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Patent # Description
2019/0083470 P38 MAP KINASE INHIBITORS FOR TREATING FRIEDREICH'S ATAXIA
The invention provides p38 MAPK inhibitors that compensate for a frataxin deficiency or mutation and methods of using the same (e.g., to treat Friedreich's...
2019/0083469 METHOD OF TREATING MULTIPLE SCHLEROSIS EMPLOYING A LSD1-INHIBITOR
Provided herein are methods for treating multiple sclerosis using (-) 5-((((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadi- azol-2-amine,...
2019/0083468 METHODS OF TREATMENT FOR CHOLESTATIC AND FIBROTIC DISEASES
The present invention relates to the compound [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate (Nitazoxanide) or...
2019/0083467 AROMATIC RING COMPOUND
Provided is a compound having a cholinergic muscarine M1 receptor positive allosteric modulator activity. A compound represented by the formula (I): ...
2019/0083466 NOVEL USE OF BIOTIN AND NATURAL ESSENTIAL OILS FOR BOVINE ANIMALS TO IMPROVE BEEF QUALITY
The present invention is made for the purpose of improving beef quality and upgrading its fat marbling standard (which is called beef marbling standard, or...
2019/0083465 Methods And Compositions For Treating Foot Or Hand Pain
The present disclosure provides novel formulations for treating foot or hand pain by topically administering a sympathomimetic drug, particularly ...
2019/0083464 SYSTEMS AND METHODS TO TREAT PAIN LOCALLY
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to...
2019/0083463 EDARAVONE DOSAGE FORM
Disclosed is an Edaravone dosage form and a use thereof in preparing a drug used for treating diseases related to oxidative stress, the dosage form being...
2019/0083462 PREVENTION OF NSAID ENTEROPATHY WITH MICROBIOTA-DERIVED TRYPTOPHAN-METABOLITE
This disclosure relates to methods and compositions for addressing conditions of dysbiosis and/or inflammation, such as enteropathy, associated with...
2019/0083461 METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISEASES
The present invention relates to a food composition and a pharmaceutical comprising D-tryptophan. The present invention further relates to D-tryptophan for use...
2019/0083460 ANALGESIC COMPOUNDS
Disclosed herein are compounds of Formulae (I), and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of...
2019/0083459 PHARMACEUTICAL COMPOSITION AND USE THEREOF
Disclosed is a pharmaceutical composition, comprising a first component and a second component, wherein the first component is selected from at least one of a...
2019/0083458 Andrographolide Treats Progressive Forms of Multiple Sclerosis
Andrographolide 240 mg/day orally is the first treatment shown to significantly benefit progressive forms of Multiple Sclerosis in human patients.
2019/0083457 MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS FOR PROTECTING, EXPANDING AND INCREASING THE POTENCY OF...
The present disclosure provides methods of protecting and expanding hematopoietic cells. The present disclosure also provides methods of increasing the potency...
2019/0083456 COMPOSITION FOR BKCA CHANNEL ACTIVATION
The present invention relates to novel compounds capable of activating BKCa channels. The use of a composition of the present invention can effectively...
2019/0083455 METHODS AND COMPOSITIONS FOR THE MODULATION OF BETA-ENDORPHIN LEVELS
Methods and compositions for treatment of pain, mood, or for the treatment of opiate withdrawal symptoms with the modulation of systemic beta-endorphin levels...
2019/0083454 PERINATAL TREATMENT WITH A FLAVONOID AGONIST OF THE TRKB RECEPTOR FOR BDNF RESCUES NEUROGENESIS AND BEHAVIOR IN...
The present invention relates to methods of restoring brain development in individuals with Down syndrome with a flavone derivative, 7,8-dihydroxyflavone...
2019/0083453 COMPOSITION COMPRISING NAPHTHOQUINONE-BASED COMPOUND AS ACTIVE INGREDIENT, FOR PREVENTING OR AMELIORATING...
The present invention relates to a composition comprising a naphthoquinone-based compound as an active ingredient, for preventing or ameliorating fatigue,...
2019/0083452 THERAPEUTIC AGENTS CONTAINING CANNABIS FLAVONOID DERIVATIVES FOR THE PREVENTION AND TREATMENT OF...
The present invention provides a cannabis-based flavonoid pharmaceutical composition including any one or more selected from the group of Apigenin, Cannflavin...
2019/0083451 SYNERGISTIC EFFECT OF ANTI-TROP-2 ANTIBODY-DRUG CONJUGATE IN COMBINATION THERAPY FOR TRIPLE-NEGATIVE BREAST...
The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors...
2019/0083450 DERIVATIVES OF KORORMICIN USEFUL AS ANTIBIOTICS
An antibiotic compound of formula (III): ##STR00001## or a salt or stereoisomer thereof; wherein R.sup.1-R.sup.3 and R.sup.5-R.sup.10 are independently selected...
2019/0083449 COMBINATION THERAPY WITH AN ANTI-HYALURONAN AGENT AND THERAPEUTIC AGENT
Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a...
2019/0083448 COMPOSITIONS AND FORMULATIONS INCLUDING CABAZITAXEL AND HUMAN SERUM ALBUMIN
This document relates to non-covalently bound complexes comprising cabazitaxel and human serum albumin. This document also relates to compositions comprising...
2019/0083447 REDUCTION OF GASTROINTESTINAL TRACT COLONISATION BY CAMPYLOBACTER
Campylobacter are the commonest reported bacterial causes of gastroenteritis in the UK and industrialized worlds. This invention relates to a method of...
2019/0083446 TOPICAL FORMULATIONS OF CHLOROPROCAINE AND METHODS OF USING SAME
Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and...
