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Patent # Description
2019/0060354 Immune-Modifying Nanoparticles for the Treatment of Inflammatory Diseases
The current invention involves the administration of negatively charged particles, such as polystyrene, PLGA, or diamond particles, to subjects to ameliorate...
2019/0060353 GLUCOCEREBROSIDE TREATMENT OF DISEASE
The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders...
2019/0060352 CHITOSAN HYDROGELS FOR ACCELERATING INVOLUTION AND PREVENTING INFECTION OF THE MAMMARY GLAND AT DRYING-OFF
A method of preventing intramammary infection and accelerating involution by administration of a biological response modifier, specifically a chitosan...
2019/0060351 BETA-GLUCAN IN COMBINATION WITH ANTI-CANCER AGENTS AFFECTING THE TUMOR MICROENVIRONMENT
The present invention relates to the combination of soluble .beta.-glucan and anti-cancer agents that affect the tumor microenvironment. Soluble .beta.-glucan...
2019/0060350 BETA-GLUCAN METHODS AND COMPOSITIONS THAT AFFECT THE TUMOR MICROENVIRONMENT
This disclosure relates to the combination of soluble .beta.-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble...
2019/0060349 TLX AND MIR-219 AS POTENTIAL THERAPEUTIC TARGETS FOR NEURODEVELOPMENTAL DISORDERS
Disclosed herein are methods of treating neurodevelopmental disorders such as schizophrenia (SCZ), bipolar disorder or depression. The methods entail...
2019/0060348 TREATMENT OF DISEASE WITH POLY-N-ACETYLGLUCOSAMINE NANOFIBERS
Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof ("sNAG nanofibers") and the use of such...
2019/0060347 MICROBUBBLE COMPLEXES AND METHODS OF USE
The present invention relates to a microbubble complex comprising a microbubble having an outer shell comprising a mixture of native and denatured albumin...
2019/0060346 METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIC INJURY TO TISSUE USING THERAPEUTIC HYPOTHERMIA
Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.
2019/0060345 PHARMACOKINETICS OF S-ADENOSYLMETHIONINE FORMULATIONS
Compositions and methods to improve the pharmacokinetic profile of S-Adenosylmethionine (SAMe) are provided, as are methods of treating various disorders using...
2019/0060344 METHODS OF TREATING TUMOR METASTASIS
The present invention provides methods for treating or suppressing tumor metastasis at a site distinct from the bladder in an individual having a urothelial...
2019/0060343 METHODS OF TREATING A BACTERIAL INFECTION USING A FIXED-DOSE PHARMACEUTICAL COMPOSITION COMPRISING THREE...
Oral administration of a solid dosage form of the present invention comprising an effective amount of rifabutin, an effective amount of clarithromycin, an...
2019/0060342 COMPOSITION CONTAINING IVERMECTIN FOR EXTERMINATING CLAVINEMA MARIAE INFECTION ON SEBASTES SCHLEGELI
The present invention relates to a composition containing Ivermectin for exterminating Clavinema mariae infection on Sebastes schlegeli, and more specifically,...
2019/0060341 AGAVACEAE EXTRACT COMPRISING STEROIDAL SAPONINS TO TREAT OR PREVENT METABOLIC DISORDER RELATED PATHOLOGIES
A saponin and sapogenin extract recovered from plants of the Agavaceae family in the form of an extract or its purified form which has beneficial effects on...
2019/0060340 NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS
A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards...
2019/0060339 METHODS FOR THE TREATMENT AND/OR PREVENTION OF CARDIOVESCULAR DISEASE BY INHIBITION OF E-SELECTIN
New methods for treating and/or preventing cardiovascular disease including, for example, myocardial infarction and atherosclerosis, by the use of at least one...
2019/0060338 GLYCOMIMETIC INHIBITORS OF PA-IL AND PA-IIL LECTINS
Compounds, compositions, and methods for the diagnosis and/or treatment of medical conditions involving infections with and colonization by Pseudomonas...
2019/0060337 COMPOSITIONS COMPRISING BETA-GLUCOGALLIN AND THERAPEUTIC APPLICATIONS THEREOF IN CONTROLLED KINETICS OF...
Disclosed are the compositions for the effective regulation of carbohydrate breakdown and absorption. More specifically, the invention discloses compositions...
2019/0060336 RESETTING BIOLOGICAL PATHWAYS FOR DEFENDING AGAINST AND REPAIRING DETERIORATION FROM HUMAN AGING
Compositions for addressing one or more of the effects of aging are described. The compositions comprise a first component comprising repair system...
2019/0060335 ORAL LIPID SUPPLEMENTS FOR TREATING PAIN AND FIBROMYALGIA
A method of oral delivery of phospholipid/inulin compositions comprising capsules, tablets, chewable wafers or powdered material in a liquid carrier in...
2019/0060334 COMPOSITIONS WITH SPECIFIC OLIGOSACCHARIDES TO PREVENT OR TREAT ALLERGIES
The present invention relates to a nutritional composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising at least one...
2019/0060333 Antibiotic kit and composition and uses thereof
The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly...
