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Patent # Description
2018/0050091 Modulation of Cancer Immunity with Type 2 Innate Lymphoid Cells, Interleukin 33, and/or Interferon Induced...
The present invention provides methods of modulating of cancer immunity using type 2 innate lymphoid cells (IL-C2s), interleukin 33 (IL-33), IFI44 or...
2018/0050090 COMPOSITIONS AND METHODS FOR SENSITIZING CELLS TO TRAIL-INDUCED APOPTOSIS
The present invention comprises pegylated TRAIL peptides and their use in conjunction with various TRAIL sensitizing agents in tumor homing nanoparticle...
2018/0050089 COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION
In some aspects, the disclosure relates to GDF/BMP antagonists and methods of using GDF/BMP antagonists to treat, prevent, or reduce the progression rate...
2018/0050088 OPHTHALMIC COMPOSITIONS AND METHODS OF USE THEREFOR
The present invention encompasses ophthalmic compositions that may be used for various conditions of the eye, and particularly, conditions of the cornea. Also...
2018/0050087 METHODS OF TREATING LIPODYSTROPHY USING FGF-1 COMPOUNDS
Provided herein are methods and compositions for treating lipodystrophy using fibroblast growth factor 1 (FGF-1) compounds.
2018/0050085 METHODS AND COMPOSITIONS FOR TREATING MYELOFIBROSIS
In part, the present disclosure relates methods for treating, preventing, or reducing the progression rate and/or severity of myelofibrosis or one or more...
2018/0050084 POLYPEPTIDE THERAPEUTICS AND USES THEREOF
Methods and composition for delivery of enzymes to a subject's airway. In some aspects, nebulized composition of enzymes, such as plasminogen activators are...
2018/0050083 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HYPERLIPIDEMIA, FATTY LIVER, ATHEROSCLEROSIS AND OTHER...
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, ...
2018/0050082 SERPINS FOR THE TREATMENT OF NEUROINFLAMMATORY DISEASES
The present invention relates to the use of serpins, including A1AT, its derivatives and analogs thereof, in the prevention or treatment of neuroinflammatory...
2018/0050081 COMPOUNDS AND METHODS FOR INCREASING HAIR GROWTH
A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to SPR4; and...
2018/0050080 BLEOMYCIN-BASED COMPOSITIONS AND USE THEREOF FOR TREATING LOOSE SKIN AND FATTY TISSUE
A composition for displacing loose skin and removing subcutaneous deposits of fatty tissue. The composition includes effective amounts of one or more...
2018/0050079 ANGIOTENSIN PEPTIDES IN TREATING MARFAN SYNDROME AND RELATED DISORDERS
The present invention provides, among other things, methods of treating Marfan Syndrome and/or a Marfan-related disorder including administering to a subject...
2018/0050078 COMPOSITION FOR IMPROVING OR PREVENTING NONALCOHOLIC FATTY LIVER
An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history...
2018/0050077 PLASMONICS-ACTIVE METAL NANOSTAR COMPOSITIONS AND METHODS OF USE
Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated...
2018/0050076 Kung Fu Gu
Kung Fu GU: a topical balm, circulatory, emollient, that helps accelerate the healing of Bruises, reduces swelling and pain as well as increasing circulation....
2018/0050075 THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR ALLEVIATING PAIN SYSTEMS
A therapeutic composition for skin use composed of essential oils derived from natural plant sources and at least one carrier oil. The compositions are...
2018/0050074 Methods of Diagnosing and Treating Dry Eye Syndrome and Compositions for Treating a Human Eye
In preferred the invention is directed to ocular compositions for the treatment of dry eye, methods for making such compositions, and suites comprising a...
2018/0050073 TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING PROSTATE CANCER, PREPARATION METHOD AND APPLICATION THEREOF
The present invention relates to a traditional Chinese medicine composition for treating prostate cancer and its preparation method and application. The...
2018/0050072 COMPOSITION AND USE OF LACTOBACILLUS FERMENTUM GMNL-296 TO PRODUCE COMPOSITION FOR IMPROVING SYMPTOMS OF...
A composition of Lactobacillus fermentum GMNL-296 and a use of Lactobacillus fermentum GMNL-296 for producing a composition to improve the infection symptoms...
2018/0050071 ANTI-AGE COMPOSITION COMPRISING A COMBINATION OF ANTIOXIDANT AGENTS IN ASSOCIATION WITH BIFIDOBACTERIA AND CELL...
An anti-age composition is described. The anti-age composition comprises a combination of antioxidant agents, such as flavonoids, anthocyanins, tannins,...
2018/0050070 BACTERIAL COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates to bacterial compositions and methods of use thereof. The bacterial compositions may include two or more bacteria of the genera...
2018/0050069 INTESTINAL MICROBE THERAPY, COMPOSITION THEREFOR AND METHOD FOR PREPARING THE SAME
The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition...
2018/0050068 METASTATIC CANCER DECOY TRAP
A method of treating or preventing cancer metastasis in a subject is described. The method includes implanting a decoy trap within the subject, the decoy trap...
2018/0050067 PLURIPOTENT STEM CELL THAT INDUCES REPAIR AND REGENERATION AFTER MYOCARDIAL INFARCTION
An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells)....