2019/0083445 METHODS OF REDUCING THE RISK OF A CARDIOVASCULAR EVENT IN A SUBJECT ON STATIN THERAPY
In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in...
2019/0083444 METHODS OF REDUCING APOLIPOPROTEIN C-III
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of...
2019/0083443 INGENOL COMPOUNDS AND USE THEREOF IN ANTI-HIV LATENCY TREATMENT
Provided in the present invention are ingenol compounds and a use thereof in preparing an anti-HIV latency drug. In particular, provided in the present...
2019/0083442 GLYCOGEN OR POLYSACCHARIDE STORAGE DISEASE TREATMENT METHOD
A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that...
2019/0083441 TREATMENT OF DISEASE WITH ESTERS OF SELECTIVE RXR AGONISTS
The present specification provides methods of treating disease with an ester of an RXR agonist or a combination of an ester of an RXR agonist and a thyroid...
2019/0083440 METHODS AND COMPOSITIONS FOR TREATING INFECTION AND INFLAMMATION WITH SELENOCYANATE
The present invention generally relates to methods and compositions for treating pulmonary infections and inflammation with a composition comprising...
2019/0083439 USE OF BIPOLAR TRANS CAROTENOIDS WITH CHEMOTHERAPY AND RADIOTHERAPY FOR TREATMENT OF CANCER
The subject disclosure relates to compounds and compositions including chemotherapy agents and/or radiation therapy with bipolar trans carotenoids, and the use...
2019/0083438 ACETYL-LEUCINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR IMPROVED MOBILITY AND COGNITIVE FUNCTION
The present disclosure is directed to acetyl-leucine or a pharmaceutically acceptable salt thereof for use in improving cognitive function, mobility, or...
2019/0083437 S- Methylcysteine Sulfoxide For Prostate Cancer Prevention And Treatment
The present invention relates to S-methylcysteine sulfoxide and compositions thereof for use in the treatment or prevention of prostate cancer. It also relates...
2019/0083436 METHODS OF DIAGNOSING CANCER
Disclosed are two methods of treating or preventing a proliferative disease as characterized and/or diagnosed by at least one selected from an accumulation of...
2019/0083435 Oral Microbiota Promotion for Immune System Associated Inflammations
A method of promoting a desired oral microbiota to treat an inflammation condition related to an allergic reaction in a subject in need of such treatment...
2019/0083434 COMPOSITIONS AND METHODS OF USING MODIFIED RELEASE SOLABEGRON FOR LOWER URINARY TRACT SYMPTOMS
This application relates to pharmaceutical compositions, comprising solabegron that are useful for the treatment of lower urinary tract symptoms such as, for...
2019/0083433 COMPOSITIONS AND METHODS OF USING MODIFIED RELEASE SOLABEGRON FOR LOWER URINARY TRACT SYMPTOMS
This application relates to pharmaceutical compositions, comprising solabegron that are useful for the treatment of lower urinary tract symptoms such as, for...
2019/0083432 METHODS AND COMPOSITIONS TO INHIBIT TOLERANCE TO OPIOIDS
The present invention provides a method of inhibiting tolerance to an opioid by a human subject in need thereof. The method comprises administering an...
2019/0083431 Methods and Compositions to Inhibit Dependence on Opioids
The present invention provides a method of inhibiting dependence to an opioid by a human subject in need thereof. The method comprises administering an...
2019/0083429 TOPICAL FERTILITY PROMOTING PRODUCT AND MANUFACTURING METHOD
Vaginal lubricants that have salts which are biomatched to salts that are naturally present in the vagina facilitate intercourse without toxic effects. Topical...
2019/0083428 SALT BALANCED VAGINAL PRODUCT AND METHOD
Topical substances that have a low buffering capacity to promote fertility by providing lubricity while minimizing disturbance to the natural pH levels present...
2019/0083427 METHODS AND MATERIALS FOR REDUCING ISCHEMIA-REPERFUSION INJURY
This document provides methods and materials for reducing ischemia-reperfusion injury. For example, methods and materials for administering ABA to reduce...
2019/0083426 COMPOSITIONS AND METHODS FOR INCREASING THE METABOLIC LIFETIME OF DEXTROMETHORPHAN AND RELATED PHARMACODYNAMIC...
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2019/0083425 FORMULATION FOR INHIBITING FORMATION OF 5-HT2B AGONISTS AND METHODS OF USING SAME
Drug combinations and their use are disclosed. A first drug is administered in combination with a second drug. The first drug such as fenfluramine is...
2019/0083424 FORMULATION FOR INHIBITING FORMATION OF 5-HT2B AGONISTS AND METHODS OF USING SAME
Drug combinations and their use are disclosed. A first drug is administered in combination with a second drug. The first drug such as fenfluramine is...
2019/0083423 METHOD OF REDUCING NEURONAL CELL DEATH WITH HALOALKYLAMINES
The present invention is directed to pharmaceutical compositions and methods of treating traumatic brain injury (TBI). The invention is also directed to...
2019/0083422 SENSE-33 COMPOSITIONS AND METHODS THEREOF FOR ENHANCING THE EXPRESSION AND/OR ACTIVITY OF NICOTINIC...
The present disclosure relates to compositions and methods thereof for enhancing the expression and/or function of Nicotinic Acetylcholine Receptors....
2019/0083421 METHOD OF TREATING CANCER USING SELECTIVE ESTROGEN RECEPTOR MODULATORS
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor...
2019/0083420 METHODS OF USING (2R, 6R)-HYDROXYNORKETAMINE AND (2S, 6S)-HYDROXYNORKETAMINE IN THE TREATMENT OF DEPRESSION,...
Disclosed is a method of treating Psychotic Depression, Suicidal Ideation, Disruptive Mood Dysregulation Disorder, Persistent Depressive Disorder (Dysthymia),...
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