of Formula (I) ##STR00001## wherein R.sup.1 and R.sup.2 are as described in the description; to pharmaceutically acceptable...
2018/0009799 HYDROXYALKYL-PIPERAZINE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS
The invention relates to compounds of Formula (I) ##STR00001## wherein n, X, R.sup.1 and R.sup.2 are as described in the description; to pharmaceutically...
2018/0009796 ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS
The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes...
2018/0009795 Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof
The present invention provides a compound of formula I: ##STR00001## a method for manufacturing the compounds of the invention, and its therapeutic uses. The...
2018/0009792 CHROMENONE INHIBITORS OF MONOCARBOXYLATE TRANSPORTERS
The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical...
2018/0009791 A NOVEL CRYSTALLINE FORM OF A BENZIMIDAZOLE DERIVATIVE AND A PREPARATION METHOD THEREOF
The present invention relates to a novel crystalline form of a benzimidazole derivative and a preparation method thereof. The novel crystalline form according to...
2018/0009789 SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES
The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R.sup.1,...
2018/0009788 BISPHENOLS CONTAINING PENDANT CLICKABLE MALEIMIDE GROUP AND POLYMERS THEREFROM
The patent discloses bisphenol monomers of formula I with pendant maleimide group connected via alkylene spacer and preparation thereof. Also, it discloses...
2018/0009786 HETEROCYCLIC COMPOUNDS AND USE THEREOF
Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using...
2018/0009785 SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such...
2018/0009782 PROTEIN TYROSINE KINASE MODULATORS AND METHODS OF USE
Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More...
2018/0009780 PIPERIDINE AND AZEPINE DERIVATIVES AS PROKINETICIN RECEPTOR MODULATORS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R.sup.1, R.sup.2, R.sup.3...
2018/0009775 LATENT ACIDS AND THEIR USE
Compounds of the formula (I) and (IA) wherein X is --O(CO)--; R.sub.1 is C.sub.1-C.sub.12haloalkyl or C.sub.6-C.sub.10haloaryl; R.sub.2 is located in position...
2018/0009774 METHOD FOR PRODUCING FURAN COMPOUND AND FURFURAL COMPOSITION
The present invention is aimed to provide an industrially advantageous method for producing a furan compound, in which a furan compound can be efficiently...
2018/0009772 Highly Selective Anti-Cancer Agents Targeting Non-Small Cell Lung Cancer and Other Forms of Cancer
Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone...
2018/0009771 FUROXAN COMPOUND, AND MANUFACTURING METHOD FOR SAME
The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor...
2018/0009770 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in...
2018/0009769 Novel formulation of metaxalone
The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone,...
2018/0009768 TETRAZOLE BASED CORROSION INHIBITORS
Disclosed are corrosion inhibitor compounds and compositions useful for preventing or inhibiting corrosion of surfaces found in cooling water applications. In...
2018/0009767 PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY
Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain,...
2018/0009766 Pyrimidone Compounds Used as Lp-PLA2 Inhibitors and Pharmaceutical Compositions Thereof
The present invention relates to pyrimidone compounds used as Lp-PLA.sub.2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone...
2018/0009763 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent...
2018/0009762 TETRAHYDROISOQUINOLINES AS SELECTIVE NADPH OXIDASE 2 INHIBITORS
Embodiments of bridged tetrahydroisoquinolines and methods for their use in selectively inhibiting nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
2018/0009761 GLUCOCEREBROSIDASE MODULATORS AND USES THEREOF
The invention provides compounds for modulating glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of...
2018/0009760 COMPOUNDS, COMPOSITIONS AND ASSOCIATED METHODS COMPRISING 3-ARYL QUINOLINES
Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis,...
2018/0009759 Quinolines and Process for the Preparation Thereof
The present invention discloses novel N-Heterocyclic compounds of formula A, [Formula A] And a ligand-enabled palladium-catalyzed process for preparation of...
2018/0009757 Tetrahydroquinoline Derivatives and Their Use as Epac Inhibitors
The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is...
2018/0009756 PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-(ACYL OR ALKYL)OXYPICOLINAMDES
A fungicidal 4-methoxy-3-acetyloxypicolinamide may be conveniently prepared in processes that include the coupling together of 4-methoxy-3-acetyloxypicolinic...
2018/0009753 METHOD FOR PREPARING AN ANTIFIBROTIC AGENT
The present invention relates to a process for the preparation of pirfenidone, an immunosuppressive drug developed for the treatment of idiopathic pulmonary...
