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Patent # Description
2019/0062379 Mutant of L1 Protein of Human Papillomavirus Type 11
Disclosed are a mutated HPV11 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle...
2019/0062378 CONFORMATIONALLY-PREORGANIZED, MiniPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS
The present invention relates to .gamma.-PNA monomers according to Formula I where substituent groups R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, B...
2019/0062377 PEPTIDOMIMETIC MACROCYCLES
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
2019/0062376 Treatments for Gastrointestinal Disorders
The present invention features peptides, compositions, and related methods for treating gastrointestinal disorders and conditions, including but not limited...
2019/0062375 COMPOSITION FOR OVERCOMING RESISTANCE TO EGFR-TARGETING AGENT
The present invention relates to methods of overcoming the resistance to an EGFR (Epidermal Growth Factor Receptor)-targeting antibody through a peptide that...
2019/0062374 MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the...
2019/0062373 METHOD OF GENERATING INTERACTING PEPTIDES
Disclosed herein is a method of designing small peptides for interacting with, binding to, or modulating the activity of, known protein or peptides. Further...
2019/0062372 METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES
The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
2019/0062371 PEPTIDE COMPOSITIONS AND RELATED METHODS
Peptide compositions and methods for inhibiting neovascularization or development of pathological or aberrant blood vessels in human or other animal subjects.
2019/0062370 METHOD OF PURIFYING ANTIFUNGAL COMPOUNDS AND EXOPOLYSACCHARIDES FROM A MICROBIAL CELL CULTURE
The present invention provides a method of enriching a lipopeptide in a microbial cell culture, the method comprising mixing an amphiphilic sulfonate and/or an...
2019/0062369 LIGAND FUNCTIONAL SUBSTRATES
A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the...
2019/0062368 POLYPEPTIDE MODIFICATION METHOD FOR PURIFYING POLYPEPTIDE MULTIMERS
The present invention provides efficient methods based on alteration of the protein A-binding ability, for producing or purifying multispecific antibodies...
2019/0062367 METHODS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
The present application relates to a method of preparing a bile acid derivative, or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof,...
2019/0062365 COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor...
2019/0062364 PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS
Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
2019/0062363 PREPARATION OF (S,S)-SECOISOLARICIRESINOL DIGLUCOSIDE AND (R,R)-SECOISOLARICIRESINOL DIGLUCOSIDE
The invention relates to processes for preparing (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside and compositions comprising...
2019/0062362 METHOD FOR OBTAINING SURFACTANT COMPOSITIONS MADE FROM ALKYL-L-GULURONAMIDES
Some embodiments relate to a novel method for obtaining surfactant compositions made from alkyl-L-guluronamides or mixtures of L-guluronamides and...
2019/0062361 REGIOSELECTIVE SILYL EXCHANGE OF PER-SILYLATED OLIGOSACCHARIDES
The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the. invention...
2019/0062360 PROCESS FOR PREPARING COMPOSITIONS COMPRISING ALKYL(ALKYL-GLUCOSIDE)URONATES, SAID COMPOSITIONS AND USE THEREOF...
The present invention relates to a novel process for preparing compositions comprising alkyl(alkyl-glucoside)uronates, from biobased or ...
2019/0062359 ORGANOSOLV PROCESS FOR THE EXTRACTION OF HIGHLY PURE LIGNIN AND PRODUCTS COMPRISING THE SAME
A highly pure lignin comprising a lignin content of at least 97% and characterized by a low carbohydrate content and substantially no sulfur content is...
2019/0062358 PRECIOUS METAL COMPOUNDS
The invention relates to tetraalkylammonium-tetra- or hexahydroxometallates such as tetraethylammonium hexahydroxoplatinate, (N(alkyl)4)y[M(OH)x], a method for...
2019/0062357 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND ORGANIC...
An organometallic compound is represented by Formula 1. An organic light-emitting device includes: a first electrode; a second electrode facing the first...
2019/0062356 PH RESPONSIVE FLUORESCENT COMPOUND, COMPOSITION FOR DETECTING MITOPHAGY USING SAME, AND METHOD FOR DETECTING...
Disclosed is a pH-responsive fluorescent compound, represented by the general formula, which is a novel pH-responsive fluorescent compound capable of being...
