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Patent # Description
2019/0070191 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER USING PHENOTHIAZINE
The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a...
2019/0070190 INHIBITORS OF POLO-LIKE KINASE 4 (PLK4) FOR TREATING PEDIATRIC EMBRYONAL TUMORS
Disclosed are methods and compositions for treating pediatric embryonal tumors. The methods and compositions utilize or include an inhibitor of polo-like...
2019/0070189 DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) FOR USE IN TREATMENT OF DISEASES...
A compound having the structure set forth in Formula (I) and Formula (II): ##STR00001## wherein the substituents Y, Z, A, B, R.sub.1, R.sub.2, R.sub.3, R.sub.4 ...
2019/0070188 PEDIATRIC DOSING FOR TREATMENT OF CANCER WITH AN EZH2 INHIBITOR
The disclosure provides a method of treating a an INI1-deficient tumor in a subject in need thereof comprising administering to the subject a ...
2019/0070187 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE MODULATORS OF GPR139
The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: ##STR00001## which are...
2019/0070186 COMPOSITIONS AND METHODS FOR IMMUNE-MEDIATED CANCER THERAPY
Disclosed herein are methods and compositions for enhancing an immune response to a solid tumor in a subject. In some embodiments, a method comprises: (a)...
2019/0070185 HSPC-SPARING TREATMENTS FOR RB-POSITIVE ABNORMAL CELLULAR PROLIFERATION
This invention is in the area of improved compounds for and methods of treating selected RB-positive cancers and other Rb-positive abnormal cellular...
2019/0070184 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES
Provided herein is a pharmaceutical composition comprising (i) a phosphodiesterase inhibitor or an adenosine receptor antagonist, (ii) a calcium channel...
2019/0070183 Targeting Casein Kinase-1 and PI3K/AKT/mTOR Pathways for Treatment of c-Myc-Overexpressing Cancers, Organ...
The invention relates to the co-administration of select proteasome and PI3K inhibitors is useful for treating c-Myc-overexpressing cancers, particularly...
2019/0070182 USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER
Disclosed are methods of treating cancer, which include administering a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically...
2019/0070181 FORMULATION OF TICAGRELOR OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
The present invention relates to a formulation of ticagrelor or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to an...
2019/0070180 COMPOSITIONS AND METHODS FOR THE TREATMENT OF A BETA-CATENIN-ASSOCIATED DISEASE OR DISORDER
Disclosed herein are methods for the treatment of cancer, comprising administering to a subject a .beta.-catenin nucleic acid inhibitor molecule and a...
2019/0070179 TLR7 AGONIST MALEATE SALT, CRYSTALLINE FORMS C, D AND E THEREOF, PREPARATION METHODS AND USES OF MALEATE SALT...
The present invention relates to a maleate salt of a compound represented by formula I, a method for preparing the salt, a pharmaceutical composition...
2019/0070178 METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS
The invention provides compositions and methods useful for treating or preventing cardiovascular disorders and lowering risk of cardiovascular events.
2019/0070177 HISTONE DEACETYLASE 6 INHIBITION FOR ENHANCING T-CELL FUNCTION DURING ANTI-TUMOR RESPONSE AND TUMOR-PEPTIDE...
Disclosed are methods whereby an effective amount of a HDAC6 inhibitor is used to activate a subjects T-cell response to tumor or tumor vaccine. Methods of...
2019/0070176 METHOD OF INCREASING BIOAVAILABILITY AND/OR PROLONGING OPHTHALMIC ACTION OF A DRUG
The present invention relates to a method of increasing the bioavailability and/or prolonging ophthalmic action of a drug, the method comprising instilling...
2019/0070175 METHODS AND COMPOSITIONS FOR TREATING DIABETES, METABOLIC SYNDROME AND OTHER CONDITIONS
Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are...
2019/0070174 METHODS OF TREATING NEURODEGENERATIVE DISEASES
Methods of using the antipsychotic drug aripiprazole in treating a neurodegenerative disease such as Machado-Joseph disease/Spinocerebellar ataxia type 3...
2019/0070173 COMBINATIONS FOR THE TREATMENT OF NEUROBLASTOMA
Disclosed are methods of treating neuroblastoma in a cancer patient by administration of a Trk inhibitor in combination with one more chemotherapeutic agents....
2019/0070172 LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS
Disclosed herein are methods for treating or preventing myeloproliferative neoplasms in a subject in need thereof, and for effecting specific clinically...
2019/0070171 ARIPIPRAZOLE INJECTABLE SUSPENSION FORMULATION HAVING PROLONGED SHELF LIFE
The present invention belongs to the field of pharmaceutical formulation, and particularly relates to an aripiprazole injectable suspension formulation having...
2019/0070170 METHOD OF SELECTIVELY INHIBITING MPGES-1
A method of selectively inhibiting the overexpression of mPGES-1 in a subject in need thereof includes a step of administering an effective amount of a...
2019/0070169 TREATMENT OF CANCER
Provided are methods relating to compositions that include a CDP-camptothecin or camptothecin derivative conjugate, e.g., CRLX101.