2018/0009752 PROCESS FOR PREPARING AN N-METHYL-SUBSTITUTED TRIACETONAMINE COMPOUND
An N-methyl-substituted triacetonamine compound can be produced by reacting at least one triacetonamine compound with formaldehyde under reductive conditions.
2018/0009751 Carbazole Derivative, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the...
To provide a light-emitting element having high luminous efficiency and to provide a light-emitting device and an electronic device which consumes low power...
2018/0009749 Pyrrole Sulfonyl Derivative, Preparation Method and Medical Use thereof
The present invention relates to a new pyrrole sulfonyl derivative, and a preparation method and medical use thereof. In particular, the present invention...
2018/0009747 NOVEL CRYSTALLINE FORM OF ATORVASTATIN HEMI-CALCIUM SALT, HYDRATE THEREOF, AND METHOD OF PRODUCING THE SAME
The present invention provides a novel crystalline form of [R--(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl- ...
2018/0009745 PROCESS FOR THE PREPARATION OF A POLYUNSATURATED KETONE COMPOUND
A process for the preparation of a polyunsaturated thiol comprising: (1) reacting a polyunsaturated alcohol in the presence of a compound of formula...
2018/0009744 PROCESSES FOR THE PREPARATION OF COMPOUNDS, SUCH AS 3-ARYLBUTANALS, USEFUL IN THE SYNTHESIS OF MEDETOMIDINE
There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula...
2018/0009742 LOW BY-PRODUCT CONTENT POLYPHENYLENE POLYMETHYLENE POLYISOCYANATES
The invention relates to polyphenyl polymethylene polyisocyanates having an NCO number of at least 29% comprising less than 2% by weight ureas, less than 8% by...
2018/0009741 BISHYDRAZONE-BASED ANTIFUNGAL AGENTS
Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or...
2018/0009739 Ligand-Enabled meta-C-H Activation Using a Transient Mediator
An alternative approach to formation of a C-C bond at a meta-position of an aromatic compound is disclosed that employs an ethylenically unsaturated bicyclic...
2018/0009738 DEVICE AND METHOD FOR THE DESALINATION OF WATER BY MEANS OF THERMAL DEIONISATION AND LIQUID-PHASE ION...
Disclosed is a method for treating water, including the extraction of at least two ionic species, the ionic species including an anionic species and a cationic...
2018/0009736 RECLAMATION OF NOBLE PRODUCTS IN A METHOD FOR PRODUCING (METH)ACRYLIC ESTER
The invention relates to a method for producing a (meth)acrylic ester with improved productivity, by transesterfication of a light alkyl (meth)acrylate with a...
2018/0009735 THERAPEUTIC COMPOUNDS AND USES THEREOF
Provided herein are compounds of formula I: ##STR00001## and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1....
2018/0009733 TWO STEP METHOD OF PRODUCING TRIARLYAMINE COMPOUNDS HAVING TWO ALKYL ALCOHOLS IN A SINGLE REACTION VESSEL
The present invention provides a simple, cost effective and time saving two step method for synthesizing triarylamines comprising two alkyl alcohols in a...
2018/0009732 PROCESS FOR PRODUCING ACETIC ACID
A process for separating or removing permanganate reducing compounds (PRC's) from a first mixture containing at least one PRC, methyl iodide, and water...
2018/0009731 METHOD FOR CATALYTIC CONVERSION OF KETOACIDS AND HYDROTREAMENT TO HYDROCARBONS
Catalytic conversion of ketoacids is disclosed, including methods for increasing the molecular weight of ketoacids. An exemplary method includes providing in a...
2018/0009730 HYDROSILANE/LEWIS ACID ADDUCT, PARTICULARLY ALUMINUM, IRON, AND ZINC, METHOD FOR PREPARING SAME, AND USE OF...
Disclosed is an adduct between a Lewis acid, preferably aluminum trichloride, iron trichloride, or zinc dichloride, and a hydrosilane;--a method for preparing...
2018/0009728 METHOD FOR PRODUCING ALPHA-OLEFIN LOW POLYMER
An object of the present invention is to provide a method for suppressing the precipitation of polymers with a high concentration dissolved in a solvent in the...
2018/0009726 PRODUCTION OF AT LEAST 1-HEXENE AND OCTENE FROM ETHENE
The invention is concerned with the production of 1-hexene and octenes from ethene. 1-Butene is optionally also to be produced. The problem addressed by the...
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