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Patent # Description
2019/0093099 ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF
The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9...
2019/0093098 METHODS AND SUBSTANCES FOR DIRECTED RNA EDITING
The invention relates to methods and substances for the targeted alteration of genetic information on an RNA level. The substances are artificially produced...
2019/0093097 MODIFIED MEMBRANE TYPE SERINE PROTEASE 1 (MTSP-1) POLYPEPTIDES AND METHODS OF USE
Provided are MTSP-1 polypeptides modified to have altered activity and/or specificity so that they cleave a complement protein, such as complement protein C3,...
2019/0093096 COMOSAIN AND BROMELAINS AS IMMUNO-THERAPY IN THE TREATING AND/OR PREVENTING VARIOUS TYPES OF CANCER IN A MAMMAL
The Cloning and Expression of Comosain's Minigene and the Methods and Compositions for treating and/or preventing various types of cancer which comprise...
2019/0093095 BOTULINUM TOXIN-HUMAN EPIDERMAL GROWTH FACTOR FUSION PROTEIN WITH INCREASED SKIN CELL PROLIFERATION AND...
A botulinum toxin-human epidermal growth factor fusion protein with increased skin cell proliferation and anti-oxidation effect has the amino acid sequence of...
2019/0093094 Methods for obtaining positive transformants of a filamentous fungal host cell
The present invention relates to methods for obtaining positive transformants of a filamentous fungal host cell, comprising: transforming a tandem construct...
2019/0093093 Polypeptides Having Cellobiohydrolase Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention...
2019/0093092 RNA GUIDED ERADICATION OF VARICELLA ZOSTER VIRUS
Compositions that specifically cleave target sequences in Herpesviridae, for example Varicella zoster virus (VZV) include nucleic acids encoding a Clustered...
2019/0093091 COMPOSITIONS FOR ERADICATING FLAVIVIRUS INFECTIONS IN SUBJECTS
Compositions that specifically cleave target sequences in Flavivirus, for example Zika virus, include nucleic acids encoding a Clustered Regularly Interspaced...
2019/0093090 Novel CRISPR-Associated Transposases and Uses Thereof
Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for...
2019/0093089 METHODS AND COMPOSITIONS RELATED TO THIOESTERASE ENZYMES
The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of...
2019/0093088 RECOMBINASE POLYMERASE AMPLIFICATION
The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination...
2019/0093087 Polypeptides Having Glucuronyl Esterase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having glucuronyl esterase activity, catalytic domains and polynucleotides encoding the polypeptides or...
2019/0093086 LIGHT-EMITTING ENZYME PROTEIN
The present invention provides a luminescent enzyme protein comprising the amino acid sequence represented by SEQ ID NO: 2, and a mutant enzyme thereof.
2019/0093085 ADENOVIRUS EXPRESSING IMMUNE CELL STIMULATORY RECEPTOR AGONIST(S)
Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
2019/0093084 ISOGENIC BLOOD-BRAIN BARRIER MODEL
A method of creating an isogenic multicellular blood-brain barrier model from iPSCs is disclosed.
2019/0093083 COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g.,...
2019/0093082 Method of Differentiating Pluripotent Stem Cells
An object is to provide a method of differentiating pluripotent stem cells. A method of differentiating pluripotent stem cells, the method comprising steps of:...
2019/0093081 PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER (PINK) CELLS FOR TREATMENT OF GLIOBLASTOMA
Provided provided herein are methods of treating a subject having a brain tumor, e.g., a glioblastoma by administering to the subject an effective amount of a...
2019/0093080 EFFICIENT GENERATION OF HUMAN RED BLOOD CELL VIA ENRICHING PERIPHERAL BLOOD ERYTHROID PROGENITORS
A population of early-stage burst-forming unit-eryhtoid (BFU-E) cells characterized by low expression of the Type III Transforming Growth Factor .beta....
2019/0093079 METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS
Provided are compositions and methods for inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to...
2019/0093078 MEDIUM COMPRISING TRANSFORMING GROWTH FACTOR BETA 1 AND BASIC FIBROBLAST GROWTH FACTOR
The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem...
2019/0093077 DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A LIVER TISSUE
Provided herein relates to devices for simulating a function of a tissue and methods of using the same. In some embodiments, the devices can be used to...
2019/0093076 SCALABLE PRIMATE PLURIPOTENT STEM CELL AGGREGATE SUSPENSION CULTURE AND DIFFERENTIATION THEREOF
The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from...
2019/0093075 METHODS AND COMPOSITIONS FOR EX VIVO EXPANSION OF VERY SMALL EMBRYONIC-LIKE STEM CELLS (VSELS)
Methods for ex vivo expansion of very small embryonic like stem cells in the absence of feeder cells are provided. In some embodiments the methods include...
2019/0093074 METHODS OF DIFFRENTIATING STEM CELL-DERIVED PROPRIOCEPTORS
The presently disclosed subject matter provides for in vitro methods of inducing differentiation of stem cells (e.g., human stem cells) into proprioceptors,...
2019/0093073 INTRACELLULAR DELIVERY
A microfluidic system for causing perturbations in a cell membrane, the system including a microfluidic channel defining a lumen and being configured such that...
