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Patent # Description
2019/0062429 Targeting tissue factor to activated platelets
The current invention relates to procoagulant fusion proteins, polynucleotides that encode said fusion proteins and cells that expresses said fusion proteins....
2019/0062428 COMBINATION OF ANTI-CD47 ANTIBODIES AND CELL DEATH-INDUCING AGENTS, AND USES THEREOF
The present disclosure relates to combinations of anti-CD47 antibodies and cell death-inducing agents. The disclosure also relates to methods for treating or...
2019/0062427 ANTI-SIGLEC-9 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0062426 ANTI-CD30 CHIMERIC ANTIGEN RECEPTORS
Chimeric antigen receptors (CARs) that specifically bind to and immunologically recognize CD30 are disclosed. Related nucleic acids, recombinant expression...
2019/0062425 TM4SF1 BINDING PROTEINS AND METHODS OF USING SAME
This present invention relates to compounds (e.g., TM4SF1 binding proteins, e.g., anti-TM4SF1 antibodies) that specifically bind to a polypeptide at an epitope...
2019/0062424 VEGF/DLL4 BINDING AGENTS AND USES THEREOF
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating...
2019/0062423 METHODS FOR REDUCTION OF PATHOLOGICAL FIBROSIS AND ASSOCIATED DISORDERS AND DISEASES
Agents and methods for treating, reducing or ameliorating pathological fibrosis and disease or disorders caused by or associated with excessive deposition of...
2019/0062422 ANTAGONISTS OF IL17C FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention provides antagonists of IL17C for use in the treatment of an inflammatory disorder.
2019/0062421 TREATMENT STRATEGY FOR NON-RESPONDERS TO 100MG SUBCUTANEOUS MEPOLIZUMAB
Disclosed herein are methods of treating severe glucocorticoid-dependent eosinophilic asthma in a subject whose asthma has been inadequately controlled with...
2019/0062420 FC Gamma RIII Binding Fibronectin Type III Domains, Their Conjugates and Multispecific Molecules Comprising Them
FN3 domains that specifically bind Fc.gamma.RII, their conjugates and antibody fusions, isolated nucleotides encoding the molecules, vectors, host cells, and...
2019/0062419 PROTEIN PURIFICATION METHODS TO REDUCE ACIDIC SPECIES
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount...
2019/0062418 USE OF TNF ALPHA INHIBITOR
The invention describes methods of treating erosive polyarthritis comprising administering a TNF.alpha. antibody, or antigen-binding portion thereof. The...
2019/0062417 ANTIBODY FACILITATING PROGRAMMED NECROSIS OF CELLS AND APPLICATION THEREOF
The present invention provides an antibody facilitating programmed necrosis of cells. The antibody can cause programmed necrosis of cells in the presence of...
2019/0062416 METHOD OF TREATING PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS
A method of treating primary focal segmental glomerulosclerosis in a patient having an APOL1 variant, comprising intravenously administering a TGF.beta....
2019/0062415 ANTIBODIES RECOGNIZING ALPHA-SYNUCLEIN
The invention provides monoclonal antibody 5C1 and related antibodies. The 5C1 antibody binds to an epitope within residues 118-126 of .alpha.-synuclein. The...
2019/0062414 ANTIBODIES FOR TREATMENT AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
The invention relates to the diagnosis and treatment of diseases,including inflammatory disorders, proliferative disorders and autoimmune diseases. The...
2019/0062413 ANTI-C5 ANTIBODIES AND METHODS OF USE
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using...
2019/0062412 GM HYBRIDOMA CELL, MONOCLONAL ANTIBODY, KIT AND PREPARATION METHOD AND USE THEREOF
The present invention provides a hybridoma cell under the accession number CGMCC No. 13827. The hybridoma cell is capable of producing a monoclonal antibody...
2019/0062411 MRKA POLYPEPTIDES, ANTIBODIES, AND USES THEREOF
The present disclosure provides MrkA binding proteins, e.g., antibodies or antigen binding fragments thereof that bind to MrkA and induce opsonophagocytic...
2019/0062410 NON-HUMAN ANIMALS HAVING A MUTANT KYNURENINASE GENE
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a mutant L-kynurenine...
2019/0062409 USE OF MODIFIED HIV-1 FOR GENERATING FULLY HUMAN ANTIBODIES
The present invention provides highly efficient methods, and compositions related thereto, for generating high titer human antibodies or antibody fragments...
2019/0062408 CONSERVED HEMAGGLUTININ EPITOPE, ANTIBODIES TO THE EPITOPE, AND METHODS OF USE
Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes to the stem region, and...
2019/0062407 AGENTS FOR INFLUENZA NEUTRALIZATION
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza...
2019/0062406 METHODS OF USE OF SECRETORY IgA
Described herein dog and cat food additives and compositions comprising secretory IgA.
2019/0062405 REGENERATION OF DAMAGED TISSUE
A method of healing a wound including contacting a wound edge with a tropoelastin or elastin derived peptide in conditions for enabling a sustained contact of...
