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Patent # Description
2019/0077820 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING CRYSTALLINE ALPHA, ALPHA-TREHALOSE DI-HYDRATE
A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an...
2019/0077819 METAL COMPLEXES FOR DEPOSITING FILMS AND METHOD OF MAKING AND USING THE SAME
Provided herein are metal-ligand complexes, and associated methods, characterized by formula ML.sub.xD.sub.y; wherein: M is a metal; x is equal to the...
2019/0077818 ORGANIC LUMINESCENT MATERIALS CONTAINING FLUORINE ANCILLARY LIGANDS
Organic luminescent materials containing fluorine ancillary ligands are disclosed, which can be used as emitters in the emissive layer of an organic...
2019/0077817 COMPOSITIONS AND METHODS FOR PHOSPHORAMIDITE AND OLIGONUCLEOTIDE SYNTHESIS
The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
2019/0077816 LIGAND COMPOUND, ORGANIC CHROMIUM COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR...
The present invention relates to a ligand compound, a catalyst system for olefin oligomerization and a method for oligomerizing an olefin using same. The...
2019/0077815 COMPOSITIONS, SYNTHESIS, AND USES OF HYDROLYZABLE SILANE MODIFIED CASHEW NUT SHELL LIQUID DERIVATIVES
The present disclosure provides cashew nut shell liquid derivatives based organosilicon products and methods and uses of preparing the same.
2019/0077814 BORON-CONTAINING SMALL MOLECULES
Compounds, pharmaceutical formulations, and methods of treating bacterial infections are disclosed.
2019/0077813 PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof; wherein the compound has formula (I): ...
2019/0077812 METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND
The present disclosure provides a method for preparing a 7.alpha.-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including:...
2019/0077811 Ginkgolide B Derivative and Preparation Method And Use Thereof
Disclosed are a compound as shown in formula I or formula II or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is selected from pyrazinyl or...
2019/0077810 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are certain crystalline forms of Compound 3, as well as pharmaceutical compositions employing the crystalline forms. Also provided are...
2019/0077809 Spirocyclic Derivatives
The present invention relates to novel spiro compounds of formula I, ##STR00001## wherein the variables have the meanings as defined in the specification, to...
2019/0077808 4-AZAPODOPHYLOTOXINS COMPOUNDS
The present disclosure relates to 4-azapodophylotoxins compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such...
2019/0077807 NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2019/0077806 PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE...
Provided herein are Heteroaryl Compounds having the following structure: ##STR00001## wherein R.sup.1-R.sup.4 are as defined herein, compositions comprising an...
2019/0077804 RIGID CHIRAL REDOX-ACTIVE ISOSCELES TRIANGULAR MATERIALS
Provided herein are rigid macrocycles comprising a first redox-active subunit and a second redox-active subunit, wherein the first redox-active unit and the...
2019/0077803 TETRACYCLINE COMPOUNDS
The present invention is directed to a compound represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. The variables...
2019/0077802 DIFLUORO-(2-SUBSTITUTED CARBAMOYL-1,6-DIAZA-BICYCLO [3.2.1] OCT-6-YLOXY) ACETIC ACID COMPOUNDS AND THEIR USE IN...
The invention discloses compounds of Formula (I), their preparation, and their use in treating a bacterial infection. ##STR00001##
2019/0077801 INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME
Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of...
2019/0077800 DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2019/0077799 RAD51 Inhibitors
This application is directed to inhibitors of RAD51 represented by the following structural formula, ##STR00001## and methods for their use, such as to treat...
2019/0077798 2-HOMOPIPERAZINE-1-YL-4H-1,3-BENZOTHIAZINE-4-ONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF 2-...
2-homopiperazine-1-yl-4H,1,3-bensothiazine-4-one derivatives of formula (I) are provided. They are usehil in the treatment of bacterial infections, in...
2019/0077797 PROCESSES FOR PREPARING 2-DIHALO RIBOLACTONES
Methods for forming 2-bromo, 2-fluoro ribofuranose intermediates and 2-chloro, 2-fluoro ribofuranose intermediates for use in preparing antiviral nucleosides...
2019/0077796 COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni...
2019/0077795 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Provided herein are various compounds, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, useful for inhibiting arginine...
2019/0077794 COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment...
2019/0077793 BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of...
2019/0077792 Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2
The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of...
2019/0077791 EGFR INHIBITOR FREE BASE OR ACID SALT POLYCRYSTALLINE FORM, PREPARATION METHOD THEREFOR, AND APPLICATION
Disclosed are an EGFR inhibitor free base or acid salt polycrystalline form, a preparation method therefor, and an application thereof. The present invention...
