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Patent # Description
2019/0106738 DNA AMPLIFICATION METHOD
The present application relates to a method of amplifying genomic DNA, comprising: (a) providing a first reaction mixture, wherein said first reaction mixture...
2019/0106737 Size-Selection of Cell-Free DNA for Increasing Family Size During Next-Generation Sequencing
A method of increasing detection of low-abundant fragments of cell-free DNA (ccfDNA) in a biological sample is disclosed and discussed. Such a method can...
2019/0106736 COMPOSITION FOR PREVENTING DRYING OF GEL, GEL COMPOSITE AND DNA CHIP CONTAINING SAID COMPOSITE, AND METHOD FOR...
The invention provides: a composition for preventing the drying of gel with which it is possible to prevent the drying of gel more easily than in the past; a...
2019/0106735 METHOD FOR ANALYZING CANCER GENE USING MULTIPLE AMPLIFICATION NESTED SIGNAL AMPLIFICATION AND KIT
According to the present disclosure, a cancer gene analysis method comprises performing multiplex polymerase chain reaction (MPCR) on a nucleic acid sample...
2019/0106734 Devices, Compositions and Methods Pertaining To Microscopic Analysis Of Microorganisms and Other Analytes of...
This invention pertains to devices, compositions and methods that can be used for the rapid determination of microorganisms, cells and other analytes of...
2019/0106733 MOLECULAR PROGRAMMING TOOLS
The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as...
2019/0106732 LONG NON-CODING RNA GENE EXPRESSION SIGNATURES IN DISEASE DIAGNOSIS
Differential expression of long non-coding RNAs (lncRNAs) and enhancer RNAs (eRNAs) are used to diagnose diseases including neurological diseases, inflammatory...
2019/0106731 NUCLEOTIDE SEQUENCE, UNIVERSAL REVERSE PRIMER, AND UNIVERSAL RT PRIMER
A nucleotide sequence having SEQ ID NO:1, a universal reverse primer having SEQ ID NO:2, and a universal RT primer are provided. In the miRNA detection method,...
2019/0106730 POLYMERIZATION OF NUCLEIC ACIDS USING PROTEINS HAVING LOW ISOELECTRIC POINTS
This disclosure relates to the use of one or more proteins (e.g., globular proteins) having a low isoelectric point and/or a limited number (e.g., zero) of...
2019/0106729 LINKED TARGET CAPTURE
The invention generally relates to sequencing library preparation methods. In certain embodiments, two or more template nucleic acids are joined together by a...
2019/0106728 DETERMINING ANALYTE CONCENTRATION FROM VARIANT CONCENTRATION DISTRIBUTION IN MEASURABLE SPECIES
A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system...
2019/0106727 Method for Measuring Protein and Nucleic Acid with Ultrahigh Sensitivity
The present invention pertains to an enzymatic measurement method using an antibody-enzyme complex or a nucleic acid probe measurement method using an...
2019/0106726 BIOLOGICAL INDICATOR
This invention relates to a biological indicator, comprising: a carrier; and a spore deposit on the carrier, wherein at least about 95% of the area of the...
2019/0106725 BIOLOGICAL INDICATOR
This invention relates to a biological indicator, comprising: a carrier; and a spore deposit on the carrier, wherein from about 70% to about 95% of the area of...
2019/0106724 BROTH MICRODILUTION METHOD FOR EVALUATING AND DETERMINING MINIMAL INHIBITORY CONCENTRATION OF ANTIBACTERIAL...
The present invention provides components, assays and methods for evaluating antibacterial effectiveness and determining minimal inhibitory concentration (MIC)...
2019/0106723 APPARATUS, SYSTEM AND METHOD FOR LIVE BACTERIA MICROSCOPY
A system for detecting microbial cells in a sample includes an apparatus configured to image at least one cell in the sample, and a cooling device. The...
2019/0106722 Production of Glycosylated Melanin Precursors in Recombinant Hosts
The invention relates to methods for producing melanin and melanin precursors, derivatives, and intermediates. In particular, recombinant microorganisms are...
2019/0106721 Method for the fermentative production of L-amino acids
A method for the fermentative production of an L-amino acid, selected from L-lysine, L-threonine and L-isoleucine, includes cultivating a bacterium of the...
2019/0106720 PRODUCTION OF XYLITOL FROM A MIXTURE OF HEMICELLULOSIC SUGARS
Materials and methods are described to produce xylitol from a mixture of hemicellulosic sugars by several routes. Examples include either as a direct...
2019/0106719 RECOMBINANT YEAST AND METHOD FOR PRODUCING ETHANOL USING THE SAME
This invention is aimed at improving an ethanol fermentation ability of a recombinant yeast strain having an ability of assimilating pentose, such as xylose or...
