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Patent # Description
2019/0070292 STABLE AQUEOUS FORMULATIONS OF ADALIMUMAB
The invention provides aqueous pharmaceutical adalimumab compositions suitable for long-term storage of adalimumab, methods of manufacture of these...
2019/0070291 GENE DETECTION ASSAY FOR IMPROVING THE LIKELIHOOD OF AN EFFECTIVE RESPONSE TO AN ErbB ANTAGONIST CANCER THERAPY
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene...
2019/0070290 COMPOSITIONS COMPRISING CROSS-SPECIES-SPECIFIC ANTIBODIES AND USES THEREOF
The present invention relates to uses of bispecific antibodies exhibiting cross-species specificity for evaluating the in vivo safety and/or activity and/or...
2019/0070289 COMBINATION CANCER THERAPY
A method and combination for treating a cancer patient by combining two distinct immuno-therapy solutions for administration to a patient within a common time...
2019/0070288 METHOD OF INDUCING TOLERANCE TO AN ALLERGEN
The present invention relates generally to the field of allergies. More particularly, the present invention provides a method for treating an allergy in a...
2019/0070287 TOLERANCE THERAPEUTIC FOR TREATING POLYPEPTIDE INDUCED IMMUNE ACTIVATION
The present disclosure is directed to compositions comprising one or more components of a polypeptide, a reovirus-derived targeting protein, and a cleavable...
2019/0070286 METHOD OF VACCINATION
The present invention relates to improved methods for vaccination of a subject. Particularly, the present invention discloses the use of skin antigen...
2019/0070285 COMPOSITION FOR TREATING HBV INFECTION
The present invention provides a composition comprising hepatitis B virus (HBV) component(s), and which may be either nucleic acid- or polypeptide-based as...
2019/0070284 Pan South American Arenavirus Live Attenuated Vaccine
Disclosed herein are methods of making attenuated Arenaviruses, compositions comprising the attenuated Arenaviruses, and methods of using the attenuated...
2019/0070283 STREPTOCOCCUS PNEUMONIAE CAPSULAR POLYSACCHARIDES AND CONJUGATES THEREOF
The invention relates to isolated Streptococcus pneumoniae serotype 15B capsular polysaccharide and processes for their preparation. The invention also relates...
2019/0070282 IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS, KITS COMPRISING THE SAME AND USES...
The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates),...
2019/0070281 PROTEINS AND IMMUNIZING COMPOSITIONS CONTAINING KLEBSIELLA PROTEINS AND METHODS OF USE
Provided herein are isolated proteins isolatable from a Klebsiella spp. Also provided are compositions that include one or more of the proteins, and methods...
2019/0070280 ONCOLYTIC VIRUS AND CHECKPOINT INHIBITOR COMBINATION THERAPY
The present invention pertains to a combination for simultaneous, separate or sequential use which comprises (a) an oncolytic virus and (b) a checkpoint...
2019/0070279 Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0070278 CRYOPRESERVATION OF APOPTOTIC CANCER CELLS FOR USE IN IMMUNOTHERAPY AGAINST CANCER
Described herein is a reliable method for preparing a potent vaccine useful for immunotherapy comprising the step of cryopreserving a population of cells...
2019/0070277 Use of Car and Bite Technology Coupled with an SCFV from an Antibody Against Human Thymidine Kinase 1 to...
Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen...
2019/0070276 Use of Car and Bite Technology Coupled with an SCFV from an Antibody Against Human Thymidine Kinase 1 to...
Modified T-cells have paratopes against human TK1 epitopes, are made by producing monoclonal antibodies that are specific to TK1, creating chimeric antigen...
2019/0070275 NEOANTIGEN COMPOSITIONS AND METHODS OF USING THE SAME IN IMMUNOONCOTHERAPY
Provided herein are, inter alia, compositions including a fusion protein containing an antigenic cancer peptide and a mature MHC class II peptide, a nucleic...
2019/0070274 L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY
Variant Erwinia chrysanthemi L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins...
2019/0070273 METHODS OF TREATING ABNORMALITIES OF THE FIRST METATARSOPHALANGEAL JOINT OF THE FOOT
A method for treating an abnormality of the first metatarsophalangeal joint of the foot of a mammal includes electrically stimulating a site on each of the...
2019/0070272 ENZYME-ACTIVATED COLLAGEN AND TISSUE MATRICES
Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated...
2019/0070271 FACTOR IX GENE THERAPY
The invention relates to a new, more potent, coagulation factor IX (FIX) expression cassette for gene therapy of haemophilia B (HB). Disclosed is a vector for...
2019/0070270 Thrombin Microcapsules, Preparation and Uses Thereof
Provided are spray-dried thrombin powders comprising microcapsules, methods of preparation and uses thereof.
2019/0070269 LYSIN POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA
The present disclosure provides methods and compositions useful for the prophylactic and therapeutic amelioration and treatment of infections caused by Gram...
