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Patent # Description
2019/0062733 METHODS FOR GENERATING SINGLE-OR MULTI-SITE MUTAGENESIS
Deep mutational scanning is a foundational tool for addressing functional consequences of large numbers of mutants, yet a more efficient and accessible method...
2019/0062732 Mapping of Genomic Interactions
The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.
2019/0062731 METHOD FOR CONSTRUCTING A PLASMA DNA SEQUENCING LIBRARY
The disclosure relates a method for constructing a plasma Deoxyribonucleic acid (DNA) sequencing library. The method includes: extracting a plasma DNA; making...
2019/0062730 METHODS OF DESIGNING PROGRAMMABLE INDUCIBLE PROMOTERS
Described herein is a method for identifying synthetic inducible promoters that have specified induction and/or repression for DNA binding proteins such as an...
2019/0062729 Improved Promoters And Compositions
The present invention relates to activatable promoters, as well as expression systems, vectors, delivery systems, reaction vessels, aqueous objects and...
2019/0062728 GENERATING RECOMBINANT AFFINITY REAGENTS WITH ARRAYED TARGETS
Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are...
2019/0062727 CANCER TREATMENT THROUGH RLIP76 PARTIAL DEPELETION
Partial depletion of RLIP76 in p53 deficient living subject has shown many health benefits. In one embodiment, partical Rlip depletion is used to prevent or...
2019/0062726 RNA ISOLATION FROM SOLUBLE URING FRACTIONS
The invention provides methods for isolating RNA from the soluble fraction of urine. The methods can be used for detecting the presence or absence of an RNA,...
2019/0062724 RNA TARGETING METHODS AND COMPOSITIONS
Provided herein are CRISPR/Cas methods and compositions for targeting RNA molecules, which can be used to detect, edit, or modify a target RNA.
2019/0062723 Sophorolipid Highly-Productive Mutant Strain
Provided is a microorganism exhibiting high production capability for sophorolipids. Disclosed is a yeast mutant strain having high sophorolipid productivity,...
2019/0062722 METHODS AND COMPOUNDS FOR REDUCING THREONYL-tRNA SYNTHETASE ACTIVITY
The invention includes, in part, methods and compounds for treating diseases and conditions characterized by elevated threonyl-tRNA synthetase (TARS) activity,...
2019/0062721 THERAPEUTIC FUSION PROTEINS
The present invention relates to the construction of a new class of Targeted Secretion Inhibitors (TSIs), which comprise a non-cytotoxic protease,...
2019/0062720 HISTIDYL-TRNA SYNTHETASE-FC CONJUGATES
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides,...
2019/0062719 BETA-LACTAMASE VARIANTS
The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated...
2019/0062718 RECOMBINANT ELASTASE PROTEINS AND METHODS OF MANUFACTURING AND USE THEREOF
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins....
2019/0062717 ENDOCELLULASES AND USES THEREOF
The invention relates to an endocellulase catalytic domain comprising the sequence of SEQ ID NO: 1 or a functionally equivalent variant of said catalytic...
2019/0062716 METHOD FOR OBTAINING A PREPARATION OF BETA-AMYLASES FROM THE SOLUBLE FRACTIONS OF STARCH PLANTS
The present invention relates to a method for obtaining a preparation of .beta.-amylases from the soluble fraction of starch plants, characterized in that the...
2019/0062715 Amylases, Nucleic Acids Encoding Them and Methods for Making and Using Them
In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and...
2019/0062714 KETOREDUCTASES
The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the...
2019/0062713 HIGHLY EFFICIENT INFLUENZA MATRIX (M1) PROTEINS
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also...
2019/0062712 A TYPE II PSEUDORABIES VIRUS ATTENUATED STRAIN, ITS PREPARATION METHOD AND APPLICATION
The present invention discloses a type II Pseudorabies virus attenuated strain and its preparation method and application. The attenuated strain of...
2019/0062711 Use Of Phosphorylated TBeta4 And Other Factors To Generate Human Induced Pluripotent Stem Cells
The present invention provides compositions and methods for inducing pluripotency in non-embryonic and/or somatic cells using exogenous Tb4, exogenous Sox2,...
2019/0062710 MEDIUM, METHODS, CELLS AND SECRETED FACTORS FOR STEM CELL CULTURE AND THERAPY
Described herein are methods and culture medium, useful for inducing polarization in multipotent stem cells. Additionally, described herein are multipotent...
2019/0062709 METHODS AND COMPOSITIONS FOR MAINTENANCE OF HEMATOPOIETIC STEM CELLS WITH PRESERVATION OF SELF-RENEWAL CAPACITY
Disclosed herein are methods of culturing hematopoietic stem cells (HSCs) that enhance preservation of the HSCs self-renewal capacity and multipotency for...
2019/0062708 Multiloop Engineered Heart Muscle Tissue
The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation...
2019/0062707 Engineered Three-Dimensional Connective Tissue Constructs and Methods of Making the Same
Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue...
