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Patent # Description
2019/0100571 CHIMERIC ANTIGEN RECEPTOR
The present invention provides a chimeric antigen receptor (CAR) comprising; (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least...
2019/0100570 ALK4:ACTRIIB HETEROMULTIMERS AND USES THEREOF
In certain aspects, the disclosure provides soluble heteromeric polypeptide complexes comprising an extracellular domain of an ALK4 receptor and an...
2019/0100569 METHOD FOR PREPARING GLUCAGON-LIKE PEPTIDES
The present invention refers to a method for preparing a glucagon-like peptide, comprising precipitation of the peptide or of a precursor peptide by means of...
2019/0100568 INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF
The present invention relates to interleukin-4 receptor-binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that...
2019/0100567 INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF
The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that...
2019/0100566 NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST LUNG CANCER, INCLUDING NSCLC, SCLC...
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
2019/0100565 A TENTOXIN SYNTHESIS GENE, A METHOD FOR PRODUCING TENTOXIN OR DIHYDROTENTOXIN USING THE SAME, AND A...
An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having...
2019/0100564 Methods for Purifying Clostridial Neurotoxin
A method for purifying a clostridial neurotoxin comprising contacting a cation exchange resin with a composition comprising a clostridial neurotoxin, wherein...
2019/0100563 PROTEINS WITH DIAGNOSTIC AND THERAPEUTIC USES
The present invention provides a recombinant protein capable of binding to complement factor H (CFH), and thereby inducing increased binding of C3d and C3b by...
2019/0100562 ANTIVIRAL PEPTIDE AND USE THEREFOR
An antiviral peptide provided by the present invention includes: (1) the signal sequence of a glycoprotein encoded for by the G gene of the vesicular...
2019/0100561 HERPES SIMPLEX VIRUS VACCINE
Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid...
2019/0100560 Ancestral Virus Sequences and Uses Thereof
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated...
2019/0100559 GAMMA-AAPEPTIDES WITH POTENT AND BROAD-SPECTRUM ANTIMICROBIAL ACTIVITY
The present invention is directed to a novel class of antimicrobial agents called .gamma.-AApeptides. The current invention provides various categories of...
2019/0100558 TEMPLATE-FIXED PEPTIDOMIMETICS
The template-fixed .beta.-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-.sup.DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-.sup.D-P- ro-Pro), disulfide bond between...
2019/0100557 PROTRANSDUZIN B, A GENE TRANSFER ENHANCER
An N-terminally protected peptide having the sequence TABLE-US-00001 (SEQ ID NO: 1) X-Glu-Cys-Lys-Ile-Lys-Gln-Ile-Ile-Asn-Met-Trp-Gln, wherein X is a group...
2019/0100556 PEPTIDE WITH ANTI-OBESITY AND ANTI-DIABETIC EFFICACY AND USE THEREOF
The present invention provides a peptide with an anti-obesity and/or anti-diabetic activity consisting of an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO:...
2019/0100555 EYE-CARE PEPTIDE, ITS COMPOSITION AND METHOD OF USING THE SAME
Disclosed is related to a synthetic peptide consisting of an amino acid sequence of ArgAsnProLeuGluGluThr (SEQ ID NO: 1). Also provided are a pharmaceutical...
2019/0100554 METHOD FOR SYNTHESIZING ETELCALCETIDE OR SALTS THEREOF
The present invention provides a method for synthesizing etelcalcetide or salts thereof, comprising the steps of: (a) synthesizing the D-amino acids in the...
2019/0100553 DIRECT ACTIVITY ASSAYS AND COMPOSITIONS FOR NUCLEOTIDE POOL SANITIZING ENZYMES
Compositions and methods are provided for detecting activity of nucleotide pool repair enzymes. In the methods of the invention, a sample suspected of having...
2019/0100552 INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF
The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of...
2019/0100551 5-FLUOROURIDINE MONOPHOSPHATE CYCLIC TRIESTER COMPOUNDS
Provided herein are 5-fluorouridine monophosphate cyclic triester compounds, their preparation and their uses, such as treating hepatocellular carcinoma and...
2019/0100550 POLYMORPHIC FORMS OF SOFOSBUVIR
The present disclosure provides novel crystalline sofosbuvir form-M3 and a process for the preparation of sofosbuvir form-M3. The crystalline sofosbuvir...
2019/0100549 FLAVONOIDE-TYPE COMPOUNDS BEARING AN O-RHAMNOSYL RESIDUE
The present invention relates to compounds of formula (II) ##STR00001## useful in the treatment of many diseases such as a skin disease, an allergy, an...
2019/0100548 Anthracycline Derivatives For Treating Tumor Diseases
The invention relates to anthracycline derivative compounds for treating tumor diseases, and related methods, compositions, and kits.
2019/0100547 METHOD FOR PREPARING 2'-O-FUCOSYLLACTOSE
The present invention relates to a method for preparing 2'-O-fucosyllactose and to the protected fucosyl donor of the formula (I) used in this method. The...
2019/0100546 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: ##STR00001## wherein, in Formula 1, groups and variables are the same as described in the specification.
2019/0100545 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC...
An organometallic compound represented by Formula 1: ##STR00001## wherein, in Formula 1, groups and variables are the same as described in the specification.
