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Patent # Description
2019/0048049 CARGOMERS
Cargomers comprising apolipoprotein molecules complexed with amphipathic molecules and one or more cargo moieties.
2019/0048048 FUSION PROTEINS AND METHODS FOR IDENTIFYING BROMODOMAIN INHIBITING COMPOUNDS
The present invention relates methods for identifying bromodomain inhibiting compounds.
2019/0048047 COMPOSITIONS AND METHODS FOR TREATMENT OF CELIAC DISEASE
The invention provides agents and vaccines for treating and diagnosing celiac disease. In particular, the present invention provides a combination of three...
2019/0048046 PROTEIN A MUTANTS HAVING HIGH ALKALI RESISTANCE AND METHODS OF USE THEREOF
A series of protein A mutants having high alkali resistance, and methods of using the protein A mutants are provided. The protein A mutants have a high binding...
2019/0048045 ACTINOBACILLUS PLEUROPNEUMONIAE RECOMBINANT TOXIN PROTEIN AND APPLICATION THEREOF
The invention relates to a recombinant Actinobacillus pleuropneumoniae toxin, having at least one epitope of Actinobacillus pleuropneumoniae toxin. When there...
2019/0048044 METHOD FOR EXTRACTING 2',3'-CYCLIC NUCLEOSIDE MONOPHOSPHATES
It relates to a method for preparation of four kinds of 2', 3'-cNMPs (2', 3'-cAMP, 2', 3'-cGMP, 2', 3'-cCMP and 2', 3'-cUMP), comprising steps of: (1) extract...
2019/0048043 Compositions and Methods Related to HIV-1 Immunogens
The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of...
2019/0048042 NON-NATURALLY OCCURING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS (PRRSV) AND METHODS OF USING
A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally...
2019/0048041 METHODS AND COMPOSITIONS FOR ANTIBODY-EVADING VIRUS VECTORS
The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid...
2019/0048040 Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the...
2019/0048039 FUNCTIONALIZED NANOPARTICLES FOR ENHANCED AFFINITY PRECIPITATION OF PROTEINS
The present invention provides a nanoparticle capable of binding specifically to a target protein in a solution and precipitating with the target protein out...
2019/0048038 METHOD FOR GENERATING CELL-PENETRATING STAPLED PEPTIDES THAT LACK NONSPECIFIC MEMBRANE-LYTIC PROPERTIES FOR...
Methods for generating cell-permeable hydrocarbon-stapled and/or stitched peptides lacking nonspecific membrane lytic properties and methods for using such...
2019/0048037 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
2019/0048036 EXCITONIC QUANTUM COMPUTING MEDIATED BY CHROMOPHORE-EMBEDDED 1-, 2-, AND 3-DIMENSIONAL DNA SCAFFOLDS
Using nucleotide architectures to very closely and precisely placed chromophores that produce quantum coherent excitons, biexcitons, and triexcitons upon...
2019/0048035 PROCESSES FOR PREPARING MACROLIDES AND KETOLIDES AND INTERMEDIATES THEREFOR
The invention described herein pertains to processes for the preparation of macrolide antibacterial agents. In particular, the invention pertains to processes...
2019/0048034 METHOD FOR PRODUCING ALPHA-HALO-TETRAACYL-GLUCOSE
There is provided an efficient and excellent preparation method of an .alpha.-halo-tetraacyl-glucose which is suitable for industrial preparation, which...
2019/0048033 ETHER COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or...
2019/0048032 Process for preparing tris[3-(alkoxysilyl)propyl] isocyanurates
A process can prepare an isocyanurate compound by hydrosilylation. The compound is a tris[3-(trialkoxysily)propyl] isocyanurate, a ...
2019/0048031 Process for preparing 3-glycidyloxypropyltrialkoxysilanes
A process can prepare a 3-glycidyloxypropylalkoxysilane of formula (I), (R')O--(CH.sub.2).sub.3--Si(OR).sub.3 (I), where R groups are independently a methyl or...
2019/0048030 SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES
The present disclosure describes novel silylated heteroaromatic derivatives, including those prepared by methods comprising the use of hydrosilanes and at...