2019/0070268 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS
Disclosed are pharmaceutical compositions comprising a drug with a laccase-reactive functional group and a laccase (EC.10.3.2) and methods for manufacturing...
2019/0070267 DEVICE FOR DRUG RECONSTITUTION AND DELIVERY
A device houses a lyophilized drug that is to be reconstituted and administered to a patient that has a disease. The device has a transparent cylinder that has...
2019/0070266 Liraglutide in Diabetic Foot Ulcer
The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.
2019/0070265 Pharmaceutical Composition for Use in the Treatment of a Neurodegenerative Disease
The present invention refers to a pharmaceutical composition for use in the treatment of a neurodegenerative disease.
2019/0070264 INTERLEUKIN 15 PROTEIN COMPLEX AND USE THEREOF
An interleukin 15 (IL-15) protein complex is provided. The IL-15 protein complex includes soluble fusion proteins (I) and (II), wherein the fusion protein (I)...
2019/0070263 MODULATING GAMMA-C-CYTOKINE ACTIVITY
Embodiments relate to peptide antagonists of -family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases,...
2019/0070262 INTERLEUKIN-18 VARIANTS AND METHODS OF USE
The present invention provides compositions and methods comprising an activator of IL-18 activity for use in therapeutic and non-therapeutic applications. The...
2019/0070261 MATERIALS AND METHODS FOR MODULATING GLUCOSE UPTAKE
The subject invention provides materials and methods for modulating cellular glucose uptake. Specifically, in accordance with one embodiment of the subject...
2019/0070260 SUPPRESSION OF CELLULAR TRANSFORMATION AND DYSPLASIA BY TOPICAL APPLICATION OF LEFTY
The present disclosure relates to suppression of cellular transformation and dysplasia by topical application of Lefty. In particular, the present disclosure...
2019/0070259 METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING CANCER
The present disclosure is directed to methods and compositions for inhibiting a cancer cell using nucleic acid sequences encoding elephant p53 or elephant p53...
2019/0070258 TARGETED OESOPHAGEAL ADMINISTRATION OF ZN-ALPHA2-GLYCOPROTEINS (ZAG), METHODS AND FORMULATIONS THEREOF
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as hypoglycemia, obesity, diabetes, and the...
2019/0070257 Methods for Prophylactically Preventing, Slowing the Progression of, or Treating Alzheimer's Disease
The present specification is directed to systems, apparatus and methods for prophylactically preventing, or for treating the progression of, Alzheimer's...
2019/0070256 SYSTEMS AND METHODS FOR IMPROVED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR
Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a...
2019/0070255 EPITOPE MIMICS
This invention pertains to the identification of antibody mediated epitope mimics and applications of the identification of said mimic peptides in the design...
2019/0070254 SWEET TASTE RECEPTOR ANTAGONIST COMPOSITIONS
The present disclosure relates to compositions comprising gymnemic acid, together with a form of zinc to block the unpleasant bitter taste of gymnemic acid as...
2019/0070253 Combination Product For The Prevention Of Sexually Transmitted Infections
Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as...
2019/0070252 CYCLOSPORIN COMPOSITIONS
A composition is disclosed herein comprising from about 0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant selected from the group consisting of...
2019/0070251 POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when...
2019/0070250 ANGIOTENSIN II ALONE OR IN COMBINATION FOR THE TREATMENT OF HYPOTENSION
The present invention relates, rider alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a...
2019/0070249 METHOD OF TREATMENT OR PROPHYLAXIS OF INFECTIONS OF THE EYE
A microbial infection in an eye of a subject is treated or prevented by topically administering to the eye an effective amount of a macromolecule or a...
2019/0070248 PEPTIDE MIMOTOPES OF THE CD3 T-CELL CO-RECEPTOR EPSILON CHAIN AND USES THEREOF
The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain...
2019/0070247 Compositions and Methods for Treatment of Hereditary Cystatin C Amyloid Angiopathy (HCCAA) and Other...
Compositions and Methods for the Treatment of Amyloid Deposit diseases, e.g., Hereditary cystatin C amyloid angiopathy and other neurodegenerative disorders,...
2019/0070246 TRADITIONAL CHINESE MEDICINE COMPOSITION AND USE THEREOF
The present disclosure relates to the field of drugs and health foods. Disclosed is a traditional Chinese medicine composition comprising LYCII FRUCTUS...
2019/0070245 NUTRIPROTECTIVE DIET
The present document describes a nutriprotective diet comprising a nutriprotective amount of a sugar plant syrup, a sugar plant syrup extract, a sugar plant...
2019/0070244 BOYSENBERRY COMPOSITIONS AND METHODS OF PREPARATION AND USE THEREOF
The present disclosure encompasses compositions prepared from Boysenberry. Also encompassed are methods of preparing these compositions and methods of using...
2019/0070243 MUSCLE-ENHANCING AGENT
The objective of the present invention is to provide a safe muscle-enhancing agent by which a muscle mass and muscular strength can be effectively increased or...
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