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Patent # Description
2018/0057889 Digital Analysis of Circulating Tumor Cells in Blood Samples
This disclosure relates to new assay methods for analysis of circulating tumor cells (CTCs) in blood samples for detection, e.g., early detection, and/or...
2018/0057888 KUB5/HERA AS A DETERMINANT OF SENSITIVITY TO DNA DAMAGE
The present disclosure is directed to methods of detecting KUB5/HERA expression levels, copy number and mutation status, particularly in cancer cells. The...
2018/0057887 HER2-REGULATED RNA AS A DIAGNOSTIC AND THERAPEUTIC TARGETS IN HER2+ BREAST CANCER
A method for treating HER2 positive breast cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to...
2018/0057886 METHOD OF TREATING LEUKEMIA BASED ON GENE EXPRESSION OF CLOCK GENES
A method of treating leukemia in a patient, the method including obtaining a plasma sample from a patient at a first time point and at a second time point,...
2018/0057885 METHODS FOR NON-INVASIVE PRENATAL PLOIDY CALLING
The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of...
2018/0057884 COMPOSITIONS AND METHODS FOR IDENTIFYING DEPRESSIVE DISORDERS
Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and...
2018/0057883 Compositions and Methods for the Diagnosis and Treatment of Lupus Nephritis
Compositions and methods for diagnosing and treating lupus nephritis are disclosed.
2018/0057882 BLOOD RNA BIOMARKERS OF CORONARY ARTERY DISEASE
The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (CAD). Methods and compositions for...
2018/0057881 METHODS OF DETECTING SNPS RELATED TO MRSA AND SSI
A method for identifying, diagnosing, and treating individuals who may be at risk developing or may have developed recurrent antibiotic resistant skin...
2018/0057880 METHODS, COMPOSITIONS, AND DIAGNOSTIC KITS FOR THE DETECTION OF ALPHA AND BETA THALASSEMIA
Disclosed are methods, compositions, and diagnostic kits for the rapid detection of certain types of .alpha.-thalassemia and .beta.-thalassemia. In some...
2018/0057879 DIAGNOSTICS FOR DETERMINING THE ONSET OF ALZHEIMER'S DISEASE
In accordance with the present invention, a methodology for diagnosing the onset of a neurodegenerative disease, such as Alzheimer's disease, is provided. For...
2018/0057878 Corn Event DAS-59122-7 and Methods for Detection Thereof
The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the...
2018/0057877 MATERIALS AND METHODS FOR IDENTIFYING GYRASE INHIBITORS
The disclosure describes the effects of transcription mediated from a promoter on the transcription mediated by divergently coupled supercoiling-sensitive...
2018/0057876 PREPARATION OF ADAPTER-LIGATED AMPLICONS
The present invention is directed to novel methods and kits to be employed for preparing adapter-ligated amplicons or a sequencing library of a target DNA,...
2018/0057875 SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
The present invention relates to systems and methods for sequencing nucleic acids, including sequencing nucleic acids in fluidic droplets. In one set of...
2018/0057874 MULTI-SEQUENCE CAPTURE SYSTEM
Systems, devices, and methods for capturing single source-specific biological material from a multi-source aggregate of biological material are disclosed and...
2018/0057873 METHODS FOR PERFORMING SPATIAL PROFILING OF BIOLOGICAL MATERIALS
Provided herein are methods and compositions for profiling the spatial distribution of a wide variety of biological molecules in a sample. The methods and...
2018/0057872 SINGLE NUCLEOTIDE DETECTION METHOD
A method of sequencing a nucleic acid such as DNA or RNA is provided. It is characterised by the steps of (1) generating a stream of single nucleoside...
2018/0057871 COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS
In some aspects, the present disclosure provides methods for identifying sequence variants in a nucleic acid sample. In some embodiments, a method comprises...
2018/0057870 TAGGED NUCLEOTIDES USEFUL FOR NANOPORE DETECTION
The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore...
2018/0057869 DETECTION OF TARGET NUCLEIC ACID SEQUENCE BY PTO CLEAVAGE AND EXTENSION-DEPENDENT NON-HYBRIDIZATION ASSAY
The present invention relates to the detection of a target nucleic acid sequence by a PCE-NH (PTO Cleavage and Extension-Dependent Non-Hybridization) assay....
2018/0057868 CLEAVABLE HAIRPIN PRIMERS
The invention describes composition and methods of use for novel hairpin blocked-cleavable primers. In one embodiment unblocking occurs through action of RNase...
2018/0057867 Methods of Hybridizing Probes to Genomic DNA
The present invention relates to methods of hybridizing nucleic acid probes to genomic DNA.
2018/0057866 GENETIC PROFILING METHODS FOR PREDICTION OF TASTE AND SCENT PREFERENCES AND GUSTATIVE AND OLFACTIVE PRODUCT...
The present invention relates to methods of gustative or olfactive product selection. In particular, the invention relates to the use of genetic profiling to...
2018/0057865 NUCLEIC ACID CLASSIFICATION
A method and system for classifying a target nucleic acid includes exposing, in a test system, one or more capture probes to the target nucleic acid. The one...
2018/0057864 COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION
A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired...
2018/0057863 DIGITAL ANALYTE ANALYSIS
The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of...
