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Patent # Description
2019/0216918 RECOMBINANT MUMPS VIRUS VACCINE
The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuV.sup.Iowa/US/06. Further, a reverse genetics system...
2019/0216917 HMPV RNA VACCINES
The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions...
2019/0216916 METHODS FOR IMPROVING VACCINE RESPONSIVENESS
The disclosure provides methods for immunizing a subject in need thereof with a prophylactic vaccine against an infectious disease, the method comprising...
2019/0216915 TRANSGENIC VERO-CD4/CCR5 CELL LINE
The present relation relates to a transgenic Vero cell line expressing CD4 and CCR5. The present invention encompasses the preparation and purification of...
2019/0216914 TILAPIA LAKE VIRUS VACCINES
The present invention relates to vaccine compositions comprising attenuated strain of Tilapia Lake Virus (TiLV) for protecting tilapia fish against infection...
2019/0216913 VACCINE CONSTRUCTS AND USES THEREOF AGAINST STAPHYLOCOCCUS INFECTIONS
There is provided a fusion construct of formula (I): X-A-linker-B-Z (I) wherein: (1) A and B are identical or different and are independently: (a) a...
2019/0216912 ANTIGEN SPECIFIC MULTI EPITOPE-BASED ANTI-INFECTIVE VACCINES
The invention provides peptide vaccines comprising the signal peptide domain of selected target antigens of intracellular pathogens. The peptide vaccines of...
2019/0216911 RECOMBINANT EIMERIA MAXIMA PROTEIN DELIVERED AS NANOPARTICLES
Provided herein are immunogenic compositions containing recombinant proteins capable of presenting all, or antigenic portions of, the Eimeria maxima, Eimeria...
2019/0216910 BIOMATERIALS FOR MODULATING IMMUNE RESPONSES
The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens.
2019/0216908 Adoptive T-Cell Therapy
The present invention generally relates to T-cells, such as CD8+ T-cells, CD4+ T-cells, CD3+ T-cells, .gamma..delta. T-cells or natural killer (NK) T-cells,...
2019/0216907 COMPOSITIONS FOR AND METHODS OF TREATING AND PREVENTING CANCER TARGETING TUMOR ASSOCIATED CARBOHYDRATE ANTIGENS
Compositions useful to induce anti-TACA immune response and kits comprising the same and methods of using the compositions to treat and prevent cancer are...
2019/0216906 POLYVALENT VENOM VACCINES, METHODS OF USE AND MAKING
This disclosure relates to materials and methods useful for vaccinating mammals against the effects of envenomation by venomous organisms (including the...
2019/0216905 TPP-1 Formulations and Methods for Treating CLN2 Disease
Formulations comprising recombinant human tripeptidyl peptidase-1 (rhTPP1) for intrathecal, intracerebroventricular, or intraocular administration, and kits...
2019/0216904 METHODS AND PHARMACEUTICALS FOR TREATMENT OF VIRAL INFECTIONS OF THE EYE
Viral infections of the eye, and particularly viral infections in the Herpesviridae and Adenoviridae families, can be treated by administration of a...
2019/0216903 METHODS OF CYTOTOXIC GENE THERAPY TO TREAT TUMORS
A method is disclosed for decreasing or retarding an increase in the size of a localized or metastatic tumor by using a combination of an immune stimulating...
2019/0216902 AMINO ACID COMPOSITION FOR COLLAGEN FORMATION
An amino acid composition for collagen formation includes a first chain unit component, a second chain unit component, and a third chain unit component of...
2019/0216901 ACTH PROPHYLACTIC TREATMENT OF RENAL DISORDERS
Provided herein are methods for prophylactic treatment of renal disorders comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog,...
2019/0216900 METHODS OF TREATING MILD BRAIN INJURY
The present disclosure provides methods for treating mild brain injury and other neurological disorders in a subject, comprising administering to the subject...
2019/0216899 SYSTEMS AND METHODS FOR CARDIAC PLEXUS NEUROMODULATION
Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying...
2019/0216898 Interleukin Combination and Use Thereof
Disclosed are an interleukin combination or fusion proteins for preventing and/or treating malignant tumors, and various products prepared with same and the...
2019/0216897 DETECTION OF CD5 AND METHODS AND COMPOSITIONS FOR MODULATING CD5
The present disclosure provides for methods and compositions for the modulation of CD5 in a subject. Also provided are methods of detecting and monitoring...
2019/0216896 Embryo Implantation
The present invention relates to methods of and compositions comprising cytokines for, improving the success rate of embryo implantation and the success rate...
2019/0216895 BOLAAMPHIPHILIC COMPOUNDS, COMPOSITIONS AND USES THEREOF
Bolaamphiphilic compounds are provided according to formula I: HG.sup.2--L.sup.1--HG.sup.1 I where HG.sup.1, HG.sup.2 and L.sup.1 are as defined herein. Provided ...
2019/0216894 Medical Use of Creg Protein for Prevention or Treatment of Overweight, Obesity and Related Diseases Thereof
Described is the use of an E1A activating gene repressor (CREG) protein, in particular to a use of a CREG protein or an active fragment thereof in manufacture...
2019/0216893 COMPOSITIONS AND METHODS OF MODULATING IMMUNE RESPONSE
Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed, herein are methods, pharmaceutical...
2019/0216892 HISTONE DEACETYLASE (HDAC) INHIBITOR UP-REGULATES CAR EXPRESSION AND TARGETED ANTIGEN INTENSITY, INCREASING...
Embodiments of the invention employ methods and compositions for enhancing potency of immune cells that express one or more therapeutic proteins. In certain...
2019/0216891 METHOD FOR MODULATING MYELINATION
A method of enhancing the myelinating activity of oligodendrocytes or progenitors thereof is disclosed. The method comprises contacting the oligodendrocytes or...
