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Patent # Description
2019/0091225 Antihelminthic Medications For Pathogenic Nematodes
Inappropriate activation of innate immune responses in nematode intestinal epithelial cells underlies the pathophysiology of some inflammatory disorders....
2019/0091224 ANTITUBERCULOSIS AGENT
The present invention relates to the use in therapy of 6-((4-(2,3-dimethylphenoxy)piperidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-di- one or a pharmaceutically...
2019/0091223 Inhibitors of Multidrug Resistance Transporter P-Glycoprotein
The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug...
2019/0091222 BENZATHINE ANALOGS
A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: ##STR00001## wherein X is a divalent linking moiety; and ...
2019/0091221 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS
Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The...
2019/0091220 TARGETING PARP1 FOR TREATMENT OF TSC AND CANCERS
The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising...
2019/0091219 Treatment of Vasomotor Symptoms
The invention relates to a method for the treatment of vasomotor symptoms comprising the administration of a therapeutically effective amount of flibanserin.
2019/0091218 LEVOCETIRIZINE AND MONTELUKAST IN THE TREATMENT OF RADIATION-MEDIATED CONDITIONS
Certain embodiments described herein include methods and formulations for treating or preventing symptoms and conditions associated with exposure to ionizing...
2019/0091217 METHODS FOR INHIBITING TIE-2 KINASE USEFUL IN THE TREATMENT OF CANCER
The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination,...
2019/0091216 MACROLIDE COMPOUNDS AND THEIR USE IN LIVER STAGE MALARIA AND RELATED DISEASE
A novel quantum-based computational process for drug discovery and design was used to identify potential novel liver-stage anti-malarial therapeutic molecules....
2019/0091215 Method of Treating Cancer
This invention is directed to the treatment of cancer, particularly ocular melanoma, with a dual inhibitor of MET and VEGF such as Compound 1. ##STR00001##
2019/0091214 USE AND COMPOSITION FOR TREATING DEMENTIA
There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient...
2019/0091213 OPHTHALMIC COMPOSITION
Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment...
2019/0091212 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR PRODUCING LOW IMPURITY CONCENTRATIONS OF THE SAME
A composition having clevidipine as an active ingredient is described. The composition includes clevidipine as an active ingredient and an amount of the...
2019/0091211 PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY
The invention provides a compound of Formula I, ##STR00001## Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment...
2019/0091210 RING-FUSED THIAZOLINO 2-PYRIDONES, METHODS FOR PREPARATION THEREOF AND THEIR USE IN THE TREATMENT AND/OR...
The present disclosure provides a combination comprising: (i) a drug against tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of...
2019/0091209 METHODS AND COMPOSITIONS FOR TREATMENT OF EPILEPTIC DISORDERS
Use of allosteric modulators and/or gaboxadol for the treatment of epileptic disorders in a subject in need thereof.
2019/0091208 USE OF FK506 FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION
A method for reducing pulmonary hypertension in a mammal that employs FK506 is provided. In certain embodiments, the method comprises administering FK506 to a...
2019/0091207 Treatment Of CDKL5 Disorders With GSK3B Inhibitor Tideglusib
Provided herein are methods of treating a CDKL5 deficiency with tideglusib or a derivative thereof.
2019/0091206 SMALL MOLECULE DUAL-INHIBITORS OF TRPV4 AND TRPA1 FOR SANITIZING AND ANESTHETIZING
Provided are methods of sanitizing a subject, and methods of anesthetizing a subject. Further provided are methods of treating and/or preventing dermatological...
2019/0091205 Methods and compositions for inhibiting mutant EGFR signaling
Methods of inhibiting mutant EGFR and methods of treating a subject afflicted with a lung cancer having a mutant EGFR, having for example a C797 mutation, are...
2019/0091204 COMPOSITIONS OF DEFERASIROX
The present invention relates to solid oral pharmaceutical compositions comprising Deferasirox or a pharmaceutical acceptable salt thereof and one or more...
2019/0091203 DOSAGE REGIMEN FOR THE TREATMENT OF ACUTE EXACERBATIONS OF INFLAMMATORY CONDITIONS
This invention relates to a novel dosage regimen for administration of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzami- de or a...
2019/0091202 PHARMACEUTICAL AGENTS TARGETING CANCER STEM CELLS
Methods for preventing or treating subjects having cancer based on the identification of pharmaceutical agents that target cancer stem cells (CSCs) have been...
2019/0091201 PKC-DELTA-I INHIBITOR FORMULATIONS AND USES THEREOF
Provided herein are formulations that can contain an effective amount of a PKC.delta. inhibitor. Also provided herein are methods of inhibiting a PKC.delta. in...
