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Patent # Description
2019/0062834 KIT FOR PREDICTING TREATMENT WITH GLUCOCORTICOIDS AND METHOD COMPRISING THE SAME
An ex vivo method and a kit for predicting the response to a treatment with glucocorticoids (GC) in patients affected by inflammatory diseases, based on...
2019/0062833 DELAYING REAL-TIME SEQUENCING
Methods, compositions, and systems are provided that allow for reliable sequencing of the initial sequence region of a sequence of interest. The methods of the...
2019/0062832 NON-INVASIVE PRENATAL DIAGNOSIS OF FETAL GENETIC CONDITION USING CELLULAR DNA AND CELL FREE DNA
Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one...
2019/0062831 DIFFERENTIAL TAGGING OF RNA FOR PREPARATION OF A CELL-FREE DNA/RNA SEQUENCING LIBRARY
In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single...
2019/0062830 CONJUGATES OF BIOMOLECULES TO NANOPARTICLES
Disclosed herein are conjugates comprising a biomolecule linked to a label that have biological activity and are useful in a wide variety of biological...
2019/0062829 METHODS AND APPARATUS FOR SINGLE MOLECULE SEQUENCING USING ENERGY TRANSFER DETECTION
Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation...
2019/0062828 POLYMERASE COMPOSITIONS & METHODS
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also...
2019/0062827 HYPER-THERMOSTABLE LYSINE-MUTANT ssDNA/RNA LIGASES
Provided herein are compositions, systems, and methods employing hyper-thermostable lysine-mutant ssDNA/RNA ligases that possesses both ssRNA ligase and ssDNA...
2019/0062826 ELECTROCHEMICAL DETECTION OF POLYMERASE REACTIONS BY SPECIFIC METAL-PHOSPHATE COMPLEX FORMATION
The present invention relates to a nucleic acid sequencing method that determines the sequence of a template nucleic acid by electrochemical means via the...
2019/0062825 MSP NANOPORES AND RELATED METHODS
Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such...
2019/0062824 SIGNAL EXTRACTION FOR A TARGET NUCLEIC ACID SEQUENCE
The present invention relates to extraction of a signal for a target nucleic acid sequence from signals for two target nucleic acid sequences in a sample. The...
2019/0062823 PORTABLE TESTING DEVICE FOR ANALYZING BIOLOGICAL SAMPLES
A portable testing device includes a hosing with an integrated touchscreen display and a receptacle in which a sample holder containing a biological sample and...
2019/0062822 METHODS AND KITS FOR HIGHLY MULTIPLEX SINGLE PRIMER EXTENSION
The present disclosure provides methods and kits for highly multiplex single primer extensions using a MutS protein and Mg2+ at a concentration higher than...
2019/0062821 REACTION CONTAINER AND BIOCHEMICAL ANALYSIS METHOD
A reaction container including a transparent base having a first surface having at least one region where recessed portions are formed and recessed from the...
2019/0062820 DETECTION DEVICE HAVING CAPTURE REGION AND DETECTION REGION
The invention features a fully-integrated rapid molecular diagnostic device that is low-cost, easy to manufacture, and simple to use. The device can serve as a...
2019/0062819 NUCLEIC ACID SEQUENCE IDENTIFICATION USING SOLID-PHASE CYCLIC SINGLE BASE EXTENSION
The present disclosure provides methods, devices and systems for detecting a presence of a nucleic acid molecule having a nucleic acid sequence. Detection of...
2019/0062818 SENSOR, REAGENT, METHOD FOR MANUFACTURING PROBE MOLECULE, AND METHOD FOR MANUFACTURING POLYMER MOLECULE
According to one embodiment, a sensor includes an ionic liquid, a probe molecule, and a sensor element. The probe molecule selectively associates with a...
2019/0062817 SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon...
2019/0062816 SINGLE NUCLEOTIDE DETECTION METHOD
A method of sequencing a nucleic acid comprising the steps of (1) generating a stream of single nucleotides by progressive pyrophosphorolysis; (2) producing at...
2019/0062815 Universal or Broad Range Assays and Multi-Tag Sample Specific Diagnostic Process Using Non-Optical Sequencing
The present invention includes a method for determining the identify of an organism or virus in a sample comprising the steps of: isolating DNA or RNA from the...
2019/0062814 NUCLEIC ACID NANOPARTICLES FOR ANALYTE DETECTION
Provided is a highly multiplex approach to disease condition diagnostics that combines nanopore sensing and nucleic acid nanoparticle (NANP) design and...
2019/0062813 SMART TOILET
Systems and methods disclosed herein relate to smart toilets (e.g. toilets with integrated stool analysis technology, urinalysis technology, deoxyribonucleic...
2019/0062812 TB BIOMARKERS
The invention relates to a method for the diagnosis of TB in a subject, the method comprising (a) providing a sample from said subject, said sample being...
2019/0062811 COMPOSITIONS AND METHODS FOR PREDICTING AND PROMOTING WEIGHT LOSS
The invention provides methods for identifying biomarkers in a patient's microbiota to predict a patient's response to a predetermined diet to promote weight...
2019/0062810 METHOD FOR DIAGNOSING HEPATIC FIBROSIS BASED ON BACTERIAL PROFILE AND DIVERSITY
The present invention concerns methods for diagnosing liver fibrosis in an obese subject, said method comprising the steps of a) determining bacterial...