2019/0216890 COMPOSITIONS, METHODS AND USES COMPRISING TENEURIN C-TERMINAL ASSOCIATED PEPTIDE -1 (TCAP-1) FOR ENHANCING...
The present matter relates to compositions comprising Teneurin C-terminal Associated Peptide-1 (TCAP-1) and methods and uses of same for enhancing and/or...
2019/0216889 METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS
Disclosed herein are methods of treating fibrosis in an individual in need thereof. The disclosed methods employ a peptide ("pUR4") in an amount effective to...
2019/0216888 USES OF BREMELANOTIDE IN THERAPY FOR FEMALE SEXUAL DYSFUNCTION
Use of a subcutaneously administered dose of between about 1.25 mg and 1.75 mg of bremelanotide or a pharmaceutically acceptable salt of bremelanotide for the...
2019/0216887 Melanocortin Receptor-Specific Peptides
Melanocortin receptor-specific cyclic peptides of the formula ##STR00001## where R.sub.1, R.sub.3, R.sub.4, R.sub.9 and R.sub.10 are as defined in the...
2019/0216886 Topical Compositions And Methods For Treating Wounds
In various embodiments, the present invention relates to a topical pharmaceutical composition for treating a skin condition, comprising a combination of...
2019/0216885 DOSING REGIMENS FOR TREATMENT OF FUNGAL INFECTIONS
The disclosure features pharmaceutical compositions, methods, and kits featuring dosing regimens and CD101, or a pharmaceutical acceptable salt or neutral form...
2019/0216884 EXTRACELLULAR HISTONES AS BIOMARKERS FOR PROGNOSIS AND MOLECULAR TARGETS FOR THERAPY
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to...
2019/0216883 USE OF PEPTIDE COMPOUNDS IN TREATING ACUTE PANCREATITIS
This invention discloses certain method of use of peptides and their analogs in the treatment of acute pancreatitis. The disclosed peptides and analogs can...
2019/0216882 Solid Pharmaceutical Compositions for Treating HCV
The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition...
2019/0216881 METHODS AND COMPOSITIONS FOR PRESERVING PHOTORECEPTOR AND RETINAL PIGMENT EPITHELIAL CELLS
Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular...
2019/0216880 COMPOSITION FOR TOPICAL USE BASED ON A CARNOSINE-MAGNESIUM COMPLEX
The present disclosure relates to a composition comprising a carnosine-magnesium complex. The composition is designed to be applied to the skin and causes an...
2019/0216879 PROTEIN INTERFACES
The present disclosure provides methods to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds can be...
2019/0216878 COMPOSITIONS FOR TREATING AND PREVENTING LAMINITIS, FOUNDER AND OVEREATING IN AN UNGULATE
The present invention relates to the production and use of feed compositions useful in the treatment and prevention of laminitis, founder and overeating,...
2019/0216877 COMPOSITION COMPRISING POLLEN AND/OR PISTIL EXTRACTS, PREPARATION PROCESS AND ASSOCIATED USES
An oral composition includes one or more extracts from a plant material selected from among pollen and/or pistils originating from plants belonging to the...
2019/0216876 METHOD FOR PROCESSING RAW SUGARCANE MAXIMIZING THE PRESERVATION OF POLICOSANOLS DURING PRODUCTION OF A NATURAL...
A method for processing sugarcane juice from raw sugarcane stalks to produce various forms of a natural sugarcane juice product preserves policosanols...
2019/0216875 POLYPHENOL COMPOSITION AND METHOD OF ITS USE AND MANUFACTURE IN THE TREATMENT OF METABOLIC DISORDERS
The invention provides a polyphenolic composition and method for its use and manufacture in the treatment of metabolic disorders. The active agents of the...
2019/0216874 COMMON BEAN (PHASEOLUS VULGARIS) EXTRACT WITH HIGH a-AMYLASE INHIBITORY ACTIVITY AND LOW HEMAGGLUTININ ACTIVITY
An improved method for making a p. vulgaris bean extract that results in an extract having high .alpha.-amylase inhibitory activity and low hemagglutinin...
2019/0216873 COMBINED PREPARATIONS OF URINARY ACIDIFIERS AND CRYSTALLIZATION INHIBITORS AND APPLICATION THEREOF FOR THE...
The present invention is related to the use of a separate, sequential or simultaneous combination of at least one urinary acidifier with at least one calcium...
2019/0216872 COMPOSITIONS FOR ENHANCING BRAIN ACTIVITY
A method for enhancing at least one of alertness, attention, concentration and memory in a person in need thereof, comprising co-administering an effective...
2019/0216871 DIABETIC FOOT CREAM
A diabetic foot cream composition for use in treating diabetic foot syndrome is described. The composition includes synergistically effective amounts of a...
2019/0216870 ENCAPSULATED CANNABINOID FORMULATIONS FOR TRANSDERMAL DELIVERY
Preparation of cannabinoid formulations containing: .DELTA.9-tetrahydrocannabinol (.DELTA.9-THC), .DELTA.8-tetrahydrocannabinol (.DELTA.8-THC), ...
2019/0216869 ENCAPSULATED CANNABINOID FORMULATIONS FOR ORAL DELIVERY
Preparation of cannabinoid formulations containing: .DELTA.9-tetrahydrocannabinol (.DELTA.9-THC), .DELTA.8-tetrahydrocannabinol (.DELTA.8-THC), ...
2019/0216868 ONCOLYTIC RHABDOVIRUS EXPRESSING IL12
Disclosed herein is an oncolytic recombinant Maraba virus whose genome comprises one or more nucleic acid sequences that, in combination, encode an...
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