2019/0091200 ULTRAPURE TETRAHYDROCANNABINOL-11-OIC ACIDS
This application is in the field of medicinal chemistry and relates to ultrapure ajulemic acid, its synthesis, pharmaceutical compositions and methods of use...
2019/0091199 THE USE OF HOMOERIODICTYOL (HED) FOR REDUCING THE GASTRIC ACID SECRETION-STIMULATING EFFECT OF...
The present invention primarily relates to the use of Homoeriodictyol (HED) or a salt thereof or a mixture of HED and one or more salts thereof or a mixture of...
2019/0091198 CANNABIONID AND CANNABIS-BASED COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS OF THE...
The invention provides compositions and methods for treating inflammatory condition of the gastrointestinal (GI) tract, specifically those related to...
2019/0091197 POTENTIATED TULATHROMYCIN
The invention relates to enhanced tulathromycin for use in the treatment, metaphylaxis or prevention of a microbial infection, characterized in that a compound...
2019/0091196 Pharmaceutical Compositions of Dimethyl Fumarate
Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
2019/0091195 USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN...
Substituted hexitol derivatives such as dianhydrogalactitol are useful in the treatment of various neoplastic pathologies. Said pathologies include ...
2019/0091194 METHODS OF TREATING AND PREVENTING ENDOTHELIAL DYSFUNCTION USING BARDOXOLONE METHYL OR ANALOGS THEREOF
The present invention concerns methods for treating and preventing endothelial dysfunction and related disorders, including, for example, pulmonary arterial...
2019/0091193 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2019/0091192 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2019/0091191 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING A FUMARIC ACID ESTER
The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are...
2019/0091189 ADMINISTRATION OF EXOGENOUS KETONE TO LOWER BLOOD GLUCOSE
Provided herein are compositions and methods for reducing blood glucose in a subject.
2019/0091188 Therapy for Transthyretin-Associated Amyloidosis
It is provided a catechol-O-methyltransferase (COMT) inhibitor for use in the prevention and/or treatment of transthyretin-associated amyloidosis. It is also...
2019/0091187 COMPOSITIONS AND METHODS FOR USE OF EFLORNITHINE AND DERIVATIVES AND ANALOGS THEREOF TO TREAT CANCERS INCLUDING...
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress...
2019/0091186 PREVENTION, TREATMENT AND REVERSAL OF DISEASE USING THERAPEUTICALLY EFFECTIVE AMOUNTS OF DICARBOXYLIC ACID...
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments...
2019/0091185 Solid Solution Compositions and Use in Chronic Inflammation
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
2019/0091184 ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE
Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods...
2019/0091183 REDOX-ACTIVATED PRO-CHELATORS
Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so...
2019/0091182 AQUAPORIN 4 FUNCTION PROMOTOR AND PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS
An aquaporin 4 function promotor contains a compound represented by Formula (1) or (2) or a pharmaceutically acceptable salt thereof, as an active ingredient. ...
2019/0091181 MITORIBOSCINS: MITOCHONDRIAL-BASED THERAPEUTICS TARGETING CANCER CELLS, BACTERIA, AND PATHOGENIC YEAST
The present disclosure relates to inhibitors of mitochondrial function. Methods of screening compounds for mitochondrial inhibition are disclosed. Also...
2019/0091180 DOSAGE REGIMEN FOR A S1P RECEPTOR AGONIST
S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the...
2019/0091179 CONGNITIVE FUNCTION WITH FENFLURAMINE
Disclosed herein are methods of improving cognitive function in a patient as measured by, for example, improvement in score on a validated scale that measures...
2019/0091178 KETOGENIC DIET COMPATIBLE FENFLURAMINE FORMULATION
A method of treating symptoms of a subtype of epilepsy, e.g., Dravet syndrome, in a patient diagnosed with a subtype of epilepsy, by administering to the...
2019/0091177 METHOD OF TREATING SELECTED PATIENT POPULATION EXPERIENCING DRAVET SYNDROME
Provided herein is a method of treating a selected patient population, wherein the patient population is selected based on a determination that the patients...
2019/0091176 METHOD OF TREATING SELECTED PATIENT POPULATION EXPERIENCING DRAVET SYNDROME
Provided herein is a method of treating a selected patient population, wherein the patient population is selected based on a determination that the patients...
2019/0091175 METHOD OF REDUCTION MEDICATION IN TREATING DRAVET SYNDROME
A method of reducing dosing of a concomitant medication in a human patient diagnosed with Dravet syndrome, by administering to the patient a therapeutically...
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