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Patent # Description
2019/0085088 ANTI-CD40 ANTIBODIES AND USES THEREOF
The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen...
2019/0085087 STROMAL GENE SIGNATURES FOR DIAGNOSIS AND USE IN IMMUNOTHERAPY
The invention provides methods for identifying an individuals with a disease or disorder who is less likely to respond to immunotherapy alone, the method...
2019/0085086 SCREENING METHODS FOR IDENTIFYING AND TREATING HIV-1 INFECTED PATIENT SUB-POPULATIONS SUITABLE FOR LONG TERM...
Certain R5 virus tropic HIV-1 subjects with viral load effectively conventionally controlled using HAART, i.e., subject having less than 50 viral copies/mL...
2019/0085085 ANTI-IL-6 RECEPTOR ANTIBODY
The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and...
2019/0085084 ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0085083 KLRG1 SIGNALING THERAPY
A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 ...
2019/0085082 ANTIBODIES AND RELATED MOLECULES AND USES THEREOF
The present invention relates to an isolated antibody, which selectively binds to CLEC14A, wherein said antibody (a) comprises at least one heavy chain...
2019/0085081 CHIMERIC ANTIGEN RECEPTOR
The present invention is directed to a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric antigen receptor comprising (a) an...
2019/0085080 B7-H4 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey,...
2019/0085079 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF MAKING
Provided are methods of generating chimeric antigen receptors (CAR). In some embodiments, library screening of CAR is performed by generating a vector encoding...
2019/0085078 M971 CHIMERIC ANTIGEN RECEPTORS
The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an...
2019/0085077 SIGLEC NEUTRALIZING ANTIBODIES
This invention relates to agents that bind human Siglecs having inhibitory activity in immune cells, and that neutralize the inhibitory activity of such...
2019/0085076 ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments,...
2019/0085075 LAG-3-Binding Molecules and Methods of Use Thereof
The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and...
2019/0085074 Antibodies Towards an Extracellular Region of NBCn1
Antibodies or antigen binding fragment thereof specifically recognizing and binding an extracellular polypeptide region of human NBCn1 are provided. Moreover,...
2019/0085073 HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding...
2019/0085072 Methods for Treating Visceral Pain by Administering Antagonist Antibodies Directed Against Calcitonin...
The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease...
2019/0085071 Antagonists to IL-6 to Raise Albumin and/or Lower CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2019/0085070 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE, AND /OR FEVER
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat...
2019/0085069 Anti-IL-12 Antibodies, Epitopes, Compositions, Methods and Uses
An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the...
2019/0085068 IL-18 BINDING MOLECULES
IL-18 participates in both innate and acquired immunity. The bioactivity of IL-18 is negatively regulated by the IL-18 binding protein (IL18BP), a naturally...
2019/0085067 COMPOSITIONS AND METHODS FOR GROWTH FACTOR MODULATION
Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth...
2019/0085066 ANTIBODIES TO HGF AND COMPOSITIONS CONTAINING
The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the...
2019/0085065 AGENTS FOR USE IN THE THERAPEUTIC OR PROPHYLACTIC TREATMENT OF MYOPIA OR HYPEROPIA
The present invention relates to agents for use in the prophylactic or therapeutic treatment of myopia in a subject, wherein said agents are capable of...
2019/0085064 METHOD TO PRODUCE A HIGHLY CONCENTRATED IMMUNOGLOBULIN PREPARATION FOR SUBCUTANEOUS USE
The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous...
2019/0085063 Compositions and Methods for Generating a Persisting Population of T Cells Useful for the Treatment of Cancer
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an...
2019/0085062 COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use...
2019/0085061 SELECTING HEADACHE PATIENTS RESPONSIVE TO ANTIBODIES DIRECTED AGAINST CALCITONIN GENE RELATED PEPTIDE
The present invention relates to methods for selecting a headache patient responsive to treatment with an anti-CGRP antibody and to methods for reducing...
2019/0085060 CELL CULTURE ADDITIVES AND THEIR USE FOR INCREASED BIOPROTEIN PRODUCTION FROM CELLS
The invention relates to a method of increasing protein biomolecule production in which a) a cell that produces a heterologous protein biomolecule is cultured,...
