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Patent # Description
2019/0060455 STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2019/0060454 AGONIST ANTIBODIES THAT BIND HUMAN CD137 AND USES THEREOF
The present disclosure relates to compounds (e.g., antibodies, or antigen-binding fragments thereof) that bind to an epitope of CD137 and agonize CD137, and to...
2019/0060453 Compositions and Methods for Diagnosing and Treating Cancer
An isolated antibody that specifically binds to an extracellular domain of human DLL4 and affects growth of a tumor comprising cancer stem cells is described....
2019/0060452 Method for Treating Melanoma Using a Herpes Simplex Virus and an Immune Checkpoint Inhibitor
The invention relates to methods of treating melanoma using a herpes simplex virus in combination with an immune checkpoint inhibitor.
2019/0060451 ANTIGEN BINDING PROTEINS THAT BIND PD-L1
There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies...
2019/0060450 Methods of Treating a Subject for a Condition
Methods are provided for treating a subject for at least one condition that includes inflammation, a blood clotting condition and autonomic nervous system...
2019/0060449 METHODS OF DISEASE ACTIVITY PROFILING FOR PERSONALIZED THERAPY MANAGEMENT
The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy....
2019/0060448 FULLY HUMAN ANTI-C-X-C CHEMOKINE RECEPTOR 3 (CXCR3) ANTIBODIES
There is disclosed compositions and methods relating to or derived from anti-CXCR3 antibodies. More specifically, there is disclosed fully human antibodies...
2019/0060447 Vaccines Having an Antigen and Interleukin-21 As An Adjuvant
Disclosed herein is a vaccine comprising an antigen and IL-21. Also disclosed herein are methods for increasing an immune response in a subject. The methods...
2019/0060446 STING ACTIVATING NANOVACCINE FOR IMMUNOTHERAPY
In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH...
2019/0060445 MIXED ALLERGEN COMPOSITIONS AND METHODS FOR USING THE SAME
Mixed allergen compositions of one, two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen;...
2019/0060444 MIXED ALLERGEN COMPOSITIONS AND METHODS FOR USING THE SAME
Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an...
2019/0060443 Immunotherapy For The Treatment Of Allergic Disease
Compositions and methods for the treatment of allergic disease include treating a subject in need thereof with a dosage of an allergen, wherein the allergen is...
2019/0060442 REOVIRIDAE VACCINE
The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a...
2019/0060441 INFLUENZA VIRUS MUTANTS AND USES THEREFOR
Disclosed herein are compositions and methods related to mutant viruses, and in particular, mutant influenza viruses. The mutant viruses disclosed herein...
2019/0060440 FCRn-Targeted Mucosal Vaccination Against RSV
Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); a modified pre-fusion respiratory...
2019/0060439 METHODS AND COMPOSITIONS FOR TREATING GLIOMA AND MEDULLOBLASTOMA BRAIN TUMORS USING THE ZIKA VIRUS
In one embodiment, the present invention is a method of treating glioma and medulloblastoma brain tumors using the Zika virus and a tumor vaccine.
2019/0060438 INFECTIOUS DISEASE VACCINES
Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or...
2019/0060437 MENINGOCOCCUS SEROGROUP X CONJUGATE
The invention provides a conjugate of a Neisseria meningitidis serogroup X capsular polysaccharide and a carrier molecule. The conjugate is typically made by...
2019/0060436 Alginate Chitosan Nanoformulation of OmpA - a Shigella Protein Subunit
Provided herein is a Formulation of OmpA including a) OmpA protein as active molecule obtained as a product of OmpA gene inserted in a plasmid comprising a...
2019/0060435 PEPTIDE VACCINE FORMULATIONS AND USE THEREOF FOR INDUCING AN IMMUNE RESPONSE
Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example,...
2019/0060434 METHODS AND COMPOSITIONS FOR THE TREATMENT OF MELANOMA
Provided herein are methods and compositions for the treatment of melanoma using anti-tumor immune cells treated with a PTD-MYC fusion protein (e.g., an HIV...
2019/0060433 KIF20A EPITOPE PEPTIDES FOR TH1 CELLS AND VACCINES CONTAINING THE SAME
Isolated KIF20A-derived epitope peptides having Th1 cell inducibility are disclosed herein. Such peptides can be recognized by MHC class II molecules and...
2019/0060432 COMPOSITIONS AND METHODS OF IDENTIFYING TUMOR SPECIFIC NEOANTIGENS
The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the...
2019/0060431 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST BREAST CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0060430 ANTIGEN-SPECIFIC T CELL RECEPTORS AND T CELL EPITOPES
The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific...
2019/0060429 VACCINE FOR THE PREVENTION OF BREAST CANCER RELAPSE
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect...
