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Patent # Description
2019/0106484 ANTIBODY AGAINST PEPTIDE ENCODED BY EXON-21 OF PERIOSTIN AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR...
The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is...
2019/0106483 Methods of Treating Fibromyalgia
The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of chronic pain and/or symptoms of chronic pain, and to a method of...
2019/0106482 RSV-SPECIFIC ANTIBODIES AND FUNCTIONAL PARTS THEREOF
This application provides antibodies and functional equivalents thereof which are capable of specifically binding RSV, as well as means and methods for...
2019/0106481 CMV NEUTRALIZING ANTIGEN BINDING PROTEINS
A supercritical extractor system may include extractor chambers coupled to a supercritical fluid pump and configured to receive a matrix for an extraction...
2019/0106480 CHIMERIC PROTEINS AND THEIR USE IN IDENTIFYING ANTI-DEUBIQUITINASE COMPOUNDS
A chimeric protein having deubiquitinase activity, methods of identifying anti-deubiquitinase compounds using chimeric proteins, and kits comprising chimeric...
2019/0106479 Immune Tolerant Elastin-Like Peptide Tetramer Guided Nanoparticles And Methods Of Use
Disclosed herein, are nanoparticles comprising one or more immune-tolerant elastin-like polypeptide tetramers and one or more immune-tolerant elastin-like...
2019/0106478 FUSION PROTEINS OF PD-1 AND 4-1BB
The present invention relates to fusion proteins comprising (a) an extracellular domain containing a polypeptide derived from PD-1 or CD40L at its N-terminus;...
2019/0106477 NOVEL IMMUNOGENIC CD1D BINDING PEPTIDES
The invention relates to isolated immunogenic peptides comprising a CD1d binding peptide, and immediately adjacent or separated from said CD1d binding peptide,...
2019/0106476 T-CELL MODULATORY MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF
The present disclosure provides T-cell modulatory multimeric polypeptides comprising two different immunomodulatory polypeptides, at least one of which is a...
2019/0106475 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) which bind the HLA-A*02 restricted peptide SLYNTVATL (SEQ ID NO: 1) derived from the HIV Gag gene...
2019/0106474 COMPOUNDS WITH REDUCED RING SIZE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND...
The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in...
2019/0106473 CONJUGATES, THEIR COMPOSITIONS, THEIR USES, AND THEIR METHODS OF MAKING
Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) including but not limited to conjugates comprising FK-506 and...
2019/0106472 Interleukin 15 (IL-15) Antagonists and Uses Thereof for the Treatment of Autoimmune Diseases and Inflammatory...
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases....
2019/0106471 MODIFIED INTERLEUKIN-7 PROTEIN
The present invention provides a modified interleukin-7 and a use thereof. The modified IL-7 or an IL-7 fusion protein of the present invention comprising the...
2019/0106470 ERYTHROPOIETIN VARIANTS
The present invention relates to novel endogenous variants of erythropoietin (EPO) and their use for treatment or prevention of a condition associated with...
2019/0106469 Over-Expression of AZF1 Improves the Rate of Anaerobic Xylose Fermentation in Engineered Yeast Strains
The present invention provides an isolated AZF1 gene sequence, recombinant vectors, and recombinant yeast which are useful in methods of enhanced biofuel...
2019/0106468 WNT/SFRP COMPLEXES, WNT-CONTAINING COMPOSITIONS, WNT-EXPRESSING CELLS, AND METHODS OF MAKING, PURIFYING, AND...
This disclosure describes isolated protein complexes including a Wnt and a sFRP; compositions including a Wnt; a cell overexpressing a Wnt and a sFRP;...
2019/0106467 CHIMERIC SPIDER SILK AND METHODS OF USE THEREOF
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength...
2019/0106466 MEDICINAL PLANTS
In one aspect the invention comprises a transgenic garlic plant expressing pokeweed antiviral protein or a fusion protein comprising pokeweed antiviral protein...
2019/0106465 GENETICALLY MODIFIED MICROALGAE
The present disclosure provides genetically modified Chlorella sorokiniana. DAD1 gene is overexpressed in wild type Chlorella sorokiniana to obtain the...
2019/0106464 REGULATION OF THE RAS/CAMP/PKA SIGNALING PATHWAY IN YEASTS
The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation...
2019/0106463 ENGINEERED POLYPEPTIDES FOR ANTIGEN DELIVERY
Recombinant high affinity Invasin polypeptide are provided herein. Further provided are methods of delivering therapeutics such as vaccines by conjugation to...
2019/0106462 Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of Dengue Virus Infection
Dengue Fever (DF) and Dengue Hemorrhagic Fever (DHR) are significant global public health problems and understanding the overall immune response to infection...
2019/0106461 INFLUENZA VIRUS VACCINES AND USES THEREOF
Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides...
2019/0106460 BINDING INHIBITORS OF THE BETA. TRANSDUCIN REPEAT-CONTAINING PROTEIN
The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (.beta.TrCP), and modulate the activity of .beta.TrCP. In...
