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Patent # Description
2019/0085341 ENGINEERED RIBOSOMAL PROMOTERS FOR PROTEIN PRODUCTION IN MICROORGANISMS
The instant disclosure is generally related to novel engineered (hybrid) promoters. In certain embodiments, the instant disclosure is directed to one or more...
2019/0085340 METHOD FOR THE FERMENTATIVE PRODUCTION OF L-AMINO ACIDS
The present invention provides a bacterium of the genus Corynebacterium, in particular of the species Corynebacterium glutamicum, having the ability to excrete...
2019/0085339 METHODS FOR HIGH TAURINE PRODUCTION IN UNICELLULAR ORGANISMS
The present invention describes an approach to produce or increase hypotaurine or taurine production in unicellular organisms. More particularly, the invention...
2019/0085338 Modified Magnetotactic Bacteria Expressing a Metallophore Specific for Cobalt and/or Nickel
The invention concerns magnetotactic bacteria modified to express metallophores and their use in bioremediation, biodetection, imaging, as well as the use of...
2019/0085337 Targeting of Human Glucocorticoid Receptor Beta in Cancer
A peptide nucleic acid (PNA) referred to herein as Sweet-P, compositions comprising the methods of making the same, mid methods of using the same, are described.
2019/0085336 TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISORDERS
A method of treating an inflammatory disorder in a subject, comprising administering to the subject in need thereof a nucleic acid molecule for inhibiting the...
2019/0085335 IN-VITRO INDUCTION OF ADULT STEM CELL EXPANSION AND DERIVATION
This invention generally relates to a composition and its method of use for inducing adult stem cell (ASC) expansion and/or derivation in vitro, using...
2019/0085334 TREATMENT OF NEUROINFLAMMATION IN NEUROLOGICAL DISORDERS
A method of decreasing the production of a pro-inflammatory cytokine in an activated cell of myeloid lineage in a subject in need thereof is provided. The...
2019/0085333 NOVEL ANTIVIRAL PROTEINS AND THEIR USES IN THERAPEUTIC METHODS
Three proteins, BCL-G (BCL2L14), CMPK2, and LAMP3, were discovered to independently restrict HIV-1 replication both in-vivo and in-vitro. Methods are described...
2019/0085332 DNA Aptamers Specific to CD2000R1 and their Therapeutic Uses
Disclosed are short DNA aptamers that selectively recognize CD200R1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune...
2019/0085331 DEFINED MULTI-CONJUGATE OLIGONUCLEOTIDES
Defined multi-conjugate oligonucleotides can have predetermined sizes and compositions. For example, in various embodiment, defined multi-conjugate ...
2019/0085330 miRNAs USEFUL FOR IDENTIFYING TARGETS ASSOCIATED WITH CANCER
Several miRNAs are described that are useful in diagnosing and treating prostate cancer, or pancreatic cancer. The miRNAs bind with targets that are associated...
2019/0085329 RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
Isolation or in vitro assembly of the Cas9-crRNA complex of the Streptococcus thermophilus CRISPR3/Cas system and use for cleavage of DNA bearing a nucleotide...
2019/0085328 IN VIVO SILENCING BY CHEMICALLY MODIFIED AND STABLE siRNA
The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides small interfering RNAs...
2019/0085327 Bacteria-Mediated Gene Modulation Via microRNA Machinery
The present invention provides a method of synthesizing, processing, and/or delivering miRNA or its precursors to eukaryotic cells using bacteria, preferably...
2019/0085326 Negative feedback regulation of HIV-1 by gene editing strategy
A CRISPR-endonuclease gene editing composition includes a guide RNA (gRNA) for targeting a specific viral sequence for cleavage by the endonuclease which...
2019/0085325 CONDITIONAL CRISPR SGRNA EXPRESSION
An expression cassette for conditional expression of a single guide RNA (sgRNA) of a CRISPR/Cas9 system, the cassette includes a promoter, an sgRNA sequence,...
2019/0085324 ASSAYS FOR MASSIVELY COMBINATORIAL PERTURBATION PROFILING AND CELLULAR CIRCUIT RECONSTRUCTION
The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present...
2019/0085323 PHAGE-DISPLAYED SINGLE-CHAIN VARIABLE FRAGMENT LIBRARIES AND USES THEREOF
Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, which comprises a plurality of phage-displayed scFvs characterized in...
2019/0085322 HIGH-SPEED IN VITRO SCREENING METHOD
The purpose of the present invention is to provide a high-speed in vitro screening method for any library selected from the group consisting of a cDNA display...
2019/0085321 MOLECULAR FILTER
A molecular filter that may include a substrate. The substrate may define a first channel, a second channel, at least one slit fluidically coupling the first...
2019/0085320 SAMPLE PREPARATION METHOD AND APPARATUS
A method of preparing a nucleic acid sample with target enrichment uses a reaction vessel, within which is added a chelating agent to a sample with heating to...
2019/0085319 SAMPLE PREPARATION METHOD AND APPARATUS
A method of preparing a nucleic acid sample with target enrichment uses a reaction vessel, within which is added a chelating agent to a sample with heating to...
2019/0085318 SOLID PHASE NEGATIVE ENRICHMENT
The invention provides methods for capturing target nucleic acid directly from bodily fluid samples, without the need for certain complex sample preparation...
