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Patent # Description
2019/0100773 METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous...
2019/0100772 NON-HUMAN ANIMALS EXPRESSING HUMANIZED C1Q COMPLEX
Disclosed herein are nucleic acids encoding for and proteins expressing chimeric C1q polypeptides, non-human animals comprising said nucleic acids, and methods...
2019/0100771 Transgenic rabbit with common light chain
Herein is reported a transgenic vector comprising a humanized light chain locus, wherein said humanized light chain locus comprises (a) a V gene segment...
2019/0100770 DESIGN METHOD FOR SYNTHETIC GENES
The present invention provides a method of designing an optimized gene which comprises altering a nucleotide sequence of a target protein gene, so that only...
2019/0100769 MASSIVELY PARALLEL COMBINATORIAL GENETICS FOR CRISPR
Described herein are methods and compositions that enable rapid generation of high-order combinations of genetic elements comprising a CRISPR guide sequence...
2019/0100768 Tospovirus Resistant Plants and Methods Thereof
The present invention provides tomato plants exhibiting resistance to TOSPO (GBNV) Virus exhibiting the traits of healthy and evenly ripened fruits without...
2019/0100767 POLYNUCLEOTIDES, POLYPEPTIDES ENCODED THEREBY, AND METHODS OF USING SAME FOR INCREASING ABIOTIC STRESS...
Provided are methods of increasing tolerance of a plant to abiotic stress, and/or increasing biomass, growth rate, vigor and/or yield of a plant. The methods...
2019/0100766 METHOD FOR INCREASING NITROGEN-USE EFFICIENCY IN PLANTS
Disclosed herein is a method of improving yield, growth and/or nitrogen use efficiency in plants comprising altering the expression profile of NRT. Also...
2019/0100765 AP2 DOMAIN TRANSCRIPTION FACTOR ODP2 (OVULE DEVELOPMENT PROTEIN 2) AND METHODS OF USE
Methods and compositions for modulating plant development are provided. Nucleotide sequences and amino acid sequences encoding Ovule Development Protein 2...
2019/0100764 PLANT PROMOTER FOR TRANSGENE EXPRESSION
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a promoter from a...
2019/0100763 Haploid Induction Compositions and Methods for Use Therefor
Provided are isolated cDNAs comprising a nucleotide sequence having at least 90% identity to SEQ ID NO: 33, SEQ ID NO: 37, SEQ ID NO: 52 or SEQ ID NO: 53. Also...
2019/0100762 NOVEL CAS9 SYSTEMS AND METHODS OF USE
Compositions and methods are provided for novel Cas9 systems, including, but not limiting to, novel guide polynucleotide/Cas9 endonucleases complexes, single...
2019/0100761 COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION AND VIRAL REPLICATION
The invention generally relates to compositions (including polynucleotides, constructs, fusion proteins, vectors, and cells) and methods of using such...
2019/0100760 METHODS AND COMPOSITIONS FOR TREATING ATHEROSCLEROSIS
In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that...
2019/0100759 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES
The present disclosure provides expression vectors comprising at least two nucleic acid sequences, namely a nucleic acid sequence encoding an anti-HPRT RNAi,...
2019/0100758 Methods of Treating Colorectal Cancer
Disclosed herein are methods for treating/and or preventing colorectal cancer using a specific inhibitor of SMAD7 expression or function. Also disclosed are...
2019/0100757 CONSERVED HBV AND HCV SEQUENCES USEFUL FOR GENE SILENCING
Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the...
2019/0100756 CpG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION INCLUDING THE SAME, AND METHOD OF INDUCING IMMUNE RESPONSE BY...
A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is...
2019/0100755 OLIGONUCLEOTIDES FOR TREATING EXPANDED REPEAT DISEASES
The invention provides for a method for selectively reducing the expression of a mutant mRNA and/or protein having an expanded nucleotide repeat relative to a...
2019/0100754 METHODS AND MEANS FOR EFFICIENT SKIPPING OF AT LEAST ONE OF THE FOLLOWING EXONS OF THE HUMAN DUCHENNE MUSCULAR...
The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD...
2019/0100753 Nuclease Resistant Polynucleotides and Uses Thereof
The invention provides, among other things, methods of stabilizing mRNA and nuclease resistant mRNA prepared in accordance with such methods. In certain...
2019/0100752 CHEMICALLY MODIFIED MESSENGER RNA'S
This invention provides messenger RNA (mRNA) molecules comprising an open reading frame that encodes a protein of interest, wherein said modified RNA comprises...
2019/0100751 METHODS FOR SORTING NUCLEIC ACIDS AND MULTIPLEXED PREPARATIVE IN VITRO CLONING
Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid...
2019/0100750 Rapid Methods for the Extraction of Nucleic Acids from Biological Samples
The invention is directed to compositions and methods for rapidly and efficiently extracting nucleic acids and/or targeted nucleic acids sequences from...
2019/0100749 A Method for Prenatal Diagnosis Using Digital PCR
The present invention relates to a method for prenatal diagnosis using digital PCR, and more particularly to a method for providing information for diagnosis...
2019/0100748 REMOVAL OF DNA FRAGMENTS IN MRNA PRODUCTION PROCESS
The present invention describes methods of removing DNA from an RNA transcript during the mRNA production process. The method embodies procedures for obtaining...
