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Patent # Description
2018/0051054 METHODS OF PROCESSING A FLUID INCLUDING A RECOMBINANT THERAPEUTIC PROTEIN AND USE THEREOF
Provided herein are methods of processing a fluid that include the use of one or both of a circuit system including a tangential flow filtration (TFF) unit and...
2018/0051053 METHOD FOR OBTAINING PEPTIDE FRAGMENT FROM ANTIBODY BY PROTEASE DECOMPOSITION REACTION WITH RESTRICTED REACTION...
The present invention provides: a method for increasing a yield, from a target monoclonal antibody, of a peptide fragment that comprises an Fab region or a...
2018/0051052 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (1): and pharmaceutical compositions thereof. Such compounds are...
2018/0051051 METHOD FOR PREPARING PRECURSOR OF GENE EXPRESSION PROBE
A method for preparing a precursor of gene expression probe is revealed. First prepare 2-deoxy-2-fluoro-3,5-di-O-benzoyl-.alpha.-D-arabinofuranosyl bromide...
2018/0051050 Biomarkers
The invention provides binding agents and assays tor insulin signal peptide. The agents and assays are useful in methods tor predicting, diagnosing, assessing...
2018/0051049 NON-CALORIC SWEETENER
Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
2018/0051048 POROUS POLYMER COMPOUND, METHOD OF SEPARATING COMPOUND TO BE SEPARATED, SINGLE CRYSTALS, METHOD OF PRODUCING...
The porous polymer compound has a three dimensional skeleton and pores and/or voids that are partitioned and formed by the three dimensional skeleton. The...
2018/0051047 TECHNOLOGY FOR EXTRACTING AND PREPARING HIGH-PURITY RAFFINOSE FROM DEFATTED WHEAT GERM
The present invention discloses a process for preparing high-purity raffinose from defatted wheat germ comprising the steps of percolate extraction of...
2018/0051046 Nickel Metal Nanoparticle Synthesis
Nickel nanoparticles can be synthesized using a variety of precursors (e.g., nickel amides [Ni(NR.sub.2).sub.2], alkyls [NR.sub.2], and alkoxides [Ni(OR).sub.2]).
2018/0051045 RUTHENIUM-SPHINGOMYELIN COMPLEXES AND METHODS FOR THEIR USE IN THE TREATMENT OF TUMORS
The described invention provides a compound comprising an organometallic complex comprising a core of ruthenium and sphingomyelin, with the option of added...
2018/0051044 FUNCTIONALIZED PHOSPHONATES VIA MICHAEL ADDITION
Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This...
2018/0051043 PHOSPHATE SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS
The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof,...
2018/0051042 METHODS FOR FORMING SATURATED (HETERO)CYCLIC BORYLATED HYDROCARBONS AND RELATED COMPOUNDS
The disclosure relates to methods for forming at least partially saturated cyclic and heterocyclic borylated hydrocarbons, as well as related compounds, which...
2018/0051040 AMINE-BORANES BEARING BORANE-INTOLERANT FUNCTIONALITIES
Disclosed herein is the preparation of functional group containing amine-boranes from the corresponding amines. The mild reaction conditions allow for the...
2018/0051039 68Ga-LABELED NOTA-CHELATED PSMA-TARGETED IMAGING AND THERAPEUTIC AGENTS
PSMA-targeted PET/SPECT agents for imaging PSMA-positive cancer and or tumor neovasculature and PSMA-targeted radiotherapeutic agent for the treatment of...
2018/0051038 MERCAPTOETHYLGLYCOL URIL COMPOUND AND UTILIZATION THEREOF
The present invention provides a novel mercaptoethylglycoluril compound. The present invention also provides a curing agent for an epoxy resin using the...
2018/0051037 Photochromic Thienochromene Compounds
The present invention relates to photochromic compounds, such as thienochromene compounds represented by the following Formulas (1a) and/or (1b). The present...
2018/0051036 COMPOUND INHIBITING ACTIVITIES OF BTK AND/OR JAK3 KINASES
The present invention relates to a compound inhibiting the activities of Bruton's tyrosine kinase (BTK) and/or Janus kinase 3 (JAK3), a pharmaceutical...
2018/0051035 THIENOPYRAZINE INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to thienopyrazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
2018/0051034 KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION
Disclosed are compounds within the scope of formula (II) or a salt or solvate thereof, medical uses involving them, and methods for their preparation ...