2019/0070168 GAP JUNCTION-ENHANCING AGENTS FOR TREATMENT OF NECROTIZING ENTEROCOLITIS AND INFLAMMATORY BOWEL DISEASE
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis ("NEC") or inflammatory bowel...
2019/0070167 PITAVASTATIN CONTAINING PREPARATION AND METHOD FOR PRODUCING SAME
The present invention provides a stable oral pharmaceutical composition comprising pitavastatin or a pharmaceutically acceptable salts thereof and at least one...
2019/0070166 Optimized Method for Treating and Curing Arthritis, Diabetes, Multiple Sclerosis and Other Autoimmune Disease
The present invention teaches a method, system and process for curing, treating and diagnosing arthritis, diabetes and other related autoimmune diseases. By...
2019/0070165 N-HYDROXYISOQUINOLINEDIONE INHIBITORS OF HBV REPLICATION
In some aspects, the present disclosure provides compounds of the formula: Formula (I) wherein the variables are defined herein are provided, which may be used...
2019/0070164 CONTROLLED RELEASE COMPOSITIONS FOR TREATMENT OF COGNITIVE, EMOTIONAL, AND MENTAL AILMENTS AND DISORDERS
A montelukast composition having a therapeutically effective amount of montelukast in a sustained release is disclosed. A montelukast composition having a...
2019/0070163 ANTITUMOR AGENT
Pharmaceuticals which are effective for treatment, prevention, and the like of cancer and have less side effects are disclosed. The antitumor agent of the...
2019/0070162 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE
The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide (Compound 1),...
2019/0070161 FORMULATIONS FOR CGRP RECEPTOR ANTAGONISTS
The instant invention relates to liquid pharmaceutical compositions containing CGRP receptor antagonists. The CGRP receptor antagonist liquid pharmaceutical...
2019/0070160 COMPOSITIONS AND METHODS OF TREATING DERMAL FIBROTIC DISORDERS
A method for preventing and/or modulating formation of a dermal fibrotic disorder includes administering a therapeutically effective amount of a multi-phase...
2019/0070159 NOVEL PHARMACEUTICAL USES
The invention provides a potassium-competitive acid blocker (P-CAB) for use in the treatment, prevention and/or reduction of gastro-esophageal reflux disease...
2019/0070158 VETERINARY COMPOSITION COMPRISING IMIDACLOPRID, MOXIDECTIN AND PRAZIQUANTEL FOR CUTANEOUS TOPICAL APPLICATION...
A monodose veterinary composition for topical application (spot on) for canines, the said composition comprising: (a) Imidacloprid, between 8.18 and 10.00%,...
2019/0070157 HYPERBARIC SOLUTION INJECTION OF LEVOBUPIVACAINE HYDROCHLORIDE COMPRISING LEVOBUPIVACAINE HYDROCHLORIDE
Disclosed herein is Hyperbaric solution for injection of Levobupivacaine Hydrochloride which comprises Levobupivacaine Hydrochloride; base/acid to adjust the...
2019/0070156 Treatment of Debilitating Fatigue
The present disclosure relates to a dopamine stabilizing agent and an anti-depressive agent for use in the treatment of disorders characterized by debilitating...
2019/0070155 PHARMACEUTICAL COMPOSITIONS OF 3-(6-(1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL) ...
A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic...
2019/0070154 NEW METHODS OF USE FOR AN ANTI-DIARRHEA AGENT
Described are methods of treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway. The methods include identifying subjects in...
2019/0070153 COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISEASES
A method of treating a pulmonary disease in a subject in need thereof includes administering to the subject a therapeutically effective amount of an agent that...
2019/0070152 DE-EPOXIDIZED EPOTHILONE DERIVATIVE PREPARATION, PREPARATION OF SAME AND USE THEREOF IN THE TREATMENT OF TUMOUR
The present application discloses a pharmaceutical preparation comprising a de-epoxidized epothilone derivative, and especially relates to a preparation...
2019/0070151 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION
The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: ##STR00001## wherein R.sup.1 is an aryl group which may have one...
2019/0070150 METHOD FOR TREATING HEPATIC ENCEPHALOPATHY
A method of treating or preventing type C Hepatic Encephalopathy in a human patient diagnosed with cirrhosis by administering a composition containing at least...
2019/0070149 PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT...
The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A...
2019/0070148 Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders
The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as...
2019/0070147 ENALAPRIL FORMULATIONS
Provided herein are stable enalapril oral liquid formulations. Also provided herein are methods of using enalapril oral liquid formulations for the treatment...
2019/0070146 SUBSTITUTED PHENYLPYRROLECARBOXAMIDES WITH THERAPEUTIC ACTIVITY IN HIV
Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.
2019/0070145 USING FATTY ACID SYNTHASE INHIBITORS TO TREAT FIBROSIS
This document relates to materials and methods for treating fibrosis (e.g., pulmonary fibrosis). For example, this document provides methods for using one or...
2019/0070144 TREATMENT OF CIRCADIAN RHYTHM DISORDERS
Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light...
2019/0070143 DIMETHYL FUMARATE PARTICLES AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising...
2019/0070141 METHODS OF TREATING MIXED DYSLIPIDEMIA
The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
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