2019/0085317 METHOD OF COLLECTING A NUCLEIC ACID
A method collects a nucleic acid from a biological sample and includes the steps of: a) mixing a support including a water-soluble neutral polymer adsorbed on...
2019/0085316 PROCESS FOR SEPARATION OF PROKARYOTIC DNA FROM EUKARYOTIC DNA IN A WHOLE BLOOD SAMPLE
A process for separating prokaryotic DNA from eukaryotic DNA in a whole blood sample infected by pathogen is provided. The process includes extracting...
2019/0085315 METHODS FOR ENHANCING THE EFFICIENCY OF GENE EDITING
The present invention provides methods of increasing the efficiency of genome editing.
2019/0085314 MUB MOTIF IS AN INHIBITOR OF E2-UBIQUITIN THIOESTER FORMATION
The present disclosure provides for peptides derived from membrane-anchored ubiquitin-fold proteins (MUB), particularly those containing a Lap-Bar-Lopp motif,...
2019/0085313 NITRILE HYDRATASE
Provided is an improved nitrile hydratase with improved catalytic activity. Also provided are DNA for coding the improved nitrile hydratase, a recombinant...
2019/0085312 Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival
A treatment method is provided in which glioblastoma is targeted by administering to a subject in an effective amount theranostic cross-linked iron oxide...
2019/0085311 SORTASE
Reported herein is a sortase comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO: 11 and that comprises...
2019/0085310 METHOD FOR PRODUCING CELLULASES WITH PRETREATED LIGNOCELLULOSIC POMACE
The invention relates to a process for producing cellulolytic or hemicellulolytic enzymes comprising A growth phase a) of a cellulolytic microorganism in a ...
2019/0085309 Cellobiohydrolase Variants and Polynucleotides Encoding Same
The present invention relates to cellobiohydrolase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising...
2019/0085308 METHODS OF GENERATING NUCLEIC ACID FRAGMENTS
Provided herein are methods of using a Cas1 polypeptide to generate nucleic fragments from a DNA substrate. These methods may be performed in vitro or in vivo....
2019/0085307 METHOD FOR USING HEAT-RESISTANT MISMATCH ENDONUCLEASE
Provided are a mismatch-specific cleavage reaction using a novel heat-resistant mismatch nuclease, a method for removing errors in a nucleic acid amplification...
2019/0085306 Lipase Variants and Polynucleotides Encoding Same
The present invention relates to lipase variants and methods of obtaining them. The present invention also relates to polynucleotides encoding the variants;...
2019/0085305 METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED...
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the...
2019/0085304 Method of Preparation of SOD Hydrolysates Powder
A method for preparing powdery superoxide dismutase (SOD) hydrolysates. SOD is hydrolyzed by cellulase and then further hydrolyzed with a solution containing a...
2019/0085303 METHANOL DEHYDROGENASE FUSION PROTEINS
Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase...
2019/0085302 KEY PHOSPHORYLATION SITE OF TEMPERATURE SENSITIVITY OF INFLUENZA A VIRUS AND USE THEREOF
A recombinant virus is obtained by mutating a codon that encodes a tyrosine residue at position 385 of NP protein in the genome of influenza A virus to a codon...
2019/0085301 RECOMBINANT AAVS HAVING USEFUL TRANSCYTOSIS PROPERTIES
The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure...
2019/0085300 METHOD FOR THE SEPARATION OF VIRUS COMPOSITIONS INCLUDING DEPLETION AND PURIFICATION THEREOF
In a first aspect, the present invention relates to a method for the purification of virus compositions as well as biological macromolecular compounds in a...
2019/0085299 CELL CULTURE SUBSTRATE, CELL CULTURE VESSEL, AND METHOD FOR CELL CULTURE
The purpose of the invention is to provide novel cell culture substrates, cell culture vessels, and methods for cell culture. A cell culture substrate having a...
2019/0085298 Three Dimensional Matrix for Cancer Stem Cells
Synthetic inert 3D gel culture systems are described that can be finely tuned to exhibit desired and predetermined physical, chemical, mechanical, and...
2019/0085297 TUMOR CELL SUSPENSION CULTURES AND RELATED METHODS
Provided are suspension-based cell culture systems and media for the timely and efficient proliferation of human tumor cell clusters from a patient, and...
2019/0085296 METHOD OF EXPANSION OF HUMAN PANCREAS PROGENITOR CELLS FROM STEM CELLS USING FEEDER-CONDITIONED MEDIA
The present disclosure provides a method of producing and expanding human pancreas progenitor cells using, for example, iPSC derived cells and a human feeder...
2019/0085295 Generation of Functional Beta Cells From Human Pluripotent Stem Cell-Derived Endocrine Progenitors
The present invention relates to generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors. The present invention also...
2019/0085294 METHODS FOR REPROGRAMMING CELLS AND USES THEREOF
A method of obtaining a neural multipotent, unipotent or somatic cell, including: i) providing a cell of a first type which is not a neural multipotent,...
2019/0085293 METHODS FOR EPICARDIAL DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS
Methods for generating high-yield, high-purity epicardial cells are described. Wnt/.beta.-catenin signaling is first activated in human cardiac progenitor...
2019/0085292 METHODS AND SYSTEMS FOR IMPROVING CELLS FOR USE IN THERAPY
Methods and systems for enhancing cell populations such as chondrocytes for tissue engineering applications, e.g., for production of neocartilage. The methods...
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