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| Patent # | Description |
|---|---|
| 2018/0162924 |
Fusion Polypeptides Capable Of Activating Receptors A fusion polypeptide comprising (A).sub.x-M-(A').sub.y, wherein A and A' are each polypeptides capable of binding a target receptor. The fusion polypeptides of... |
| 2018/0162923 |
B1SP FUSION PROTEIN THERAPEUTICS, METHODS, AND USES Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to... |
| 2018/0162922 |
T CELL RECEPTORS WITH IMPROVED PAIRING The present invention relates to modified T cell receptor (TCR) .alpha. or .beta. chains, or heterodimers comprising the same, wherein in the variable domain... |
| 2018/0162921 |
HIGH AFFINITY T CELL RECEPTOR AND USE THEREOF The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same,... |
| 2018/0162920 |
PROTEASE-RESISTANT LIPIDATED GLP-1 ANALOGS The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and... |
| 2018/0162919 |
MULTIVALENT REGULATORY T CELL MODULATORS This disclosure provides compounds that contain an IL-2 receptor-binding moiety and an ST2-binding moiety. The methods described in the present disclosure... |
| 2018/0162918 |
IL-37 VARIANTS This invention relates to polypeptides, including variants of interleukin-37 (IL-37), and related therapeutics and compositions. The invention also relates to... |
| 2018/0162917 |
RECOMBINANT PROTEINS AND THEIR THERAPEUTIC USES A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression... |
| 2018/0162916 |
METHOD FOR PRODUCTION OF MOTH PHEROMONES IN YEAST The present disclosure relates to methods for production of (Z)-11-hexadecen-1-ol in a yeast cell using desaturases and fatty acyl-CoA reductase. Also... |
| 2018/0162915 |
METHODS AND COMPOSITIONS FOR MODIFYING PLANT ARCHITECTURE AND DEVELOPMENT Methods and compositions useful for modifying plant architecture and development are provided herein. Plants with altered levels of MATE-efflux polypeptides... |
| 2018/0162914 |
METHODS OF OPTIMIZING NUCLEOTIDE SEQUENCES ENCODING ENGINEERED INFLUENZA
PROTEINS The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized... |
| 2018/0162913 |
METHODS FOR POTENTIATING AN IMMUNE RESPONSE USING DEPOT-FORMING AND
NON-DEPOT-FORMING VACCINES The present disclosure provides methods, vaccines and kits for potentiating an immune response to an antigen in a subject. The methods comprise administering... |
| 2018/0162912 |
CYTOKINE A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine... |
| 2018/0162911 |
POLYPEPTIDES FOR THE DIAGNOSIS AND THE TREATMENT OF C3 NEF ASSOCIATED C3
GLOMERULOPATHY The present invention relates to polypeptides for the diagnosis and treatment of C3 NeF associated C3 Glomerulopathy. In particular, the present invention is... |
| 2018/0162910 |
DE NOVO STRUCTURAL PROTEIN DESIGN FOR MANUFACTURING HIGH STRENGTH
MATERIALS Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming... |
| 2018/0162909 |
CONOTOXIN PEPTIDE K-CPTX-BTL03, PREPARATION METHOD THEREFOR, AND USES
THEREOF Provided are a conotoxin peptide .kappa.-CPTx-bt103 and a derivative polypeptide. The amino acid sequence of the conotoxin peptide is indicated by SEQ ID NO:... |
| 2018/0162908 |
CONOTOXIN PEPTIDE K-CPTX-BTL02, PREPARATION METHOD THEREFOR, AND USES
THEREOF Provided is a new conotoxin peptide .kappa.-CPTx-btl02. The conotoxin peptide .kappa.-CPTx-btl02 has derivative polypeptide that has an amino acid sequence... |
| 2018/0162907 |
STABILIZED MINIMAL COILED-COIL MIMETICS This invention relates to a macrostructure that includes an antiparallel coiled-coil structure shown below or a parallel coiled-coil structure shown below and... |
| 2018/0162906 |
CAHUITAMYCINS AND METHODS OF MAKING AND USING THE SAME Provided herein are biofilm inhibitors obtained from marine microbial derived natural product extracts from Streptomyces gandocaensis, resulting in biofilm... |
| 2018/0162905 |
MACROCYCLIC PROLINE DERIVED HCV SERINE PROTEASE INHIBITORS The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit serine... |
| 2018/0162904 |
IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions... |
| 2018/0162903 |
METHOD FOR THE REDUCTION OF VIRAL TITER IN PHARMACEUTICALS Disclosed are methods and devices for the optimization of virus removal from solutions. A method of filtering a process fluid comprising a product includes... |
| 2018/0162902 |
POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies... |
| 2018/0162901 |
Method For Facilitating Extraction Of A Fraction From A Biological Sample A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a... |
| 2018/0162900 |
POLYMORPHIC FORMS OF AN OXYSTEROL AND METHODS OF MAKING THEM Compositions and methods for preparing OXY133 polymorphs Form C to Form I are provided. The methods include subjecting a slurry of OXY133 to conditions... |
| 2018/0162899 |
CYCLIC DINUCLEOTIDES AS STING AGONISTS Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of... |
