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Patent # Description
2019/0083521 COMBINATION THERAPY FOR TREATING CANCER
The disclosure relates to combinations comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly...
2019/0083520 N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto
This disclosure relates to certain N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to...
2019/0083519 MITHRAMYCIN DERIVATIVES HAVING INCREASED SELECTIVITY AND ANTI-CANCER ACTIVITY
Mithramycin side chain carboxylic acid (MTM-SA) derivative are provided, which include a substituted amino acid derivative, a substituted amino acid dipeptide...
2019/0083518 COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA
Disclosed are compositions and methods for treating, amelioriating, reversing and/or preventing (acting as a prophylaxis): a respiratory condition involving an...
2019/0083517 SMALL MOLECULE-MEDIATED RESTORATION OF AIRWAY SURFACE PHYSIOLOGY IN HUMAN CYSTIC FIBROSIS LUNG EPITHELIA
Provided herein are complexes comprising amphotericin B (AmB) or derivatives and sterols. Also provided herein are methods of treating cystic fibrosis using...
2019/0083516 NUTRITIONAL SUPPLEMENT FOR INCREASING CELLULAR LEVELS OF N-ACETYLNEURAMINATE
The instant invention relates to a composition useful as a nutritional supplement comprising acetylated neuraminate (NeuAc), and/or a compound selected from...
2019/0083515 THYROMIMETICS FOR THE TREATMENT OF FATTY LIVER DISEASES
The present invention is directed toward the use of thyromimetic compounds that are thyroid receptor ligands, pharmaceutically acceptable salts thereof; and to...
2019/0083514 Vitamin D Composition
The invention is directed to compositions of vitamin D having enhanced bioavailability and enhanced stability. Methods of making and using the compositions of...
2019/0083513 METHODS OF TREATING VITAMIN D INSUFFICIENCY IN CHRONIC KIDNEY DISEASE
Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering repeat doses of...
2019/0083512 INTRAVITREAL DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF OCULAR CONDITIONS
The disclosure teaches precisely engineered biodegradable drug delivery systems and methods of making and utilizing such systems. In aspects, the biodegradable...
2019/0083511 ENZYMATIC PROCESS FOR OBTAINING 17 ALPHA-MONOESTERS OF CORTEXOLONE AND/OR ITS 9,11-DEHYDRODERIVATIVES
The present invention refers to a new enzymatic process for obtaining 17.alpha.-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the...
2019/0083510 METHODS AND COMPOSITIONS FOR TREATING ENDOMETRIAL CANCER
Provided herein are, inter alia, methods and compositions for treating cancer in a subject in need thereof comprising a therapeutically effective amount of a...
2019/0083509 OXYGENATED CHOLESTEROL SULFATES FOR THERAPY OF DISORDERS CAUSED BY AT LEAST ONE OF ATTENUATED LEPTIN ACTIVITY...
Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin...
2019/0083508 USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
The present invention relates to methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases.
2019/0083507 ADRENOCEPTORS ANTAGONISTS FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE CONDITIONS
The present disclosure teaches methods for treating and preventing a variety of neurodegenerative conditions and symptoms associated therewith, including...
2019/0083505 TREATMENT OF NEURODEGENERATIVE DISEASES, CAUSATION OF MEMORY ENHANCEMENT, AND ASSAY FOR SCREENING COMPOUNDS FOR...
Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The...
2019/0083504 METHOD OF TREATING MEDULLOBLASTOMA WITH AN EZH2 INHIBITOR
The disclosure provides a method of treating a medulloblastoma in a subject in need thereof comprising administering to the subject a therapeutically-effective...
2019/0083503 (+)-AZASETRON FOR USE IN THE TREATMENT OF EAR DISORDERS
Disclosed is a method for treating ear disorders, including the administration of (+)-azasetron, or a pharmaceutically acceptable salt and/or solvate thereof.
2019/0083502 TREATMENT OF ERECTILE DYSFUNCTION AND OTHER INDICATIONS
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use...
2019/0083501 METHODS FOR TREATING LIVER TISSUE
Methods and kits are provided for administering a hypoxia-activated bioreductive agent by applying the agent locally to liver tissue when hepatic arterial...
2019/0083500 Combination of PI3K Inhibitor and C-Met Inhibitor
The present invention relates to a pharmaceutical combination which comprises (a) a phosphatidylinositol 3-kinase inhibitor or pharmaceutically acceptable salt...
2019/0083499 CHLOROBENZENE SUBSTITUTED AZAARYL COMPOUNDS
The invention provides a series of chlorobenzene substituted azaaryl compounds having activity in inhibiting cancer cell growth and low toxicity to normal...
2019/0083498 THERAPIES FOR HEMATOLOGIC MALIGNANCIES
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In...
2019/0083497 MODULATION OF BLOOD BRAIN BARRIER PERMEABILITY
The present invention relates to a method of increasing blood brain barrier permeability in a subject. This method involves selecting a subject who would...
