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Patent # Description
2019/0062783 OPTIMIZED LENTIVIRAL TRANSFER VECTORS AND USES THEREOF
The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell. The lentiviral transfer vector may be...
2019/0062782 FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA
The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent...
2019/0062781 COMPOSITIONS AND METHODS COMPRISING MALE FERTILITY SEQUENCES
Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants...
2019/0062780 Pesticidal Genes and Methods of Use
Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal...
2019/0062779 METHOD FOR OBTAINING GLYPHOSATE-RESISTANT RICE BY SITE-DIRECTED NUCLEOTIDE SUBSTITUTION
The present invention discloses a method for obtaining glyphosate-resistant rice by a site-directed nucleotide substitution, and also relates to a method...
2019/0062778 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing, at...
2019/0062777 PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES
The present invention provides a method for controlling undesired vegetation at a plant cultivation site, the method comprising the steps of providing a plant...
2019/0062776 Drought Tolerant Plants
Described are methods and compositions for enhancing drought tolerance in plants. Nucleic acid constructs therefore are also described. Transgenic plants are...
2019/0062775 SALT TOLERANT ORGANISMS
Disclosed herein are transformed non-vascular photosynthetic organisms that are salt tolerant, nucleotides and vectors useful in conducting such ...
2019/0062774 Enhancing Photosynthesis
Certain embodiments of the present invention relate to methods and products for enhancing the rate of photosynthesis in a plant. In addition, certain...
2019/0062773 ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING NITROGEN USE EFFICIENCY,...
Provided are methods of increasing nitrogen use efficiency, yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality and/or abiotic stress...
2019/0062772 TRANSCRIPTION FACTOR SEQUENCES FOR CONFERRING ADVANTAGEOUS PROPERTIES TO PLANTS
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of...
2019/0062771 SPATIALLY MODIFIED GENE EXPRESSION IN PLANTS
The invention provides methods of engineering plants having lignin deposition or xylan deposition that is substantially localized to the vessels of xylem...
2019/0062770 GRASSES WITH ENHANCED STARCH CONTENT
Methods and compositions for the production of monocot plants with increased starch content in stems are provided. In accordance with the invention, novel...
2019/0062769 LATEX PRODUCTION TRANSCRIPTION FACTORS AND METHODS OF ENHANCING LATEX PRODUCTION
The invention provides methods of engineering latex-producing plants, e.g., guayule plants, to increase latex production. The invention additionally provides...
2019/0062768 IDENTIFICATION AND CHARACTERIZATION OF UDP-GLUCOSE:PHLORETIN 4'-O-GLUCOSYLTRANSFERASE FROM MALUS X DOMESTICA BORKH
A method of producing trilobatin is disclosed. The method comprising contacting a polypeptide comprising an amino acid sequence at least 90% identical to SEQ...
2019/0062767 METHOD AND SYSTEM FOR EXPRESSING FOREIGN GENE IN A PLANT
A method is provided for expressing a foreign gene, comprising the steps of: (a) producing a plant which functionally expresses an RNA1 genome and/or an RNA2...
2019/0062766 METHOD FOR CREATING TRANSFORMED PLANT
A method to transforming a plant includes coating a microparticle having a diameter of 0.3 to 0.9 .mu.m with at least one type of nucleic acid, bombarding a...
2019/0062765 PLANT GENOME EDITING METHOD
A method for editing a plant genome includes coating a microparticle with at least one type of nucleic acid and/or at least one type of protein, introducing a...
2019/0062764 ALPHA AMYLASE VARIANT AND USE THEREOF
Provided is an .alpha. amylase variant obtained by the mutation or deletion of at least one amino acid residue in the amino acid sequence of a parent .alpha....
2019/0062763 MICROORGANISMS WITH NADPH ESCAPE VALVES TO PROVIDE REDUCED PHOTODAMAGE AND INCREASED GROWTH IN HIGH LIGHT...
Microorganisms with NADPH escape valves are described. The NADPH escape valves convert NADPH to NADP and decrease photodamage and/or increase ATP production,...
2019/0062762 Modification of RNA, Producing an Increased Transcript Stability and Translation Efficiency
It was the object of the present invention to provide RNA with increased stability and translation efficiency and means for obtaining such RNA. It should be...
2019/0062761 ULTRASOUND METHOD
A method of regulating at least one cellular process in one or more cells by exposing the one or more cells to ultrasound, characterised in that the method...
2019/0062760 Methods and Systems for Autoinduction of Protein Expression
Methods and systems for autoinduction of gene expression, without the need to add exogenous inducers. A dual genetic element system, which includes a first,...
2019/0062759 GENERATION OF ACYL AMINO ACIDS
Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered...
2019/0062758 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS
The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic...
