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Patent # Description
2019/0106434 N-[3-[2-AMINO-5-(1,1-DIFLUOROETHYL)-4,4A,5,7-TETRAHYDROFURO[3,4-D][1,3]OXA- ...
The present invention provides N-[3-[2-Amino-5-(1,1-difluoroethyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]ox- ...
2019/0106433 THIENOPYRIMIDINE INHIBITORS OF ATYPICAL PROTEIN KINASE C
The present application provides a compound of formula (I) ##STR00001## or a salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A, G, M,...
2019/0106432 PROCESS FOR IMPROVED OXYCODONE SYNTHESIS
Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of...
2019/0106431 NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as...
2019/0106430 3-(CARBOXYMETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES
The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2019/0106429 3-((Hetero-)Aryl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in...
2019/0106428 METHOD OF PREPARATION OF FLORASULAM
The present disclosure concerns a method for preparing florasulam which involves treating a solution of 2,6-difluoroaniline in 1,2-propylene glycol with: a)...
2019/0106427 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Heterocyclic compounds as Wee1 inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular...
2019/0106426 IMIDAZOPYRAZINES AS LSD1 INHIBITORS
The present invention is directed to imidazo[1,2-a]pyrazine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
2019/0106425 HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS
The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: ...
2019/0106424 PYRIMIDO-DIAZEPINON KINASE SCAFFOLD COMPOUNDS AND METHODS FOR TREATING P13K-MEDIATED DISORDERS
The present invention relates to use of pyrimido-diazepinone compounds that are able to modulate protein kinases such as PI3K-.gamma. and PI3K-.delta., which...
2019/0106423 COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE
Provided herein, inter alia, are compounds and methods for modulating Bruton's Tyrosine Kinase.
2019/0106422 PYRROLOPYRIMIDINE DERIVATIVES AS MPS1/TTK KINASE INHIBITORS
Disclosed herein are novel compounds that are Mps1/TTK inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds...
2019/0106421 PHARMACEUTICAL FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND MANUFACTURING METHOD THEREOF
The present invention relates to a process for producing crystalline and amorphous forms of a diazabicyclooctane derivative represented by Compound (I) and...
2019/0106420 JAK Kinase Inhibitor Compounds for Treatment of Respiratory Disease
The invention provides compounds of formula (I): ##STR00001## wherein X is ##STR00002## and the variables are defined in the specification, or a ...
2019/0106419 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF
Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting HPK1 activity and pharmaceutical compositions comprising such compounds....
2019/0106418 NEW TOLL-LIKE RECEPTOR 9 ANTAGONISTS
The present invention relates to a compound or a pharmaceutically acceptable salt thereof or a solvate thereof or a pharmaceutical composition comprising said...
2019/0106417 BIFUNCTIONAL MOLECULES FOR DEGRADATION OF EGFR AND METHODS OF USE
The present application provides bifunctional compounds of Formula (I): ##STR00001## which act as protein degradation inducing moieties for EGFR and/or a mutant...
2019/0106416 PROCESS FOR THE PREPARATION OF PROPIONIC ACID DERIVATIVES
The invention relates to a process for the preparation of a compound of formula (I) ##STR00001## or a salt thereof.
2019/0106415 LKB1-AMPK ACTIVATORS FOR THERAPEUTIC USE IN POLYCYSTIC KIDNEY DISEASE
Compounds can be used for treating polycystic kidney disease (PKD). As such, these compounds can be used in associated methods. The methods can include: method...
2019/0106414 SUBSTITUTED-INDOLE-COMPOUNDS AS ESTROGEN RECEPTOR DOWN-REGULATORS
Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof...
2019/0106413 INHIBITOR COMPOUNDS
The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1)....
2019/0106412 SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS
Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering...
2019/0106411 HETEROCYCLIC COMPOUND
Provided is a compound of formula (I) or an N-oxide thereof, wherein Het.sup.1 represents Het.sup.1-1, Het.sup.1-2, Het.sup.1-3, Het.sup.1-4 or Het.sup.1-5,...
2019/0106410 PLINABULIN COMPOSITIONS
Disclosed herein are plinabulin polymorphs, compositions, their use and preparation as therapeutic agents. In particular, some embodiments relate to plinabulin...
2019/0106409 NOVEL TYPES OF C-3 SUBSTITUTED KYNURENIC ACID DERIVATIVES WITH IMPROVED NEUROPROTECTIVE ACTIVITY
The invention relates to C-3 substituted kynurenic acid derivatives with the general formula (I) wherein R.sup.1 is C.sub.1-7alkyl-, ...
