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Patent # Description
2019/0083672 DISINFECTING APPARATUS DEVICE
A disinfecting apparatus may include a shelf securable to a wall; a mount configured to secure the shelf to the wall; at least one UV light source coupled to...
2019/0083671 HUMIDIFIER WITH AROMATHERAPY TRAY
The humidifier disclosed herein may include a trap door for housing one or more chemically impregnated filter papers, referred to herein as "aroma pads,"...
2019/0083670 AROMA DIFFUSER
An aroma diffuser includes a liquid storage means, an enclosure provided with a mounting cavity, a gas supply means and a seal. The enclosure is covered on a...
2019/0083669 A HYDROGEN PEROXIDE EVAPORATION DEVICE, AND A METHOD FOR EVAPORATING HYDROGEN PEROXIDE
An evaporation device for evaporating hydrogen peroxide is provided. The device comprises a housing body having at least two fluid channels arranged therein....
2019/0083668 DEVICES, SYSTEMS AND METHODS FOR TREATING MULTIPLE MEDICAL DEVICES HAVING PASSAGEWAYS WITH OZONE GAS
The present disclosure is generally related to systems, methods and devices for providing ozone treatment of multiple medical devices including passageways. In...
2019/0083667 LIGHTING DEVICE THAT DEACTIVATES DANGEROUS PATHOGENS WHILE PROVIDING VISUALLY APPEALING LIGHT
A lighting device configured to deactivate MRSA bacteria in air in an environment, including a housing; a light-emitting diode (LED) configured to emit light...
2019/0083666 MULTI FUNCTIONAL SHOE SANITIZER AND METHOD OF USING IT
Portable multifunctional device designed for sanitizing of inner and outer surfaces of shoes, sanitizing of air, water, household items and surfaces, treatment...
2019/0083665 ANTIBODIES TO IL-6 AND USE THEREOF
The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for...
2019/0083664 PET TRACER FOR IMAGING OF NEUROENDOCRINE TUMORS
There is provided a radiolabelled peptide-based compound for diagnostic imaging using positron emission tomography (PET). The compound may thus be used for...
2019/0083663 CARBONIC ANHYDRASE IX TARGETING AGENTS AND METHODS
The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of...
2019/0083662 IGF-1R MONOCLONAL ANTIBODIES AND USES THEREOF
The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their...
2019/0083661 HIGH PURITY THERAPEUTIC BONE AGENTS
This invention relates to radioactive, bone-seeking, pharmaceutical methods, compositions and formulations that have a lower impurity profile, a longer shelf...
2019/0083660 METHOD FOR INCREASING DISPERSION STABILITY OF NANOPARTICLES AS T1 MRI CONTRRAST AGENT AND T1 MRI CONTRAST...
The present invention improves an existing contrast agent, especially, a T1 contrast agent, and adopts a strategy in which the T1 contrast material is...
2019/0083659 GADOLINIUM CHELATE COMPOUNDS FOR USE IN MAGNETIC RESONANCE IMAGING
A compound having the formula of tetragadolinium [4,10-bis(carboxylatomethyl)-7-{-3,6,12,15-tetraoxo-16-[4,7,10-tris(carbo- ...
2019/0083658 COMPOSITIONS AND METHODS FOR DETECTION AND MODULATION OF T CELL MEDIATED IMMUNE RESPONSES AGAINST VIRAL VECTORS...
Compositions and methods are provided for inhibiting T cell mediated destruction of virally transduced, trangene containing cells.
2019/0083657 AAV-MEDIATED EXPRESSION USING A SYNTHETIC PROMOTER AND ENHANCER
An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods...
2019/0083656 METHODS AND COMPOSITIONS UTILIZING CPF1 FOR RNA-GUIDED GENE EDITING
Compositions include endonucleases of the family Cpf1 (CRISPR from Prevotella and Francisella 1); and at least one guide RNA (gRNA) complementary to a target...
2019/0083655 VIVO RNA OR PROTEIN EXPRESSION USING DOUBLE-STRANDED CONCATEMERIC DNA INCLUDING PHOSPHOROTHIOATED NUCLEOTIDES
A method for in vivo RNA or protein expression is provided. The method includes introducing a double-stranded concatemeric DNA into a eukaryotic cell to...
2019/0083654 Synthetic Compound for Improving Efficiency of Transfection
The invention concerns a synthetic compound for enabling transfection of eukaryotic cells by means of an amphiphilic block copolymer which synthetic compound...
2019/0083653 Systems and Methods for Nucleic Acid Expression In Vivo
The present invention provides compositions, systems, kits, and methods for generating expression of one or more proteins and/or biologically active nucleic...
2019/0083652 USING DREADD FOR NEURONAL MODULATION IN TREATING NEURONAL DISEASES
A method for treating a patient suffering from a neuronal hypo-kinetic disease or a neuronal hyper-kinetic disease by modulating neuronal activity in the:...
2019/0083651 AAV-MEDIATED SUBCELLULAR TARGETING OF HETEROLOGOUS RHODOPSINS IN RETINAL GANGLION CELLS
Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are...
2019/0083650 TKI PERMEABILITY ENHANCERS
Provided herein are, inter alia, methods useful for delivering nucleic acids and kinase inhibitors to a cell. The methods provided herein include the delivery...
2019/0083649 CROSSLINKED POLYMER NANO-ASSEMBLIES AND USES THEREOF
The invention provides powerful methods and compositions for designing, selecting, fine-tuning and optimizing polymer nanogel and other supramolecular...
