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Patent # Description
2019/0105321 TREATMENT FOR DIABETES IN PATIENTS INAPPROPRIATE FOR METFORMIN THERAPY
The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases,...
2019/0105320 PHARMACEUTICAL COMPOSITIONS FOR INTRAOCULAR ADMINISTRATION AND METHODS FOR FABRICATING THEREOF
Pharmaceutical compositions for intraocular injection are described, the compositions consisting essentially of a therapeutically effective quantity of an...
2019/0105319 VESICULAR MONOAMINE TRANSPORTER 2 INHIBITORS FOR TREATING STUTTERING
Provided herein are pharmaceutical compositions comprising a vesicular monoamine transporter 2 (VMAT2) inhibitor (e.g., deutetrabenazine) and an excipient...
2019/0105318 EMETINE COMPOUNDS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION
The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of...
2019/0105317 Stabilizing Camptothecin Pharmaceutical Compositions
Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can...
2019/0105316 Inhalable Nicotine Formulations, and Methods of Making and Using Thereof
The present invention provides dry powder formulations comprising nicotine, methods of using the same, and methods for making the same. The dry powder...
2019/0105315 COMPOSITIONS AND METHODS FOR TREATMENT RELATED TO FALL AND FALL FREQUENCY IN NEURODEGENERATIVE DISEASES
The present disclosure provides methods and compositions for treating fall-related symptoms in patients with neurodegenerative diseases such as Parkinson's...
2019/0105314 Methods and Compositions for Treating Aging-Associated Impairments Using CCR3-Inhibitors
Methods of improving neurodegenerative disease with CCR3 modulating agents are provided. The methods include administering a therapeutically effective amount...
2019/0105313 PSILOCYBIN COMPOSITIONS
Methods and compositions are disclosed for enhancing neurogenesis, resolving neuropathy and improving neurological health and functioning using fungal extracts...
2019/0105312 P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including...
2019/0105311 P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including...
2019/0105310 PHARMACEUTICAL FORMULATIONS COMPRISING A PYRIDYLAMINOACETIC ACID COMPOUND
Provided is a pharmaceutical preparation for treatment or prevention of glaucoma or ocular hypertension, comprising 0.0003 to 0.01% (w/v) of isopropyl...
2019/0105309 Formylated N-heterocyclic derivatives as FGFR4 inhibitors.
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; ##STR00001## a method for manufacturing said compound,...
2019/0105308 METHODS OF TREATING DEVELOPMENTAL DISORDERS AND/OR SEIZURE DISORDERS WITH FLUPIRTINE
Methods of treating developmental disorders and/or seizure disorders with flupirtine or a pharmaceutically acceptable salt thereof are provided. The methods...
2019/0105307 NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound...
2019/0105306 TIOTROPIUM INHALATION SOLUTION FOR NEBULIZATION
The present invention relates to a sterile pharmaceutical composition comprising tiotropium or a pharmaceutically acceptable salt thereof, for inhalation via...
2019/0105305 PARASITICIDAL ORAL VETERINARY COMPOSITIONS COMPRISING SYSTEMICALLY-ACTING ACTIVE AGENTS, METHODS AND USES THEREOF
This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting...
2019/0105304 TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme...
2019/0105303 PHARMACEUTICAL COMBINATIONS
Provided herein are pharmaceutical combinations comprising (a) a B-Raf inhibitor, or a pharmaceutically acceptable salt thereof, (b) at least one mitogen...
2019/0105302 1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS
The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the...
2019/0105301 Ready to Use Ketorolac Formulations
Disclosed in certain embodiments is a pharmaceutical composition for parenteral administration comprising: an aqueous solution comprising ketorolac or a...
2019/0105300 ALA AND SALT FORMULATION
The addition of a salt to an ALA formulation that is dissolved in the mouth unexpectedly significantly reduces the degree of burning or irritation from ALA...
2019/0105299 LYMPH DIRECTING PRODRUGS
The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that promote transport of a pharmaceutical agent to...
2019/0105298 CANNABIS-ENRICHED ENZYMATICALLY TREATED THERAPEUTIC COMPOSITION
A cannabis-enriched enzymatically treated therapeutic composition. A therapeutic composition is described including water, glucose, glucose reaction product...
2019/0105297 METHOD OF TREATMENT
Embodiments of the invention relate to the treatment of sleep disturbances in individuals with Smith-Magenis Syndrome (SMS).
2019/0105296 DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this...
2019/0105295 Method Of Treatment Of Obesity
The present invention provides compositions and pharmaceutical compositions of GPR84 agonists and GPR120 agonists for us in the treatment of obesity and...
2019/0105294 AMINO ACID COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIVER DISEASES
This disclosure provides pharmaceutical compositions comprising amino acid entities and uses thereof. Methods for improving liver function and for treating...