2019/0106408 METHOD FOR PREPARING THE ANHYDROUS CRYSTALLINE FORM OF ISONIAZID-DERIVED HYDRAZONE, THUS PRODUCED CRYSTALLINE...
A method for preparing the anhydrous crystalline form of isoniazid-derived hydrazone (8-hydroxyquinoline-2-carboxaldehyde isonicotinoyl hydrazone), to the thus...
2019/0106407 SYNTHESIS OF INDAZOLES
The present invention relates to a novel method of preparing a 2-substituted indazole of structure: (I), to intermediate compounds, and to the use of...
2019/0106406 Tetrahydroisoquinoline Derivatives
The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from...
2019/0106405 SOLID FORMS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)M- ...
Solid forms comprising 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)m- ethyl)-2,2-difluoroacetamide, compositions comprising the...
2019/0106404 PROCESS FOR SYNTHESIZING 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)-PYRIDIN-3-YL)METHOXY)BENZAL- DEHYDE
Disclosed herein are processes for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzal- dehyde (also referred to herein as...
2019/0106403 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers,...
2019/0106402 Physical Form Of A SGR Modulator
A crystalline form of 2,2-difluoro-N-[(1R,2S)-3-methyl-1-{[1-(1-methyl-6-oxo-1,6-dihydropyridin- -3-yl)-1H-indazol-5-yl]oxy}-1-phenylbutan-2-yl]propanamide...
2019/0106401 COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,- ...
Described herein are coformer salts of (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,- ...
2019/0106400 Process For Preparing Pleuromutilin
The present disclosure provides processes for preparing (+)-pleuromutilin and synthetic (+)-pleuromutilin produced therefrom. Also provided are intermediates...
2019/0106399 MANNITOL BASED GELATORS FOR OIL SPILLAGE APPLICATIONS
In accordance with the present subject matter there is provided sugar-based compounds of formula I, methods of making such compounds, gels comprising such...
2019/0106398 COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE
There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of...
2019/0106397 EPOXIDATION USING PEROXYGENASE
The invention relates to enzymatic methods for epoxidation of a non-cyclic aliphatic alkene, or a terpene.
2019/0106396 BIS-DIAZENIUMDIOLATE COMPOUNDS AS ANTI-CANCER AGENTS
A series of double-component, bis O.sup.2-aryl diazeniumdiolate derivatives are provided, of which each molecule can release up to four nitric oxide molecules....
2019/0106395 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND...
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having...
2019/0106394 SUBSTITUTED BENZOXAZINE AND RELATED COMPOUNDS
The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa,...
2019/0106393 [4-(1,3,3-TRIMETHYL-2-OXO-3,4-DIHYDRO-1H-QUINOXALIN-7-YL)PHENOXY]ETHYLOXY COMPOUND OR SALT THEREOF
The present invention relates to defined quinoxalin-2-one compounds or a pharmaceutically acceptable salt or a hydrate or a solvate thereof. The compounds,...
2019/0106392 HDAC INHIBITORS FOR THE TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY
The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are...
2019/0106391 COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES
The present invention describes spirobifluorene derivatives substituted by pyridine and/or pyrimidine groups, especially for use in electronic devices. The...
2019/0106390 COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT USING SAME, AND ELECTRONIC DEVICE COMPRISING SAME
Provided are an organic electric element and an electronic device thereof comprising a mixture of the compounds of Formula 1 and Formula 2 as a phosphorescent...
2019/0106389 NOVEL FORMS OF APREMILAST
The present disclosure is directed to novel forms of apremilast and pharmaceutical compositions comprising any of the novel forms of apremilast. Also provided...
2019/0106388 DERIVATIVES OF PYRROLE-2,5-DIONES HAVING A FUNGICIDAL ACTIVITY, THEIR AGRONOMICAL COMPOSITIONS AND USE THEREOF
Derivatives of pyrrole-2,5-diones having formula (I): (I) are described, together with agronomic compositions containing said derivatives having formula (I)...
2019/0106387 NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA
Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need...
2019/0106386 AZIRIDINYL CONTAINING COMPOUNDS AND METHODS OF INACTIVATING NUCLEIC ACID MOLECULES USING THE SAME
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more...
2019/0106385 COMPOUNDS, THEIR PREPARATION, RELATED COMPOSITIONS, CATALYSTS, ELECTROCHEMICAL CELLS, FUEL CELLS, AND USES THEREOF
In some embodiments, this application relates to inventive compounds (e.g., Formula (I), Formula (II), thiosemicarbazones and/or thiosemicarbazones and their...
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