2018/0051033 INHIBITORS OF LATE SV40 FACTOR (LSF) AS CANCER CHEMOTHERAPEUTICS
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present...
2018/0051032 METHOD OF MANUFACTURING STEREOISOMERS OF BUPRENORPHINE AND ANALOGUES THEREOF
The present invention relates to a method of preparing a compound of Formula II-a' or Formula II-b', wherein R.sup.I represents hydrogen or a linear, branched...
2018/0051031 SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE
seco-Cyclopropapyrroloindole compounds of formula (I) ##STR00001## where Hal, R.sup.1, R.sup.2, and R.sup.3 are as defined in the application, are potent...
2018/0051030 PYRROLOTRIAZINE INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to pyrrolotriazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
2018/0051029 PYRROLOPYRIDAZINE INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to pyrrolopyridazine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
2018/0051028 PYRAZOLOPYRIMIDINE INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to pyrazolopyrimidine inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
2018/0051027 CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY
The present invention relates to carboxamide inhibitors of IRAK4 of formula (I) and provides compositions comprising such inhibitors, as well as methods...
2018/0051026 POLYMORPHS OF IBRUTINIB
The present invention provides crystalline forms of Ibrutinib and processes for their preparation.
2018/0051025 XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME
The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of...
2018/0051024 2-OXO-IMIDAZOPYRIDINES AS REVERSIBLE BTK INHIBITORS AND USES THEREOF
The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
2018/0051023 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2a, R.sup.2b, R.sup.3-R.sup.6, a, b, Z, and X are as ...
2018/0051022 DEUTERATED PALBOCICLIB
This invention relates to novel pyrido[2,3-d]pyrimidinones of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof. This invention also provides...
2018/0051021 BICYCLIC KETONE SULFONAMIDE COMPOUNDS
The present invention provides compounds of Formula (I), ##STR00001## wherein: ##STR00002## as defined in the specification, an enantiomer, diastereomer,...
2018/0051020 COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO TRPA1
Compounds and compositions for treating disorders related to TRPA1 are described herein.
2018/0051019 Composition and Method for Treating Metabolic Disorders
Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of...
2018/0051018 QUINUCLIDINE DERIVATIVE
Provided is a novel therapeutic agent for chronic obstructive pulmonary disease. Provided are a quinuclidine derivative and a medicament comprising the ...
2018/0051017 AGENT FOR TREATMENT OF SCHIZOPHRENIA
The present invention provides a novel method for treatment of schizophrenia which can improve wide-ranging symptoms of schizophrenia, especially positive...
2018/0051016 2-HOMOPIPERAZINE-1-YL-4H-1,3-BENZOTHIAZINE-4-ONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF 2-...
2-homopiperazine-1-yl-4H-1, 3-bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in...
2018/0051015 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
The invention is directed to a formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2a, R.sup.2b and R.sup.3-R.sup.7...
2018/0051014 NEW METAL PLATING COMPOSITIONS
Reaction products of diamines with the reaction products of monoamines and bisanhydrides are included as additives in metal electroplating baths. The metal...
2018/0051013 Heterocyclic Compounds and Methods of Use
This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration...
2018/0051012 DIACYLGLYCEROL ACYL TRANSFERASE 2 INHIBITORS
Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in...
2018/0051011 AMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS
The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to...
2018/0051010 PYRIDAZINE DERIVATIVES AS RORc MODULATORS
Compounds of formula I: ##STR00001## or pharmaceutical salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. Also disclosed are...
2018/0051009 COMPOUNDS, COMPOSITIONS, AND METHODS
The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or...
2018/0051008 TETRAZOLINONE COMPOUND AND USE THEREOF
A tetrazolinone compound represented by formula (1): ##STR00001## wherein R.sup.1 represents a hydrogen atom, a C1-C3 alkyl group optionally having one or more...
2018/0051007 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE INCLUDING SAME
The present specification relates to a hetero-cyclic compound and an organic light emitting device comprising the same.
2018/0051006 DIRECT AMPK ACTIVATORS
Disclosed are benzimidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure ...
2018/0051005 THERAPEUTIC COMPOUNDS
The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): ##STR00001## ##STR00002## which are useful in the treatment of a...
2018/0051004 CRYSTALLINE FORMS OF A BIPHENYL COMPOUND
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piper- idin-4-yl...
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