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Patent # Description
2018/0185496 POLYMER-SEMAXANIB MOIETY CONJUGATES
The invention relates to (among other things) polymer-semaxanib moiety conjugates and related compounds. A compound of the invention, when administered by any...
2018/0185495 THERAPEUTIC COMPOSITIONS OF ALPHA-L-IDURONIDASE, IDURONATE-2-SULFATASE, AND ALPHA-GALACTOSIDASE A AND METHODS...
The present invention provides pharmaceutical compositions comprising an a blood brain barrier peptide and a human peptide, such as an alpha-L-iduronidase...
2018/0185494 PHARMACEUTICAL FORMULATION
Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition...
2018/0185493 TWO-COMPONENT SYSTEM
A two-component system for the preparation of a hydrogel for preventing and/or treating a periodontal disease, selected from the group consisting of...
2018/0185492 MICRO-NANO MEDICAL ADSORBENT RESIN POWDER MATERIAL
A micro-nano medical adsorbent resin powder material is a high-molecular polymer including carbon ions, hydrogen ions, and oxygen ions. The powder material...
2018/0185491 COCHLEATES MADE WITH SOY PHOSPHATIDYLSERINE
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and...
2018/0185490 ANTIFUNGAL PREPARATIONS INTENDED FOR THE TOPICAL TREATMENT OF ONYCHOMYCOSIS
Antifungal preparations in solution in gamma-butyrolactone, useful for the topical treatment of onychomycosis, whose therapeutic effect may be reinforced by...
2018/0185489 DEPOT PREPARATION CONTAINING CITRIC ACID ESTER
To provide a depot formulation for which depot formation is easy, and is capable of maintaining the depot form for a long period as desired, and in the case of...
2018/0185488 FORMULATIONS OF BENDAMUSTINE
Methods of treatment using bendamustine formulations designed for small volume intravenous administration are disclosed. The methods conveniently allow shorter...
2018/0185487 METHOD TO ACHIEVE EXTENDED EXPRESSION OF DNA INFUSED INTO LIVER
Materials and methods for treating a patient to express a therapeutic agent comprising administering a Kupffer cell-suppressing substance in combination with a...
2018/0185486 PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE
The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, ...
2018/0185485 Polymeric Nanoparticles for Enhancing HIFU-Induced Ablation
In the field of medical therapy, more in particular in the field of ablation therapy using ultrasound, such as high intensity focused ultrasound (HIFU),...
2018/0185484 PREPARATION AND USE OF PLATELET PRODUCTS
The present disclosure relates to improved methods for the preparation and platelet products for administration to subjects in need thereof
2018/0185483 COMBINATION OF A PD-1 ANTAGONIST AND A LISTERIA-BASED VACCINE FOR TREATING PROSTATE CANCER
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Listeria based strain that...
2018/0185482 CHECKPOINT REGULATOR ANTAGONISTS
Checkpoint regulator antagonists that bind specifically to TIGIT, PD-1 and/or PD-L1 are disclosed. Also disclosed are methods of making and using the...
2018/0185481 ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are...
2018/0185480 ANTIBODIES SPECIFIC TO HUMAN T-CELL IMMUNOGLOBULIN AND ITIM DOMAIN (TIGIT)
Provided is a natural killer (NK) cell killing of various tumors is inhibited in the presence of ligands of TIGIT, an inhibitory receptor present on all human...
2018/0185479 A CHECKPOINT INHIBITOR AND A WHOLE CELL MYCOBACTERIUM FOR USE IN CANCER THERAPY
An immunomodulator for use in the treatment, reduction, inhibition or control of a neoplastic disease in a patient intended to undergo checkpoint inhibition...
2018/0185478 TREATMENT FOR MYOPATHY
Provided herein are methods and compositions for the treatment of myopathies.
2018/0185477 QSOX1 AS AN ANTI-NEOPLASTIC DRUG TARGET
The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such...
2018/0185476 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING LYMPHOCYTE PROLIFERATION IN A SUBJECT IN NEED THEREOF
The present invention relates to methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof. In particular,...
2018/0185475 DRUG REGIMEN FOR TREATMENT OF CEREBRAL ISCHEMIA
Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth...
2018/0185474 PD-1 Peptide Inhibitors
This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of...
2018/0185473 LIPID VESICLE COMPOSITIONS AND METHODS OF USE
The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use...
2018/0185472 METHOD OF PAINTING MICROVESICLES
The present invention relates to a method to modify and/or to isolate exosomes and other naturally occurring plasma membrane derived microvesicles, by...
2018/0185471 POLYVALENT VACCINE
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as...
2018/0185470 Peptide Sequences and Compositions
The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides,...
2018/0185469 COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME
Disclosed herein are methods and compositions for treating or preventing Porcine reproductive and respiratory syndrome (PRRS) infection in a subject.
