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Patent # Description
2019/0216816 COMBINATION THERAPIES
Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor, or pharmaceutically acceptable form thereof, in...
2019/0216815 COMBINATION THERAPY COMPRISING A POLYUNSATURATED KETONE AND A FOLIC ACID PARTNER
A synergistic pharmaceutical composition for simultaneous, parallel, sequential separate use comprising a polyunsaturated ketone and a folic acid partner. The...
2019/0216814 LIQUID FORMULATIONS OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRI- ...
A liquid formulation of (S)--N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyri- midin-3-yl)-3-hydroxypyrrolidine-1-carboxamide,...
2019/0216813 SUBSTITUTED IMIDAZO[1,5-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
The invention provides substituted imidazo[1,5-a]pyrimidines and related organic compounds, compositions containing such compounds, medical kits, and methods...
2019/0216812 THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are compounds of Formula (I)-(III), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are...
2019/0216811 Inhibitors of Multidrug Resistance Transporter P-Glycoprotein
The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug...
2019/0216810 SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF
Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing...
2019/0216809 TREATMENT OF CANCER
Provided herein are compositions and methods for the treatment of a hematological malignancy. Also disclosed herein are compositions and methods for the...
2019/0216808 HEPATITIS B ANTIVIRAL AGENTS
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit the...
2019/0216807 COMBINATIONS OF A PYRIMIDINE CONTAINING NNRTI WITH RT INHIBITORS
The present invention concerns combinations of a pyrimidine containing NNRTI with nucleoside reverse transcriptase inhibitors and nucleotide reverse...
2019/0216806 NOVEL USES
This invention relates to the new use of the compound (I) or pharmaceutical acceptable salts thereof and pharmaceutical compositions containing it for the...
2019/0216805 Pharmaceutical Compositions Comprising Sorbitan Esters
The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic...
2019/0216804 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FIBROSIS
The present invention relates to methods, and pharmaceutical compositions for the treatment of fibrosis. In particular, the present invention relates to a...
2019/0216803 METHODS OF TREATING DEPRESSION WITH VORTIOXETINE
The present disclosure relates to methods of transitioning patients or obese patients being treated with vortioxetine to treatment with a monoamine oxidase...
2019/0216802 COMBINATIONS OF OPIOID/TLR4 ANTAGONISTS AND ACETAMINOPHEN FOR USE IN THE TREATMENT OF EMOTIONAL PAIN AND INSOMNIA
Disclosed are compositions for the treatment of emotional pain, physical pain, and insomnia comprising a compound comprising an opioid antagonist that treats...
2019/0216801 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION
Described herein are dosage forms of enantiomerically enriched (S)-bupropion or enantiomerically enriched (R)-bupropion. The (S)-bupropion or the (R)-bupropion...
2019/0216800 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION
Described herein are dosage forms of enantiomerically enriched (S)-bupropion or enantiomerically enriched (R)-bupropion. The (S)-bupropion or the (R)-bupropion...
2019/0216799 Compositions For Affecting Weight Loss
Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and...
2019/0216798 BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2019/0216797 Buprenorphine-wafer for drug substitution therapy
The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral,...
2019/0216796 LOWER DOSAGE STRENGTH IMIQUIMOD FORMULATIONS AND SHORT DOSING REGIMENS FOR TREATING GENITAL AND PERIANAL WARTS
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or ...
2019/0216795 Predicting Optimal Chemotherapy For CRC
Methods are provided herein for identifying whether a cancer patient, for example a colorectal cancer patient, will be responsive to treatment with a...
2019/0216794 WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED...
The present invention provides specific small molecule compounds that modulate degradation and stability of Wiskott-Aldrich Syndrome protein (WASp), methods...
2019/0216793 COMPOSITIONS AND METHODS FOR TREATING NEGATIVE SYMPTOMS IN NON-SCHIZOPHRENIC PATIENTS
The present disclosure describes compositions and methods for treating at least one negative symptom in a human subject who does not have a clinical diagnosis...
2019/0216792 CDK1 INHIBITORS OF ACETYL CHRYSIN MANNICH BASE DERIVATIVES, SYNTHESIS AND USE THEREOF
Provided is a series of acetyl Chrysin Mannich base derivatives with the structures illustrated in the following scheme: wherein R.sub.1 is acetyl and R.sub.2...
2019/0216791 FORMULATIONS OF PIMAVANSERIN
Provided herein are capsules containing pimavanserin, processes for manufacturing said capsule, and pharmaceutical compositions containing pimavanserin.
2019/0216790 Methods for Treating Pruritis
The present disclosure provides compositions and methods for treating chronic itch.
