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Patent # Description
2019/0071506 SPECIFIC PHOTOIMMUNO-THERANOSTICS FOR DETECTION AND ELIMINATION OF SKIN CANCER CELLS
The technology provided herein generally relates to novel specific photoimmuno-theranostics for the use in detection and elimination of skin cancer cells. The...
2019/0071505 COMPOSITIONS AND METHODS FOR ACTIVATION OF NK CELLS KILLING OF PROSTATE CANCER AND BREAST CANCER CELLS
Certain embodiments are directed to methods of treating LLT1 expressing cancer by administering to a subject having an LLT1 expressing cancer an LLT1 inhibitor.
2019/0071504 Methods And Compositions For Treating And Preventing Disease Associated With Alpha 8 Beta 1 Integrin
Provided herein are monoclonal antibodies that recognize, bind to, and block interactions of other molecules with integrin .alpha.8.beta.1. Also provided...
2019/0071503 Humanized Anti-HLA-DR Antibodies
The present invention concerns compositions and methods of use of humanized anti-HLA-DR antibodies. In preferred embodiments, the antibodies induce apoptosis...
2019/0071502 METHODS AND COMPOSITIONS FOR TARGETING A COMPLEX COMPRISING NON-CLASSICAL HLA-I AND NEOANTIGEN IN CANCER
Disclosed herein are methods and compositions for targeting a complex comprising a non-classical HLA-I and a neoantigen in cancer. Further disclosed herein are...
2019/0071501 ANTI-HUMAN PD-1 HUMANIZED MONOCLONAL ANTIBODY AND APPLICATION THEREOF
The present invention relates to the biomedicine field, in particular to an anti-human PD-1 humanized monoclonal antibody and its applications. The invention...
2019/0071500 CD8 BINDING AGENTS
The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to...
2019/0071499 HUMAN ANTI-IFN-ALPHA ANTIBODIES
Provided are novel IFB-a binding molecules of human origin, particularly human-derived anti-IFN-.alpha. antibodies as well as IFN-.alpha. binding fragments,...
2019/0071498 Human IL-23 Antigen Binding Proteins
Antigen binding proteins that bind to human IL-23 protein arc provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the...
2019/0071497 IL-21 Binding Proteins and Uses Thereof
The present disclosure provides proteins comprising antigen binding sites of antibodies that bind to interleukin-21 (IL-21) and uses thereof, e.g., in therapy.
2019/0071496 PHARMACEUTICAL FORMULATIONS OF TNF-ALPHA ANTIBODIES
The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are...
2019/0071495 METHODS AND COMPOSITIONS FOR DELIVERING MRNA CODED ANTIBODIES
The present invention provides, among other things, methods and compositions for delivering an antibody in vivo by administering to a subject in need thereof...
2019/0071494 Compositions and Methods for Treating Parkinson's Disease
A composition and a method for the treatment of a neurodegenerative disorder is provided. The composition includes an inhibitor of RANTES and/or an inhibitor...
2019/0071493 TGFbeta1-BINDING IMMUNOGLOBULINS AND USE THEREOF
Disclosed herein are immunoglobulins, such as antibodies, and antigen binding portions thereof, that specifically bind complexes of GARP-TGF.beta.1,...
2019/0071492 COMPLEMENT FACTOR Bb ANTIBODIES
The present disclosure relates to antibodies and polynucleotides encoding the same, which may be used to prevent, control, or reduce the activity of the...
2019/0071491 ANTI-TRANSTHYRETIN ANTIBODIES
The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or...
2019/0071490 Preventing Post-Ictal Headaches
Disclosed herein are methods of preventing incidence of a migrainous or non-migrainous post-ictal headache, and/or at least one secondary symptom associated...
2019/0071489 NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE
Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these...
2019/0071488 POLYOMAVIRUS NEUTRALIZING ANTIBODIES
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and...
2019/0071487 TNFRSF14 / HVEM PROTEINS AND METHODS OF USE THEREOF
In some aspects the present invention provides methods for the treatment of B-cell lymphomas. Some such methods involve administration of HVEM ectodomain...
2019/0071486 METHOD AND COMPOSITION FOR TREATING NEURONAL HYPER-EXCITABILITY
The present invention provides a therapy for treating loss of GABA-mediated pre-synaptic inhibition after spinal injury. The therapeutic regimen includes...
2019/0071485 Novel Substitution Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More...
2019/0071484 A TRANSPOSON-BASED TRANSFECTION SYSTEM FOR PRIMARY CELLS
The present invention relates to the field of genetic engineering, in particular, to a transposon-based transfection kit suitable for transfection of primary...
2019/0071483 ANTIBODY PEPTIDE CONJUGATES THAT HAVE AGONIST ACTIVITY AT BOTH THE GLUCAGON AND GLUCAGON-LIKE PEPTIDE 1 RECEPTORS
Described are antibody peptide conjugates (APCs) comprising an antibody conjugated to a peptide analog of glucagon, which have been modified to be resistant to...
