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Patent # Description
2019/0060304 AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES
Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating...
2019/0060303 METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS
The present invention relates to the field of cancer therapy. Specifically, provided are methods of treating cancer, for example, peripheral T-cell lymphoma...
2019/0060302 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
2019/0060300 Self-Emulsifying Compositions of CB2 Receptor Modulators
Disclosed are stable self-emulsifying compositions comprising at least one CB2 receptor modulator, a self-emulsifying vehicle and optionally at least one...
2019/0060299 Pirfenidone Treatment for Patients with Atypical Liver Function
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone...
2019/0060298 NEW DRUG FOR THE TREATMENT AND/OR PREVENTION OF DEPRESSIVE DISORDERS
A compound having the following formula (I): ##STR00001## for its use as a drug in the treatment and/or the prevention of depression, with the proviso that the...
2019/0060297 Methods and Compositions to Inhibit Adverse Effects Associated with Vaccinations
The invention relates to methods of inhibiting side effects associated with vaccination in a human subject in need thereof. The method comprises administering...
2019/0060296 DISCOVERY OF SMALL MOLECULES THAT TARGET THE ANDROGEN RECEPTOR AND USES
Provided herein are methods useful for identifying compounds that modulate the activity of an androgen receptor, or variant thereof. In particular, this...
2019/0060295 PHARMACEUTICAL COMPOSITION OF A COMBINATION OF TRAMADOL-ETORICOXIB HYDROCHLORIDE FOR THE TREATMENT OF PAIN
The present disclosure relates to a pharmaceutical composition of a combination of tramadol-etoricoxib hydrochloride for the treatment of pain. The production...
2019/0060294 PHARMACEUTICAL COMPOSITIONS
The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the...
2019/0060293 5-PHENYLAZAINDOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
Provided is a compound which is useful as an AMPK activator. The compound is represented by formula: ##STR00001## wherein the symbols are defined in the...
2019/0060292 MACROCYCLE AND COMPOSITION COMPRISING THEREOF
A macrocycle represented by formula (I) and a pharmaceutical composition comprising the macrocycle, or a crystalline form, pharmaceutically acceptable salt,...
2019/0060291 AZETIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
The present invention relates to an azetidine derivative for use as a Janus kinase (JAK) inhibitor, a drug composition comprising same, a preparation method...
2019/0060290 METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION COMPRISING PYRROLO-FUSED SIX-MEMBERED HETEROCYCLIC COMPOUND
The present invention provides a method for preparing a pharmaceutical composition containing a pyrrolo-fused six-membered heterocyclic compound or a...
2019/0060289 METHODS OF TREATING AUTOPHAGY-ASSOCIATED DISORDERS AND RELATED PHARMACEUTICAL COMPOSITIONS, DIAGNOSTICS,...
The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques...
2019/0060288 TOPICAL COMPOISITION COMPRISING TACROLIMUS
The present invention relates to a composition for topical application comprising: a first discontinuous phase comprising a first oil and tacrolimus; a second...
2019/0060287 TIZANIDINE FORMULATIONS
The disclosure is directed to pharmaceutical compositions comprising of Tizanidine or a pharmaceutically acceptable salt thereof which controllably modulate...
2019/0060286 Chemotherapeutic Methods
Disclosed herein are chemotherapeutic methods for the treatment of cancer in humans. In at least one specific embodiment, the method can include administering...
2019/0060285 COMBINATION THERAPY FOR TREATMENT OF OVARIAN CANCER
This invention relates to methods of treating a patient with ovarian cancer having deficiencies in homologous recombination (HR) comprising administering to...
2019/0060284 PHARMACOLOGICAL MODULATORS OF NAV1.1 VOLTAGE-GATED SODIUM CHANNELS ASSOCIATED WITH MECHANICAL PAIN
The present invention provides the use of compounds which selectively block the Nav1.1 subtype of voltage-gated sodium (Nav) channels, whose role in...
2019/0060283 PHARMACEUTICAL DOSAGE FORMS
The present invention relates to pharmaceutical dosage forms for oral administration comprising the drug substance ...
2019/0060282 IMIDAZOLYLAMIDE DERIVATIVE
The present invention pertains to an imidazolylamide derivative represented by formula (1) that exhibits an exceptional suppressive effect on cancer cell...
2019/0060281 COMPOSITIONS AND TREATMENT METHODS FOR DIAPER DERMATITIS AND SKIN IRRITATION
Disclosed herein are topical compositions and treatment methods for protecting the skin and alleviating symptoms of dermatitis, including "diaper rash", and...
2019/0060280 SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF
This invention is directed to selective androgen receptor degrader (SARD) compounds pharmaceutical compositions and uses thereof in treating early prostate...
2019/0060279 DOSAGE REGIMEN FOR THE TREATMENT OF ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
This invention relates to a novel dosage regimen for administration of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzami- de or a...
2019/0060278 METHOD FOR INHIBITING TUMOR METASTASIS
A leukotriene C4 and D4 antagonist is used to inhibit tumor metastasis by acting to inhibit tumor cell adhesion to endothelial cells, thereby preventing tumor...
