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Patent # Description
2019/0084987 Small Molecule Histone Methyltransferase SUV39H1 Inhibitor and Uses Thereof
Compositions for the inhibition of SUV39H1 methyltransferase activity and methods of use thereof are provided. The disclosed compositions may be used for...
2019/0084986 HETEROCYCLIC COMPOUND, AND ORGANIC ELECTROLUMINESCENCE DEVICE AND ORGANIC ELECTROLUMINESCENCE DISPLAY DEVICE...
Provided are a heterocyclic compound represented by Formula 1 and an organic electroluminescence device and an organic electroluminescence display device...
2019/0084985 WEE1 KINASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME
A compound, or a pharmaceutically acceptable salt thereof, having a chemical structure of formula (I) or formula (II), and methods of using these compounds to...
2019/0084984 CALCIUM CHANNEL AGONISTS
Embodiments of calcium channel agonists, as well as methods of making and using the calcium channel agonists, are disclosed. The disclosed calcium channel...
2019/0084983 MITRAGYNINE ALKALOIDS AS OPIOID RECEPTOR MODULATORS
The present invention provides a compound having the structure: ##STR00001## or a pharmaceutically acceptable salt or ester thereof, and a method of treating a...
2019/0084982 ANTIBACTERIAL CYCLOPENTA[C]PYRROLE SUBSTITUTED 3,4-DIHYDRO-1H-[1,8]NAPHTHYRIDINONES
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of...
2019/0084981 Bromodomain Inhibitors
The present invention provides for compounds of formula (I) ##STR00001## wherein R.sup.x, R.sup.y, R.sup.x1, L.sup.1, G.sup.1, A.sup.1, A.sup.2, A.sup.3, and...
2019/0084980 Amide-Sulfamide Derivatives, Compositions, and Uses Related to CXCR4 Inhibition
This disclosure relates amide-sulfamide compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula I,...
2019/0084979 WATER-SOLUBLE MYOSIN 2 INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL, NEUROPATHIC OR PSYCHIATRIC DISEASES
The present invention relates to highly soluble, non-fluorescent and photostable myosin inhibitors; especially, for in vivo inhibition of the ATPase activity...
2019/0084978 STABLE SNS-595 COMPOSITIONS AND METHODS OF PREPARATION
Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially...
2019/0084977 TRICYCLIC KINASE INHIBITORS OF MELK ANDS METHODS OF USE
Provided herein are tricyclic small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK). The compounds are useful for treating cancer and...
2019/0084976 COMPOUNDS AND THEIR METHODS OF USE
Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that...
2019/0084975 COMPOUNDS, COMPOSITIONS, AND METHODS
The present disclosure relates generally to compounds of formula (I) or a pharmaceutically acceptable salt, prodrug, deuterated analog, tautomer, stereoisomer,...
2019/0084974 PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF
The present invention comprises compounds of Formula I and their use in the inhibition of cell proliferation in therapeutic treatments. Pharmaceutical...
2019/0084973 READ-THROUGH COMPOUND PRODRUGS SUPPRESSING PREMATURE NONSENSE MUTATIONS
Premature termination codon readthrough prodrug compounds, compositions thereof, and methods of making and using the same are provided. In certain embodiments,...
2019/0084972 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, ##STR00001## wherein Q, Z, R.sup.2, R.sup.3 and m are as...
2019/0084971 METHODS FOR PREPARING OLTIPRAZ
The invention provides improved methods of synthesizing oltipraz, which result in higher overall yield and better purity of the desired product.
2019/0084970 STRIGOLACTONE FORMULATIONS AND USES THEREOF
Disclosed herein plant propagation materials, methods of manufacturing, formulations and uses thereof. The plant propagation materials disclosed herein may...
2019/0084969 FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
2019/0084968 FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
2019/0084967 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
The present invention describes carbazolyl compounds substituted by electron-deficient heteroaryl groups, especially for use as triplet matrix materials in...
2019/0084966 SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS
The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.
2019/0084965 AMINE CATIONIC LIPIDS AND USES THEREOF
The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such...
2019/0084964 Benzocyanine Compounds
Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological...
2019/0084963 Solid Forms Of an HIV Capsid Inhibitor
The present disclosure relates to pharmaceutically acceptable salts, cocrystals, and crystalline forms thereof, of a compound which is ...
2019/0084962 SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof ##STR00001## in which q, R.sup.11, R.sup.12, R.sup.13 and...
