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Patent # Description
2019/0092845 ANTI-ANGPTL3 ANTIBODIES AND USES THEREOF
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human...
2019/0092844 Compositions and Methods for Prophylaxis and/or Therapy of Disorders that Correlate with DENND1A Variant 2
Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse...
2019/0092843 COMPOSITIONS COMPRISING AN ANTI-C5 ANTIBODY
The present application relates to methods and compositions employing an antibody that inhibits activation of the complement system and can be used to prevent...
2019/0092842 ANTI-CGRP COMPOSITIONS AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the...
2019/0092841 Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide and Methods Using Same
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2019/0092840 METHOD FOR ISOLATION OF SOLUBLE POLYPEPTIDES
Polypeptides with desirable biophysical properties such as solubility, stability, high expression, monomericity, binding specificity or non-aggregation,...
2019/0092838 RECOMBINANT YEAST STRAINS
This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the...
2019/0092837 PRION PROTEIN-DENDRIMER CONJUGATES FOR USE IN TREATMENT OF ALZHEIMER DISEASE
The present invention relates to PrP-derived peptide fragments with SEQ ID NO: 1 or SEQ ID NO: 2 or SEQ ID NO: 3 or SEQ ID NO: 4 for use as a medicament in the...
2019/0092836 CARBOHYDRATE CONTENT OF CTLA4 MOLECULES
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions...
2019/0092835 COMPOSITIONS AND METHODS FOR PRODUCING A COMPOSITION
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions...
2019/0092834 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide GVYDGREHTV (SEQ ID NO: 1) derived from the germline cancer...
2019/0092833 INSULIN RECEPTOR PARTIAL AGONISTS
Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
2019/0092832 INTERFERON-BETA ANALOG PEPTIDE
An interferon-beta (IFN.beta.) analog peptide including a plurality of amino acid substitutions in an amino acid sequence of IFN.beta. as set forth in SEQ ID...
2019/0092831 COMPOSITIONS AND METHODS FOR TARGETED CYTOKINE DELIVERY
The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to a...
2019/0092830 INTERLEUKIN 15 FUSION PROTEIN FOR TUMOR TARGET THERAPY
Disclosed is a tumor-targeting fusion protein comprising at least (i) a IL-15 peptide or a variant or functional fragment thereof, (ii) a IL-15R.alpha....
2019/0092829 INHIBITION OF IL-17 PRODUCTION
The invention concerns inhibition of the production of proinflammatory cytokine interleukin-17 (IL-17) by T cells, using an antagonist of interleukin-23...
2019/0092828 ALTERNATIVE NUCLEIC ACID MOLECULES CONTAINING REDUCED URACIL CONTENT AND USES THEREOF
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides...
2019/0092827 Trapped Chemokine Variants as Therapeutic Agents for Inflammation-Related Diseases Including Infections,...
The present invention includes composition and methods of using a recombinant dimeric chemokine covalently modified by introducing a disulfide bond across a...
2019/0092826 ANTIMICROBIAL KINOCIDIN COMPOSITIONS AND METHODS OF USE
The present invention provides novel kinocidin peptides comprising a C-terminal portion of a kinocidin, wherein the C-terminal portion encompasses an...
2019/0092825 INHIBITOR OF ASTROCYTE TNF ALPHA FOR USE IN THE TREATMENT OF NEUROLOGICAL DISEASES
Disclosed is a human mutated form of NGF including two mutations, a first mutation being represented by the substitution of the proline amino acid in position...
2019/0092824 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0092823 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST LUNG CANCER, INCLUDING NSCLC, SCLC...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0092822 BH4 Stabilized Peptides And Uses Thereof
Provided herein are polypeptides containing stabilized BH4 domains of BCL-2 family proteins that are capable of binding and/or inactivating and/or modulating...
2019/0092821 PEPTIDE EXHIBITING HAIR GROWTH PROMOTING ACTIVITY AND/OR MELANIN PRODUCTION PROMOTING ACTIVITY AND USE THEREOF
The present invention relates to a peptide exhibiting hair growth promoting activity and/or melanin production promoting activity, a composition for preventing...
2019/0092820 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR HUMAN AND AVIAN H5N1 INFLUENZA
Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus...
2019/0092819 Desmoglein 2 (DSG2) Binding Proteins and Uses Therefor
The present invention provides recombinant adenoviral compositions and methods for their use in treating disorders associated with epithelial tissues.
2019/0092818 CHIMERIC POLYPEPTIDES AND USES THEREOF
The invention provides novel peptides (e.g., linkers) and polypeptide compositions comprising the linkers (e.g., fusion proteins) and methods of using the...
