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Patent # Description
2019/0060405 ISOLATED INTERLEUKIN-34 POLYPEPTIDE FOR USE IN PREVENTING TRANSPLANT REJECTION AND TREATING AUTOIMMUNE DISEASES
The invention relates to an isolated interleukin-34 (IL-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune...
2019/0060404 USE OF VEGF-B FOR TREATING DISEASES INVOLVING NEOANGIOGENESIS
The invention discloses a method for treating a disease involving neoangiogenesis, including administering VEGF-B to a subject; and, a pharmaceutical...
2019/0060403 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2019/0060402 METHOD OF ENHANCING DOPAMINERGIC NEURONAL CELL GROWTH OR SURVIVAL WITH MANF
Methods and compositions for enhancing dopaminergic neuronal cell growth or survival by administration of mesencephalic astrocyte-derived neurotrophic factor...
2019/0060401 TREATING NEURODEGENERATIVE DISEASES WITH PROGRANULIN
The invention relates to methods and compositions for treating a neurodegenerative disease. More particularly, the present invention is directed to methods of...
2019/0060400 USE OF DESIGNER RECEPTORS EXCLUSIVELY ACTIVATED BY DESIGNER DRUGS AND ULTRASOUND IN THE TREATMENT OF SEIZURE...
Methods and compositions for treating a seizure disorder are provided which include administering to the patient a vector encoding a modified receptor for...
2019/0060399 GLYCOPEPTIDES AND USES THEREOF
The present invention provides glycopeptides comprising a peptide that is covalently linked to a saccharide. The peptide portion of the glycopeptides of the...
2019/0060398 USE OF LINGO-4 ANTAGONISTS IN THE TREATMENT OF CONDITIONS INVOLVING DEMYELINATION
The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the...
2019/0060397 TOPICAL CYCLOSPORINE-CONTAINING FORMULATIONS AND USES THEREOF
Provided herein are formulations for topical ophthalmic formulations containing 0.087-0.093 wt % of cyclosporine, and methods of making and using such...
2019/0060396 Inducing Cell Death By Hyperactivation of Motility Networks
Methods of inducing cell death by hyperactivation of motility networks are provided.
2019/0060395 Granular Pharmaceutical Composition
The present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a...
2019/0060394 Therapeutic inhibitor for EBV-associated tumor with tailor responsive optical imaging
The present disclosure provides peptides useful as inhibitors of the dimerization interface of EBNA1. The present disclosure also provides methods for treating...
2019/0060393 STABLE COMPOSITIONS OF PEPTIDE EXPOXY KETONES
The invention relates to pharmaceutical compositions that provide improved solubility and stability for peptide epoxy ketones. More specifically, the invention...
2019/0060392 USE OF CELL-PERMEABLE PEPTIDE INHIBITORS OF THE JNK SIGNAL TRANSDUCTION PATHWAY FOR THE TREATMENT OF CHRONIC OR...
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal...
2019/0060391 POWDER FORMULATION HAVING HYPOGLYCEMIC AND HYPOLIPIDEMIC FUNCTIONS AND METHOD FOR PREPARING THE SAME
The present disclosure relates to the field of health care products, disclosing a powder made from inulin, FOLIUM CYCLOCARYA PALIURUS, RHIZOMA DIOSCOREA...
2019/0060390 ACTIVE INGREDIENT OBTAINED FROM OPHIOPOGON JAPONICUS FOR THE TREATMENT OF ATOPIC DERMATITIS
Methods of treatment for atopic dermatitis in a human subject or animal, the methods comprising administering topically to the human subject or animal an...
2019/0060389 COMPOSITIONS COMPRISING KAKADU PLUM EXTRACT OR ACAI BERRY EXTRACT
A method of treating skin in need thereof is disclosed. The method can include topically applying to the skin a composition consisting of kakadu plum extract,...
2019/0060387 COMPOSITIONS AND METHODS OF BDNF ACTIVATION
Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable...
2019/0060386 OPTIMUM RATIO FOR HERBS COMBINATION OBTAINED BY USING SCIENTIFIC-BASED FORMULA FOR HYPERTENSION TREATMENT AND A...
The present invention relates to a hypertension treatment. More particularly, the present invention relates to combination of four herbs' extract including 95%...
2019/0060385 Compositions Providing Improved Eye Comfort
The present invention relates to compositions providing improved substantivity, comfort and/or feel to the eye upon application. The present invention further...
2019/0060384 COMPOSITION FOR TREATMENT OR PREVENTION OF LUNG CANCER AND A METHOD THEREFORE
The present invention relates to a composition for the treatment or prevention of lung cancer, including gefitinib and a Lonicera japonica extract, and more...
2019/0060383 COMPOSITIONS AND METHODS FOR CONTROLLING CARBOHYDRATE AND FAT METABOLISM
A composition comprising at least: a single extract obtained from a mixture of at least two plants selected from Chrysanthellum indicum, Cynara scolymus,...
2019/0060382 PROCESS FOR PREPARING A CRASSOCEPHALUM CREPIDIOIDES EXTRACT, EXTRACT PREPARED THEREBY AND USE OF THE EXTRACT
The present invention provides a process for the preparation of a Crassocephalum crepidioides extract, and the extract prepared thereby. The present invention...
2019/0060381 CANNABINOID COMPOSITIONS, METHODS OF MANUFACTURE AND USE THEREOF
Provided are oral pharmaceutical compositions comprising sustained release or a combination of sustained and immediate release formulation of cannabinoids, a...