2019/0084961 Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing...
A compound having the following formula: ##STR00001## or a pharmaceutically acceptable salt thereof. A medicament or pharmaceutical composition contains the...
2019/0084960 SELECTIVE C-KIT KINASE INHIBITOR
The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a...
2019/0084959 PYRIDINYLMETHYL CARBAMIMIDOYLCARBAMATE DERIVATIVES AND THEIR USE AS AOC3 INHIBITORS
The invention relates to new heteroaryl derivatives of the formula wherein X is selected from the group consisting of: N and CH; X is selected from the group...
2019/0084958 PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF
Provided herein are compounds I, II or III and compositions useful in increasing PPAR8 activity. The compounds and compositions provided herein are useful for...
2019/0084957 4-SULFUR PENTAFLUORIDE PHENOL COMPOUND AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR SULFUR...
Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted...
2019/0084955 SUBSTITUTED NAPHTHO[2,3-b]FURANS AS WATER-SOLUBLE PRODRUGS FOR PREVENTING AND/OR TREATING CANCER
The present invention provides compounds represented by formula (1A), or pharmaceutically acceptable salts. Compounds represented by formula (1A), or...
2019/0084954 DIBENZOFURAN AND DIBENZOTHIOPHENE DERIVATIVES AND ORGANIC LIGHT-EMITTING DEVICES CONTAINING THEM
A compound of formula (I) wherein Z is a group of formula (II) and Core is selected from groups of formula (IIIa) or (IIIb) wherein X is S or O; R.sup.1 is a...
2019/0084953 CARBONATE-PROMOTED CARBOXYLATION REACTIONS FOR THE SYNTHESIS OF VALUABLE ORGANIC COMPOUNDS
A method for synthesizing a dicarboxylate containing an aromatic heterocycle is provided. A carboxylic acid containing a heterocycle is provided. A...
2019/0084952 PROCESS FOR PRODUCING 2,5-FURANDICARBOXYLIC ACID DIALKYL ESTER
Disclosed herein are processes for producing 2,5-furandicarboxylic acid dialkyl ester. In one embodiment, the process comprises a) contacting 2,5-furan...
2019/0084951 Conversion of Biomass
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
2019/0084950 PROCESS FOR PREPARING OXATHIAZIN-LIKE COMPOUNDS
Oxathiazin-like compounds, processes for making new oxathiazin-like compounds, compounds useful for making oxathiazin-like compounds, and their uses are...
2019/0084949 NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
The present invention provides a compound having the structure: ##STR00001## or a pharmaceutically acceptable salt or ester thereof.
2019/0084948 Efficient and scalable synthesis of 2-(1'H-Indole-3'-Carbonyl)-thiazole-4-carboxylic acid methyl ester and ...
Methods of synthesizing 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) and structural analogs thereof. The methods include...
2019/0084947 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in...
2019/0084946 METHODS USING HDAC11 INHIBITORS
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for...
2019/0084945 METHODS USING HDAC11 INHIBITORS
The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for...
2019/0084944 COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF
The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds witin the methods...
2019/0084943 CHLORO-PYRAZINE CARBOXAMIDE DERIVATIVES WITH EPITHELIAL SODIUM CHANNEL BLOCKING ACTIVITY
This invention provides compounds of the formula I: ##STR00001## and their pharmaceutically acceptable salts, useful as sodium channel blockers, compositions...
2019/0084942 PROCESS FOR PREPARING SUBSTITUTED 9,10-DIOXO-9,10-DIHYDROANTHRECENES AND 6H-ANTHRA[1,9-CD]ISOXAZOL-6-ONES
The disclosure provides processes of preparing compounds of Formula (I) and Formula (IV), their salts, and intermediates thereof, wherein R.sup.1' R.sup.2'...
2019/0084941 COMPOUNDS AND METHODS OF TREATING INFECTIONS
The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The...
2019/0084940 BENZAMIDE DERIVATIVES
Disclosed are benzamide derivatives useful in slowing the expansion of cancer cells.
2019/0084939 ANALOGS OF FEXARAMINE AND METHODS OF MAKING AND USING
Novel compounds having a formula ##STR00001## embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also...
2019/0084938 PYRAZOLE COMPOUND
The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT.sub.2C antagonistic action (antidepressive and anxiolytic...
2019/0084937 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS
Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety...
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