2019/0062809 ELECTROCHEMICAL DETECTION OF BACTERIAL AND/OR FUNGAL INFECTIONS
The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically...
2019/0062808 Methods and Apparatus for Amplifying Nucleic Acids
The present invention relates to methods and apparatuses for amplifying, detecting, and optionally quantifying, nucleic acids. In one aspect the method...
2019/0062807 SUBSTRATES AND METHODS USEFUL IN SEQUENCING
A hydrogel network includes a hydrogel polymer having a coupling site, an oligonucleotide conjugated at a terminal end to the hydrogel polymer at the coupling...
2019/0062806 NUCLEIC ACID PRESERVATION SOLUTION AND METHODS OF MANUFACTURE AND USE
Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a...
2019/0062805 METHODS OF DEPLETING A TARGET MOLECULE FROM AN INITIAL COLLECTION OF NUCLEIC ACIDS, AND COMPOSITIONS AND KITS...
Provided are methods of depleting a target nucleic acid from an initial collection of nucleic acids. Aspects of the methods include contacting the initial...
2019/0062804 Method of Making Polynucleotides Using Closed-Loop Verification
A method for making a polynucleotide is provided including (a) delivering one or more reaction reagents including an error prone or template independent DNA...
2019/0062803 ELECTROCHEMICAL DETECTION OF BACTERIAL AND/OR FUNGAL INFECTIONS
The present disclosure relates to methods and devices for amplifying a plurality of targets in a single PCR run while distinguishing between clinically...
2019/0062802 RAPID NUCLEIC ISOLATION METHOD AND FLUID HANDLING DEVICES
A novel assay and a suite of devices may isolate nucleic acids from prokaryotic and eukaryotic cells and prepare samples for real-time (quantitative)...
2019/0062801 SYSTEMS AND METHODS FOR ELECTROCHEMICAL ASPARTATE TRANSAMINASE (AST) AND ALANINE TRANSAMINASE (ALT) DETECTION...
A system for electrochemically detecting AST and ALT includes a first sampler for producing pyruvate from ALT and a second sampler for producing pyruvate from...
2019/0062800 METHODS OF ATTACHING PROBES TO MICROORGANISMS AND METHODS OF USE THEREOF
Methods that include combining a probe with a composition including a microorganism, wherein the probe includes a targeting portion that interacts with a...
2019/0062799 DETECTION OF BETA-HEMOLYTIC PATHOGENS
The present invention relates to the field of diagnostics and more particularly to the detection of beta-hemolytic pathogens. More specifically, the present...
2019/0062798 COENZYME-LINKED GLUCOSE DEHYDROGENASE AND POLYNUCLEOTIDE ENCODING THE SAME
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability...
2019/0062797 Vectors and host cells comprising a modified SV40 promoter for protein expression
The present disclosure is directed to expression vectors, comprising a weakened SV40 promoter, and recombinant mammalian cells capable of producing high levels...
2019/0062796 PRODUCTION OF STEVIOL GLYCOSIDES IN RECOMBINANT HOSTS
The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
2019/0062795 ENDONUCLASE-ASSISTED ISOTHERMAL AMPLIFICATION USING CONTAMINATION-FREE REAGENTS
Disclosed are methods and kits for endonuclease-assisted DNA amplification reaction using decontaminated primer solutions that are pre-treated with a nuclease....
2019/0062793 Compositions and Methods For Making (S)-Norcoclaurine and (S)-Norlaudanosoline, and Synthesis Intermediates Thereof
Methods that may be used for the manufacture of the chemical compound (S)-norcoclaurine, (S)-norlaudanosoline, and (S)-norcoclaurine or (S)-norlaudanosoline...
2019/0062792 PROCESSES FOR PRODUCING FERMENTATION PRODUCTS
The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and optionally a...
2019/0062791 PRODUCTION OF BIOFUELS, BIOCHEMICALS, AND MICROBIAL BIOMASS FROM CELLULOSIC PULP
Methods for production of alcohol, biomolecules, and/or microbial biomass using cellulosic pulp as a feedstock are provided. Cellulosic pulp is contacted with...
2019/0062790 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0062789 GENOME EDITING IN RATS USING ZINC-FINGER NUCLEASES
Disclosed herein are methods and compositions for genome editing of one or more loci in a rat, using fusion proteins comprising a zinc-finger protein and a...
2019/0062788 LIPID NANOPARTICLE METHODS AND COMPOSITIONS FOR PRODUCING ENGINEERED ERYTHROID CELLS
Carriers such as lipid nanoparticles are useful for delivering payloads (such as RNA, DNA, proteins, or small molecules) to cells such as erythroid cells. This...
2019/0062787 ELECTROPORATION CUVETTES FOR AUTOMATION
The present disclosure relates to an electroporation device that may include many electroporation units and electroporation systems that can be used in an...
2019/0062786 METHODS AND COMPOSITIONS FOR THE ACTIVATION OF GAMMA-DELTA T-CELLS
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular,...
2019/0062785 MULTIVALENT VACCINES FOR RABIES VIRUS AND CORONOVIRUSES
The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a...
2019/0062784 REPLICATION-DEFECTIVE ARENAVIRUS VECTORS
The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic...
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