2019/0060428 FORMULATIONS FOR NEOPLASIA VACCINES AND METHODS OF PREPARING THEREOF
The present invention relates to neoplasia vaccine or immunogenic composition formulation for the treatment or prevention of neoplasia in a subject and to...
2019/0060427 METHODS AND COMPOSITIONS FOR SUSTAINED IMMUNOTHERAPY
This disclosure provides methods of making functionalized PEG iron oxide nanoparticles.
2019/0060426 METHOD AND APPARATUS FOR MICRONEEDLE TRANSDERMAL DELIVERY
A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous...
2019/0060425 AADC POLYNUCLEOTIDES FOR THE TREATMENT OF PARKINSON'S DISEASE
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides encoding AADC for the treatment of...
2019/0060424 Sumoylation of Serca2A and Cardiovascular Disease
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a...
2019/0060423 INJECTION PARADIGM FOR ADMINISTRATION OF BOTULINUM TOXINS
Disorders such as headaches can be treated by administration of a botulinum toxin to a patient suffering therefrom, such as a migraine headache. A combined a...
2019/0060422 COMPOSITION COMPRISING BOTULINUM TOXIN
The present invention concerns a composition comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and its use of the treatment or prevention...
2019/0060421 TREATMENT OF ABNORMAL CUTANEOUS SCARRING
The invention relates to the prevention and treatment of pathologic scars using APC or analogue thereof.
2019/0060420 METHOD FOR PREVENTING OR TREATING RADIATION AND CHEMICAL DAMAGE
The present invention relates to use of plasminogen in prevention, treatment, amelioration and/or elimination of radiation and chemical damage and related...
2019/0060419 METHODS FOR TREATING HYPOPHOSPHATASIA IN ADOLESCENTS AND ADULTS
The disclosure features methods for treating hypophosphatasia (HPP) in a patient (e.g., adolescent or adult having HPP) exhibiting physical impairments or...
2019/0060418 COMPOSITIONS FOR PREVENTING OR TREATING SEPSIS OR SEPTIC SHOCK COMPRISING ADK PROTEIN AS ACTIVE INGREDIENT
The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine...
2019/0060417 COMPOSITIONS AND METHOD FOR MANIPULATING PIM-1 ACTIVITY IN CIRCULATORY SYSTEM CELLS
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase PIM-1, and methods for...
2019/0060416 SURFACTANT PROTEIN D FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH LUNG INJURY
Surfactant protein D (SP-D) is a member of the collectin family of collagenous lectin domain-containing proteins that is expressed in epithelial cells of the...
2019/0060415 HEALTH PROMOTING COMPOSITION AND METHODS OF USE SUPPLEMENT
The present disclosure is directed to a composition or nutritional supplement containing undenatured Type II collagen in combination with a Vitamin B compound...
2019/0060414 METHODS OF TREATING EPILEPSY, SEIZURE DISORDERS AND SUDDEN UNEXPECTED DEATH IN EPILEPSY
The present system is directed in several embodiments to a method of administration of a therapeutic composition for treatment of seizures resulting from...
2019/0060413 Treatment Of Hyperinsulinemic Hypoglycemia With Exendin-4 Derivatives
In one aspect, methods of treating hyperinsulinemic hypoglycemia comprising administration of an effective amount of a derivative of an exendin-4 peptide are...
2019/0060412 PHARMACEUTICAL COMPOSITION AND MANUFACTURING METHOD THEREOF
The present invention relates to the field of polypeptides, and particularly, provides a pharmaceutical composition and a manufacturing method thereof. The...
2019/0060411 Insulin Glargine/Lixisenatide Fixed Ratio Formulation
The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin...
2019/0060410 Pharmaceutical Formulation Comprising GLP-1 Analogue and Preparation Method Thereof
The present invention discloses a pharmaceutical composition comprising GLP-1 analogs. In one embodiment, the composition further comprises buffers,...
2019/0060409 STABLE LIQUID GONADOTROPIN FORMULATION
The present invention pertains in general to the field of the stabilization of gonadotropin formulations, in particular liquid formulations of gonadotropins....
2019/0060408 METHODS AND COMPOSITIONS FOR TREATMENT OF CONDITIONS ASSOCIATED WITH ELEVATED TRIGLYCERIDES
Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The...
2019/0060407 USE OF INTERLEUKIN 2 FOR TREATING SPONDYLOARTHRITIS
The invention relates to the use of interleukin-2 in treating spondyloarthritis in a human subject, wherein IL-2 is to be administered at a dose of about I to...
2019/0060406 IL-1RA BASED COMPOSITIONS AND TREATMENTS
This disclosure relates to a stem cell treatment. This disclosure also relates to an IL-1RA treatment. This disclosure also relates to a composition comprising...
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