2019/0060277 MELATONIN MINI-TABLETS AND METHOD OF MANUFACTURING THE SAME
The instant invention is generally directed to a patient-friendly drug delivery system for targeted populations, such as pediatric and geriatric patients....
2019/0060276 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GLIOMAS
Pharmaceutical compositions of selective EP2 antagonists exemplified by small molecules TG4-155 and TG6-10-1 effective for treating gliomas, and methods for...
2019/0060275 Administration of hypoxia activated prodrugs and antiangiogenic agents for the treatment of cancer
Administration of a hypoxia activated prodrug in combination with an antiangiogenic agent is useful for treating cancer.
2019/0060274 D-PROLINE DERIVATIVES AS SAP DEPLETING AGENT
The present invention relates to the compound ((2R,2'R)-bis(((tetrahydro-2H-pyran-4-carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate),...
2019/0060273 Method of increasing the bioavailability of silybin
One example embodiment relates to a method of increasing bioavailability of silybin in a person. The method includes providing silybin and a flavonoid to the...
2019/0060272 Water Soluble Flavonoids
Methods for obtaining a stable solution to enhance bioavailability of flavonoids (e.g. Taxifolin/Dihydromericetine, or Quercetin) include the following steps:...
2019/0060271 CROSSLINKER ENHANCED REPAIR OF CONNECTIVE TISSUES
A protein crosslinker delivery device includes a body and a protein crosslinker held in a synthetic or natural biodegradable polymer. The body, a coating on...
2019/0060270 DISINFECTANT AGENT
The invention relates to an agent for the disinfection of body surfaces and the destruction of bacterial metabolic products on body surfaces, said agent...
2019/0060269 Brain Derived PPARa Ligands
Methods of modulating peroxisome proliferator-activated receptor .alpha. (PPAR.alpha.) activity in a cell in a subject In need thereof are provided. The...
2019/0060268 COMPOSITIONS AND METHODS FOR PREVENTING, ALLEVIATING, AND TREATING NEUROLOGICAL INJURY FOLLOWING HEAD TRAUMA
Compositions and methods of treatment and prevention for trauma-related brain injury are disclosed herein. In certain aspects, disclosed is a method for...
2019/0060267 COMPOSITION FOR AND METHOD TO INCREASE SERUM ADIPONECTIN AND REDUCE BODY FAT
The invention provides methods and compositions for reducing the percentage of body fat in an animal or human and increasing the level of adiponectin in an...
2019/0060266 PHARMACEUTICAL COMPOSITIONS OF TIOPRONIN AND METHODS FOR PREPARING THEREOF
Pharmaceutical compositions are described herein, the compositions consisting essentially of anhydrous suspensions of therapeutically effective quantity of a...
2019/0060265 Methods and Compositions for Treatment of Acute Lung Injury
A method of treating acute lung injury (ALI) in a patient suspected of having ALI is disclosed. The method includes administering to the patient a...
2019/0060264 ENTERICALLY COATED CYSTEAMINE, CYSTAMINE AND DERIVATIVES THEREOF
The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The ...
2019/0060263 COMPOSITIONS CONTAINING BENZOATE COMPOUND AND TANNIC ACID FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS
Compositions (e.g., pharmaceutical compositions or nutraceutical compositions) comprising a benzoate compound and an excipient, wherein the excipient is tannic...
2019/0060262 ENHANCED EXPRESSION OF RNA VECTORS
The present invention relates to methods and compositions for enhancing expression from RNA expression vectores. The invention is based upon the observation...
2019/0060261 ACTIVE COMBINATIONS OF PERILLIC ACID AND ACTIVITY ENHANCING SUBSTANCES
The present invention relates to compositions of perillic acid compounds and activity enhancing substances, therapeutic and non-therapeutic uses of the...
2019/0060260 N-BROMOTAURINE SOLUTIONS AND EMULSIONS AGAINST ABNORMAL CELLS
In a method of producing aqueous solutions of N-bromotaurine (Taurine Bromanine, NBrT) with taurine with latter addition of NaOBr, and emulsions of these...
2019/0060259 Compositions and Methods for Treating Diabetic Retinopathy
Compositions and methods for treating diabetic retinopathy or symptoms thereof are provided. The disclosed compositions and methods for treating diabetic...
2019/0060258 HEPATITIS B ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R (I) which inhibit the...
2019/0060257 ANALGESIC COMPOUNDS
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an...
2019/0060256 METHODS FOR THE BIOSYNTHESIS OF TAURINE OR HYPOTAURINE IN CELLS
The present invention describes an approach to increase taurine or hypotaurine production in prokaryotes. More particularly, the invention relates to genetic...
2019/0060255 ACAT1 Inhibitors for Treating Cancer
Provided are methods and compositions for the treatment of cancer using an ACAT1 inhibitor. The cancer may be any of melanoma, lymphoma, esophageal cancer,...
2019/0060254 COMPOSITIONS AND METHODS FOR TREATING MOTOR DISORDERS
This invention provides methods utilizing ketamine for the treatment of motor disorders and/or side effects associated with certain medications used in the...
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