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Patent # Description
2018/0043034 GENE AUGMENTATION THERAPIES FOR INHERITED RETINAL DEGENERATION CAUSED BY MUTATIONS IN THE PRPF31 GENE
The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mRNA processing factor 31 (PRPF31).
2018/0043033 AMATOXIN-ANTIBODY CONJUGATES
The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.
2018/0043032 Stabilization of Therapeutic Agents to Facilitate Administration
The present invention provides for a carrier complex for administration of therapeutic agents. In one aspect, an isolated C. botulinum carrier complex is...
2018/0043031 AMPHIPATHIC PEPTIDE
The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell....
2018/0043030 DEGRADABLE THIOL-ENE POLYMERS AND METHODS OF MAKING THEREOF
Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example,...
2018/0043029 STABILIZED POLYMERIC CARRIERS FOR THERAPEUTIC AGENT DELIVERY
Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock...
2018/0043028 POLYMER-SUNITINIB CONJUGATES
The invention relates to (among other things) polymer-sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a...
2018/0043026 ALTERNATING AND SEMI-ALTERNATING POLY(ESTER-ANHYDRIDE) COPOLYMERS
A copolymer characterized by alternating or semi-alternating ester and anhydride bonds, methods for its production and use thereof, particularly as a carrier...
2018/0043025 PROTEIN TRANSDUCTION DOMAINS MIMICS
The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers...
2018/0043024 EYEDROPS
Provided is an ophthalmic solution for treatment or prevention of lid wiper epitheliopathy, which is capable of imparting sufficient lubricity to a corneal...
2018/0043023 DOSE SELECTION OF ADJUVANTED SYNTHETIC NANOCARRIERS
Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
2018/0043022 NOVEL LIGHT-ACTIVATED COMPOSITIONS AND METHODS USING THE SAME
The invention includes light-activated compositions and methods that are useful for promoting cell death or growth. In certain embodiments, the compositions...
2018/0043021 ANTI-GLUCOSAMINIDASE PASSIVE IMMUNIZATION FOR STAPHYLOCOCCUS AUREUS INFECTIONS
The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S....
2018/0043020 METHOD OF REDUCING IMMUNOGENICITY OF DRUG PRODUCTS
The present invention is directed to methods for reducing immunogenicity of a drug product, utilizing filling a container wherein the filled container has no...
2018/0043019 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0043018 Stable Aqueous Formulations of Adalimumab
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2018/0043017 PHARMACEUTICAL COMPOSITIONS COMPRISING 0.5 MG DOSE OF SYNTHETIC HUMAN PEPTIDES FOR TREATING SYSTEMIC LUPUS...
Provided is a method of treating a human subject suffering from systemic lupus erythematosus (SLE) and having at least one organ system categorized by the...
2018/0043016 PHARMACEUTICAL COMPOSITIONS COMPRISING 0.25 MG DOSE OF SYNTHETIC HUMAN PEPTIDES FOR TREATING SYSTEMIC LUPUS...
Provided is a method of treating a human subject suffering from systemic lupus erythematosus (SLE) and having at least one organ system categorized by the...
2018/0043015 SUBSTANCES, VACCINES AND METHODS FOR DIAGNOSING AND REDUCING INCIDENCES OF TRANSPLANT REJECTION
Methods and products for diagnosing, treating and/or delaying onset of chronic allograft rejection, including cardiac allograft vasculopathy. In an exemplary...
2018/0043014 Compositions Using Antibodies Directed to GPNMB and Uses Thereof
The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to GPNMB, and uses of such antibodies. The present...
2018/0043013 CYTOTOXIC AGENTS COMPRISING NEW MAYTANSINOIDS (DM4)
New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the .alpha.-carbon atom bearing the sulfur atom are disclosed. Also...
2018/0043012 COMPOUNDS FOR IMPROVING THE HALF-LIFE OF VON WILLEBRAND FACTOR
The invention relates to a compound, preferably an antibody, capable of binding to the receptor protein CLEC10A for use in the treatment of a blood coagulation...
2018/0043011 PI3-Kinase Inhibition and LAG-3 Checkpoint blockade as a Combination Therapy for Cancer
This disclosure provides methods of treating cancer comprising administering at least one PI3K inhibitor and at least one LAG-3 checkpoint inhibitor. Suitable...
2018/0043010 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2018/0043009 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular,...
2018/0043008 RECALL ANTIGEN FOR PROMOTING T-HELPER TYPE 1 RESPONSE
Provided herein is a method of stimulating a systemic T helper cell type 1 response in a person in need thereof, the method comprising: injecting a composition...
2018/0043007 INFLUENZA VIRUS VECTORS AND USES THEREFOR
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein...