2018/0185468 PARENTERAL NOROVIRUS VACCINE FORMULATIONS
The present invention relates to single dose parental vaccine compositions comprising mixtures of monovalent Norovirus virus-like particles. Methods of...
2018/0185467 COMPOSITIONS AND METHODS FOR MODULATING VIRAL INFECTION
Compositions and methods useful for treating and/or preventing a flavivirus infection are provided.
2018/0185466 RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA) FOOT AND MOUTH DISEASE VIRUS (FMDV) VACCINE
The present invention relates to modified poxviral vectors and to methods of making and using the same. In particular, the invention relates to recombinant...
2018/0185465 POLYSACCHARIDE VACCINE FORMULATIONS AND PROCESSES FOR INDUSTRIAL PRODUCTION OF BACTERIAL POLYSACCHARIDES
The present invention relates to the field of combined vaccine compositions which are effective against all forms of meningococcal diseases as well as typhoid...
2018/0185464 CHIMERIC PROTEINS
The present invention is directed generally to chimeric proteins that can facilitate targeting of nanoparticulate carriers to antigen presenting cells, and to...
2018/0185463 ALLOGENIC TUMOR CELL VACCINE
The described invention provides a tumor cell vaccine comprising genetically modified tumor cell line of a particular tumor type that stably expresses high...
2018/0185462 PEPTIDES FOR INDUCING CHAGAS DISEASE RESPONSES
The present disclosure relates to vaccine formulations and their use in treating and preventing Chagas Disease.
2018/0185461 TREATMENT AND DETECTION OF TRYPANOSOMES
The present invention relates to methods and compositions for preventing, treating and diagnosing infection by trypanosomes. The invention also relates to the...
2018/0185460 METHOD FOR TREATING PREMATURE EJACULATION WITH A BOTULINUM NEUROTOXIN
Methods for prolongation of climax time in a patient in need thereof are presented, as are methods for treating premature ejaculation by local administration...
2018/0185459 MODULATION OF FACTOR Xa INHIBITOR-MEDIATED BLOOD LOSS BY PARTIAL AND TRANSIENT ADMINISTRATION OF ANTIDOTE
The present disclosure provides unit dose formulations and methods to reduce, stop or prevent bleeding in a patient undergoing anticoagulant therapy with a...
2018/0185458 Compositions and Methods for Treating Celiac Sprue Disease
Disclosed herein are compositions and methods for treating celiac sprue.
2018/0185457 TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II
Methods of treating glycogen storage disease type II, by administering acid .alpha.-glucosidase, are described, as are compositions for use in treatment of...
2018/0185456 Glucose Oxidase Compositions As A Neonate Anticonvulsant
Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic...
2018/0185455 PREPARATION COMPRISING FACTOR VIII AND VON WILLEBRAND FACTOR PEPTIDES
A composition comprising a complex of Factor VIII and one or more Von Willebrand Factor peptides, wherein the Von Willebrand Factor peptides comprise at least...
2018/0185454 AGENT FOR PREVENTING ONSET OF IDIOPATHIC OSTEONECROSIS OF FEMORAL HEAD AND/OR SUPPRESSING PROGRESS OF SAME
[Problem] To provide an agent for preventing the onset of idiopathic osteonecrosis of the femoral head and/or suppressing the progress of the same. [Solution]...
2018/0185453 METHOD OF TREATING DIABETES TYPE 2 BY ADMINISTERING ULTRARAPID ACTING INSULIN
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial...
2018/0185452 Dry Growth Hormone Composition Transiently Linked to a Polymer Carrier
The present invention relates to dry compositions of rhGH polymer prodrug containing a lyoprotectant and, optionally, one or more than one excipient. Such...
2018/0185451 Methods Comprising Continuous Administration of a GLP-1 Receptor Agonist and Co-administration of a Drug
Provided is a method for administering to a subject, via an implantable delivery device, a continuous subcutaneous dose of glucagon-like peptide-1 (GLP-1)...
2018/0185450 EXENDIN-4 DERIVATIVES AS DUAL GLP1/GLUCAGON AGONISTS
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
2018/0185449 COMPOSITIONS AND METHODS FOR TREATING CUTANEOUS CONDITIONS
A composition for treating cutaneous condition is provided and has 0.001-1.000 wt. % Aloe Barbadensis Leaf Juice, 1.000-40.000 wt. % Cyclopentasiloxane and...
2018/0185448 COMPOSITION AND METHOD FOR INDUCING ANTI-INFLAMMATORY RESPONSE
The present invention relates generally to metabolic detoxification, and more particularly to a composition and method for inducing an anti-inflammatory...
2018/0185447 COMPOSITION CONTAINING PALMULTANG EXTRACT FOR PROMOTING PROLIFERATION OF STEM CELLS DERIVED FROM BONE MARROW
The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and...
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