2019/0060332 CONCENTRATED THERAPEUTIC PHOSPHOLIPID COMPOSITIONS
The invention relates to concentrated therapeutic phospholipid compositions; methods for treating or preventing diseases associated with cardiovascular...
2019/0060331 AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS
The present invention provides aza-heteroaryl derivatives of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, ...
2019/0060330 APPLICATION OF 4-HYDROXY SALICYLANILIDE IN PREPARATION OF ANTI-MYELOMA OR ANTI-LYMPHOMA DRUGS
The present invention provides an application of 4-hydroxyl salicylanilide in preparation of drugs for preventing or treating lymphoma or multiple myeloma.
2019/0060329 Treating Vitamin D Insufficiency and Deficiency with 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3
Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally...
2019/0060328 TREATMENT OF HEPATIC STEATOSIS RELATED OLIGO-OVULATION
The present invention relates to a method and composition for use in treating a condition that benefits from the reduction of hepatic and/or visceral fat, such...
2019/0060327 Methods and Compositions for Treating Psoriasis
Method and composition for treating psoriasis and other skin disorders.
2019/0060326 TESTOSTERONE ESTER TRIGLYCERIDE FORMULATIONS
Testosterone ester triglyceride formulations, optionally further including adducts. Methods of in-situ control of the manufacture or formation of such adducts...
2019/0060325 STABILIZED SOLID DOSAGE FORM
The present invention provides a solid dosage form suppressing the increase of by-products due to dimerization of a drug compound having an amino group and a...
2019/0060324 POLYNUCLEOTIDE-POLY(DIOL) CONJUGATES, PROCESS OF PREPARATION AND USES THEREOF
The present disclosure provides a conjugate of formula (I) ##STR00001## wherein each wherein each X, Nt, R, n, m and j are as defined herein. There is also...
2019/0060323 STABILIZED FORMULATIONS OF CNS COMPOUNDS
Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise...
2019/0060322 SUBSTITUTED BENZENE COMPOUNDS
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds...
2019/0060321 C5aR ANTAGONISTS
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions,...
2019/0060320 MEDICAL USE OF PHARMACEUTICAL COMBINATION OR COMPOSITION
The present invention relates to a certain DPP-4 inhibitor for use in combination with metformin in CKD patients.
2019/0060319 PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF
The present disclosure provides pyrrolopyrimidine compounds and methods of use therefor. For example, the disclosure provides certain pyrrolopyrimidine...
2019/0060318 Methods and Compositions for Treating Thyroid-Related Medical Conditions with Reduced Folates
The present invention provides methods and compositions for treating thyroid-related medical conditions. Many thyroid-related medical conditions exist that go...
2019/0060317 COMPOSITIONS AND METHODS FOR TREATING CANCER
Ritanserin is shown to be an inhibitor of diacylglycerol kinase alpha (DGK.alpha.) and to be cytotoxic to glioblastoma and melanoma cells. Ritanserin treatment...
2019/0060316 [6R]-MTHF - an efficient folate alternative in 5-fluorouracil based chemotherapy
The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering the...
2019/0060315 [6R]-MTHF multiple bolus administration in 5-fluorouracil based chemotherapy
The present invention relates to the treatment of solid tumors in humans such as cancer, especially colorectal cancer (CRC), which involves administering...
2019/0060314 TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS
Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious...
2019/0060313 Immuno-Gene Combination Therapy
"In situ vaccination" using immuno-gene therapy has the ability to induce polyclonal anti-tumor responses directed by the patient's immune system. Patients...
2019/0060312 SUSTAINED-RELEASE VORICONAZOLE-CONTAINING THERMOGEL AND USES THEREOF
The present disclosure provides veterinary formulations comprising a therapeutically effective amount of a voriconazole and a polymer. The disclosure also...
2019/0060311 COMPOSITIONS AND METHODS FOR TREATMENT OF VITILIGO
Methods of treating vitiligo using JAK/STAT modulating compounds are provided herein. The JAK/STAT modulating compounds may be selected from ...
2019/0060310 Protein Kinase C Inhibitors and Uses Thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and...
2019/0060309 MDM2 INHIBITORS AND COMBINATIONS THEREOF
The present disclosure relates to a pharmaceutical combination comprising (a) an Mdm2 inhibitor and (b)(i) a MEK inhibitor and/or (b)(ii) Bcl2 inhibitor,...
2019/0060308 PHARMACEUTICAL COMPOSITION COMPRISING AN OMEGA-3 FATTY ACID AND A HYDROXY-DERIVATIVE OF A STATIN AND METHODS OF...
In various embodiments, the present invention provides compositions and methods for treating and/or preventing a cardiovascular-related disease in subject in...
2019/0060307 INDIVIDUAL AND COMBINATION OF MDVI-1 AND NUTLIN-3 FOR TOPICAL OR INTRAVITREAL OPHTHALMIC USE
Disclosed are pharmaceutical compositions comprising mdivi-1 and nutlin-3, individually and in combination, for topical or intravitreal ophthalmic delivery and...
2019/0060306 ENHANCEMENT OF IMPAIRED MOTOR AND MENTAL FUNCTIONS, USING DEXTROMETHORPHAN AND OXIDASE ENZYME INHIBITOR
During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control...
2019/0060305 HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
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