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| Patent # | Description |
|---|---|
| 2018/0161454 |
COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR
IMMUNOSTIMULATION The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the... |
| 2018/0161453 |
COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR
IMMUNOSTIMULATION The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the... |
| 2018/0161452 |
COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR
IMMUNOSTIMULATION The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the... |
| 2018/0161451 |
COMPLEXES OF RNA AND CATIONIC PEPTIDES FOR TRANSFECTION AND FOR
IMMUNOSTIMULATION The present invention relates to a complexed RNA, comprising at least one RNA complexed with one or more oligopeptides, wherein the oligopeptide, which has the... |
| 2018/0161450 |
SDR5-FC FUSION PROTEIN MUTANT AND USE THEREOF The present disclosure discloses a human sDR5-Fc fusion protein in the preparation of adjuvant therapy for myocardial ischemia-reperfusion injury. The sDR5-Fc... |
| 2018/0161449 |
FORMATION OF CYCLOSPORIN A/CYCLODEXTRIN NANOPARTICLES Methods of forming cyclosporin/cyclodextrin complex nanoparticles and microparticles, and administration of the nano- and microsuspension formed to an eye of a... |
| 2018/0161448 |
LONG-ACTING INSULIN OR INSULIN ANALOGUE CONJUGATE The present invention relates to insulin and/or an insulin analogue conjugate, and a use thereof, wherein the insulin and/or insulin analogue have improved in... |
| 2018/0161447 |
METHODS AND COMPOSITIONS FOR NUCLEIC ACID AND PROTEIN PAYLOAD DELIVERY Provided are methods and compositions for delivering a nucleic acid, protein, and/or ribonucleoprotein payload to a cell. Also provided are delivery molecules... |
| 2018/0161446 |
ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL
COMPOSITION AND USES THEREOF Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo... |
| 2018/0161445 |
METHODS FOR IMPROVING THE ADSORPTION OF POLYSACCHARIDE-PROTEIN CONJUGATES
AND MULTIVALENT VACCINE FORMULATION... The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable... |
| 2018/0161444 |
COMPOSITIONS AND METHODS FOR TRANSPORT ACROSS THE BLOOD BRAIN BARRIER Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx protein which can be... |
| 2018/0161443 |
GROWTH HORMONE POLYPEPTIDES AND METHODS OF MAKING AND USING SAME The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the... |
| 2018/0161442 |
METHODS FOR THE TREATMENT OF LEPTOMENINGEAL CARCINOMATOSIS The present invention features a method of treating leptomeningeal carcinomatosis in a subject using a peptide-therapeutic conjugate as exemplified by the... |
| 2018/0161441 |
STAPLED ACID-SENSITIVE ENDOSOME DISRUPTING ALGINATES An agent comprising: an algin crosslinked with acetal linkages; and at least one cation coupled to the crosslinked algin. |
| 2018/0161440 |
ANTIBODY-SN-38 IMMUNOCONJUGATES WITH A CL2A LINKER The present invention concerns improved methods and compositions for preparing SN-38 conjugates of proteins or peptides, preferably immunoconjugates of... |
| 2018/0161439 |
Acid-Labile Lipophilic Prodrugs of Cancer Chemotherapeutic Agents The present application discloses an acid labile lipophilic molecular conjugate of cancer chemotherapeutic agents and methods for reducing or substantially... |
| 2018/0161438 |
Aqueous Ophthalmic Composition The present invention relates to an aqueous ophthalmic composition that contains (A) vaseline and (B) at least one selected from the group consisting of a... |
| 2018/0161437 |
Foamed Medical devices with Additives A medical device including an implantable medical prosthesis that can be reshaped into a scaffold to support the bodily tissues and bones. Additionally, the... |
| 2018/0161436 |
NERVE GROWTH FACTOR COMPOSITION AND POWDER INJECTION The present invention discloses nerve growth factor composition and an injection powder comprising the following components: 10 .mu.g/mL-100 .mu.g/mL of a... |
| 2018/0161435 |
Low Toxicity Topical Active Agent Delivery System An active agent delivery composition is provided that allows topical delivery of active agents including vitamin A and its derivatives. A polyhalogenic vehicle... |
| 2018/0161434 |
USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO TREAT DIARRHEA IN
SUBJECTS WITH DISEASES OR TREATMENTS... The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically... |
| 2018/0161433 |
SIZE TUNABLE MICROBIAL MIMETICS FOR IMMUNOTHERAPY OF THYROID CARCINOMAS
AND SOLID TUMORS This invention describes novel immunogenic complexes, which are designed to trigger a robust host immune response against cancer cells by co-opting the immune... |
| 2018/0161432 |
FKBP52-TAU INTERACTION AS A NOVEL THERAPEUTICAL TARGET FOR TREATING THE
NEUROLOGICAL DISORDERS INVOLVING TAU... The invention relates generally to neuroprotection and repair in neurological disorders involving Tau dysfunction (including Alzheimer's disease). The... |
| 2018/0161431 |
PROTON INDUCED BORON CAPTURE THERAPY The present disclosure provides methods of treating a biological tissue using a proton beam. A method includes the steps of: irradiating a proton beam to a... |
| 2018/0161430 |
COMBINATIONS OF A PHOTOSENSITIZER WITH A HYDROGEN SULFIDE DONOR,
THIOREDOXIN INHIBITOR OR NITROXIDE FOR USE IN... The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen... |
| 2018/0161429 |
CANCER THERAPY TARGETING TETRASPANIN 33 (TSPAN33) IN MYELOID DERIVED
