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Patent # Description
2019/0071456 CRYSTALLINE BETA-LACTAMASE INHIBITOR
A crystalline compound of formula (I): ##STR00001## The compound of formula (I) is a .beta.-lactamase inhibitor and may be administered in combination with an...
2019/0071455 1-ARYLCARBONYL-4-OXY-PIPERIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. ...
2019/0071454 DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE
The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided...
2019/0071453 Heterocyclic-substituted Pyridinopyrimidinone Derivative as CDK Inhibitor and Use thereof
The present invention relates to a heterocyclic-substituted pyridinopyrimidinone derivative and the use thereof as a therapeutically effective cyclin-dependent...
2019/0071452 PENTACYCLIC COMPOUND
The present invention provides compounds represented by formulas (I) to (VI) or pharmaceutically acceptable salts thereof. ##STR00001##
2019/0071451 ASYMMETRIC PROCESS FOR THE PREPARATION OF THIENO-INDOLES DERIVATIVES
The present invention relates to a new process for the preparation of thieno-indole derivatives of formula (la) or (Ib), exploiting an asymmetric synthesis for...
2019/0071450 BICYCLIC COMPOUNDS FOR DIAGNOSIS AND THERAPY
The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a...
2019/0071449 SOLID STATE FORMS OF SPIRO-OXINDOLE COMPOUNDS
The present invention provides solid state forms of certain spiro-oxindole compounds, such as funapide and the racemic mixture of funapide and its...
2019/0071448 PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES
A compound compound having the structure: ##STR00001## or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound...
2019/0071447 PYRAZOLOPYRIMIDINE DERIVATIVES
The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as...
2019/0071446 SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AS PROTEIN KINASE INHIBITORS
The present invention provides protein kinase having one of the following structures (I), (II) or (III): ##STR00001## or a stereoisomer, prodrug, tautomer or...
2019/0071445 ORGANIC COMPOUNDS
The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, pharmaceutically acceptable salt and/or...
2019/0071444 SPIROINDOLINONES AS DDR1 INHIBITORS
The present invention relates to compounds of formula (I): ##STR00001## or pharmaceutically acceptable salts thereof, as well as processes for their...
2019/0071443 TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES
The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as...
2019/0071442 NEW CRYSTAL FORMS OF PALBOCICLIB, AND PREPARATION METHOD AND USE THEREFOR
A plurality of new crystal Forms I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII and XIV of ...
2019/0071441 PYRAZOLE DERIVATIVE MANUFACTURING METHOD
The present invention provides a method for manufacturing a compound represented by formula (I). With this method, provided are a method for manufacturing a ...
2019/0071440 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2019/0071439 HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I), methods of using the compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. The...
2019/0071438 1, 4, 8-Triazaphenanthrene Derivatives For The Treatment Of Neurodegenerative Disorders
The invention relates to compounds of formula (I), particularly for the use thereof as a medicament, especially in the treatment or prevention of ...
2019/0071437 PROTEIN KINASE INHIBITORS
The present invention is directed to novel protein kinase inhibitors comprising the chemical compound ...
2019/0071435 GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are...
2019/0071434 MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER
Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X.sup.1, X.sup.2, R.sup.1-4 and...
2019/0071433 BENZIMIDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T))
Benzimidazole sulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use...
2019/0071432 NEW 2-SUBSTITUTED INDAZOLES, METHODS FOR PRODUCING SAME, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAME, AND USE...
The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment...
2019/0071431 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same.
2019/0071430 Organic Compound with Triazine and Benzimidazole as Core and Application thereof in Organic Electroluminescent...
An organic compound has a structure represented by formula (1): ##STR00001## and Ar.sub.1 represents phenyl, naphthyl, biphenyl, terphenyl, anthryl, ...
2019/0071429 MULTIPLE-FUNCTIONAL PROBE AND USES THEREOF
Disclosed herein are a multi-functional probe and uses thereof. The multi-functional probe has a main structure represented by chemical Formula (1), and is...
2019/0071428 NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3-YLVINYL)PYRIMIDINE
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of...
2019/0071427 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof
The present disclosure relates to a 2,4-disubstituted pyrimidine derivative and the use thereof as a therapeutically effective cyclin-dependent kinase (CDK)...
2019/0071426 SOLID STATE FORMS OF NILOTINIB SALTS
The present disclosure relates to solid state forms of Nilotinib fumarate and Nilotinib hydrochloride L-tartaric acid co-crystals, processes for preparation...
2019/0071425 TETRAHYDROISOQUINOLINES AS PRMT5 INHIBITORS
A compound of formula (I) wherein: n is 1 or 2; p is 0 or 1; R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d are independently selected from the group consisting of...
2019/0071424 WNT Signaling Pathway Inhibitors for Treatments of Disease
Compounds and compositions are provided as inhibitors of the Wnt/.beta.-catenin pathway for the treatment of diseases that implicate the same.
2019/0071423 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071422 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071421 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071420 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071419 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071418 QUINAZOLINONES AND AZAQUINAZOLINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders,...
2019/0071417 ANTIBACTERIAL COMPOUNDS AND USES THEREOF
The present invention relates to compounds of formula (I) including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof,...
2019/0071416 COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS
Compounds For Inhibition Of Cancer and Epigenesis. The present invention relates to quinolines and 5,6,7,8-tetrahydroacridines of the formula (I) wherein...
2019/0071415 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for...
2019/0071414 CRYSTALLINE 4-AMINO-2-(2,6-DIOXOPIPERIDINE-3-YL)ISOINDOLINE-1,3-DIONE DIHYDRATE, COMPOSITIONS AND METHODS OF...
Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate. Pharmaceutical compositions comprising the crystalline ...
2019/0071413 Cyclobutyl-Imidazolidinone Compounds
The present invention provides a compound of Formula I ##STR00001## wherein Q is selected from the group consisting of --CH(CH.sub.3).sub.2 and ##STR00002## ...
2019/0071412 ANTIDIABETIC BICYCLIC COMPOUNDS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
2019/0071411 AROMATIC AMINE DERIVATIVE, LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, ELECTRONIC DEVICE, AND LIGHTING DEVICE
Provided is a novel aromatic amine derivative represented by General Formula (G1) below. (In the formula, A represents oxygen or sulfur, and R.sup.1 to R.sup.7...
2019/0071410 3-Phenyl-7-Hydroxy-Isocoumarins as Macrophage Migration Inhibitory Factor (MIF) Inhibitors
Provided herein are 3-phenyl-7-hydroxy-isocoumarin compounds which are MIF inhibitors; compositions comprising said inhibitors and methods for treating or...
2019/0071409 EPOXY COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, METHOD OF PRODUCING EPOXY COMPOUND, AND REACTIVE DILUENT
The present invention discloses a monoepoxy compound represented by the following Formula (1), a curable composition containing the same, a cured product...
2019/0071408 POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF
The present invention relates to a compound of formula III, wherein, R is selected from the group consisting of C.sub.1-C.sub.4 alkyl, substituted or...
2019/0071407 ISOXAZOLINE DERIVATIVES AS INSECTICIDES
The present invention relates to compounds formula (I): ##STR00001## wherein P is P1, P2, heterocyclyl or heterocyclyl substituted by one to five Z; ...
2019/0071406 METHOD FOR PRODUCING ISOCYANURIC ACID DERIVATIVE HAVING TWO HYDROCARBON GROUPS
A method for producing an isocyanuric acid derivative having two hydrocarbon groups including: a first step of obtaining a compound of Formula (1); a second...
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