2019/0083648 HARNESSING QUANTUM DOTS TO STUDY, VISUALIZE, AND PROMOTE IMMUNE TOLERANCE
Provided are compositions and methods for promoting tolerance to auto-immune antigens. In general the compositions include quantum dots (QDs) that are in...
2019/0083647 VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS
The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles...
2019/0083646 MUTANT SMOOTHENED AND METHODS OF USING THE SAME
The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired...
2019/0083645 NOVEL ANTI-CLAUDIN ANTIBODIES AND METHODS OF USE
Provided herein are novel anti-CLDN antibodies and antibody drug conjugates (ADC), including derivatives thereof, and methods of using the same to treat...
2019/0083644 DUAL FUNCTION ANTIBODIES SPECIFIC TO GLYCOSYLATED PD-L1 AND METHODS OF USE THEREOF
Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1, block binding of PD-L1 to PD-1 and promote internalization and...
2019/0083643 PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF
This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in...
2019/0083642 TREATMENTS UTILIZING A POLYMER-PROTEIN CONJUGATE
A composition for use in treating a condition associated with degeneration of articular cartilage and/or with subchondral bone loss is disclosed herein. The...
2019/0083641 ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-FOLATE RECEPTOR ANTIBODY CONJUGATES, AND...
The present disclosure relates to antibody conjugates with binding specificity for folate receptor alpha (FOLR1) and its isoforms and homologs, and...
2019/0083640 POLYCOMPLEXES OF POLY-LYSINE COMPOUNDS FOR PREVENTING AND/OR COMBATTING AMYOTROPHIC LATERAL SCLEROSIS
A polycomplex comprising multiple Poly-lysine compounds, said Poly-lysine compounds being composed of at least one small molecule conjugated with a ...
2019/0083639 SCAVENGER RECEPTOR UPTAKE FOR FABRY DISEASE ENZYME REPLACEMENT THERAPY
The present invention relates to a composition comprising a lysosomal enzyme conjugated to a negatively charged scavenger receptor ligand. In some embodiments,...
2019/0083638 NICLOSAMIDE-CONJUGATED POLYPEPTIDE NANOPARTICLES
Disclosed herein are conjugates of a therapeutic compound and polypeptides, such as a conjugate of niclosamide and an elastin-like polypeptide. These...
2019/0083637 TUMOR CELL-SPECIFIC RESPONSIVE SELF-ASSEMBLING DRUG NANOCONJUGATE
Disclosed is a drug conjugate as a prodrug that is degraded by cathepsin B specifically expressed in tumor tissues to release doxorubicin. The drug conjugate...
2019/0083636 METHODS OF TREATING DISEASES RELATED TO NET FORMATION WITH PARENTERAL ADMINISTRATION OF POLYSIALYLATED DNASE I
The present invention provides conjugates of deoxyribonuclease enzymes with water soluble polymers such as PSA having improved pharmacokinetic attributes....
2019/0083635 GLUCOCORTICOID COMBINED WITH POLYETHYLENE GLYCOL-MODIFIED INTERLEUKIN 2 FOR TREATING RESPIRATORY DISEASE
The present invention provides an inhalable pharmaceutical composition comprising a glucocorticoid and a polyethylene glycol (PEG)-modified interleukin-2 for...
2019/0083634 POLYMER LINKERS AND THEIR USES
Provided herein are poly-1-hydroxymethylethylene hydroxymethyl formal (PHF)-based drug delivery systems. Also disclosed are methods of making antibodydrug...
2019/0083633 OLIGOLACTIC ACID CONJUGATES AND MICELLES WITH ENHANCED ANTICANCER EFFICACY
The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle...
2019/0083632 PLANT STEROIDS AND USES THEREOF
The invention relates to a drug conjugate including a drug and a plant steroid. The drug conjugate may target the drug for intestinal cell delivery, and thus...
2019/0083631 CARBONIC ANHYDRASE IX INHIBITOR CONJUGATES AND USES THEREOF
The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of...
2019/0083630 METHODS FOR IMPROVED DELIVERY OF AMINOTHIOLS, DIMERS OF AMINOTHIOLS, AND HETERODIMERS COMPOSED OF AMINOTHIOLS
The disclosure relates to methods of improving safety, efficacy, or both, of pharmaceutically active aminothiol compounds by delivering them in a ...
2019/0083629 PROTEIN BASED EXCIPIENT FOR ACTIVE PHARMACEUTICAL INGREDIENTS
Provided herein is a pharmaceutical formulation comprising a protein based excipient in combination with an active pharmaceutical ingredient (API) wherein said...
2019/0083628 PHARMACEUTICAL COMPOSITION PARTICLES AND ORALLY DISINTEGRATING PREPARATION INCLUDING THE SAME
Provided are pharmaceutical composition particles which are capable of achieving both of masking of an unpalatable taste and improvement in dissolution...
2019/0083627 Pharmaceutical Composition Containing Tacrolimus and Preparation Methods Thereof
Disclosed are a pharmaceutical composition comprising tacrolimus and a preparation method thereof.
2019/0083626 DRUG DELIVERY COMPOSITIONS AND USES THEREOF
Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery...
2019/0083625 PHARMACEUTICAL FORMULATIONS CONTAINING CORTICOSTEROIDS FOR TOPICAL ADMINISTRATION
Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and...
2019/0083624 Solid Solution Compositions and Use in Severe Pain
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2019/0083623 Solid Solution Compositions and Use in Cardiovascular Disease
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
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