2018/0057862 COMPOSITIONS AND METHODS TO DETECT LEGIONELLA PNEUMOPHILA NUCLEIC ACID
Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and...
2018/0057861 SEQUENCE, TECHNIQUE PLATFORM, AND METHOD FOR IN VITRO DETECTING CLOSTRIDIUM DIFFICILE RIBOTYPE 027
The invention relates to a sequence, a technique platform, and a method for in vitro detecting Clostridium difficile ribotype 027. The technology platform...
2018/0057860 ENZYME PREPARATION CONTAINING THERMOSTABLE DNA POLYMERASE, METHOD FOR PRODUCING SAME, AND METHOD FOR DETECTING...
Disclosed is a thermostable DNA polymerase preparation which can illimitably reduce the risk of false positivity in the detection of a subject microorganism...
2018/0057859 METHOD FOR IDENTIFYING RARE CELL TYPES BY SINGLE CELL ASSISTED DECONVOLUTION OF POPULATION GENE EXPRESSION DATA
The invention provides methods of identifying the gene expression profile of a cell type present within a population of cells using single cell expression data...
2018/0057858 METHOD AND KIT FOR DETECTING BACTERIA OF GENUS NITROBACTER
Provided is a method for detecting a bacterium of the genus Nitrobacter, comprising: a first step of amplifying a nucleotide using a test DNA as a template and...
2018/0057857 ENZYME REACTION REAGENT HAVING DRIED FORM AND METHOD FOR PREPARING THE SAME
A method for producing a dry reagent composition includes preparing a reagent solution including a Good's buffer in a concentration of more than 2.5 mM, an...
2018/0057856 SELECTIVE ULTRASONIC LYSIS OF BLOOD AND OTHER BIOLOGICAL FLUIDS AND TISSUES
The present invention features methods for selective lysis of endogenous cells in a biological sample. In preferred embodiments, the methods of the invention...
2018/0057855 SOLID PHASE NUCLEIC ACID TARGET CAPTURE AND REPLICATION USING STRAND DISPLACING POLYMERASES
A method and kit for the capture and purification of specific nucleic acids from a sample with affinity capture probes on a solid support and for the...
2018/0057854 METHODS AND COMPOSITIONS TO DETECT THE LEVEL OF LYSOSOMAL EXOCYTOSIS ACTIVITY AND METHODS OF USE
Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia...
2018/0057853 ANTIMICROBIAL SUSCEPTIBILITY TESTING DEVICE, ANTIMICROBIAL SUSCEPTIBILITY TESTING KIT, AND ANTIMICROBIAL...
Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts...
2018/0057852 Spectrometric Analysis of Microbes
A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke,...
2018/0057851 Biosensor and Production Method for Same
The disclosure relates to a biosensor including electrodes, a hydrophilic region or layer, and a reagent layer that contains an enzyme and a mediator, and...
2018/0057850 UDP-GLYCOSYLTRANSFERASES FROM SOLANUM LYCOPERSICUM
The present invention relates to polypeptides having UDP-Glycosyltransferase activity derived from Solanum lycopersicum and having the amino acid sequence set...
2018/0057849 Microorganisms and Methods for Producing Sialylated and N-Acetylglucosamine-Containing Oligosaccharides
The invention provides compositions and methods for engineering bacteria to produce sialylated and N-acetylglucosamine-containing oligosaccharides, and the use...
2018/0057848 POLYHYDROXYALKANOATE COPOLYMER COMPOSITIONS AND METHODS OF MAKING THE SAME
A polyhydroxyalkanoate copolymer composition is provided. The composition comprises a plurality of polyhydroxyalkanoate copolymer molecules. The ...
2018/0057847 Silicone Oil as Reaction or Separation Medium for Ester Synthesis
Silicone oil is a reaction medium or separation medium, or both, for ester synthesis. Enzyme-catalyzed esterification is conducted in the silicone oil, with...
2018/0057846 PARTIALLY BUFFERED FREE ACID AND/OR KETONE BLEND FOR RAPID ONSET KETOSIS AND METABOLIC THERAPY
A foodstuff can include a free acid .beta.-hydroxybutyrate, and a base. The .beta.-hydroxybutyrate, and base, are present at a less than 1:1 molar equivalence....
2018/0057845 METHOD FOR PREPARING p-VINYL PHENOLS
A biocatalytic method is provided for preparing p-vinyl phenols by a three-step, one-pot reaction according to the following reaction scheme: ##STR00001## ...
2018/0057844 INOSITOL PREPARATION METHOD
An inositol preparation method by enzymatic catalysis uses starch and cellulose or substrates thereof as substrates. Raw materials are converted to inositol by...
2018/0057843 METHODS FOR BIOSYNTHESIS OF ISOBUTENE
The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-CoA dehydratase, a ...
2018/0057842 VECTORS AND METHODS FOR TARGETED INTEGRATION IN LOCI COMPRISING CONSTITUTIVELY EXPRESSED GENES
The invention relates to a vector comprising: a 5' nucleic acid that is homologous to a genomic sequence 5' of a stop codon of a constitutively expressed gene;...
2018/0057841 METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer...
2018/0057840 RAAV VECTOR COMPOSITIONS, METHODS FOR TARGETING VASCULAR ENDOTHELIAL CELLS AND USE IN TREATMENT OF TYPE I DIABETES
Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also...
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