2019/0077790 4-CYANO-BENZYL CARBAMIMIDOYLCARBAMATE DERIVATIVES AND THEIR USE AS AOC3 INHIBITORS
The invention relates to new benzonitrile derivatives of the formula (I) wherein R.sup.1 to R.sup.3 and A are as defined in the description and Claims, to...
2019/0077789 PIPERAZINYL NORBENZOMORPHAN COMPOUNDS AND METHODS FOR USING THE SAME
Disclosed herein, inter alia, are piperazinyl norbenzom orphan compounds and uses thereof, including, for example, methods for treating a CNS disease, treating...
2019/0077788 METAL-ORGANIC HYBRID STRUCTURES BUILT WITH MULTI-DIRECTIONAL POLYDENTATE LIGANDS
A compound represented by Chemical Formula 1 according to the present invention can coordinate with metal ions to form a bidirectional or multidirectional...
2019/0077787 NOVEL IMIDE DERIVATIVES AND USE THEREOF AS MEDICINE
Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic...
2019/0077786 HETEROCYCLIC COMPOUNDS AND USE THEREOF
Disclosed are compounds of formula (I) below or pharmaceutically acceptable salts thereof: ##STR00001## in which each of variables R.sup.1-R.sup.6, L, m, and n...
2019/0077785 INHIBITORS FOR SOLUBLE EPOXIDE HYDROLASE (SEH) AND FATTY ACID AMIDE HYDROLASE (FAAH)
The present invention provides compounds that are dual inhibitors of soluble epoxide hydrolase and fatty acid amide hydrolase. The present invention also...
2019/0077784 Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
The invention discloses compounds of Formula (I), ##STR00001## wherein A.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and n are as defined herein. The present...
2019/0077783 MIXTURES OF CANNABINOID COMPOUNDS, AND PRODUCTION AND USE THEREOF
Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for...
2019/0077782 Transparent Glassy Cannabinoid Compositions
The disclosure provides methods and compositions for providing shatter formulations taking the form of crystalline polymorphs, where methods of preparation...
2019/0077780 Method for Preparing Halohydrin and Epoxide
Provided is a method for preparing an epoxide by halohydrination, the method comprising: (1) halohydrination: adding H.sub.2O, a halogen(s) and an olefin...
2019/0077779 A PROCESS FOR THE PREPARATION OF PROPYLENE OXIDE
A continuous process for the preparation of propylene oxide, comprising a start-up stage and normal run stage, wherein the normal run stage comprises (i)...
2019/0077778 METHOD FOR PRODUCING ETHYLENE OXIDE
According to the present invention, there is provided means for suppressing the occurrence of corrosion on the inner tube side in a heat exchanger and enabling...
2019/0077777 NICOTINIC ACID DERIVATIVES, THEIR PREPARATION AND THE USE THEREOF
A nicotinic acid derivative is represented by formula (I), and a pharmaceutically acceptable salt or solvate thereof. ##STR00001## In formula (I), Z is selected...
2019/0077776 REAGENTS AND METHODS FOR BIOORTHOGONAL LABELING OF BIOMOLECULES IN LIVING CELLS
Tetrazine non-canonical amino acids, methods for genetic encoding proteins and polypeptides using the tetrazine amino acids, proteins and polypeptides...
2019/0077775 PROCESS FOR THE PREPARATION OF TRISODIUM ...
The present invention relates to a process for the preparation of Trisodium (4-{[(1S.3R)-1-([1,1'-biphenyl]-4-yl-methyl)-4-ethoxy-3-methyl-- ...
2019/0077774 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS
Disclosed herein, inter alia, are compositions and methods useful for treating liver diseases and metabolic diseases.
2019/0077773 DIPHENYL DERIVATIVES AND USES THEREOF
The present disclosure provides a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, and its therapeutic uses for activating a...
2019/0077772 CHEMICAL MODULATORS OF IMMUNE CHECKPOINTS AND THERAPEUTIC USE
Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of...
2019/0077771 PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE
The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole,...
2019/0077770 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR
In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles, which are modulators the pregnane X receptor...
2019/0077769 Compound for Enhancing the Coupling Degree of Complex TRPV4- KCa2.3 and Anti-hypertension Applications thereof
The applicant provides a compound for enhancing the space coupling degree of an endothelial cell ion channel complex TRPV4-KCa2.3 and anti-hypertension...
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