2018/0050066 SURGICAL WOUND HEALING COMPOSITION AND METHOD OF APPLYING THE SAME
Compositions and methods are disclosed for improving the healing of surgical wounds, and specifically for improving the survival rate, color retention rate,...
2018/0050065 CHIMERIC ANTIGEN RECEPTOR
The present invention provides a chimeric antigen-receptor (CAR)-forming polypeptide comprising: (i) an antigen-binding domain; (ii) a coiled-coil spacer...
2018/0050064 METHOD FOR PRODUCING EYE DROPS
The invention relates to a method for producing eye drops, the thus obtained eye drops and to a kit which comprises the eye drops.
2018/0050063 METHODS OF MEDIATING MACROPHAGE PHENOTYPES
Methods of inducing a polarization of macrophages. The method includes obtaining a blood fraction, fractionating the blood fraction to produce a blood...
2018/0050062 DIALYSIS PRECURSOR COMPOSITION PRODUCT
The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with...
2018/0050061 RONEPARSTAT COMBINED THERAPY OF MULTIPLE MYELOMA
The present invention relates to roneparstat for use in a combined therapy for the treatment of multiple myeloma. In particular it has unexpectedly been found...
2018/0050060 PREECLAMPSIA
The invention provides a method of treating preeclampsia, fetal growth restriction (FGR or IUGR), obesity in pregnancy, post-partum cardiomyopathy (heart...
2018/0050059 DELIVERY OF RNA TO DIFFERENT CELL TYPES
RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The...
2018/0050058 NUCLEIC ACID APTAMER SPECIFICALLY BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 AND METHOD OF DETECTING AVIAN...
This invention relates to a nucleic acid aptamer specifically binding to avian influenza virus subtype H5 and a method of detecting avian influenza virus...
2018/0050057 CRYSTAL-WATER-FREE CALCIUM DIBUTYRYLADENOSINE CYCLOPHOSPHATE CRYSTAL FORM AND PREPARATION METHOD AND...
Disclosed are a crystallization water-free calcium dibutyryladenosine cyclophosphate crystal form, and a preparation method and a use thereof. In an X-ray...
2018/0050056 CONJUGATE INCLUDING CORE AND SIALIC ACID OR DERIVATIVE THEREOF BOUND TO SURFACE OF CORE AND USE THEREOF
Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in...
2018/0050055 Exploiting nutrient deprivation for modulation of glycosylation - research diagnostic, therapeutic, and...
Drug delivery to the cancer cells during its treatment is challenging. Most of the cancer drug cannot reach to the target because of its complex membrane...
2018/0050054 Administration of Nicotinamide Mononucleotide in the Treatment of Disease
Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases...
2018/0050053 COMPOSITIONS FOR ORAL ADMINISTRATION OF ZOLEDRONIC ACID OR RELATED COMPOUNDS FOR TREATING COMPLEX REGIONAL PAIN...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
2018/0050052 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1-R.sup.6, a, b, Z, and X are as defined in the specification, or...
2018/0050051 FUMAGILLOL DERIVATIVES
Disclosed are compounds of Formula 1, ##STR00001## stereoisomers thereof and pharmaceutically acceptable salts of the compounds and stereoisomers, wherein...
2018/0050050 FRANKIAMICIN A COMPOSITIONS AND METHODS
In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In...
2018/0050049 COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES
The compositions and methods disclosed herein provide for treatments of ocular disorders of the eye, such as ocular surface diseases as well as those...
2018/0050048 CONJUGATE COMPOUNDS OF URSODEOXYCHOLIC, BERBERINE OR L-CARNITINE, AND COMPOSITIONS AND METHODS THEREOF
The invention provides novel conjugate compounds having at least one of a moiety derived from ursodeoxycholic acid, or eicosapentaenoic acid, or ...
2018/0050047 CORTEXOLONE 17alpha-PROPIONATE FOR USE IN THE TREATMENT OF SKIN WOUNDS AND/OR ATROPHIC SKIN DISORDERS
The present invention provides cortexolone 17.alpha.-propionate for use in the treatment of skin wounds and/or atrophic skin disorders. The present invention...
2018/0050046 FULVESTRANT FORMULATIONS
The invention provides a fulvestrant composition comprising not more than 2% total impurities that comprises a nonionic surfactant and/or a ricinoleate vehicle...
2018/0050045 METHOD FOR INHIBITING THE EXPRESSION OF ABC TRANSPORTER PROTEIN
A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an...
2018/0050044 COBALT-POLYPYRIDYL COMPLEX FOR TREATMENT OF CANCER, A PHARMACEUTICAL COMPOSITION AND A KIT COMPRISING IT
A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the...
2018/0050043 Inhibition of DUX4 Expression Using Bromodomain and Extra-Terminal Domain Protein Inhibitors (BETi)
The use of BETi as a potential treatment for FSHD is provided. Specifically, the use of BETi, and particularly selective BETi for BRD4, are shown to inhibit...
2018/0050042 Novel Formulation of Meloxicam
Unit dosage forms of meloxicam containing either 5 mg or 10 mg of meloxicam that provide effective pain relief and have desirable pharmacokinetic properties...
2018/0050041 Compositions and Methods for Treating Niemann Pick C Disease
The present invention relates to the use of PIKfyve inhibitors to treat Niemann-Pick disease type C, and related compositions and methods.
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