SUPPRESSOR CELLS Methods for treating cancer, e.g., in conjunction with anti-cancer therapy, like immunotherapy, and for identifying candidate therapeutic agents, by targeting... |
| 2018/0161428 |
Prostate Specific Membrane Antigen Binding Protein Disclosed herein are PSMA binding proteins with improved binding affinities, and robust aggregation profiles. Also described are multispecific binding proteins... |
| 2018/0161427 |
COMBINATION OF AN ANTI-IL-10 ANTIBODY AND A CPG-C TYPE OLIGONUCLEOTIDE FOR
TREATING CANCER The present disclosure describes combination therapies comprising an anti-IL-10 antibody or antigen-binding fragment thereof and a CpG-C type oligonucleotide,... |
| 2018/0161426 |
IN VITRO CELL CULTURE METHODS FOR BETA-THALASSEMIA USING ACTIVIN TYPE II
RECEPTOR LIGAND TRAPS Provided herein are methods of treating beta-thalassemia in a subject comprising administering to the subject an activin type II receptor (ActRII) signaling... |
| 2018/0161425 |
NOVEL PROTEIN STRUCTURE USED FOR EFFICIENT ANTIBODY PRODUCTION IN
IMMUNIZATION A method of enhancing immune response is provided, including covalent linking an amphipathic peptide to an antigen to form an antigen-complex composition; and... |
| 2018/0161424 |
VACCINE COMPOSITION AND PREPARATION METHOD AND USE THEREOF The present disclosure relates to a vaccine composition, wherein the vaccine composition comprises an immune amount of fowl adenovirus Fiber-2 protein or an... |
| 2018/0161423 |
LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION
OF ANTI-HIV ANTIBODIES The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV... |
| 2018/0161422 |
NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A)
SEQUENCE OR A POLYADENYLATION SIGNAL... The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a... |
| 2018/0161421 |
RECOMBINANT VACCINIA VIRUS HAVING HEMAGGLUTININ PROTEIN GENES DERIVED FROM
NOVEL INFLUENZA VIRUSES Provided are a highly-safe recombinant vaccinia virus that is effective in preventing the onset of symptoms due to infection by novel influenza viruses, and a... |
| 2018/0161420 |
Modified H7 Hemagglutinin Glycoprotein of the Influenza A/Shanghai/2/2013
H7 Sequence The present invention is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with... |
| 2018/0161419 |
METHODS FOR IMPROVING THE EFFICACY OF VACCINE ANTIGENS The present technology is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with... |
| 2018/0161418 |
Modified H7 Hemagluttinin Glycoprotein of the Influenza A/Shanghai/2/2013
H7 Sequence The present invention is directed to a sequence modification of the H7 hemagglutinin glycoprotein of the Influenza A/Shanghai/2/2013 H7 sequence together with... |
| 2018/0161417 |
Immortalized Porcine Alveolar Macrophage The present invention relates to immortalized porcine alveolar macrophages (PAMs), to cell cultures comprising such PAMs, to methods for the immortalization of... |
| 2018/0161416 |
EXOSOMES AND THEIR USE AS VACCINE The present invention provides exosomes isolated from an animal, wherein the animal (a) has overcome a disease caused by a pathogen, and (b) it is free from... |
| 2018/0161415 |
Stable, Spray Dryed, Immunogenic, Viral Compositions Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode... |
| 2018/0161414 |
VACCINE COMPRISING LACTOBACILLUS STRAINS FOR TREATING PROSTATE
INFLAMMATION AND BENIGN PROSTATE HYPERPLASIAS The invention relates to vaccines for treating prostate inflammation and benign prostate hyperplasias (stages I and II) comprising Lactobacillus strains in an... |
| 2018/0161413 |
INFECTIOUS PLASMODIUM SPOROZOITES GROWN IN VITRO The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is... |
| 2018/0161412 |
EXTENDED PROTECTION PROTEIN VACCINES AGAINST INFECTIOUS AGENTS Protein-based vaccines against infectious agents, including malaria and Zika virus, are described. The protein-based vaccines include an antigen domain and an... |
| 2018/0161411 |
ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides... |
| 2018/0161410 |
Methods to Treat Diseases with Protein, Peptide, Antigen Modification and
Hemopurification The current invention discloses methods to modify protein and peptide and antigen to treat disease such as pathogen infection, autoimmune diseases and cancer.... |
| 2018/0161409 |
Method of Treating Proteinuria in Pregnancy A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic... |
| 2018/0161408 |
SITE-SPECIFIC POLYETHYLENE GLYCOLYLATED (PEGYLATED) ASPARAGINASE,
PREPARATION METHOD THEREFOR AND USE THEREOF The present application discloses a PEGylated asparaginase and use thereof. In this application, the polyethylene glycol (PEG) is coupled to the N-terminal... |
| 2018/0161407 |
Novel Method of Treating Macular Degeneration using Botulinum Toxin-Based
Pharmaceuticals Formulations and methods of treatment are disclosed for prevention and/or treatment of visual loss from age-related macular degeneration. The disclosed... |
| 2018/0161406 |
Botulinum Neurotoxin Compositions Present invention provides a stable pharmaceutical composition comprising botulinum neurotoxin, anesthetic in a buffer. Present invention also provides a... |
| 2018/0161405 |
IMPROVED METHODS FOR TREATING OCULAR DISEASES BY GENE THERAPY The invention relates to a pharmaceutical composition comprising a recombinant adeno-associated virus (r AAV) vector carrying a nucleic acid sequence encoding... |
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