2019/0048029 MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2019/0048028 BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the...
2019/0048027 BETA-LACTAMASE INHIBITOR
A beta-lactamase inhibitor having a formula (I). Also provided is a method of using the beta-lactamase inhibitor for prevention or treatment of diseases.
2019/0048026 Boron-Containing Small Molecules
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal...
2019/0048025 Preparation Of Difluoro Chelato Borate Salts
A process for preparing a difluoro chelato borate salt comprising an anion A of formula (I) ##STR00001## wherein ##STR00002## is a bidentate radical derived...
2019/0048024 SYNTHETIC PROCESSES AND INTERMEDIATES
The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.
2019/0048023 CRYSTAL OF COMPOUND HAVING JAK-INHIBITING ACTIVITY
An object of the present invention is to provide a compound with an excellent JAK1 inhibitory activity. The compound of the invention has JAK1 inhibitory activity,...
2019/0048022 MACROCYCLIC IMMUNOMODULATORS
Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (I) or (II): ##STR00001## including stereoisomers and...
2019/0048021 ORGANIC SEMICONDUCTOR COMPOSITION, ORGANIC THIN FILM COMPRISING SAME, AND USE THEREOF
In the present invention, a composition comprising two types of thienothiophene compounds selected from the group consisting of the compounds indicated by...
2019/0048020 DEUTERIUM-MODIFIED CFTR MODULATORS
This invention relates to novel 4,4,5,5,7,7-hexamethyl-5,7-dihydro-4H-thieno[2,3-c]pyranyl compounds, and pharmaceutically acceptable salts thereof. This...
2019/0048019 COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY
The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically...
2019/0048018 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS,...
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone...
2019/0048017 METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively,...
2019/0048016 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding...
2019/0048015 SEMICONDUCTING POLYMER
Compounds of formula (I) and polymers comprising at least a structure of formula (II), wherein T.sup.1 or T.sup.2 are independently of each other a group of...
2019/0048014 Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
The disclosure is directed to compounds of Formula I ##STR00001## Pharmaceutical compositions comprising compounds of Formula I, as well as methods of their use...
2019/0048013 VASOPRESSIN RECEPTOR ANTAGONISTS AND PRODUCTS AND METHODS RELATED THERETO
Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their...
2019/0048012 Triazolopyridines And Triazolopyrimidines That Lower Stress-Induced P-Tau
Pharmaceutical compounds, compositions, methods, and uses therefor are presented using selected triazolopyridines and triazolopyrimidines to inhibit or reduce...
2019/0048011 COMPOSITIONS COMPRISING FOLIC ACID DERIVATIVES, THEIR PREPARATIONS AND METHODS OF USE
Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.
2019/0048010 Mercaptopurine Hemihydrate
Provided herein is a new mercaptopurine form, as a hemihydrate, and methods of making and using the same.
2019/0048009 Methods for Preparing Bis-Tetrahydroisoquinoline-Containing Compounds
(-)-Jorumycin, ecteinascidin 743, saframycin A and related compounds, methods of preparing the same, formulations comprising the compounds, and methods of...
2019/0048007 TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES
The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as...
2019/0048006 BIARYL KINASE INHIBITORS
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
2019/0048005 NAPHTHYRIDINE DERIVATIVES AS ALPHA V BETA 6 INTEGRIN ANTAGONISTS FOR THE TREATMENT OF E.G. FIBROTIC DISEASES
A compound of formula (I) or a salt thereof: ##STR00001## wherein R.sub.1 represents a five-membered aromatic heterocycle selected from a N- or a C-linked mono-...
2019/0048004 OCTAHYDRO FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
2019/0048003 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
The invention relates to small molecule imaging tools.
2019/0048002 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
The invention relates to small molecule imaging tools.
2019/0048001 IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND...
Disclosed herein are novel iodonium analogs having anticancer and anti-inflammatory activity.
2019/0048000 HETEROARYL CARBOXAMIDE COMPOUNDS AS INHIBITORS OF RIPK2
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, X, Y, and HET are...
2019/0047999 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor...
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