2018/0043006 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING RHINOVIRUS INFECTIONS
An analysis of human CD4.sup.+ T-cell epitopes of RV capsid proteins with cross-reactive potential was performed, peptide epitopes of RV-A16 capsid proteins...
2018/0043005 IMMUNOGENIC COMPOSITION COMPRISING ELEMENTS OF C. DIFFICILE CDTB AND/OR CDTA PROTEINS
The present invention relates to immunogenic compositions comprising isolated Clostridium difficile CDTb and/or CDTa protein. In particular the isolated...
2018/0043004 MODIFIED ENDOTOXIC BACTERIA LIPOPOLYSACCHARIDE (VARIANTS), COMBINATION OF MODIFIED LIPOPOLYSACCHARIDES...
For the first time individual (free from impurities of penta- and hexa-acetylated derivatives) di-, tri- and tetra-acetylated S-LPS of endotoxic bacteria and...
2018/0043003 REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS
Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a...
2018/0043002 GLYCOCONJUGATE VACCINE FOR LEISHMANIASIS
Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of...
2018/0043001 PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT OF UTERINE FIBROIDS
A method of treating uterine fibroid in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective...
2018/0043000 TREATMENT OF SOCIAL ANXIETY DISORDER, OBSESSIVE COMPULSIVE DISORDER AND PANIC DISORDER USING BOTULINUM TOXIN
Methods are disclosed for treating social anxiety disorder, obsessive compulsive disorder, and/or panic disorder in a subject. The methods include...
2018/0042999 Multimodal Antimicrobial Therapy
The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-Staphylococcal...
2018/0042998 TARGETING GDF6 AND BMP SIGNALING FOR ANTI-MELANOMA THERAPY
The invention features methods of treating melanoma by modulating an activity of GDF6 in melanoma cells. In one aspect, the methods involve downregulating an...
2018/0042997 MEMORY OR LEARNING IMPROVEMENT USING PEPTIDE AND OTHER COMPOSITIONS
The present invention generally relates to compositions and methods for topical or transdermal delivery, including treatment and prevention of learning and...
2018/0042996 Hydrogel-Linked IL-1ra Prodrug
The present invention relates to a hydrogel-linked IL-Ira prodrug or pharmaceutically acceptable salt thereof. It further relates to a pharmaceutical...
2018/0042995 METHODS OF MAKING AND USING SOLUBLE MHC MOLECULES
Provided herein is a novel K.sub.on-rate assay and an improved TCR ligand k.sub.off-rate assay, which enables a broader application through a novel combination...
2018/0042994 METHODS OF TREATING DISEASES RELATED TO MITOCHONDRIAL FUNCTION
Uses of agent which downregulate an activity or expression of a component participating in the mitochondrial apoptotic pathway are disclosed.
2018/0042993 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING DAMAGE TO THE HEART
Provided herein are methods and compositions for preventing and treating damage to the heart subsequent to myocardial infarction (MI) resulting from harmful...
2018/0042992 TREATMENT OF EYE DISEASE
A method of treating an eye disease comprising administering an adeno-associated virus (AAV) vector to a mammalian subject by subretinal injection, wherein the...
2018/0042991 RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION
The present invention relates to recombinant Glut1 adeno-associated viral vector (rAAV) constructs and related methods for restoring Glut1 expression in Glut1...
2018/0042990 METHOD FOR IMPROVING AN INTESTINAL MICROFLORA AND PROMOTING GROWTH OF ANIMALS BY USING COLICIN OR MICROORGANISM...
The present invention discloses use of a colicin Ib and a microorganism expressing the colicin Ib, to improve animal's intestinal microflora, and an effect of...
2018/0042989 IMMUNOMODULATORY COMPOSITIONS
Immunomodulator formulations for use in the treatment of disease of the GI tract. The formulations comprise a hydroxylase inhibitor and/or an ...
2018/0042988 CYCLOSPORINE FORMULATIONS FOR USE IN THE PREVENTION OR TREATMENT OF PULMONARY CHRONIC GRAFT REJECTION
The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention...
2018/0042987 METHOD FOR TREATING CANCER
The present disclosure relates to a method of treating prostate cancer comprising administering to a subject in need thereof a therapeutically effective amount...
2018/0042986 Chemical Induction of Lactation in Prepubescent Non-Human Mammals
The present invention describes a method of inducing lactation in non-human mammals by using a single administrations of an estrogen compound, a dopaminergic...
2018/0042985 Methods of Improving Behavioral Therapies
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or...
2018/0042984 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ARTHRITIS
The present invention relates to: a pharmaceutical composition for preventing or treating arthritis, which comprises synthetic polypeptides; injections for...
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