2019/0060380 Methods of Identifying Bacteriophages that can Infect and Kill Host-Adapted Infectious Pathogenic Bacteria
The subject matter of the instant invention relates to methods of enhancing harvesting of phages against a targeted host bacteria, as well as methods of...
2019/0060379 Probiotics and Prebiotics Compound Preparation and Processing Method thereof
A probiotics and prebiotics compound preparation and a processing method thereof are provided. The processing method includes the following processing steps:...
2019/0060378 METHODS FOR THE DIETARY MANAGEMENT OF IRRITABLE BOWEL SYNDROME AND CARBOHYDRATE MALABSORPTION
The invention relates generally to digestive disorders, and in particular to methods for treating irritable bowel syndrome by increasing carbohydrate...
2019/0060377 STRAINS AND METHODS USEFUL FOR MYCOTOXINS
The disclosure relates to strains, compositions and methods for detoxifying a mycotoxin. In another embodiment, the disclosure relates to strains, compositions...
2019/0060376 METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND MANIPULATING MICROBES IN TUMORS
In some embodiments, methods of determining that a subject is likely to have cancer are provided. Such methods may include amplifying a microbial DNA sample in...
2019/0060375 SYSTEM AND METHOD FOR AFFECTING INTESTINAL MICROBIAL FLORA
Described is a system for affecting intestinal microbial flora. The system includes an intestinal sleeve that is implanted in a patient and bypasses a section...
2019/0060374 SKIN PROBIOTIC FORMULATION
Microbes can be genetically modified to express biomolecules that are beneficial to mammals and/or to reduce, or eliminate, expression of harmful virulence...
2019/0060373 SUBPOPULATIONS OF SPORE-LIKE CELLS AND USES THEREOF
Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one...
2019/0060372 AMNIOTIC FLUID COMPOSITION AND METHOD OF USING
A composition for treating a patient with a tissue disease or malformity has a composition containing amniotic fluid. The amniotic fluid has a quantity of...
2019/0060371 METHODS FOR CONTROLLED PROLIFERATION OF VESTIBULAR STEM CELLS / GENERATING INNER EAR HAIR CELLS USING WNT AND...
Provided are compositions and methods for using Wnt agonist, GSK3-alpha inhibitor, or GSK3-beta inhibitors in combination with TGF-beta inhibitors to induce...
2019/0060370 PHOTORECEPTORS AND PHOTORECEPTOR PROGENITORS PRODUCED FROM PLURIPOTENT STEM CELLS
Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are...
2019/0060369 MICROVESICLES (MVS) DERIVED FROM ADULT STEM CELLS FOR USE IN THE THERAPEUTIC TREATMENT OF A TUMOR DISEASE
The invention is in the field of therapeutic treatment of tumours. The inventors have found that microvesicles derived from adult stem cells exert a remarkable...
2019/0060368 Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles And Uses Thereof In Autoimmune Diseases
Pharmaceutically acceptable preparations of extracellular vesicles derived from activated MSCs are provided. These preparations are essentially free of MSCs,...
2019/0060367 3-D COLLAGEN SCAFFOLD-GENERATED EXOSOMES AND USES THEREOF
Described herein is a method for treating and/or ameliorating at least one symptom associated with traumatic brain injury in a subject, the method comprises...
2019/0060366 HIGHLY ENGRAFTABLE HEMATOPOIETIC STEM CELLS
The present inventions relates to highly engraftable hematopoietic stem cell (heHSC) and related methods of production and use for the treatment of stem cell...
2019/0060365 PHARMACEUTICAL COMPOSITION FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND METHOD THEREOF
Disclosed is a pharmaceutical composition for treating chronic obstructive pulmonary disease, comprising an effective amount of human mesenchymal stem cells,...
2019/0060364 INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using...
2019/0060363 INTRACELLULAR GENOMIC TRANSPLANT AND METHODS OF THERAPY
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using...
2019/0060362 RAR SELECTIVE AGONISTS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER IMMUNOTHERAPY
Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least one Retinoic Acid Receptor agonist.
2019/0060361 METHODS AND COMPOSITIONS RELATING TO REGULATORY T CELLS
As described herein, the activity of Treg cells can be mediated by cathepsin inhibition, e.g., in tumor environments, cathepsin inhibition results in increased...
2019/0060360 CATIONIC BINDER, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND METHOD OF USING THE SAME
The present invention provides a pharmaceutical composition for treating a patient suffering from or predisposed to hyperphosphatemia, which contains...
2019/0060359 TREATMENT OF NEURODEGENERATIVE DISEASE WITH SODIUM CHLORITE
The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia...
2019/0060358 STUFFY NOSE DEBLOCKING COMPOSITION HAVING ANTIVIRAL ACTIVITY
A pharmaceutical composition has a stuffy nose deblocking activity. The composition includes a hyperosmolar aqueous solution of a non-ionic osmolality...
2019/0060357 COMPOSITION AND METHOD FOR TREATING MIGRAINES
Disclosed are compositions for treating or preventing migraine headaches and related headaches.
2019/0060356 NOVEL OPHTHALMIC COMPOSITION AND METHODS OF USE
Described are stable topical formulations useful in the treatment of viral infection, demodex infection, fungal infection and bacterial infection of the eye,...
2019/0060355 NOVEL OPHTHALMIC COMPOSITION AND METHODS OF USE
Described are stable topical formulations useful in the treatment of viral infection, demodex infection, fungal infection and bacterial infection of the eye,...
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