2019/0092817 FUNCTIONAL LIGANDS TO PEPTIDES
The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for...
2019/0092816 STAPLED PEPTIDES AND USES THEREOF
Cyclized peptides derived from the hyaluronan binding region of RHAMM are provided. Pharmaceutical compositions and methods for using the peptides and...
2019/0092815 PEPTIDE COMPOSITIONS
The present invention relates to polypeptide compounds that are modulators (e.g., agonists and antagonists) of the melanocortin-4 receptor (MC4R) and...
2019/0092814 Peptide
The present invention relates to a method of preventing or treating hemorrhagic shock (HS), or ameliorating symptoms associated with HS in an individual, by...
2019/0092813 IMMUNOGENIC WT-1 PEPTIDES AND METHODS OF USE THEREOF
This invention provides peptides, immunogenic compositions and vaccines, and methods of treating, reducing the incidence of, and inducing immune responses to a...
2019/0092812 CYCLIC PEPTIDE CONJUGATES AND METHODS OF USE
The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound...
2019/0092811 Pediococcus Acidilactici Derived Antimicrobial Hexapeptide and Preparation Method Thereof
The invention discloses a Pediococcus acidilactici derived antimicrobial hexapeptide and a preparation method thereof and belongs to the field of ...
2019/0092810 Thiol-ene Based Peptide Stapling and Uses Thereof
In one aspect, the invention relates to compositions comprising stapled peptides, methods of making same, pharmaceutical compositions comprising same, and...
2019/0092809 NEUROPEPTIDE S RECEPTOR (NPSR) AGONISTS
Neuropeptide S receptor agonists are provided. The NPS agonists include peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S...
2019/0092808 SYNTHESIS AND COMPOSITION OF RAPAFUCIN LIBRARIES
A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided. ##STR00001##
2019/0092807 PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF 11-METHYLENE STEROIDS
The invention relates to a process for the preparation of 11-methylene steroids through selective olefination of the ketone at position 11. The resulting...
2019/0092806 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2019/0092805 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide...
2019/0092804 URACYL SPIROOXETANE NUCLEOSIDES
The present invention relates to compounds of the formula I: ##STR00001## including any possible stereoisomers thereof, wherein R.sup.9 has the meaning as...
2019/0092803 METHOD FOR PRODUCING P1,P4-DI(URIDINE 5'-) TETRAPHOSPHATE
A method for producing P.sup.1,P.sup.4-di(uridine 5'-)tetraphosphate (UP.sub.4U) that can avoid reduction of the synthetic efficiency without using UTP free is...
2019/0092802 ANTAGONISTS OF NK1 RECEPTORS DERIVED FROM CARBOHYDRATES, PRODUCTION METHOD AND MEDICAL USE
The invention relates to a compound of general formula (I), and to the use thereof in medicine, or for the production of a medicament for the treatment of...
2019/0092801 METHOD FOR PREPARING SUCRALOSE-6-ACETATE IN BIPHASIC LIQUID-LIQUID SYSTEM
The present invention discloses a method for preparing sucralose-6-acetate in a biphasic liquid-liquid system. The method comprises slowly dropwise adding an...
2019/0092800 LIQUID CHROMATOGRAPHIC SEPARATION OF CARBOHYDRATE TAUTOMERS
The present invention provides a novel, simple and reliable method for the separation of carbohydrate tautomers. The method comprises steps of ...
2019/0092799 FUSING AGENT INCLUDING A METAL BIS(DITHIOLENE) COMPLEX
An example of a fusing agent includes a metal bis(dithiolene) complex, a thiol surfactant, a polar aprotic solvent, and a balance of water. In an example of a...
2019/0092798 ORGANIC METAL COMPLEX, METHOD FOR PREPARING THE SAME, AND LIGHT-EMITTING ELEMENT INCLUDING THE SAME
Provided are an organic metal complex, its preparation method and light-emitting element containing the complex. The organic metal complex is selected from...
2019/0092797 LOW DK PHOSPHOROUS CONTAINING HARDENER USEFUL FOR HALOGEN FREE, FLAME RETARDANT POLYMERS AND USE
A Formula of a phosphorous fire-retardant hardener having fire-retardant and heat-resistant properties as well as a low-dielectric constant. With a preparation...
2019/0092796 PHOSPHOHISTIDINE MIMETICS AND ANTIBODIES TO SAME
Provided are phosphonopyrazole-based phosphohistidine analogs that are useful as haptens for the preparation of immunogens, immunogens that include these...
2019/0092795 WATER-SOLUBLE ACETAMINOPHEN ANALOGS
The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a...
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