2019/0062404 Composition and Method for Therapeutic Agent Delivery During Pregnancy
A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino...
2019/0062403 PURIFICATION OF FACTOR VIII SUBSPECIES
The present invention relates to a method for purifying a Factor VIII (FVIII) subspecies from a composition comprising FVIII, said method comprising an anion...
2019/0062402 ACVR1-FC FUSION PROTEIN, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
The present invention provides an ACVR1-Fc fusion protein, a nucleic acid sequence encoding said fusion protein, a vector or a host cell comprising said...
2019/0062401 Immunotherapy against melanoma and other cancers
A method of treating a patient who has melanoma includes administering to said patient a composition containing a population of activated T cells that...
2019/0062400 T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
The present disclosure provides variant immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present...
2019/0062399 CARBOHYDRATE CONTENT OF CTLA4 MOLECULES
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions...
2019/0062398 HIGH AVIDITY HPV T-CELL RECEPTORS
The present invention pertains to novel high avidity antigen recognizing constructs against Human Papilloma Virus antigens. The invention provides novel T cell...
2019/0062397 ANALOGUES OF PARATHYROID HORMONE (1-34) THAT FUNCTION AS AGONISTS OF THE PARATHYROID HORMONE RECEPTOR-1 AND...
Described are polypeptide analogs of parathyroid hormone (PTH) that include an unnatural amino acid substitution at positions 7 or 8 from the N-terminus of the...
2019/0062396 COMPOSITION COMPRISING RECOMBINANT HUMAN THYROID STIMULATING HORMONE AND METHOD FOR PRODUCING RECOMBINANT HUMAN...
The present invention relates to a composition for the diagnosis and treatment of recurrent thyroid cancer comprising recombinant human thyroid stimulating...
2019/0062395 IL-2 SUPERAGONISTS IN COMBINATION WITH ANTI-PD-1 ANTIBODIES
Human interleukin-2 (IL-2) muteins or variants thereof are provided. In particular, provided are IL-2 muteins that have an increased binding capacity for...
2019/0062394 Improved Therapeutic Control of Proteolytically Sensitive, Destabilized Forms of Interleukin-12
The present invention relates to modified forms of IL-12. These modified forms of IL-12 may be engineered to have a shortened in vivo half-life compared and/or...
2019/0062393 CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be...
2019/0062392 METHODS FOR TREATING FATTY LIVER DISEASE
In certain aspects, the present invention provides compositions and methods for treating fatty liver disease by administering an antagonist of an ActRIIB...
2019/0062391 USE OF VEGF-B FOR TREATING DISEASES INDUCED BY OXIDATIVE INJURY
The invention discloses a method for treating a disorder or a disease induced by an oxidative stress injury, including administering VEGF-B to a subject; and,...
2019/0062390 Method for Producing An Active Hepatocyte Growth Factor (HGF)
The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using...
2019/0062389 PEPTIDE DERIVED FROM GPC3, PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF CANCER USING SAME,...
The present invention provides a peptide containing 8 or more consecutive amino acid residues in an amino acid sequence of any of SEQ ID NOS: 1 to 11 and...
2019/0062388 COMPOSITIONS AND METHODS OF USING THERAPEUTIC p53 PEPTIDES AND ANALOGUES
The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using...
2019/0062387 METHOD FOR ESTABLISHING EUKARYOTIC EXPRESSION CELL LINE OF CD36 MUTANT GENE THAT ENCODES CD36 DEFICIENCY
A method for establishing eukaryotic expression cell line of CD36 mutant gene that encodes CD36 deficiency, the method including: (1) extracting total RNA from...
2019/0062386 PEPTIDE INHIBITORS OF CALCIUM CHANNELS
The present invention relates to fragments of SPLUNC1 protein that bind to calcium channels and inhibit calcium influx into airway smooth muscle and other...
2019/0062385 COMPOSITIONS AND METHODS FOR TREATMENT OF DISORDERS RELATED TO CEP290
Compositions are provided that comprise a recombinant vector carrying a nucleic acid sequence encoding a fragment of CEP290 lacking all or part of its...
2019/0062384 NOVEL BT TOXIN RECEPTORS AND METHODS OF USE
The disclosure relates to Bt toxin resistance management. One embodiment relates to the isolation and characterization of polynucleotides and polypeptides...
2019/0062383 Kv1.3 Antagonists and Methods of Use
The present invention relates to Kv1.3 antagonists, and polynucleotides encoding them, and methods of making and using the foregoing.
2019/0062382 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal...
2019/0062381 GENETICALLY ALTERED PLANTS HAVING WEEPING PHENOTYPE
Genetically altered eudicots that have the altered phenotype of weeping are provided. The genetically altered eudicots contain a genetic alteration that...
2019/0062380 FUSION PROTEINS FOR PROMOTING AN IMMUNE RESPONSE, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF MAKING AND USE...
Disclosed herein are compositions, cells, kits, and methods for inducing an immune response in a subject. The compositions can be used as vaccines or vaccine...
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