2019/0071482 Modified Bovine G-CSF Polypeptides And Their Uses
Modified bovine G-CSF polypeptides and uses thereof are provided.
2019/0071481 Improved Coding Sequence For Human G-CSF
The present invention relates in general to a nucleic acid encoding human granulocyte-colony stimulating factor (G-CSF), wherein the first leucine residue...
2019/0071480 Recombinant Polypeptides and Nucleic Acid Molecules, Compositions, and Methods of Making and Uses Thereof
The present disclosure provides recombinant polypeptides, homodimeric and heterodimeric proteins comprising the recombinant polypeptides, nucleic acid...
2019/0071479 PURIFIED BIGLYCAN VARIANTS AND METHODS OF USE THEREOF
A further characterization and purification of recombinant human biglycan is provided. A biglycan polypeptide that lacks glycosaminoglycan side chains and is...
2019/0071478 PEPTIDE HAVING HAIR GROWTH-PROMOTING ACTIVITY AND/OR MELANIN GENERATION-PROMOTING ACTIVITY, AND USE THEREOF
The present invention provides: a peptide which shows a hair growth-promoting activity and/or a melanin generation-promoting activity; a composition for...
2019/0071477 Recombinant complement Factor H-immunoglobulin fusion protein with complement regulatory activity, and...
The invention discloses a recombinant complement factor H (CFH)-immunoglobulin (Ig) fusion protein CFH-Ig with complement regulating activity, more...
2019/0071476 OPSIN POLYPEPTIDES AND METHODS OF USE THEREOF
The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are...
2019/0071475 NANOSPHERES OF SEC14-LIKE PROTEINS AND COGNATE LIGANDS
The present invention relates to a nanosphere comprising an equal number of a human SEC14-like protein and a cognate ligand of said SEC14-like protein as well...
2019/0071474 PRODUCTION OF GIBBERELLINS IN RECOMBINANT HOSTS
The invention relates to recombinant microorganisms and methods for producing gibberellin compounds and gibberellin precursors.
2019/0071473 REGULATION OF SUBCELLULAR LIPID DISTRIBUTION
The present invention provides a modified oleosin protein, a polynucleotide sequence encoding the modified protein, and a method for regulating subcellular...
2019/0071472 Methods of Producing Aggregate-Free Monomeric Diphtheria Toxin Fusion Proteins and Therapeutic Uses
The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence...
2019/0071471 Composition for Immunization Against Streptococcus Pneumoniae
This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a...
2019/0071470 ANTIMICROBIAL PEPTIDES AND METHODS OF USE THEREOF
Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent...
2019/0071469 THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and...
2019/0071468 PEPTIDE INHIBITORS OF SODIUM CHANNELS
The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium...
2019/0071467 PHARMACOLOGICALLY ACTIVE PEPTIDE COMPOUND, PROCESS FOR THE PREPARATION AND USE THEREOF
Object of the invention is a synthetic peptide, in particular a synthetic peptide to be used as medicament, in particular to be used in the treatment of...
2019/0071466 CRYSTAL OF REDUCED GLUTATHIONE AND METHOD FOR PRODUCING SAME
According to the present invention, a crystal of reduced glutathione having a reduced content of impurities, particularly L-cysteinyl-L-glycine and a method...
2019/0071465 ANTAGONISTS OF CB1 RECEPTOR
The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of...
2019/0071464 SPINOSYN DERIVATIVES AS INSECTICIDES
Compositions and methods for the production of derivatives of spinosyns are provided. The method produces spinosyn derivatives that exhibit activity towards...
2019/0071463 METHOD FOR PREPARING A MIXTURE OF MONOSACCHARIDES AND/OR OF OLIGOSACCHARIDES AND/OR OF POLYSACCHARIDES VIA...
The reuse of the sugars from the by-products of the paper and cellulose industries and lignocellulosic biorefineries and facilitating the extraction and the...
2019/0071462 PROCESS FOR SYNTHESIS OF INDENES
The present invention relates to a new process for the synthesis of 2,3,4,5,6,7-substituted indenes, which are useful precursors for the formation of certain...
2019/0071461 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
A compound having an ancillary ligand L.sup.1 having the formula: ##STR00001## Formula I is disclosed. The ligand L.sup.1 is coordinated to a metal M having an...
2019/0071460 BIS(6-METHYL-3-SULPHOPHENYL)(2-METHYLPHENYL)PHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME
Provided are a water-soluble triarylphosphine for a palladium catalyst, which has high selectivity in a telomerization reaction and is easily recovered with...
2019/0071459 NOBLE METAL-FREE HYDROSILYLATABLE MIXTURE
The invention relates to a hydrosilylatable mixture M containing: (A) a compound with at least one hydrogen atom directly bonded to Si, (B) a compound...
2019/0071458 CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING THE SAME
A condensed-cyclic compound and an organic light-emitting device including the same are provided. The compound is represented by the formula ##STR00001## ...
2019/0071457 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS ...
4-Amino-6-(heterocyclic)picolinic acids and their derivatives; 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their derivatives; and methods of using...
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