2019/0083496 METHODS AND COMPOSITIONS FOR TREATMENT OF ZIKA VIRUS INFECTION
The present disclosure is directed to methods and compositions that are useful in combating the spread of Zika virus infections, such as, but not limited to,...
2019/0083495 Methods Of Preventing Or Reducing A Fibrotic Response Using CSF1R Inhibitors
Described herein are methods of preventing or reducing fibrosis comprising administering CSF1R inhibitors, coating formulations comprising CSF1R inhibitors,...
2019/0083494 Therapeutic Compositions
The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with...
2019/0083493 COMPOSITIONS AND METHODS FOR TREATMENT OF FRAGILE X SYNDROME
Disclosed are methods of alleviating or preventing one or more symptoms associated with fragile X syndrome in an individual in need thereof via administration...
2019/0083492 TOPICAL MINOXIDIL COMPOSITION
The present invention is related to a topical Minoxidil foam or spray composition, wherein the excipient 1,3-propanediol used for the first time as a solvent...
2019/0083491 SMALL MOLECULES INHIBITORS OF RAD51
Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form...
2019/0083490 COMPOSITION COMPRISING FINE PARTICLE AND PROCESS THEREOF
The present invention relates to a comprising (A) an active ingredient which is hardly soluble in water, but soluble in a C.sub.1-4 lower alcohol that may...
2019/0083489 METHODS FOR INDUCING AN IMMUNE RESPONSE BY INHIBITION OF NONSENSE MEDIATED DECAY
Provided herein, inter alia, are compositions and methods for generating a immune response in an individual and/or inducing the expression of neoantigens on...
2019/0083488 COMPOSITIONS AND METHODS FOR MINIMIZING OR REVERSING AGONIST-INDUCED DESENSITIZATION
Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated...
2019/0083487 EFFICACY OF ANTI-HLA-DR ANTIBODY DRUG CONJUGATE IMMU-140 (hL243-CL2A-SN-38) IN HLA-DR POSITIVE CANCERS
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-HLA-DR antibody or antigen-binding antibody fragment. The...
2019/0083486 THE USE OF GLUCOCORTICOID RECEPTOR MODULATORS TO POTENTIATE CHECKPOINT INHIBITORS
This invention provides a method that combines a checkpoint inhibitor and a glucocorticoid receptor modulator to treat cancer, e.g., a checkpoint inhibitor...
2019/0083485 METHODS FOR TREATING IMMUNODEFICIENCY DISEASE
The present invention relates to methods of treating patients with WHIM syndrome or related disorders, such as myelokathexis, in which X4P-001 is administered...
2019/0083484 Formulations And Pharmacokinetics Of Deuterated Benzoquinoline Inhibitors Of Vesicular Monoamine Transporter 2
The present invention relates to new pharmaceutical compositions comprising benzoquinoline compounds, and methods to inhibit vesicular monoamine transporter 2...
2019/0083483 BROMODOMAIN AND EXTRA-TERMINAL PROTEIN INHIBITOR COMBINATION THERAPY
The present disclosure relates generally to compositions and methods of treating neoplastic diseases or cancers, such as glioblastoma and non-Hodgkin's...
2019/0083482 PRMT5 INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2019/0083481 METHODS FOR USING FXR AGONISTS
The invention provides methods for modulating the activity of farnesoid X receptors (FXRs) using specific FXR agonists, in particular for treating or...
2019/0083480 Treatment of Neurodegenerative Conditions by Disruption of Rhes
The invention is directed to the treatment of tauopathic neurodegenerative conditions and the underlying processes thereof. Based on the discovery that Rhes...
2019/0083479 COMBINATION MEDICATION
This invention provides a combination medication including an anti-diabetic prescription medication and at least one suitable complementary compound which is...
2019/0083478 Choline salt forms of an HIV capsid inhibitor
The present disclosure relates to choline salts, and crystalline forms thereof, of a compound which is ...
2019/0083477 Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures
Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract...
2019/0083476 ENHANCERS OF NOTCH SIGNALING AND THE USE THEREOF IN THE TREATMENT OF CANCERS AND MALIGNANCIES MEDICABLE BY...
The present invention relates to the use for enhancing Notch signaling in an individual, of a compound showing the general formula (I) and/or a ...
2019/0083475 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR
This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid...
2019/0083474 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS
The present invention relates to 1-aza-bicycloalkyl derivatives of formula I, ##STR00001## wherein X is CH.sub.2 or a single bond; Y is a group of formula ...
2019/0083473 AZABICYCLOOCTANE DERIVATIVES AS FXR AGONISTS FOR USE IN THE TREATMENT OF LIVER AND GASTROINTESTINAL DISEASES
The invention provides methods for modulating the activity of farnesoid X receptors (FXRs) using compounds of Formula (I) or (II). In particular, the invention...
2019/0083472 SECURININE AND NORSECURININE ANALOGUE COMPOUNDS FOR THE TREATMENT OF MYELOID DISORDERS
The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these...
2019/0083471 BUCCAL, POLAR AND NON-POLAR SPRAY CONTAINING ZOLIPIDEM
Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral...
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