2019/0062355 IONIC TAGS FOR SYNTHESIS OF OLIGORIBONUCLEOTIDES
The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of...
2019/0062354 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
A polycyclic compound and an organic electroluminescence device including the same, the polycyclic compound being represented by Formula 1: ##STR00001##
2019/0062353 SUBSTITUTED DIHYDROPYRROLOPYRAZOLE COMPOUND
Methods of producing a compound represented by formula (I) or a pharmacologically acceptable salt thereof include: ##STR00001## wherein L.sup.1 is an optionally...
2019/0062352 SUBSTITUTED ASYMMETRIC UREAS AS MODULATORS OF GHRELIN RECEPTOR ACTIVITY
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin...
2019/0062351 CHARGE-TRANSPORTING VARNISH
This charge-transporting varnish, which includes a charge-transporting substance such as an aniline derivative or a thiophene derivative, an onium borate salt...
2019/0062350 METHODS FOR PRODUCING BORYLATED ARENES
Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted...
2019/0062349 COMPOUND FOR SPECIFICALLY BINDING TO AMYLOID B-PROTEIN
Provided is a compound for specifically binding to amyloid .beta.-protein. The compound has thereon a nuclide with a large thermal neutron capture cross...
2019/0062348 COMPOUND AND COLOR CONVERSION FILM COMPRISING SAME
The present specification relates to a compound represented by Chemical Formula 1, and a color conversion film, a backlight unit and a display apparatus...
2019/0062347 METHOD FOR PRODUCING METAL ORGANYLS
The invention relates to a method for producing organometallic compounds RMn (M=alkali or alkaline earth element, R=alkyl residue) where n=valence of the metal...
2019/0062346 Method for Producing 7h-pyrrolo[2, 3-d]pyrimidine Derivative and Intermediate Thereof
The present invention provides a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative that is useful as a janus kinase (JAK) inhibitor; an...
2019/0062345 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2019/0062344 CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES
To provide novel pesticides, especially insecticides or acaricides. A condensed heterocyclic compound represented by the formula (1) or its salt, or N-oxide...
2019/0062343 DIAMIDE MACROCYCLES HAVING FACTOR XIA INHIBITING ACTIVITY
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
2019/0062342 NOVEL ANTIBACTERIAL AGENTS
This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides preventing, treating, or ameliorating...
2019/0062341 TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity,...
2019/0062340 CORTISTATIN ANALOGS
Specific cortistatin derivatives with advantageous properties for in vivo administration to a host, including a human, in need thereof are provided. These...
2019/0062339 HEMI-SYNTHETIC TRILOBINE ANALOGS FOR USE AS A DRUG
The invention concerns a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof as well as a pharmaceutical composition...
2019/0062338 TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR
Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds...
2019/0062337 PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF ...
The present invention provides processes and intermediates for the preparation of {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl- ...
2019/0062336 HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS
This application relates to compounds of Formula (I): ##STR00001## or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of...
2019/0062335 IMIDAZOPYRAZINONES AS PDE1 INHIBITORS
The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
2019/0062334 ORGANIC COMPOUNDS
This invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or...
2019/0062333 CXCR4 RECEPTOR ANTAGONISTS
The compounds of formula (I) are antagonists of the CXCR4 receptor ##STR00001## Wherein R.sup.1, X, Y and R.sup.2 are as defined in the claims.
2019/0062332 PROCESS FOR THE PREPARATION OF LEDIPASVIR AND INTERMEDIATES THEREOF
The present invention relates to process for preparation of ledipasvir of formula 1 and its novel intermediates. The process involves reaction of compound of...
2019/0062331 6,7-DIHYDRO-5H-PYRROLO[3,4-B]PYRIDIN-5-ONE ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR
The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine...
2019/0062330 KRAS G12C INHIBITORS
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the...
2019/0062329 ALKYL CHAIN MODIFIED IMIDAZOQUINOLINE TLR7/8 AGONIST COMPOUNDS AND USES THEREOF
Disclosed are alkyl chain modified 1H-imidazoquinoline compounds, derivatives and analogs thereof, as Toll-like receptor-7 and -8 agonists for enhancing immune...
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