2019/0105293 FORMULATION AND METHOD FOR THE PREVENTION AND/OR TREATMENT OF HANGOVER SYMPTOMS
A formulation and a method for treating, preventing, ameliorating or alleviating in a patient the symptoms of hangover, or of veisalgia, associated with a bout...
2019/0105292 RECEPTOR SUBTYPE AND FUNCTION SELECTIVE RETINOID AND REXINOID COMPOUNDS IN COMBINATION WITH IMMUNE MODULATORS...
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or...
2019/0105291 Treatment of cholestatic pruritus
Treatment of cholestatic pruritus by therapy with seladelpar or a salt thereof.
2019/0105290 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING TRIGEMINAL AUTONOMIC CEPHALGIAS, MIGRAINE, AND VASCULAR...
The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other...
2019/0105289 Compounds for use in the treatment of cancer
It is an aim of the present invention to provide inhibitors of human diphtheria toxin-like ADP-ribosyltransferases, such as ARTD10, for use as a medicine. It...
2019/0105288 EPINEPHRINE FORMULATIONS
Pharmaceutical compositions comprising epinephrine, methods of administration, and methods of making the same. Compositions may comprise at least one of an...
2019/0105287 Liposomal Curcumin for Treatment of Cancer
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human...
2019/0105286 Curcuminoid Compositions and Preparation Methods
Provided herein are solid form water soluble curcuminoid compositions, including a curcuminoid; and a solubilization matrix, wherein the solubilization matrix...
2019/0105285 Curcuminoid Chlorophyllin (CHL) Compositions And Methods of Preparation And Use
Provided herein are solid form water soluble curcuminoid compositions, including a curcuminoid; and a solubilization matrix, wherein the solubilization matrix...
2019/0105284 Compositions of Xanthorrhizol and Tocochromanol (Tocotrienol), and Methods of Use
A dietary supplement composition provided synergistic effects of xanthorrhizol and tocotrienol on malignancies. A blend of xanthorrhizol and delta tocotrienol...
2019/0105283 DELIVERY SYSTEMS
Methods for manufacturing drug delivery systems are provided. The drug delivery systems may include a substrate coated with at least one polymer and at least...
2019/0105282 THIN-SHELL POLYMERIC NANOPARTICLES AND USES THEREOF
A polymeric nanoparticle that has a size of 30-600 nm in outer diameter and contains a polymeric shell, less than 25 nm in thickness and impermeable to water,...
2019/0105281 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides...
2019/0105280 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF
The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides...
2019/0105279 MICROFLUIDICS DEVICE FOR FABRICATION OF LARGE, UNIFORM, INJECTABLE HYDROGEL MICROPARTICLES FOR CELL ENCAPSULATION
The devices, methods, and compositions disclosed herein accomplish robust cell encapsulation in polymer microparticles using a vertically oriented microfluidic...
2019/0105278 SHELLAC MICROCAPSULE FORMULATIONS AND COMPOSITIONS
The present invention relates to microcapsules comprising a core containing an active substance, which are characterised by a coating layer system comprising...
2019/0105277 PHARMACEUTICAL COMPOSITION COMPRISING AN ATYPICAL ANTIPSYCHOTIC AGENT AND METHOD FOR THE PREPARATION THEREOF
The present invention relates to controlled release pharmaceutical formulations comprising an atypical antipsychotic agent such as Paliperidone in the form of...
2019/0105276 EXTENDED RELEASE PHARMACEUTICAL FORMULATION
The invention provides an oral extended release formulation for the treatment of treatment-resistant depression and treatment-resistant anxiety.
2019/0105275 ORAL PHARMACEUTICAL COMPOSITIONS OF MESALAZINE
Described herein are pharmaceutical compositions for the oral administration of mesalazine, as well as methods of making such pharmaceutical compositions, and...
2019/0105274 TABLETS CONTAINING ARGININE AT HIGH CONCENTRATION
The invention provides a tablet that contains free-form arginine at a high content, suppresses cracking and collapse due to moisture absorption, is superior in...
2019/0105273 ACTIVE INGREDIENT CONTAINING STABILISED SOLID MEDICINAL FORMS AND METHODS FOR THE PRODUCTION THEREOF
The invention relates to solid medicinal forms containing at least one active ingredient and at least one pharmaceutically compatible, water soluble drying...
2019/0105272 SYSTEM AND APPLIANCE FOR EXTENDING THE PRODUCTION OF NITRIC OXIDE BY SPINACH EXTRACT MICROENCAPSULATED POWDER...
Disclosed are a method and an appliance for extending the production of nitric oxide by microencapsulated spinach extract powder and acidic gel. The appliance...
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