2019/0100747 PURIFICATION AND DETECTION OF ANALYTES
A sample preparation module accepts a sample including a target analyte. The sample preparation module processes the sample through several reaction chambers...
2019/0100746 USE OF AN AQUEOUS COMPOSITION FOR DISSOLVING BIOMOLECULES FROM A TISSUE SAMPLE
The present invention relates to the use of an aqueous composition for dissolving biomolecules from a tissue sample and to a method of using an aqueous...
2019/0100745 NOVEL CAS SYSTEMS AND METHODS OF USE
Compositions and methods are provided for genome modification of a target sequence in the genome of a cell. The methods and compositions employ a guide...
2019/0100744 METHOD OF MAKING A VACCINE
A method of producing attenuated cells for a mammalian vaccine comprising killing or attenuating the cells with a high energy, low heat UV light.
2019/0100743 METHOD OF MAKING A VACCINE
A method of producing attenuated cells for a mammalian vaccine comprising killing or attenuating the cells with a high energy, low heat UV light.
2019/0100742 3-METHYLCROTONIC ACID DECARBOXYLASE (MDC) VARIANTS
Described are 3-methylcrotonic acid decarboxylase (MDC) variants showing an improved activity in converting 3-methylcrotonic acid into isobutene as well as...
2019/0100741 BIOSYNTHESIS OF PRODUCTS FROM 1-CARBON COMPOUNDS
An engineered microbe that contains a designed platform for the conversion of one-carbon substrates to chemical products is described. The designed platform...
2019/0100740 Modified Strains for the Production of Recombinant Silk
Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the...
2019/0100739 METHODS FOR THE MANUFACTURE OF PROTEOLYTICALLY PROCESSED POLYPEPTIDES
The present invention relates to a novel protcolytically active polypeptide and various uses of the polypeptide (and others) in screening and manufacturing...
2019/0100738 A Liquid Formulation of Alpha-Amylase
The present disclosure relates to liquid enzyme formulations containing one or more alpha-amylases for use in starch processing, wherein the pH of the enzyme...
2019/0100737 PEPTIDE-MEDIATED DELIVERY OF RNA-GUIDED ENDONUCLEASE INTO CELLS
A composition is disclosed that comprises at least one protein component of an RNA-guided endonuclease (RGEN) and at least one cell-penetrating peptide (CPP),...
2019/0100736 METHOD FOR USING HEAT-RESISTANT MISMATCH ENDONUCLEASE
Provided are a mismatch-specific cleavage reaction using a novel heat-resistant mismatch nuclease, a method for removing errors in a nucleic acid amplification...
2019/0100735 Neurodegenerative disorders
A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a...
2019/0100734 PHYTASE
Polypeptides having phytase activity and polynucleotide sequences encoding the phytases are provided. The gene expresses the phytase at a level of at least 7...
2019/0100733 FACTORS FOR THE PRODUCTION AND ACCUMULATION OF POLYUNSATURATED FATTY ACIDS (PUFAS) DERIVED FROM PUFA SYNTHASES
Factors For the Production and Accumulation of Polyunsaturated Fatty Acids (PUFAs) Derived from PUFA Synthases Abstract Disclosed are novel enhancing factor...
2019/0100732 ASSAY FOR THE REMOVAL OF METHYL-CYTOSINE RESIDUES FROM DNA
An isolated polynucleotide encoding a fusion protein which comprises a catalytically inactive CRISPR associated 9 (dCas9) protein linked to a TET protein is...
2019/0100731 EX-VIVO INTESTINAL CULTURE MODEL, METHODS OF PRODUCING SAME AND USES THEREOF
A method of preparing an ex-vivo intestinal culture model is provided. The method comprising: (a) providing an intestinal tissue sample; (b) treating the...
2019/0100730 TREATING DIABETES WITH GENETICALLY MODIFIED BETA CELLS
Described herein are human transgenic beta cells expressing fugetactic levels of CXCL12 to a subject in need thereof. Also described herein are beta cells...
2019/0100729 TREATING DIABETES WITH GENETICALLY MODIFIED BETA CELLS
Described herein are human transgenic beta cells expressing fugetactic levels of CXCL12 to a subject in need thereof. Also described herein are beta cells...
2019/0100728 CULTURE MEDIUM FOR EPITHELIAL STEM CELLS AND ORGANOIDS COMPRISING THE STEM CELLS
The invention relates to a method for culturing epithelial stem cells, isolated tissue fragments comprising the epithelial stem cells, or adenoma cells, and...
2019/0100727 Cells for Therapy of the Heart
According to the invention fibroblast-like cells obtained from heart muscle biopsies, which are CD90 negative, CD105 positive, CD117 negative and/or CD166...
2019/0100726 METHOD TO OBTAIN VEGETABLE FIBERS FROM THE ISOLATION AND CULTIVATION OF MERISTEMATIC CELLS
A method to obtain vegetable fibers from vegetable specimen xylematic tissue meristematic cambial cells is provided. The method implies the identification and...
2019/0100725 CELL CULTURE MEDIUM AND CULTURE MEDIUM SUPPLEMENT
In one aspect, the present disclosure relates to a substantially albumin-free, chemically defined medium for efficiently supporting stem cell differentiation...
2019/0100724 CELL CULTURE MEDIUM, CULTURE METHOD, AND ORGANOID
The present invention provides a cell culture medium with which serum-free long-term culture of an epithelial stem cell, an epithelial cancer cell, or a tissue...
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