2019/0100544 ORGANIC LUMINESCENT MATERIALS CONTAINING TETRAPHENYLENE LIGANDS
Organic luminescent materials containing tetraphenylene ligands are disclosed, which can be used as emitters in the emissive layer of an organic...
2019/0100543 IRIDIUM COMPLEX AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME
The present invention discloses an iridium complex of formula (1) and an organic electroluminescence device employing the iridium complex as the phosphorescent...
2019/0100542 CRYSTAL FORM OF TENOFOVIR ALAFENAMIDE SALT, PREPARATION METHOD AND USE THEREOF
Disclosed are a new polymorph II, crystal form A and B of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]- methoxy]propyl]adenine...
2019/0100541 DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER
The invention provides compounds of the formula: ##STR00001## R.sup.1 is OR.sup.11, or NR.sup.5R.sup.5'; R.sup.2 is H or F; R.sup.5 is H, C.sub.1-C.sub.6alkyl,...
2019/0100540 METHOD FOR PRODUCING MONOMER FOR SINGLE-STRANDED NUCLEIC ACID MOLECULE
A compound represented by formula (3): ##STR00001## or an enantiomer thereof can be obtained by comprising: reacting a compound represented by formula (1): ...
2019/0100539 POLYARYLATION OF POLYHEDRAL BORANES
A polyarylborane comprising a substituted polyhedral borane comprising at least 3 exohedrally bonded aryl groups, wherein the substituted polyhedral borane is...
2019/0100538 PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF
The present invention provides processes for the preparation of baricitinib of Formula I and an intermediate of Formula V. The present invention also provides...
2019/0100537 CURCUMIN-BORON COMPLEX AND PHARMACEUTICAL CONTAINING SAME
Provided is a compound which is bioapplicable and amyloid-selective, and is useful as an amyloid oxygenation catalyst applicable not only to A.beta. peptides...
2019/0100536 ANDROGEN RECEPTOR MODULATING COMPOUNDS
The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions...
2019/0100535 6-ARYL-7-SUBSTITUTED-3-(1H-PYRAZOL-5-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]T- HIADIAZINES AS INHIBITORS OF THE...
Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are...
2019/0100534 Cephem Compounds with Latent Reactive Groups
Cephem and penem compounds having a styrylmethylene moiety at the 3-position in the cephem or penem ring to which a positively charged leaving group is bonded...
2019/0100533 PROCESS FOR PREPARING CARBAMOYLPYRIDONE DERIVATIVES AND INTERMEDIATES
The present invention relates to the preparation of carbamoylpyridone derivatives such as the compound of formula (VI): ##STR00001##
2019/0100532 PROCESS FOR PREPARING PYRIDINONE CARBOXYLIC ACID DERIVATIVES AND INTERMEDIATES
The present invention relates to the preparation of the pyridinone carboxylic acid of formula IV: ##STR00001##
2019/0100531 HETEROCYCLIC COMPOUND USED AS FGFR INHIBITOR
A heterocyclic compound is described, which is an inhibitor of FGFR (fibroblast growth factor receptor). Specifically, it is a compound represented by the...
2019/0100530 BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
The invention provides novel compounds having the general formula I: ##STR00001## wherein R.sup.1, the A ring and the B ring are as described herein, ...
2019/0100529 POLYMORPH OF DPPIV INHIBITOR MALEATE AND PREPARATION METHOD THEREFOR
The invention describes a polymorph of (R)-methyl-2-(3-aminopiperidin-1-yl)-3-(2-cyanobenzyl)-4-carbonyl-3,4-dih- ydrothiophene[3,2-d]pyrimidine-6-carboxylic...
2019/0100528 EGFR INHIBITOR, PREPARATION METHOD AND USE THEREOF
Epidermal growth factor receptor (EGFR) inhibitors are provided. In particular, 4-substituted-2-(N-(5-substituted ally amide)phenyl)amino)pyrimidine...
2019/0100527 Process For Preparing AD-35
Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention...
2019/0100526 Fused Hexacyclic Imidazole Derivatives as Modulators of TNF Activity
A series of substituted fused hexacyclic benzimidazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are...
2019/0100525 Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity
A series of substituted fused pentacyclic benzimidazole derivatives, and analogues thereof, being potent modulators of human TNF.alpha. activity, are...
2019/0100524 FIRST-IN-CLASS OF SHMT2 AND MTHFD2 INHIBITORS AS ANTITUMOR AGENTS
A compound of the Formula I and optionally a pharmaceutically acceptable salt thereof is provided: ##STR00001## Formula I, wherein, R is one selected from the...
2019/0100523 SYNTHESIS OF 2'-FLUORO-6'-METHYLENE-CARBOCYCLIC ADENOSINE (FMCA) AND 2'-FLUORO-6'-METHYLENE-CARBOCYCLIC...
The invention provides a new convergent approach for the synthesis of 2'-fluoro-6'- methylene-carbocyclic adenosine (FMCA) and ...
2019/0100522 PROCESSES FOR THE PREPARATION OF CIS-4-[2-{[(3S,4R)-3-FLUOROOXAN-4-YL]AMINO}-8-(2,4,6-TRICHLOROANILINO)-9H- ...
Provided herein are processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H- ...
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