2019/0062706 SELECTIVE EXPANSION OF DIFFERENT SUBPOPULATIONS OF T CELLS BY THE ALTERATION OF CELL SURFACING SIGNALS AND...
This invention relates, inter alia, to compositions of expanded T cell populations, methods for the expansion of T cell populations and methods for using such...
2019/0062705 METHODS FOR THE PRODUCTION OF THERAPEUTIC, DIAGNOSTIC, OR RESEARCH ANTIBODIES
Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and...
2019/0062704 METHOD OF CELL CULTURE
The present invention discloses a method for culturing human limbal stem cells comprising the steps of: pre-treating a feeder cell; seeding the feeder cells in...
2019/0062703 METHODS OF PRODUCING RPE CELLS AND COMPOSITIONS OF RPE CELLS
The present invention provides improved methods For producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The...
2019/0062702 METHOD FOR DIRECT TRANSDIFFERENTIATION REPROGRAMMING INTO NEURONS USING ELECTROMAGNETIC-INDUCED METAL NANOPARTICLES
The present invention relates to a method for direct transdifferentiation into neurons using metal nanoparticles magnetized by an electromagnetic field, and to...
2019/0062701 METHOD FOR INDUCING DIFFERENTIATION OF NEURAL STEM CELLS USING PATTERNED HYDROGEL
The present invention provides a method for inducing differentiation of neural stem cells. The present invention provides optimized differentiation conditions...
2019/0062700 In Vitro Production of Medial Ganglionic Eminence Precursor Cells
Methods and systems for generating MGE precursor cells in vitro as well as compositions of enriched MGE precursor cells are provided. The methods and systems...
2019/0062699 HIGHLY FUNCTIONAL HEPATOCYTE AND USE THEREOF
The object is to obtain a highly functional hepatocyte that has a high ammonia-metabolizing function and is theoretically able to infinitely proliferate from a...
2019/0062698 DERIVATION OF EMBRYONIC STEM CELLS AND EMBRYO-DERIVED CELLS
This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the...
2019/0062697 Cell Differentiation Marker and its Uses
The use of Dub3 protein, a nucleic acid molecule coding for the protein, or an inhibitor of the activity and/or of the expression of the protein for modulating...
2019/0062696 USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS
The present invention provides NRP1 as a cell surface marker for isolating human cardiomyogenic ventricular progenitor cells (HVPs), in particular progenitor...
2019/0062695 DEVICE FOR IN VITRO CULTURE OF EMBRYOS AND FABRICATION METHOD THEREOF
A device for in vitro culture of embryos includes: an array having at least one well formed therein; and a bottom surface formed in the well and made of...
2019/0062694 Manufacture and Cryopreservation of Fucosylated Cells for Therapeutic Use
Compositions for and methods of manufacturing a fucosylated cell population are provided. The method may include expansion of the cells and/or cryopreservation...
2019/0062693 METHOD FOR PRODUCING DRIED MICROBIAL CELLS
An object is to provide a method for producing dried microbial cells with a high viable cell survival rate after long-term storage at a high temperature. A...
2019/0062692 ENHANCED THERMAL STABILITY FOR ADENOVIRAL VECTORS THROUGH SPRAY DRYING
The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of...
2019/0062691 FILTER DEVICE FOR CAPTURING TARGET CELL AND TARGET CELL COLLECTING METHOD USING THE SAME
The present invention relates to a filter device for capturing a target cell and a target cell collecting method using the same. A filter substrate by which a...
2019/0062690 Expanded Bed Affinity Selection
Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation...
2019/0062689 CULTURE MONITORING SYSTEM, CONTROL METHOD, AND COMPUTER-READABLE MEDIUM
A culture monitoring system includes: an image acquisition device that is arranged in an incubator and acquires an image of a biological sample cultured in the...
2019/0062688 Apparatus and Methods for Bioprocesses and Other Processes
Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses. A module comprising a valve, a filter...
2019/0062687 REGENERATED HAIR FOLLICLE PRIMORDIUM AGGREGATION MANUFACTURING METHOD, HAIR FOLLICLE TISSUE-CONTAINING SHEET,...
The present invention provides a method for manufacturing a regular and high-density regenerated hair follicle primordium aggregation similar to the hair...
2019/0062686 MICROFLUIDIC DEVICE FOR CULTURING CELLS
A microfluidic device (10) for culturing and/or analysing at least one cell type is disclosed. The device (10) comprises a plurality of chambers (30), arranged...
2019/0062685 MULTIWELL IMAGING PLATE AND METHOD FOR INCUBATING NON-ADHERENT CELLS
The invention relates to a multiwell imaging plate and a method for incubating non-adherent cells. The multiwell imaging plate includes multiple wells, at...
2019/0062684 Microfluidic System for Reproducing Functional Units of Tissues and Organs In Vitro
A microfluidic system including a number of microfluidic devices having a first perfusion path and a second separate perfusion path; the microfluidic devices...
2019/0062683 Cell Expansion
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be...
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