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Patent # Description
2019/0218239 DEHYDROGENATION OF NEAT FORMIC ACID
A formic acid decomposition catalyst system includes organometallic complexes having formula 1: ##STR00001## wherein: M is a transition metal; E is P, N, or C...
2019/0218238 AMINOIODOSILANES AND METHODS OF SYNTHESIZING THESE AMINOIODOSILANES
Methods of synthesizing aminoiodosilanes are disclosed. The reaction to produce the disclosed aminoiodosilanes is represented by the formula: ...
2019/0218237 ORGANIC PHOSPHORUS-BASED COMPOUND, AND FLAME RETARDANT AND FLAME-RETARDANT PRODUCT COMPRISING THE SAME
An organic phosphorus-based compound which satisfies the following requirements (i) to (viii) and is represented by the following formula (1): (i) the organic...
2019/0218236 SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY
Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these...
2019/0218235 Phthalonitrile Monomer Modified with Organophosphorus Fragments, a Method of Producing thereof, a Binder Based...
A method of obtaining modified phthalonitriles comprising organophosphorus fragments, binding agents based thereon, and products produced with the use thereof,...
2019/0218234 PROCESS FOR THE PURIFICATION OF L-ALPHA-GLYCEROPHOSPHORYLCHOLINE
A process for the purification of L-.alpha.-glycerophosphorylcholine is described, wherein L-.alpha.-glycerophosphorylcholine is crystallized from DMSO or from...
2019/0218233 GROUP 4 TRANSITION METAL-CONTAINING FILM FORMING COMPOSITIONS FOR VAPOR DEPOSITION OF GROUP 4 TRANSITION...
Group 4 transition metal-containing film forming compositions comprising Group 4 transition metal azatrane precursors are disclosed. Also disclosed are methods...
2019/0218232 Preparation Of Aromatic-Substituted Silylamines By The Dehydrogenative Coupling Of Aromatic-Substituted Amine...
The present disclosure is directed at methods of forming an N--Si silyl bond, the method comprising contacting an organic substrate comprising an aromatic...
2019/0218231 Crystal Forms And Salt Forms Of 7h-Pyrrolo[2,3-D]Pyrimidine Compounds And Preparation Method Thereof
The present invention discloses crystal forms and salt forms of a 7H-pyrrolo[2,3-d]pyrimidine compounds and preparation methods thereof, and further discloses...
2019/0218230 FUSED BICYCLIC INHIBITORS OF MENIN-MLL INTERACTION
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to fused bicyclic compounds,...
2019/0218229 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMTORY DISEASE
Provided herein are compounds that inhibit the phosphorylation of MAPK and thus are useful in compositions and methods for treating cancer and inflammatory...
2019/0218228 ANTI-CANCER AGENTS AND PREPARATION THEREOF
Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat...
2019/0218227 SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS
The present invention relates spiro-cyclic amine derivatives of the formula (1) wherein R1; R2; R3; Q; --W-T-; R5; Z; and A have the definitions provided in...
2019/0218226 PRODRUGS OF ANTICANCER AGENTS INDOTECAN AND INDIMITECAN
Indenoisoquinoline topoisomerase I (Top1) inhibitors are a novel class of anticancer agents. The present invention discloses series of prodrugs of two...
2019/0218225 NOVEL CHIRAL SYNTHESIS OF N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]- PYRAZINES
Disclosed is a novel chiral synthesis of N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]- pyrazines of Formula (I), avoiding the use...
2019/0218224 COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be...
2019/0218223 COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE
Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be...
2019/0218222 PROCESS FOR THE PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIM- ...
Process for preparing (S)--N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a] pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide (formula I) or a...
2019/0218221 COMPOSITIONS FOR ACTIVATING PYRUVATE KINASE
Compositions for the activation of PKR are provided, as well as therapeutic administration of the compositions for the treatment of pyruvate kinase-related...
2019/0218220 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the ATP binding site. The invention...
2019/0218219 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS
The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and...
2019/0218218 N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS
The invention provides a compound of Formula (I) ##STR00001## or a pharmaceutically acceptable salt of the compound, wherein R.sup.1, R.sup.2, R.sup.3, Z,...
2019/0218217 Tetrahydro-Pyrido-Pyrimidine Derivatives as PI3Kdelta inhibitors
The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), ##STR00001## wherein Y, R1, R2 and m are as defined in the...
