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Patent # Description
2018/0008685 SHEEP NEMATODE VACCINE
The present invention is based upon the identification of a number of antigens derived from species of the genus Teladorsagia, which can be used to raise...
2018/0008683 INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF...
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements...
2018/0008682 USE OF GENETICALLY ENGINEERED STRAIN VNP20009-M IN PREVENTING AND TREATING CANCER METASTASIS
The present disclosure provides uses of genetically engineered attenuated Salmonella typhimurium strain VNP20009-M in preventing and treating cancer...
2018/0008681 HUMAN-ENZYME MEDIATED DEPLETION OF CYSTINE FOR TREATING PATIENTS WITH CYSTINURIA
Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, in certain aspects...
2018/0008680 Messenger RNA Therapy for the Treatment of Ornithine Transcarbamylase Deficiency
The present invention provides, among other things, methods of treating ornithine transcarbamylase (OTC) deficiency, including administering to a subject in...
2018/0008677 MODIFIED VASOACTIVE INTESTINAL PEPTIDES
The present invention provides modified Vasoactive Intestinal Peptides (VIPs), encoding polynucleotides and vectors, as well as pharmaceutical compositions...
2018/0008676 THERAPY FOR VITILIGO
The present invention relates to a therapy for vitiligo. In particular the present invention provides a pharmaceutical composition comprising an alpha...
2018/0008674 Use Of Immunomodulatory Effective Kits For The Immunotherapeutic Treatment Of Patients Suffering From Myeloid...
The present invention relates to a method for selecting an immunomodulatory kit, selected for an individual patient, for use in the treatment of patients...
2018/0008673 TREATMENT OF RIGHT VENTRICULAR DYSFUNCTION DUE TO PRESSURE OVERLOAD
A method is disclosed for inducing right ventricular (RV) adaptive remodeling in a patient suffering from pulmonary hypertension (PH) due to pressure overload...
2018/0008671 PROLONGED ANTI-DIABETIC EFFECT OF FIBROBLAST GROWTH FACTOR 1 (FGF1)
Disclosed are compositions and methods for inducing sustained diabetes remission by single administration of FGF1 to the brain. The composition and methods...
2018/0008670 CHIMERIC ANTIGEN RECEPTOR TARGETING OF TUMOR ENDOTHELIUM
Disclosed are methods, protocols, and compositions of matter related to utilization of chimeric antigen receptor (CAR) expressing cells for the targeting of...
2018/0008669 ID4 PROTEIN RESTORES WILD TYPE P53 ACTIVITY
A compound and method for treating cancer, in particular prostate cancer. Id4 reverts mutant p53 activity to its wild type physiological status and activity....
2018/0008667 CELL PENETRATING ANTIBODIES
Provided herein are cell penetrating conjugates. The conjugates include a non-cell penetrating protein attached to a phosphorothioate nucleic acid or...
2018/0008664 NOVEL PEPTIDES AND PEPTIDOMIMETICS
Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or...
2018/0008659 ANTI-INFLUENZA VIRUS COMPOSITION CONTAINING PONCIRUS TRIFOLIATA EXTRACT AS ACTIVE INGREDIENT
The present invention relates to an anti-influenza virus composition containing a Poncirus trifoliata extract as an active ingredient. The composition of the...
2018/0008658 METHOD FOR PRODUCING A COMPLEX OF BIOLOGICALLY ACTIVE SUBSTANCES EXHIBITING HYPOGLYCEMIC ACTIVITY
The invention relates to medicine and chemical and pharmaceutical industry, in particular, to methods for producing a complex of biologically active substances...
2018/0008652 PROBIOTIC FOR INFANTILE COLIC
The invention provides a bacterial composition which comprises from 10.sup.4 to 10.sup.12 cfu/g of Pediococcus pentosaceus cells which have the ability to...
2018/0008650 BARRIER LAYER
A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device...
2018/0008649 ADHERENT STROMAL CELLS DERIVED FROM PLACENTAS OF MULTIPLE DONORS AND USES THEREOF
Pharmaceutical compositions comprising adherent stromal cells (ASCs) are provided. The ASCs are obtained from at least two donors. Articles of manufacture...
2018/0008648 SCAFFOLD-SEEDED ORAL MUCOSA STEM CELLS
A method of treating a spinal cord injury in a subject in need thereof is disclosed. The method comprises implanting a scaffold into the spinal cord of a...
2018/0008646 METHOD FOR CULTIVATING VASCULAR SMOOTH MUSCLE CELLS
The present invention provides a method for culturing vascular smooth muscle cells, which includes culturing vascular smooth muscle cells in suspension in a...
2018/0008642 PURIFIED MESENCHYMAL STEM CELL COMPOSITIONS AND METHODS OF PURIFYING MESENCHYMAL STEM CELL COMPOSITIONS
One or more purified mesenchymal stem cell pharmaceutical compositions and methods of manufacture utilizing centrifugal filtration are disclosed. Threshold...
2018/0008638 Methods for Enhancing Efficacy of Therapeutic Immune Cells
The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor--CAR) that activates an immune response upon binding a cancer...