2019/0106459 COMPOUNDS, LINKER-DRUGS AND LIGAND-DRUG CONJUGATES
A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently,...
2019/0106458 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount...
2019/0106457 METHOD FOR PREPARING S-Bz-MAG3 AS A PRECURSOR OF CONTRAST MEDIA
The present invention provides a method for preparing S-Bz-MAG3 as a precursor of contrast media. Thioglycolic acid and benzoyl chloride are taken for the...
2019/0106456 COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME
Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other...
2019/0106455 METHOD FOR PREPARING A FARNESOID X RECEPTOR AGONIST
The invention relates to a process for preparing a compound of formula (I) ##STR00001## in particular obeticholic acid and intermediates suitable for its ...
2019/0106454 COMPOUNDS LINKED WITH A SACCHARIDE METAL COMPLEX AND USES THEREOF
The present disclosure provides compounds linked with a saccharide-metal complex. The compounds are designed to protect organs by inducing acquired...
2019/0106453 COMPLEXES OF NUCLEIC ACID MOLECULES AND METALS
Provided is a conductive nucleic acid-metal complex including a polyG and PolyC consisting nucleic acids associated with a plurality of metal atoms, and...
2019/0106452 RNA NANOPARTICLES FOR BRAIN TUMOR TREATMENT
The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the...
2019/0106451 MANNOSE-DERIVED ANTAGONISTS OF FIMH USEFUL FOR TREATING DISEASE
The present invention relates to mannoside derivative compounds useful as inhibitors of FimH and methods for the treatment or prevention of urinary tract...
2019/0106450 Mannose Derivatives for Treating Bacterial Infections
The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: ##STR00001## The...
2019/0106449 METHODS FOR PRODUCING FERRIC MALTOL COMPOSITIONS FROM LIGAND MODIFIED AND LIGAND COATED FERRIC HYDROXIDES
Methods for producing ferric maltol compositions, such as ferric trimaltol, are described in which maltolis reacted with a ligand modified ferric hydroxide...
2019/0106448 MANGANESE (III) CATALYZED C--H AMINATIONS
Reactions that directly install nitrogen into C--H bonds of complex molecules are significant because of their potential to change the chemical and biological...
2019/0106447 Guanine Analogs as Telomerase Substrates and Telomere Length Affectors
This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are...
2019/0106446 BENZOTRIAZOLE DERIVATIVE, PREPARATION PROCESS AND THE USE THEREOF
The present invention relates to a benzotriazole derivative, a preparation process thereof and the use thereof in preparation of the lubricating oil...
2019/0106445 QUATERNARY AMMONIUM ETIDRONATES
The present invention provides a quaternary ammonium etidronate compound (QAE) comprising a quaternary ammonium cation and an etidronate anion, having the...
2019/0106444 STABILIZER FOR PRODUCING A POLYESTER RESIN, PROCESS FOR PREPARING THE SAME, PROCESS FOR PRODUCING THE POLYESTER...
A stabilizer for producing a polyester resin comprises a phosphate ester composition which includes a phosphate ester compound having Formula (I), ##STR00001## ...
2019/0106443 METHOD FOR PRODUCING AN IONIC LIQUID
The present invention is directed to a method of preparing an alkoxy silane functional ionic liquid comprising reacting a halogenated compound comprising a...
2019/0106442 LITHIUM ALKYLSILICONATE COMPOSITION, COATING, AND METHOD OF MAKING SAME
A method of making a lithium alkylsiliconate composition comprising adding an alkylalkoxysilane to a first mixture comprising lithium hydroxide and water to...
2019/0106441 Mixtures Of Cyclic Branched Siloxanes Of The D/T Type And Conversion Products Thereof
Mixtures of cyclic branched siloxanes having exclusively D and T units, with the proviso that the cumulative proportion of the D and T units having Si-alkoxy...
2019/0106440 COMPOSITION OF MATTER
The method relates to the field of asymmetric allylic amination and comprises preparing a chiral N-substituted allylic amine compound from the corresponding...
2019/0106439 HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER
Disclosed herein are heterocyclic compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of...
2019/0106438 PROCESS FOR THE PREPARATION OF 6-(2-HYDROXY-2-METHYLPROPOXY)-4-(6-(6-((6-METHOXYPYRIDIN-3-YL)METHYL)-3,6- ...
In some embodiments, provided herein is a process for preparing a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, as disclosed...
2019/0106437 FUSED HETEROCYCLIC COMPOUND
Provided is a compound represented by the following formula, or a salt thereof: ##STR00001## [wherein each symbol is as defined herein.].
2019/0106436 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular...
2019/0106435 PROCESS FOR PREPARING CARBAMOYLPYRIDONE DERIVATIVES AND INTERMEDIATES
The present invention relates to the preparation of carbamoylpyridone derivatives such as the compound of formula (VIII): ##STR00001##
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