| 2018/0162897 |
TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM The present invention provides fluorine substituted tricyclic nucleosides of formula (I) wherein: the substituents are as defined in the claims. The present... |
| 2018/0162896 |
Synthesis of Phosphoramidates A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as... |
| 2018/0162895 |
METHOD FOR PREPARING NICOTINAMIDE MONONUCLEOTIDE (NMN) The present invention provides a method for preparing nicotinamide mononucleotide (NMN) by biocatalysis. The method includes a step of catalytically reacting a... |
| 2018/0162894 |
PROCESSES FOR THE PREPARATION OF GALNAC ACID DERIVATIVES The invention comprises a new process for the preparation of GalNAc derivatives of the formula I ##STR00001## wherein n is an integer between 0 and 10 and its... |
| 2018/0162893 |
UTILITY OF NEMATODE SMALL MOLECULES The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present... |
| 2018/0162892 |
CHLORINATION OF SUCROSE-6-ESTERS There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said... |
| 2018/0162891 |
METHOD AND AN APPARATUS FOR FORMING A LIGNIN FRACTION, A LIGNIN
COMPOSITION AND ITS USE The invention relates to a method and an apparatus for forming a lignin fraction from crude lignin which has been processed by means of a treatment step... |
| 2018/0162890 |
Phosphepine Matrix Compound for a Semiconducting Material The present invention is directed to a compound comprising at least one phosphepine ring and having the phosphorous atom of the phosphepine ring substituted... |
| 2018/0162889 |
PHOSPHINE OXIDE ALKYL AMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS MODULATORS
OF IL-12, IL-23, AND/OR IFN ALPHA... Compounds having the following formula I: ##STR00001## or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined... |
| 2018/0162888 |
FURAN-CONTAINING FLAME RETARDANT MOLECULES A furan-containing flame retardant molecule includes a furan moiety bonded to a phosphorus moiety via a phosphoryl linkage or via a phosphinyl linkage. |
| 2018/0162887 |
METATITANIC ACID PARTICLE, COMPOSITION FOR FORMING PHOTOCATALYST, AND
PHOTOCATALYST A metatitanic acid particle including bonded thereon a metal-containing compound which has a hydrocarbon group, wherein the metatitanic acid particle has an... |
| 2018/0162886 |
COORDINATIVELY UNSATURATED TITANIUM CATECHOLATE COMPLEXES AND PROCESSES
ASSOCIATED THEREWITH Coordinatively saturated titanium (IV) coordination compounds containing catecholate ligands can be desirable active materials for flow batteries and other... |
| 2018/0162885 |
COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts... |
| 2018/0162884 |
POLYENE COMPOUND, PREPARATION METHOD AND USE THEREOF Disclosed are a polyene compound, preparation method and use thereof. Provided in the present invention is the preparation method of a polyene compound I,... |
| 2018/0162883 |
AMINE SUBSTITUTED TRISILYLAMINE AND TRIDISILYLAMINE COMPOUNDS AND
SYNTHESIS METHODS THEREOF Halogen free amine substituted trisilylamine and tridisilylamine compounds and a method of their preparation via dehydrogenative coupling between the... |
| 2018/0162882 |
GROUP 4 METAL ELEMENT-CONTAINING COMPOUND, METHOD OF PREPARING THE SAME,
PRECURSOR COMPOSITION INCLUDING THE... The present disclosure provides a Group 4 metal element-containing novel compound, a method of preparing the Group 4 metal element-containing compound, a... |
| 2018/0162881 |
HIGHLY REACTIVE METAL HYDRIDES, PROCESS FOR THEIR PREPARATION AND USE The invention relates to powdery, highly reactive alkali and alkaline earth hydride compounds, and to mixtures with elements of the third main group of the... |
| 2018/0162880 |
METHOD FOR PRODUCING METAL ORGANYLS The invention relates to a method for producing organometallic compounds RMn (M=alkali or alkaline earth element, R=alkyl residue) where n=valence of the metal... |
| 2018/0162879 |
JANUS KINASE INHIBITOR Disclosed are a series of Janus kinase inhibitors, and particularly disclosed are a compound or pharmaceutically acceptable salts thereof of Formula (I) and... |
| 2018/0162878 |
ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as... |
| 2018/0162877 |
PYRAZOLOPYRIDINAMINES AS MKNK1 AND MKNK2 INHIBITORS The present invention relates to substituted pyrazolopyridinamine compounds of general formula (I) as described and defined herein, to methods of preparing... |
| 2018/0162876 |
NITROGEN-CONTAINING TRICYCLIC DERIVATIVES HAVING HIV REPLICATION
INHIBITORY ACTIVITY The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same.... |
| 2018/0162875 |
HETEROCYCLIC COMPOUND AND USE THEREOF Provided is a compound represented by the formula (I): ##STR00001## wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA ... |
| 2018/0162874 |
SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous... |
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