2019/0062757 Heterologous Expression of Taurine in Microorganisms
Non-naturally occurring microorganisms are provided that produce taurine and/or taurine precursors, e.g., hypotaurine, sulfoacetaldehyde, or cysteate,...
2019/0062756 COMPOUNDS FOR MODULATING FC-EPSILON-RI-BETA EXPRESSION AND USES THEREOF
Methods for treating diseases and conditions mediated by the high affinity IgE receptor (Fc.epsilon.RI). Antisense oligomers for modulating splicing of mRNA...
2019/0062755 MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods,...
2019/0062754 5-HALOURACIL-MODIFIED MICRORNAS AND THEIR USE IN THE TREATMENT OF CANCER
The present disclosure provides nucleic acid compositions that incorporate one or more halouracil molecules. More specifically, the present disclosure reveals...
2019/0062753 Read Through Of Truncated Proteins In Premature Termination Codon Diseases Using An Optimized Genetic Codon...
Provided is a method for high-efficiently reading through a nonsense mutation site in a pathogenic gene in a monogenic hereditary disease and restoring the...
2019/0062752 Transcription Factor Trapping by RNA in Gene Regulatory Elements
Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least...
2019/0062751 TUMOR CELL MALIGNANT TRANSFORMATION SUPPRESSOR AND ANTI-TUMOR AGENT
The present invention provides an anti-tumor agent and a suppressor for suppressing malignant transformation such as acquisition of metastatic ability or...
2019/0062750 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FILOVIRUS INFECTIONS
The present invention relates to methods and pharmaceutical compositions for the treatment of filovirus infections. In particular, the present invention...
2019/0062749 SIRNA, PHARMACEUTICAL COMPOSITION AND CONJUGATE WHICH CONTAIN SIRNA, AND USES THEREOF
Disclosed are a small interfering nucleic acid specifically inhibiting HBV gene expression, and a pharmaceutical composition and a siRNA conjugate which...
2019/0062748 Polyconjugates for Delivery of RNAi triggers to Tumor Cells In Vivo
The present invention is directed compositions for delivery of RNA interference (RNAi) triggers to integrin positive tumor cells in vivo. The compositions...
2019/0062747 POLYPEPTIDE INHIBITORS OF SMAD3 POLYPEPTIDE ACTIVITIES
This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides...
2019/0062746 RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic,...
2019/0062745 MICRORNA COMPOSITION FOR THE TREATMENT OF NEUROBLASTOMA
Certain embodiments are directed to methods of identifying neuroblastoma differentiation-inducing compounds or agent and their use in treating neuroblastoma.
2019/0062744 Oligomeric Compounds and Compositions for use in Modulation of Small Non-Coding RNAs
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric...
2019/0062743 MULTIMERIC OLIGONUCLEOTIDE COMPOUNDS
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides...
2019/0062742 ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
2019/0062741 METHODS AND COMPOSITIONS FOR INHIBITING PMP22 EXPRESSION
The present embodiments provide methods, compounds, and compositions useful for inhibiting PMP22 expression and for treating, preventing, or ameliorating a...
2019/0062740 COMPOSITIONS AND METHODS OF USING piRNAS IN CANCER DIAGNOSTICS AND THERAPEUTICS
Aberrantly expressed piRNAs, genetically associated piRNAs and their relationship with cancer risk and severity are provided. Compositions and methods of using...
2019/0062739 Mitochondrial Genome Editing and Regulation
Methods and compositions of altering mitochondrial DNA of a eukaryotic cell are provided using one or more of a mitochondrial specific adeno-associated virus...
2019/0062738 Method and System for the Diagnosis, Prevention or Treatment of Alzheimer s and Related Disease by Measuring,...
The present invention features systems and methods for preventing amyloid plaque development by treating plaque precursors to arrest or reverse binding of the...
2019/0062737 GATA-3 INHIBITORS FOR USE IN THE TREATMENT OF TH2-DRIVEN ASTHMA
The invention relates to GATA-3 inhibitors for use in the treatment of Th2-driven asthma, in particular to DNAzymes directed at GATA-3 for use in the treatment...
2019/0062736 IN SITU AND IN VIVO ANALYSIS OF CHROMATIN INTERACTIONS BY BIOTINYLATED DCAS9 PROTEIN
The present invention includes a method for detecting or isolating one or more specific genomic target regions and molecules interacting therewith comprising:...
2019/0062735 CRISPR-CPF1-RELATED METHODS, COMPOSITIONS AND COMPONENTS FOR CANCER IMMUNOTHERAPY
CRISPR/Cpf1-related compositions and methods for treatment of cancer.
2019/0062734 GRNA FUSION MOLECULES, GENE EDITING SYSTEMS, AND METHODS OF USE THEREOF
Disclosed herein are gRNA fusion molecules, comprising a gRNA molecule linked, e.g., covalently or non-covalently, to a template nucleic acid; gene editing...
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