2019/0106718 LIGNOCELLULOSIC CONVERSION PROCESS COMPRISING SULFUR DIOXIDE AND/OR SULFUROUS ACID PRETREATMENT
Provided herein is a process for producing one or more products from a lignocellulosic feedstock. The process comprises treating the lignocellulosic feedstock...
2019/0106716 Biocementation Methods and Systems
The invention is directed to kits, compositions, tools and methods comprising a cyclic industrial process to form biocement. In particular, the invention is...
2019/0106715 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0106714 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0106713 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0106712 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0106711 METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific...
2019/0106710 Oncogenic Models Based on Delivery and Use of the CRISPR-Cas Systems, Vectors and Compositions
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2019/0106709 HSV VECTORS WITH ENHANCED REPLICATION IN CANCER CELLS
An oncolytic HSV vector comprising an NF-.kappa.B response element or an Oct-3/4-SOX2 response element in a regulatory region of a viral gene that affects...
2019/0106708 EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION IN LIVESTOCK
Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease...
2019/0106707 Compositions and Methods for Inducing Resistance to Soybean Cyst Nematode Via RNAI
RNAi compositions and methods are provided which inhibit soybean nematode cyst infestation. Also disclosed are plants comprising said RNAi.
2019/0106706 METHOD OF INHIBITING PLANT VIRUS PATHOGEN INFECTIONS BY CRISPR/CAS9-MEDIATED INTERFERENCE
A genetically modified tobacco plant or tomato plant resistant to at least one pathogenic geminiviridae virus species is provided. The plant comprises a...
2019/0106705 HERBICIDE TOLERANT PROTEIN, CODING GENE THEREOF AND USE THEREOF
A herbicide tolerant protein SUM1, a coding gene thereof and a use thereof, wherein the herbicide tolerant protein comprises: (a) a protein having an amino...
2019/0106704 REGULATION OF ZINC DEFICIENCY AND TOLERANCE IN PLANTS
The invention relates to a method to change the capacity of a plant for adaptation to changes in the zinc concentration in the environment, especially the...
2019/0106703 METHODS AND COMPOSITIONS FOR GENERATING DOUBLED HAPLOID PLANTS AND USE OF SAME IN BREEDING
The present invention generally provides methods to generate plants with high frequency of spontaneous haploid genome doubling for use in doubled haploid...
2019/0106702 EXPRESSION OF PROTEINS IN GRAM-NEGATIVE BACTERIA WHEREIN THE RATIO OF PERlPLASMIC VOLUME TO CYTOPLASMIC VOLUME...
Provided are modified Gram-negative bacteria having an increased periplasmic volume. Also provided are methods of expressing exogenous genes in the bacteria...
2019/0106701 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL,...
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents...
2019/0106700 siRNA And Their Use In Methods And Compositions For Inhibiting The Expression Of The ORAI1 Gene
The invention relates to siRNA molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the ORAil gene. The...
2019/0106699 siRNA Targeting LDHA
Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize...
2019/0106698 METHOD FOR APTAMER PAIR SELECTION
Methods for selecting single or multiple aptamer pairs against target molecules in free solution have been developed. These methods utilize novel cooperative...
2019/0106696 CHIRAL DESIGN
The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of...
2019/0106695 OLIGONUCLEOTIDE COMPOSITIONS AND USES THEREOF
The present invention provides oligonucleotide inhibitors of miR-155 and compositions thereof. The invention further provides methods for treating cancer such...
2019/0106694 GNAQ Targeted dsRNA Compositions and Methods for Inhibiting Expression
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a G-alpha q subunit (GNAQ) of a heterotrimeric G gene, and methods of using the...
2019/0106693 Methods of Making and Using Guide RNA for Use With Cas9 Systems
CRISPR/Cas Systems are provided where guide RNAs include one or more selected RNA sequences for delivery to a target nucleic acid sequence.
2019/0106692 POLYNUCLEOTIDE CAPTURE MATERIALS, AND METHODS OF USING SAME
Methods for processing polynucleotide-containing biological samples, and materials for capturing polynucleotide molecules such as RNA and/or DNA from such...
2019/0106691 GLYCOSYLATION INDEPENDENT PROTEINS
A engineered alpha-galactosidase A polypeptide comprising SEQ ID NO: 1 having at least one non-glycosylation mutation; and at least one glycosylation...
2019/0106690 Cellulase Variants And Polynucleotides Encoding Same
Provided are cellulase variants and polynucleotides encoding the variants. And provided are nucleic acid constructs, vectors, and host cells comprising the...
2019/0106689 XYLANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to xylanase variants, polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the...
2019/0106688 FUSION PROTEIN FOR CRISPR/CAS SYSTEM AND COMPLEX COMPRISING THE SAME AND USES THEREOF
Provided are a fusion protein used in a CRISPR/Cas system, a complex including the same, and uses thereof. The fusion protein may efficiently be used as an...
2019/0106687 Engineered CRISPR-Cas9 Nucleases with Altered PAM Specificity
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
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