2019/0216789 Pharmaceutical Compositions Of Metabotropic Glutamate 5 Receptor (MGLU5) Antagonists
Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The...
2019/0216788 PHARMACEUTICAL SUSPENSION DOSAGE FORM OF BENZIMIDAZOLE COMPOUNDS AND PROCESS OF PREPARATION THEREOF
The present invention relates to a solid oral pharmaceutical dosage form suitable for making a suspension comprising acid labile benzimidazole compounds and...
2019/0216787 PRODRUGS OF PHENOLIC TRPV1 AGONISTS IN COMBINATION WITH LOCAL ANESTHETICS AND VASOCONSTRICTORS FOR IMPROVED...
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate...
2019/0216786 USE OF 2-{4-[(4-{[1-CYCLOPROPYL-3-TETRAHYDRO-2H-PYRAN-4-yl)-1H-PYRAZOL-4yl- ]OXY}...
The present invention relates to novel methods of using 2-{4-[(4-{[1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy- ...
2019/0216785 METHODS AND COMPOSITIONS FOR TREATMENT OF EPILEPTIC DISORDERS
Use of allosteric modulators and/or gaboxadol for the treatment of epileptic disorders in a subject in need thereof.
2019/0216784 PARASITICIDAL COMPOSITIONS COMPRISING AN ISOXAZOLINE ACTIVE AGENT, METHODS AND USES THEREOF
This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a...
2019/0216783 Veliparib in Combination With Carboplatin for the Treatment of Triple Negative Breast Cancer
The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount...
2019/0216782 NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2019/0216781 METHODS FOR TREATING HETEROTOPIC OSSIFICATION
The invention features dosing regimens and pharmaceutical formulations for oral administration of palovarotene. The dosing regimens can reduce heterotopic...
2019/0216780 Use Of Carbamate Compound In Order To Preventatively Treat Headaches
The present invention relates to a pharmaceutical composition for preventatively treating headaches, containing: a carbamate compound of chemical formula 1 or...
2019/0216779 USE OF NEUROKININ-1 ANTAGONISTS TO TREAT A VARIETY OF PRURITIC CONDITIONS
The disclosure relates to the use of neurokinin-1 (NK-1) antagonists, such as serlopitant, in treating acute or chronic pruritus associated with a variety of...
2019/0216778 PYRROLIDONE CARBOXYLIC ACID (PCA) FOR OPHTHALMIC USE
The present invention relates to pyrrolidone carboxylic acid (PCA) and/or pharmaceutically acceptable salts or derivatives thereof for use in the treatment of...
2019/0216777 COMPOSITIONS AND METHODS FOR TREATING ALOPECIA
The present invention is directed to a composition for treating alopecia containing minoxidil, cyclosporine A and a compound that binds FK506 binding protein 4...
2019/0216776 LISINOPRIL COMPOSITIONS WITH AN INGESTIBLE EVENT MARKER
Provided herein are compositions for the ingestible administration of lisinopril. In some embodiments the compositions comprise lisinopril and silicon. In some...
2019/0216775 COMPOSITIONS AND METHODS FOR TREATING ALOPECIA
The present invention is directed to a composition for treating alopecia containing minoxidil, cyclosporine A and a compound that binds FK506 binding protein 4...
2019/0216774 TRPV4 ANTAGONISTS
The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
2019/0216773 METHODS TO MOBILIZE PROGENITOR/STEM CELLS
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred...
2019/0216772 Antioxidant-Containing Food Composition for Use in Enhancing Antiviral Immunity in Companion Animals
The invention encompasses methods for enhancing the ability of a companion animal to resist and/or overcome viral infections. The methods of the invention...
2019/0216771 COMPOSITIONS AND METHODS FOR CANCER THERAPY
The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, and one or...
2019/0216770 PHARMACEUTICAL PREPARATIONS
Pharmaceutical preparations are proposed, comprising bitter-masking acting substances for reducing and/or inhibiting gastric acid secretion induced by food...
2019/0216769 Topical Application of Delphinidin Compounds Treats Rosacea
Topical application of Delphinidin twice per day treats rosacea and maintains normal healthy skin in patients with rosacea. Delphinidin applied topically...
2019/0216768 PREPARATIONS OF TAXANES FOR INTRAVENOUS ADMINISTRATION AND THE PREPARATION METHOD THEREOF
The present invention relates to the field of medical technology. More specifically, the present invention relates to a preparation of taxanes for intravenous...
2019/0216767 TOPICAL THERAPY FOR THE TREATMENT OF SKIN KERATOSES USING NANOPARTICLES OF TAXANES
Disclosed are methods useful for the topical therapeutic treatment of skin keratoses including precancerous skin keratoses such as actinic keratosis using...
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