2019/0085059 MYCOPLASMA PNEUMONIAE IMMUNOLOGICAL DETECTION METHOD AND KIT
[Problem] An object of the present invention is to provide a detection marker that can simply and rapidly detect Mycoplasma pneumoniae, which is a pathogen of...
2019/0085058 DNA Antibody Constructs And Method Of Using Same
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a...
2019/0085057 MAST CELL STABILIZERS FOR TREATMENT OF HYPERCYTOKINEMIA AND VIRAL INFECTION
The present invention relates to methods for treating hypercytokinemia and viral infections associated with hypercytokinemia using a mast cell stabilizing...
2019/0085056 ANTIBODY-LIKE PEPTIDES FOR QUANTIFYING THERAPEUTIC ANTIBODIES
The present invention relates to a labeled chimeric non-therapeutic antibodylike protein comprising, in a hypervariable region thereof, an enzyme cleavable...
2019/0085055 ENGINEERED IMMUNOGLOBULIN HEAVY CHAIN-LIGHT CHAIN PAIRS AND USES THEREOF
The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an...
2019/0085054 VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS
There are disclosed TIMP-3 muteins, variants and derivatives, nucleic acids encoding them, and methods of making and using them.
2019/0085053 SYNTHETIC LUNG SURFACTANT WITH ENHANCED STABILITY AND EFFECTIVENESS
Peptides suitable for preparation of lung surfactants are described. Examples include one that include a first fragment comprising the amino acid sequence of...
2019/0085052 METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with...
2019/0085051 T1R TASTE RECEPTORS AND GENES ENCODING SAME
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are provided. Specifically, T1R G...
2019/0085050 POLYPEPTIDES AND USES THEREOF FOR REDUCING CD95-MEDIATED CELL MOTILITY
The present invention relates to polypeptides and uses thereof for reducing CD95-meditated cell motility. In particular, the present invention relates to a...
2019/0085049 Pulsed Introduction of Low-Dose RANKL as a Therapy for Diet-Induced Atherosclerosis
Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (Tc.sub.REG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc.sub.REG)...
2019/0085048 MHC Multimers, Methods for Their Generation, Labeling and Use
The present invention describes novel methods to generate MHC multimers and methods to improve existing and new MHC multimers. The invention also describes...
2019/0085047 ANTI-HUMAN PAPILLOMAVIRUS 16 E7 T CELL RECEPTORS
Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E7.sub.11-19....
2019/0085046 HLA CLASS II-RESTRICTED T CELL RECEPTORS AGAINST MUTATED RAS
Disclosed is an isolated or purified T cell receptor (TCR), wherein the TCR has antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog...
2019/0085045 METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against...
2019/0085043 FUSION PROTEINS FOR TREATING A METABOLIC SYNDROME
The invention is directed to a fusion protein comprising at least one FGF-21 (fibroblast growth factor-21) compound and at least one GLP-1R (glucagon-like...
2019/0085042 FUSION POLYPEPTIDE COMPRISING THE EXTRACELLULAR BINDING DOMAIN OF GROWTH HORMONE RECEPTOR
The invention relates to fusion polypeptides comprising the extracellular domain of growth hormone linked either directly or indirectly to a polypeptide...
2019/0085041 SECRETORY PROTEIN
The present application discloses a secretory protein, including polypeptide sequence, nucleic acid sequence, operating principle and application area of sDSS1...
2019/0085040 PEPTIDE MODULATORS OF SPECIFIC CALCINEURIN PROTEIN-PROTEIN INTERACTIONS
Methods of modulating the interaction between calcineurin and a calcineurin-binding protein partner are provided. Aspects of the methods include contacting a...
2019/0085039 Fluorescent Protein
Provided is a green-yellow fluorescent protein with high pH stability (with reduced pH sensitivity). In one or more embodiments, the fluorescent protein is a...
2019/0085038 PLANT TRAITS CONFERRED BY ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES
Provided are isolated polypeptides, isolated polynucleotides encoding same, nucleic acid constructs comprising same, transgenic cells expressing same,...
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