2019/0093072 METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS
Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More...
2019/0093071 3D Printing Of A Cellularised Scaffold
The present invention relates to a process for producing a droplet assembly, which droplet assembly comprises a plurality of droplets, wherein each of said...
2019/0093070 METHOD OF PRODUCING THREE-DIMENSIONAL TISSUE HAVING VASCULAR SYSTEM STRUCTURE, AND THREE-DIMENSIONAL TISSUE...
Provided is a method for producing a three-dimensional tissue having a vascular system structure, said method comprising: (a) a step for forming a vascular...
2019/0093069 Thin Film Cell Encapsulation Devices
Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of...
2019/0093068 METHOD FOR MODIFYING THE MORPHOLOGY OF COAGULANT TYPE AGGREGATED FILAMENTOUS FUNGI
The object of the invention is a method for modifying the morphology of coagulant type aggregated filamentous fungi comprising: a) the encapsulation of the...
2019/0093067 Paenibacillus Sp. Strain, Cultivation Method and Use of the Same
Provided are a new Paenibacillus sp. strain, the deposit number of which is CGMCC No. 8333, and a method for culturing the exopolysaccharide; and an...
2019/0093066 CYANOBACTERIA HAVING IMPROVED PHOTOSYNTHETIC ACTIVITY
This disclosure describes modified photosynthetic microorganisms, including Cyanobacteria that have a reduced amount of a light harvesting protein (LHP) and...
2019/0093064 Passive Acoustic Method of Determining Oxygen Production and Photosynthesis Rate of Algae
A bioreactor having passive acoustic quantification of photosynthetic rate determination, comprising a tank for holding a fluid medium for photosynthetic...
2019/0093063 Loading Platform For Three-Dimensional Tissue Engineered Scaffolds
A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human...
2019/0093062 BIOPROCESSING
Bioreactors are provided that include a vessel and a jet mixer disposed in the vessel. Methods that utilize the bioreactors are provided, involving placing a...
2019/0093061 APPARATUS AND METHODS FOR MAGNETIC MIXING
Methods and systems for magnetic mixing. Particular embodiments relate to applying a magnetic field to move a magnetically responsive component in a chamber.
2019/0093060 CELL CULTURE BASE MATERIAL FOR TRAIT INDUCTION CONTROL OF MESENCHYMAL STEM CELLS AND TRAIT CONTROL METHOD THEREOF
A cell culture base material for trait induction control of mesenchymal stem cells including an uneven pattern on a surface to which cells adhere and of which...
2019/0093059 CELL CULTURE DEVICE AND CELL CULTURE METHOD
A cell culture device includes a storage tank having one or a plurality of cell culture units. The cell culture units includes a culture liquid main chamber...
2019/0093058 CELL CULTURE DEVICE AND CELL CULTURE METHOD
A cell culture device includes a storage tank having one or a plurality of cell culture units. Each of the cell culture units includes a first liquid storage...
2019/0093057 UNITARY LAUNDRY DETERGENT ARTICLE
A unitary laundry detergent article that is completely or substantially water-soluble, which contains two or more non-fibrous, surfactant-containing sheets...
2019/0093056 COMPOSITION FOR SURFACE TREATMENT, METHOD FOR PRODUCING COMPOSITION FOR SURFACE TREATMENT, SURFACE TREATMENT...
A composition for surface treatment according to the present invention is used for treating the surface of an object to be polished after polishing, the...
2019/0093055 LAUNDRY METHOD, USE OF POLYPEPTIDE AND DETERGENT COMPOSITION
The present invention concerns a method for laundering a textile, the use of a polypeptide having DNase activity and a detergent composition comprising a...
2019/0093054 DETERGENT COMPOSITIONS COMPRISING LIPASES
Detergent compositions that include a lipase variant of a parent lipase which has lipase activity and includes one or more substitutions corresponding to G23S,...
2019/0093053 MULTIUSE, ENZYMATIC DETERGENT AND METHODS OF STABILIZING A USE SOLUTION
Stabilized use solutions of low phosphorus, alkali metal carbonate detergents employing enzymes for cleaning compositions are disclosed. In particular, the...
2019/0093052 PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2019/0093051 SURFACE TREATMENT COMPOSITION, PREPARATION METHOD THEREOF, SURFACE TREATMENT METHOD USING THE SAME
A surface treatment composition according to the present invention is used for treating a surface of a polished object to be polished which is obtained after...
2019/0093050 USE OF PROPOXYLATED SURFACTANT OR POLYMER IN FOAMING APPLICATIONS TO CONTROL VISCOELASTICITY IN HIGHLY ACTIVE...
Antimicrobial or non-antimicrobial compositions, sanitizing compositions and other compositions combining use of a propoxylated EO/PO block copolymer...
2019/0093049 PROCESS FOR CONTROLLING THE MALODOR "SWEAT", USING BACTERIAL SPORES CAPABLE OF INHIBITING OR PREVENTING THE...
The present disclosure generally relates to a method for degrading laundry malodor "sweat" preferably with regard to the treatment of hard and/or soft...
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