2019/0218216 PYRIDOPYRIMIDINES DERIVATIVES COMPOUNDS
The present invention describes new pyridopyrimidine derivatives compounds with structure represented by General Formula (I): ##STR00001## or pharmaceutically...
2019/0218215 CYANO-SUBTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30
The present invention relates to a class of cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in...
2019/0218214 Inhibition of BMP Signaling Compounds, Compositions and Uses Thereof
Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of...
2019/0218213 FUSED PYRIMIDINE PIPERIDINE CYCLIC DERIVATIVE, PREPARATION PROCESS AND USE THEREOF
The present invention relates to the fused pyrimidine piperidine cyclic derivative represented by the following formula (I) and a pharmaceutically acceptable...
2019/0218212 HETEROARYL COMPOUNDS FOR KINASE INHIBITION
Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical...
2019/0218211 NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5-DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE...
The present invention provides, inter alia, compounds of formula I as protein kinase modulators, methods of preparing them, pharmaceutical compositions...
2019/0218210 CRYSTAL FORM OF PYRROLOQUINOLINE QUINONE SODIUM SALT AND PREPARATION METHOD AND USE THEREOF
Provided are crystal forms I, II, III and IV of a pyrroloquinoline quinone sodium salt and a preparation method thereof. Also provided are a pharmaceutical...
2019/0218209 CRYSTAL FORMS OF NBI-98854, PREPARATION METHOD AND USE THEREOF
The present disclosure relates to novel crystalline forms of NBI-98854 (as shown in formula I), preparation process and use thereof. The crystalline forms of...
2019/0218208 BICYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS
Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering...
2019/0218207 3-(Pyridin-3-yl)-Acrylamide and N-(Pyridin-3-yl)-Acrylamide Derivatives and Their Use as PAK or NAMPT Modulators
The invention generally relates to cyclic compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable...
2019/0218206 NEOPETROSIDES A AND B, AND SYNTHESIS METHOD THEREOF
The present invention relates to novel pyridine nucleoside compounds, Neopetroside A (NPS A) and Neopetroside B (NPS B) obtained by fractionating an extract of...
2019/0218205 PYRAZOLE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS
The present invention provides a selection of compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for...
2019/0218204 BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
2019/0218203 Neuroprotective Compounds and Use Thereof
Provided herein is compositions and methods for reducing one or both of axonal degeneration and neuronal cell death associated with a disease.
2019/0218202 PROCESS OF MAKING SOMATOSTATIN MODULATORS
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
2019/0218201 POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of...
2019/0218200 POTASSIUM CHANNEL MODULATORS
Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or...
2019/0218199 NOVEL CATIONIC PHOTOINITIATOR AND PREPARATION METHOD AND USE THEREOF
This invention discloses a novel cationic photoinitiator and a preparation method and use thereof. The cationic photoinitiator has a structure as represented...
2019/0218198 CALLYSPONGIOLIDE, ANALOGS THEREOF AND USES THEREOF
Described herein are compounds of the formula (I)-(III) (or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof), as well as...
2019/0218197 DAPAGLIFLOZIN CRYSTAL FORM AND PREPARATION METHOD AND USE THEREOF
Disclosed are a new dapagliflozin crystal form and a preparation method and use thereof. In particular, disclosed are a crystal form E of ...
2019/0218196 FURANE DERIVATIVES AS INHIBITORS OF ATAD2
The invention relates to furane derivatives of formula (I) as inhibitors of ATAD2, a process for their preparation and use thereof.
2019/0218195 SINGLE STEP PROCESS FOR THE SYNTHESIS OF FURFURYL ETHYL ETHER
The present invention provides a single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol,...
2019/0218194 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
2019/0218193 SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS
Disclosed are compounds of Formula (I), Formula (II), Formula (III), and Formula (IV) or salts thereof, wherein R.sub.2 is --OH or --OP(O)(OH).sub.2; and...
2019/0218192 TRIFLUOROACETYL HYDRAZIDE COMPOUNDS AND MEDICAL USES THEREOF
The present invention relates to trifluoroacetyl hydrazide compounds and medical uses thereof. The compounds have a structure of the following formula: ...
2019/0218191 PROCESSES FOR THE PREPARATION OF URACIL DERIVATIVES
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and...
2019/0218190 THERAPEUTIC COMPOUNDS
The invention provides compounds formula (I) and salts thereof: ##STR00001## wherein R.sup.1-R.sup.4 have any of the values defined in the specification. The...
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