2018/0008636 PEROXIDE FORMULATIONS AND METHODS AND APPLICATORS FOR USING THE SAME
Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and...
2018/0008635 TRACE ELEMENTS
A trace element solution comprises at least the following metals: zinc; manganese; selenium; and copper; and which comprises a concentration of the metals of...
2018/0008634 KITS AND METHODS FOR NUTRITION SUPPLEMENTATION
The present invention relates to methods of co-administration of various vitamins and mineral compositions, and in a specific embodiment, said methods comprise...
2018/0008630 POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF
One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the...
2018/0008629 Compositions and Methods for Treating NLRP3 Inflammasome-Related Diseases and Disorders
The present invention provides compositions and methods for treating or preventing an NLRP3 immunosome-related disorder. In one embodiment, the method includes...
2018/0008628 SULPHATED HYALURONIC ACIDS AS REGULATOR AGENTS OF THE CYTOKINE ACTIVITY
The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro-...
2018/0008626 COMBINATION OF HYALURONIC ACID AND MACROGOL AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
The invention relates to a new combination of hyaluronic acid and macrogol, pharmaceutical compositions containing said combination and the use of the...
2018/0008625 COMPOSITION COMPRISING CHITOSAN FOR USE IN THE PREVENTION AND/OR IN THE TREATMENT OF INCONTINENCE AND/OR...
Composition comprising chitosan for use in the prevention and/or treatment of incontinence and/or impotence in a subject undergoing prostatectomy.
2018/0008624 Pharmaceutical Compositions Comprising Ledipasvir And Sofosbuvir
The present invention relates to novel pharmaceutical compositions comprising Ledipasvir and Sofosbuvir as well as to methods for their preparation.
2018/0008623 NUTRITIONAL COMPOSITIONS COMPRISING HUMAN MILK OLIGOSACCHARIDES AND NUCLEOTIDES AND USES THEREOF FOR TREATING...
Disclosed are nutritional compositions including human milk oligosaccharides and nucleotides that can be administered to preterm infants, term infants,...
2018/0008621 SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the...
2018/0008620 METHODS OF TREATING NEUROLOGICAL INFLAMMATORY DISORDERS
Methods of treating neurological inflammatory disease or seizures caused by neuroinflammation by administering cPMP are described. Treating neuroinflammatory...
2018/0008618 HEALTH CARE
The treatment of Type 2 diabetes involving the use of a regimen comprising: (A) one or more glucose-lowering drugs (G-LDs) which function to lower the amount...
2018/0008615 NASAL PHARMACEUTICAL COMPOSITIONS WITH A POROUS EXCIPIENT
Described herein are nasal pharmaceutical compositions comprising a porous excipient and an active agent, wherein the active agent is loaded onto a surface of...
2018/0008614 PLATINUM COMPOUNDS, COMPOSITIONS, AND USES THEREOF
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
2018/0008610 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
2018/0008609 Compositions Useful for Treating Herpes Simplex Keratitis, and Methods Using Same
The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes...
2018/0008606 COMPOSITION FOR USE IN INCREASING ENGRAFTMENT EFFICACY OF HAEMATOPOETIC STEM CELLS AFTER TRANSPLANTATION
The present invention provides the new use of composition comprising at least one inhibitor of dipeptidyl peptidase IV (DPP-IV) for increasing migration and...
2018/0008602 COMBINATION THERAPY WITH AN ANTITUMOR ALKALOID
The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor...
2018/0008601 NANOPARTICULATE COMPOSITIONS AND FORMULATIONS OF PIPERAZINE COMPOUNDS
The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the...
2018/0008600 Tablet Comprising 7-[4-(4-benzo[b]thiopen-4-yl-piperazin-1 -yl)butoxy]-1H-Quinolin-2-One or a Salt Thereof
This invention relates to a tablet containing, as an active ingredient, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt...
2018/0008599 PHARMACEUTICAL PREPARATION COMPRISING BREXPIPRAZOLE AND SUBSTITUTED BETA-CYCLODEXTRIN
Provided is an aqueous pharmaceutical preparation comprising 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one (compound (I)) or a salt...
2018/0008598 ANTIBACTERIAL NASAL COMPOSITIONS AND RELATED METHODS
Methods for treatment of infections, such as nasal infections, sinus infections, ear infections, and/or lung infections, along with related compositions. In...
2018/0008597 PHARMACEUTICAL COMPOSITIONS COMPRISING DEXTROMETHORPHAN AND QUINIDINE FOR THE TREATMENT OF DEPRESSION, ANXIETY,...
Pharmaceutical compositions and methods for treating depression, anxiety, and neurodegenerative diseases and cognitive disorders, such as dementia and...
2018/0008596 Processes For Preparing Morphinan-6-One Products With Low Levels Of Alpha, Beta-Unsaturated Ketone Compounds
The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of...
2018/0008594 USE OF OPIOID ANTAGONISTS
Embodiments of the invention provide methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell...
2018/0008592 TREATMENT OF UREMIC PRURITUS
The present invention relates to methods for treating uremic pruritus with anti-pruritic compositions, wherein the method provides a therapeutic effect in a...
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